7 research outputs found
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
- Aasvang Gunn Marit
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abdulle Abdishakur M.
- Abera Semaw Ferede
- Abraham Biju
- Abu-Raddad Laith J.
- Abyu Gebre Yitayih
- Adebiyi Akindele Olupelumi
- Adedeji Isaac Akinkunmi
- Ademi Zanfina
- Adou Arsene Kouablan
- Adsuar Jose C.
- Afshin Ashkan
- Agardh Emilie Elisabet
- Agarwal Arnav
- Agrawal Anurag
- Ahmad Kiadaliri Aliasghar
- Ajala Oluremi N.
- Akinyemiju Tomi F.
- Al-Aly Ziyad
- Alam Khurshid
- Alam Noore K. M.
- Aldhahri Saleh Fahed
- Aldridge Robert William
- Alemu Zewdie Aderaw
- Alexander Lily T.
- Ali Raghib
- Alkerwi Ala’a
- Alla Francois
- Allebeck Peter
- Alsharif Ubai
- Altirkawi Khalid A.
- Alvarez Martin Elena
- Alvis-Guzman Nelson
- Amare Azmeraw T.
- Amberbir Alemayehu
- Amegah Adeladza Kofi
- Amini Heresh
- Ammar Walid
- Amrock Stephen Marc
- Andersen Hjalte H.
- Anderson Benjamin O.
- Anderson H. Ross
- Antonio Carl Abelardo T.
- Anwari Palwasha
- Arnlov Johan
- Artaman Al
- Asayesh Hamid
- Asghar Rana Jawad
- Assadi Reza
- Atique Suleman
- Avokpaho Euripide Frinel G. Arthur
- Awasthi Ashish
- Ayala Quintanilla Beatriz Paulina
- Azzopardi Peter
- Bacha Umar
- Badawi Alaa
- Bahit Maria C.
- Balakrishnan Kalpana
- Barac Aleksandra
- Barber Ryan M.
- Barker-Collo Suzanne L.
- Barnighausen Till
- Barquera Simon
- Barregard Lars
- Barrero Lope H.
- Basu Sanjay
- Batis Carolina
- Bazargan-Hejazi Shahrzad
- Beardsley Justin
- Bedi Neeraj
- Beghi Ettore
- Bell Brent
- Bell Michelle L.
- Bello Aminu K.
- Bennett Derrick A.
- Bensenor Isabela M.
- Berhane Adugnaw
- Bernabe Eduardo
- Betsu Balem Demtsu
- Beyene Addisu Shunu
- Bhala Neeraj
- Bhansali Anil
- Bhatt Samir
- Bhutta Zulfiqar A.
- Biadgilign Sibhatu
- Bikbov Boris
- Biryukov Stan
- Bisanzio Donal
- Bjertness Espen
- Blore Jed D.
- Borschmann Rohan
- Boufous Soufiane
- Bourne Rupert R. A.
- Brainin Michael
- Brauer Michael
- Brazinova Alexandra
- Breitborde Nicholas J. K.
- Brenner Hermann
- Broday David M.
- Brugha Traolach S.
- Brunekreef Bert
- Burnett Richard
- Butt Zahid A.
- Cahill Leah E.
- Calabria Bianca
- Campos-Nonato Ismael Ricardo
- Cardenas Rosario
- Carpenter David O.
- Carrero Juan Jesus
- Casey Daniel C.
- Castaneda-Orjuela Carlos A.
- Castillo Rivas Jacqueline
- Castro Ruben Estanislao
- Catala-Lopez Ferran
- Cercy Kelly
- Chang Jung-Chen
- Charlson Fiona J.
- Chiang Peggy Pei-Chia
- Chibalabala Mirriam
- Chimed-Ochir Odgerel
- Chisumpa Vesper Hichilombwe
- Chitheer Abdulaal A.
- Choi Jee-Young Jasmine
- Christensen Hanne
- Christopher Devasahayam Jesudas
- Ciobanu Liliana G.
- Coates Matthew M.
- Cohen Aaron J.
- Colquhoun Samantha M.
- Contreras Manzano Alejandra G.
- Cooper Leslie Trumbull
- Cooperrider Kimberly
- Cornaby Leslie
- Cortinovis Monica
- Crump John A.
- Cuevas-Nasu Lucia
- Damasceno Albertino
- Dandona Lalit
- Dandona Rakhi
- Darby Sarah C.
- Dargan Paul I.
- das Neves Jose
- Davis Adrian C.
- Davletov Kairat
- de Castro E Filipa
- De la Cruz-Gongora Vanessa
- De Leo Diego
- Degenhardt Louisa
- Del Gobbo Liana C.
- del Pozo-Cruz Borja
- Dellavalle Robert P.
- Deribew Amare
- Des Jarlais Don C.
- Dharmaratne Samath D.
- Dhillon Preet K.
- Diaz-Torne Cesar
- Dicker Daniel
- Ding Eric L.
- Dorsey E. Ray
- Doyle Kerrie E. (Aunty) (R19631)
- Driscoll Tim R.
- Duan Leilei
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- Duncan Bruce Bartholow
- Elyazar Iqbal
- Endries Aman Yesuf
- Ermakov Sergey Petrovich
- Erskine Holly E.
- Eshrati Babak
- Esteghamati Alireza
- Estep Kara
- Fahimi Saman
- Faraon Emerito Jose Aquino
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- Farinha Carla Sofiae Sa
- Faro Andre
- Farvid Maryam S.
- Farzadfar Farshad
- Feigin Valery L.
- Fereshtehnejad Seyed-Mohammad
- Fernandes Jefferson G.
- Ferrari Alize J.
- Fischer Florian
- Fitchett Joseph R. A.
- Fleming Tom
- Foigt Nataliya
- Foreman Kyle
- Forouzanfar Mohammad H.
- Fowkes F Gerry R.
- Franklin Richard C.
- Frostad Joseph J.
- Fullman Nancy
- Furst Thomas
- Futran Neal D.
- Gakidou Emmanuela
- Garcia-Basteiro Alberto L.
- Gebrehiwot Tsegaye Tewelde
- Gebremedhin Amanuel Tesfay
- Geleijnse Johanna M.
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- Gething Peter W.
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- Giroud Maurice
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- Giussani Giorgia
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- Goodridge Amador
- Gopalani Sameer Vali
- Gotay Carolyn C.
- Goto Atsushi
- Gouda Hebe N.
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- Gupta Rajeev
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- Horita Nobuyuki
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- Htet Aung Soe
- Hu Guoqing
- Huang John J.
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- Idrisov Bulat T.
- Ileanu Bogdan Vasile
- Inoue Manami
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- Jacobsen Kathryn H.
- Jahanmehr Nader
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- Jansen Henrica A. F. M.
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- Krueger Hans
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- Kuchenbecker Ricardo S.
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- Lim Stephen S.
- Liu Patrick Y.
- Liu Shiwei
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- Logroscino Giancarlo
- Lopez Alan D.
- Lotufo Paulo A.
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- Lunevicius Raimundas
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- Mahdavi Mahdi
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- Mapoma Chabila C.
- Marcenes Wagner
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- Martinez-Raga Jose
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- Matzopoulos Richard
- Mayosi Bongani M.
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- McKee Martin
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- Mehari Alem
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- Mekonnen Alemayehu B.
- Melaku Yohannes Adama
- Memish Ziad A.
- Mendoza Walter
- Mensah George A.
- Mensink Gert B. M.
- Meretoja Atte
- Meretoja Tuomo J.
- Mesfin Yonatan Moges
- Mhimbira Francis Apolinary
- Millear Anoushka
- Miller Ted R.
- Mills Edward J.
- Mirarefin Mojde
- Misganaw Awoke
- Mock Charles N.
- Mohammadi Alireza
- Mohammed Shafiu
- Mokdad Ali H.
- Mola Glen Liddell D.
- Monasta Lorenzo
- Montanez Hernandez Julio Cesar
- Montico Marcella
- Moradi-Lakeh Maziar
- Morawska Lidia
- Mori Rintaro
- Mozaffarian Dariush
- Mueller Ulrich O.
- Mullany Erin
- Mumford John Everett
- Murray Christopher J. L.
- Murthy Gudlavalleti Venkata Satyanarayana
- Nachega Jean B.
- Naghavi Mohsen
- Naheed Aliya
- Nangia Vinay
- Nassiri Nariman
- Neal Bruce
- Newton John N.
- Ng Marie
- Nguyen Quyen Le
- Nisar Muhammad Imran
- Nkamedjie Pete Patrick Martial
- Norheim Ole F.
- Norman Rosana E.
- Norrving Bo
- Nyakarahuka Luke
- Obermeyer Carla Makhlouf
- Ogbo Felix A. (S31810)
- Oh In-Hwan
- Oladimeji Olanrewaju
- Olivares Pedro R.
- Olsen Helen
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- Olusanya Jacob Olusegun
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- Ota Erika
- Pa Mahesh
- Pana Adrian
- Park Eun-Kee
- Parry Charles D.
- Parsaeian Mahboubeh
- Patel Tejas
- Paternina Caicedo Angel J.
- Patil Snehal T.
- Patten Scott B.
- Patton George C.
- Pearce Neil
- Pereira David M.
- Perico Norberto
- Pesudovs Konrad
- Petzold Max
- Phillips Michael Robert
- Piel Frederic B.
- Pillay Julian David
- Plass Dietrich
- Polinder Suzanne
- Pond Constance D.
- Pope C. Arden
- Pope Daniel
- Popova Svetlana
- Poulton Richie G.
- Pourmalek Farshad
- Prasad Noela M.
- Qorbani Mostafa
- Rabiee Rynaz H. S.
- Radfar Amir
- Rafay Anwar
- Rahimi-Movaghar Vafa
- Rahman Mahfuzar
- Rahman Mohammad Hifz Ur
- Rahman Sajjad Ur
- Rai Rajesh Kumar
- Rajsic Sasa
- Raju Murugesan
- Ram Usha
- Rana Saleem M.
- Ranganathan Kavitha
- Rao Puja
- Razo Garcia Christian Aspacia
- Refaat Amany H.
- Rehm Colin D.
- Rehm Jurgen
- Reinig Nikolas
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Resnikoff Serge
- Ribeiro Antonio L.
- Rivera Juan A.
- Roba Hirbo Shore
- Rodriguez Alina
- Rodriguez-Ramirez Sonia
- Rojas-Rueda David
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- Ronfani Luca
- Roshandel Gholamreza
- Roth Gregory A.
- Rothenbacher Dietrich
- Roy Ambuj
- Saleh Muhammad Muhammad
- Salomon Joshua A.
- Sanabria Juan R.
- Sanchez-Nino Maria Dolores
- Sanchez-Pimienta Tania G.
- Sanchez-Riera Lidia
- Sandar Logan
- Santomauro Damian F.
- Santos Itamar S.
- Sarmiento-Suarez Rodrigo
- Sartorius Benn
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- Schmidt Maria Ines
- Schneider Ione J. C.
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- Schutte Aletta E.
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- Scott James G.
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- Servan-Mori Edson E.
- Shaddick Gavin
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- Shi Peilin
- Shibuya Kenji
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- Silveira Dayane Gabriele Alves
- Silverberg Jonathan I.
- Simard Edgar P.
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- Singh Abhishek
- Singh Jasvinder A.
- Singh Prashant Kumar
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- Soljak Michael
- Soneji Samir
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- Sposato Luciano A
- Sreeramareddy Chandrashekhar T.
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- Steel Nicholas
- Stein Dan J.
- Stein Murray B.
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- Sunguya Bruno F.
- Sur Patrick J.
- Swaminathan Soumya
- Sykes Bryan L.
- Szoeke Cassandra E. I.
- Tabares-Seisdedos Rafael
- Takahashi Ken
- Talongwa Roberto Tchio
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- Tavakkoli Mohammad
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- Tedla Bemnet Amare
- Tefera Worku Mekonnen
- Tegegne Teketo Kassaw
- Tekle Dejen Yemane
- Terkawi Abdullah Sulieman
- Thakur J. S.
- Thomas Bernadette A.
- Thomas Matthew Lloyd
- Thomson Alan J.
- Thorne-Lyman Andrew L.
- Thrift Amanda G.
- Thurston George D.
- Tillmann Taavi
- Tobe-Gai Ruoyan
- Tobollik Myriam
- Topor-Madry Roman
- Topouzis Fotis
- Towbin Jeffrey Allen
- Tran Bach Xuan
- Tsala Dimbuene Zacharie
- Tsilimparis Nikolaos
- Tura Abera Kenay
- Tuzcu Emin Murat
- Tyrovolas Stefanos
- Ukwaja Kingsley N.
- Undurraga Eduardo A.
- Uneke Chigozie Jesse
- Uthman Olalekan A.
- van Donkelaar Aaron
- van Os Jim
- Varakin Yuri Y.
- Vasankari Tommi
- Veerman J. Lennert
- Venketasubramanian Narayanaswamy
- Violante Francesco S.
- Vollset Stein Emil
- Vos Theo
- Wagner Gregory R.
- Wagner Joseph A.
- Waller Stephen G.
- Wang Haidong
- Wang Jian Li
- Wang Linhong
- Wang Yanping
- Weichenthal Scott
- Weiderpass Elisabete
- Weintraub Robert G.
- Werdecker Andrea
- Westerman Ronny
- Whiteford Harvey A.
- Wijeratne Tissa
- Wiysonge Charles Shey
- Wolfe Charles D. A.
- Won Sungho
- Woolf Anthony D.
- Wubshet Mamo
- Xavier Denis
- Xu Gelin
- Yadav Ajit Kumar
- Yakob Bereket
- Yalew Ayalnesh Zemene
- Yano Yuichiro
- Yaseri Mehdi
- Ye Pengpeng
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Younis Mustafa Z.
- Yu Chuanhua
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zhao Yi
- Zhou Maigeng
- Zhu Jun
- Zipkin Ben
- Zodpey Sanjay
- Zuhlke Liesl Joanna
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Forouzanfar MH, Afshin A, Alexander LT, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. LANCET. 2016;388(10053):1659-1724.Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors-the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57.8% (95% CI 56.6-58.8) of global deaths and 41.2% (39.8-42.8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211.8 million [192.7 million to 231.1 million] global DALYs), smoking (148.6 million [134.2 million to 163.1 million]), high fasting plasma glucose (143.1 million [125.1 million to 163.5 million]), high BMI (120.1 million [83.8 million to 158.4 million]), childhood undernutrition (113.3 million [103.9 million to 123.4 million]), ambient particulate matter (103.1 million [90.8 million to 115.1 million]), high total cholesterol (88.7 million [74.6 million to 105.7 million]), household air pollution (85.6 million [66.7 million to 106.1 million]), alcohol use (85.0 million [77.2 million to 93.0 million]), and diets high in sodium (83.0 million [49.3 million to 127.5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Copyright (C) The Author(s). Published by Elsevier Ltd
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
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- Bang Andrew
- Bao Riyue
- Bao Yangyi
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- Bauman Julie
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- Bauml Joshua
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- Repasky Elizabeth
- Reshef Ran
- Restifo Nicholas
- Ribas Antoni
- Ribas Antoni
- Richardson Jennifer H
- Richardson Jennifer H
- Ridnour Lisa
- Rimoldi Donata
- Rinchai Darawan
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- Roberts David D
- Roberts David D
- Robinson William
- Rodriguez Anthony
- Rodriguez-Cruz Tania
- Roelands Jessica
- Roen Diana
- Rogers Connie J
- Rose Jason
- Ross Merrick
- Rothwell William T
- Rowlinson Scott
- Ruchko Sergey
- Ruth Nicola
- Ryan Kevin
- Saeed Abu Z
- Saenger Yvonne M
- Saenger Yvonne M
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- Saims Dan
- Saito Takuro
- Salata Daria
- Salazar Rachel
- Saleh Rachidi
- Salerno Elise
- Samiulla Dodheri
- Sams Lillian
- Sanborn J. Z
- Sanborn Rachel E
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- Santo Gregg E
- Santos João
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- Sarnaik Amod A
- Sasaki Eiji
- Saser Kate A
- Sasikumar Pottayil
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- Saunthararajah Yogen
- Sausen Mark
- Savolt Akos
- Sawant Deepali
- Sayers Thomas J
- Sayers Thomas J
- Scales Stephanie
- Schad Sara
- Schaeffeler Elke
- Schaer David
- Scharping Nicole
- Scharping Nicole
- Scheel Birgit
- Schindler Ulrike
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- Schlom Jeffrey
- Schlom Jeffrey
- Schlom Jeffrey
- Schlom Jeffrey
- Schlunegger Kyle
- Schluns Kimberly S
- Schmidt Carl
- Schmidt Emmett
- Schmidt Manuel
- Schoenfeld Jonathan
- Schoenhals Jonathan
- Scholler Nathalie
- Scholz Alexander
- Schreiber Taylor H
- Schroeder Andreas
- Schwab Matthias
- Schwartz Anthony L
- Schwartz Anthony L
- Schwendeman Anna
- Scrivens Maria
- Sebastian Martin
- Sefrin Julian P
- Segal Neil H
- Seibel Tobias
- Senbabaoglu Yasin
- Senter Peter D
- Senzer Neil
- Serpa Gregory
- Setiady Yulius
- Sette Alessandro
- Sevdali Maria
- Sexton Holly
- Sexton Holly
- Seymour Len
- Sgarrella Francesco
- Shabanowitz Jeffrey
- Shabanowitz Jeffrey
- Shafren Darren
- Shafren Darren
- Shafren Darren
- Shakya Reena
- Shamalov Katerina
- Shanker Anil
- Shanker Anil
- Sharma Manish
- Sharma Meenu
- Sharma Naveen
- Sharma Padmanee
- Shayan Gulidanna
- Shea Sofia
- Shehade Hussein
- Sheikh Nadeem A
- Shekarian Tala
- Shepard Dale
- Sherry Lorcan
- Shi Feng
- Shi Jian
- Shih Vincent F
- Shimizu Atsushi
- Shrestha Yashaswi
- Shrivastav Shruti
- Shuman Stewart
- Shuster Alexandr
- Shwonek Peter
- Sidney John
- Siebenaler Kristen
- Silk Ann
- Silk Ann W
- Silva John
- Simmons John
- Simoes Ines
- Sims Jennifer S
- Singh Manisha
- Singson Victoria
- Singson Victoria
- Siurala Mikko
- Siurala Mikko
- Sivado Eva
- Sivan Ayelet
- Sjöberg Madeleine
- Skaletskaya Anna
- Skoble Justin
- Slansky Jill
- Slingluff Craig L
- Slingluff Craig L
- Slingluff Craig L
- Slingluff Craig L
- Slingluff Craig L
- Slomovitz Brian M
- Smith Ernest
- Smith Jill
- Smith Kelly
- Smith Kelly
- Smith Leia
- Smolkin Mark E
- Smolkin Mark E
- Smolkin Mark E
- Snook Adam E
- Snzol Mario
- Sokolove Jeremy
- Solowiej Jim
- Somanchi Srinivas
- Sondel Paul M
- Soneson Charlotte
- Song Xiao-Tong
- Sotayo Alaba
- Sotirovska Natalija
- Spada Filomena
- Speers Ellen
- Speiser Daniel E
- Spektor Alexander
- Spranger Stefani
- Spurgeon Stephen
- Squalls Olivia
- Srirangam Jay
- Srivastava Raghvendra
- Staab Mary J
- Stack Edward
- Staelens Ludovicus
- Starzynska Teresa
- Steadman Lora
- Steadman Lora
- Stefano Pierini
- Stefano Pierini
- Stefano Pierini
- Steggerda Susanne
- Stein Paul L
- Stelow Edward B
- Sternby Malin
- SternJohn Julius
- Stewart Al
- Stock Wendy
- Stone Geoffrey W
- Stosnach Claudia
- Straub Tobias
- Straus Jane
- Streiner Nicole
- Ståhle Magnus
- Su Yu-Lin
- Sudarshan Naremaddepalli
- Sugarbaker David
- Sukari Ammar
- Sultan Hussein
- Sun Shaoli
- Sundararaman Srividya
- Sung Leonard
- Suresh Rahul
- Surguladze David
- Suryawanshi Satyendra
- Suryawanshi Satyendra
- Suzuki Akiko
- Suzuki Ryuji
- Sweis Randy F
- Taback Bret
- Tagliaferri Mary
- Talbert Erin
- Tallarico John
- Tan Joanne B
- Tan Joanne B L
- Tan Wei
- Tan Yann C
- Tanaka Maki
- Tang Chad
- Tannir Nizar M
- Tannir Nizar M
- Taylor Allison
- Taylor Matthew
- Tcherepanova Irina
- ter Meulen Jan
- ter Meulen Jan
- Terabe Masaki
- Terabe Masaki
- Termini James
- Tetzlaff Michael
- Tewary Poonam
- Thakurta Anjan
- Thayer Matt
- Theodoraki Marie-Nicole
- Thimme Robert
- Thomas Portia
- Thomas Remy
- Thomas Vincent
- Thompson John A
- Thounaojam Menaka
- Thounaojam Menaka
- Thurston Gavin
- Tighe Rober
- Tilahun Ashenafi
- Tillé Laure
- Timmerman John
- Tipton Kimberly A
- Tipton Kimberly A
- Tognon Christina E
- Tomai Mark A
- Toms Anne
- Torno Sebold
- Torrey Heather
- Torti Vince
- Toth Laszlo
- Trager James B
- Trappey Alfred F
- Trivedi Sumita
- Truesdell Peter
- Tsang Kwong
- Tsang Kwong
- Tsang Kwong Y
- Tsaparikos Konstantinos
- Tsouko Efrosini
- Tsujikawa Takahiro
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- Tsujikawa Takahiro
- Tuck David
- Tumang Joseph
- Tumang Joseph
- Turbitt William J
- Turk Andrew T
- Tyner Jeffery W
- Tähtinen Siri
- Tähtinen Siri
- Uecker Darrin
- Uecker Darrin
- Uecker Darrin
- Ugel Stefano
- Ugel Stefano
- Uhlik Mark
- Ujhelyi Mihaly
- Ullenhag Gustav
- Unfricht Darryn
- Ungerleider Richard
- Urban Julie
- Urban Julie
- Valsesia-Wittmann Sandrine
- Valsesia-Wittmann Sandrine
- Van der Meijs Pien
- van Vugt Marianne
- van Zutphen Mariëlle
- Vanamee Eva
- Vanderslice Peter
- VanderVeen Laurie
- Vanpouille-Box Claire I
- VanVlasselaer Peter
- Varhegyi Nikole
- Vasilakos John P
- Vaske Charles
- Vassilev Lotta
- Velcheti Vamsidhar
- Velculescu Victor
- Verma Amita
- Verma Amita
- Vetto John
- Vianden Christina
- Vietsch Eveline E
- Vignali Dario
- Vignali Dario
- Vogel Katharina
- Volkmuth Wayne
- Volz Barbara
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- Vu Tuyen
- Wada Hiroshi
- Wagtmann Nicolai
- Waldman Michelle
- Waldman Scott A
- Waller John
- Wallraven Gladice
- Walsh Richard
- Walters Ian B
- Wang Ena
- Wang Ena
- Wang Hongjie
- Wang Ping
- Wang Shangzi
- Wang Weiyi
- Wang Ximi K
- Wang Yi
- Wang Ziming
- Ward Stephen T
- Waugh Katherine
- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R
- Weiner David
- Weiner Louis M
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
- Wenthe Jessica
- Wenthe Jessica
- Werner Lauryn R
- West Brian
- West James
- West James
- Wheatley Courtney
- Whetstone Ryan
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C
- Whiting Chan C
- Wicha Max S
- Wicha Max S
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W
- Wilkinson Robert W
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Chihunt
- Wong Deborah J
- Wong Gabriel
- Wong Kenneth R
- Wong Kenneth R
- Wong Michael K
- Wood Laura
- Woodside Darren G
- Workman Creg
- Wu Bill X
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Ylösmäki Erkko
- Young Gregory
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W
- Young Steve W
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
UN RECORRIDO DESDE LA PALEONTOLOGÍA HASTA LA BIOTECNOLOGÍA EN EL DESIERTO
- Author
- Carlos Cruz Guzmán
- Claudia Martínez Vázquez
- Crescencio Urias Garcia
- Cuauhcihuatl Vital Garcia
- César Octavio Licón Trillo
- David Jonathan Lara Reimers
- Diana Uresti
- Edgar Palacios Quiñonez
- Eduardo Pacheco Rodriguez
- Felisa Josefina Aguilar Arellano
- Francisco Javier García de León
- Gissel Méndez
- Hector Rivera-Sylva
- Irma Enriquez
- Ivan Erick Sánchez Uribe
- Jose Ruben Guzman Gutierrez
- José Antonio Reyes Solís
- José María Arguijo-Núñez
- José Nicolás Lauro Aldama Meza
- José Valero Galván
- Lorena Patricia Licon Trillo
- Luis Javier Carrera Campos
- Maria Viloria
- Martha Patricia Olivas Sanchez
- Miroslava Quiñonez Martínez
- Nubia Alejandra Morales Lara
- Pablo Antonio Lavín
- Raquel González Fernández
- Raymundo Rivas
- Rocio Alejandra
- Ruben Herrera y Cairo
- Sandra Perez Alvarez
- Silvia Ivet Nava Maldonado
- Publication venue
- 'Journal of Psychology and Behavioral Sciences of the UACJS'
- Publication date
- 01/01/2023
- Field of study
Health-status outcomes with invasive or conservative care in coronary disease
- Author
- Alexander K.P.
- Baloch K.
- Bangalore S.
- Boden W.E.
- Cohen D.J.
- Diaz A.
- Gosselin G.
- Harrell F.E.
- Hochman J.S.
- ISCHEMIA Research Group: Joseph Ricci A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Raba\ue7a, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fern\ue1ndez Mart\uednez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, Andr\ue9 Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej \u141abyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Pe\uf1aranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezi\u144ska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard J\ue4ger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Car\uedsi A Polanczyk, Carita Krannila, Carla Vicente, Carl-\uc9ric Gagn\ue9, Carlo Briguori, Carlos Pe\uf1a Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Bj\uf6rklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adri\ue1n Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Nicollet, Eric Peterson, Erick Alex\ue1nderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, F Marin Ortu\uf1o, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Fl\ue1via Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidovi\u107, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Llad\uf3, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, Jo\ue3o Reynaldo Abbud, Jo\ue3o V Vitola, Joaqu\uedn V Pe\uf1afiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Vieira, Jos\ue9 M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padr\uf3, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio C\ue9sar Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna \u141oboz-Grudzie\u144, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kuku\u142a, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Lo\uefc Bi\ue8re, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de P\ue1dua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Vald\ue9s Ch\ue1varri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena \u141anocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Ma\u142gorzta Celi\u144ska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Val\ue9rio Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Mar\ueda Fernanda Canales, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moys\ue9s de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Ca\uf1avate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdo\u144czyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula Garc\ueda-Gonz\ue1lez, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vu\u10di\u107, Radmila Lyubarova, Radoslaw Pracon, Raewyn Fisher, Rafael Beyar, Rafael Diaz, Rafael Selgas, Raffaele Bugiardini, Raffaele Fanelli, Raisa Kavalakkat, V S Rajalekshmi, Rajat S Barua, Rajeev Menon, Rajesh Gopalan Nair, Rajesh Francis, Rajiv Narang, Rakesh Yadav, Ralph Alan Huston, T Ramakrishnan, Ramesh de Silva, Rami El Mahmoud, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ramona Stevens, Ran Leng, Ranjan Kachru, Ranjit Kumar Nath, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Raymond W Little, Raymundo Ocaranza Sanchez, Rebecca J Wimmer, Rebecca Bariciano, Rebecca Otis, Rebekah R Herrmann, Reem Yunis, Reinette Hampson, Renato Abdala Karam, Renee C Hessian, Renee Kaneshiro, Reshma Ravindran, Reto Andreas Gamma, Reyna Bhandari, Reza Arsanjani, Ricardo L Lopes, Ricardo Mendes Oliveira, Ricardo Costa, Richa Bhatt, Richard F Davies, Richard H J Trimlett, Richard Goldweit, Rik Hermanides, Rine Nakanishi, Rinu R Sidh, Risha Patel, Rita Coram, Rizwan A Siddiqui, Rob S Beanlands, Robert J Hamburger, Robert K Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto Ren\ue9 Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth P\ue9rez-Fern\ue1ndez, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simovi\u107, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, T\ue9odora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nu\uf1ez, Virginia Fern\ue1ndez-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-R\uedos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek P\ue9pin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
- Jones P.G.
- Mark D.B
- Maron D.J.
- Mavromatis K.
- Mavromichalis S.
- Newman J.D.
- O'Brien S.M.
- Reynolds H.R.
- Rosenberg Y.
- Spertus J.A.
- Stone G.W.
- Weintraub W.S.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline
Initial invasive or conservative strategy for stable coronary disease
- Author
- Alexander K.P.
- Ali Z.A.
- Bangalore S.
- Berger J.S.
- Berman D.S.
- Bhargava B.
- Bockeria O.
- Boden W.E.
- Broderick S.
- Bruce Ferguson T.
- Chaitman B.R.
- Demkow M.
- Doerr R.
- Elghamaz A.
- Gabriel Steg P.
- Goodman S.G.
- Gosselin G.
- Harrell F.E.
- Harrington R.A.
- Held C.
- Hochman J.S.
- Hueb W.A.
- ISCHEMIA Research Group: Joseph Ricci A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Raba\ue7a, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fern\ue1ndez Mart\uednez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, Andr\ue9 Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej \u141abyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Pe\uf1aranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezi\u144ska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard J\ue4ger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Car\uedsi A Polanczyk, Carita Krannila, Carla Vicente, Carl-\uc9ric Gagn\ue9, Carlo Briguori, Carlos Pe\uf1a Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Bj\uf6rklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adri\ue1n Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Nicollet, Eric Peterson, Erick Alex\ue1nderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, F Marin Ortu\uf1o, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Fl\ue1via Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidovi\u107, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Llad\uf3, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, Jo\ue3o Reynaldo Abbud, Jo\ue3o V Vitola, Joaqu\uedn V Pe\uf1afiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Vieira, Jos\ue9 M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padr\uf3, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio C\ue9sar Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna \u141oboz-Grudzie\u144, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kuku\u142a, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Lo\uefc Bi\ue8re, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de P\ue1dua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Vald\ue9s Ch\ue1varri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena \u141anocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Ma\u142gorzta Celi\u144ska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Val\ue9rio Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Mar\ueda Fernanda Canales, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moys\ue9s de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Ca\uf1avate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdo\u144czyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula Garc\ueda-Gonz\ue1lez, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vu\u10di\u107, Radmila Lyubarova, Radoslaw Pracon, Raewyn Fisher, Rafael Beyar, Rafael Diaz, Rafael Selgas, Raffaele Bugiardini, Raffaele Fanelli, Raisa Kavalakkat, V S Rajalekshmi, Rajat S Barua, Rajeev Menon, Rajesh Gopalan Nair, Rajesh Francis, Rajiv Narang, Rakesh Yadav, Ralph Alan Huston, T Ramakrishnan, Ramesh de Silva, Rami El Mahmoud, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ramona Stevens, Ran Leng, Ranjan Kachru, Ranjit Kumar Nath, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Raymond W Little, Raymundo Ocaranza Sanchez, Rebecca J Wimmer, Rebecca Bariciano, Rebecca Otis, Rebekah R Herrmann, Reem Yunis, Reinette Hampson, Renato Abdala Karam, Renee C Hessian, Renee Kaneshiro, Reshma Ravindran, Reto Andreas Gamma, Reyna Bhandari, Reza Arsanjani, Ricardo L Lopes, Ricardo Mendes 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Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simovi\u107, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, T\ue9odora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas 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Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-R\uedos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek P\ue9pin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
- Jeffries N.O.
- John Mancini G.B.
- Keltai M.
- Kirby R.
- Kohsaka S.
- Krishnan M.N.
- Kwong R.Y.
- Lopes R.D.
- Lopez-Sendon J.
- Maggioni A.P.
- Mark D.B.
- Maron D.J.
- Mavromatis K.
- Mavromichalis S.
- Miller T.D.
- Min J.K.
- Moorthy N.
- Newman J.D.
- O'Brien S.M.
- Peteiro J.
- Picard M.H.
- Reynolds H.R.
- Rockhold F.W.
- Rosenberg Y
- Ruzyllo W.
- Selvanayagam J.B.
- Senior R.
- Shaw L.J.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Szwed H.
- White H.D.
- Williams D.O.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, 121.8 percentage points; 95% CI, 124.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used
Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.
- Author
- Aasvang Gunn Marit
- Abbafati Cristiana
- Abbasoglu Ozgoren Ayse
- Abd-Allah Foad
- Abera Semaw F
- Aboyans Victor
- Abraham Biju
- Abraham Jerry Puthenpurakal
- Abu-Rmeileh Niveen ME
- Abubakar Ibrahim
- Aburto Tania C
- Achoki Tom
- Adelekan Ademola
- Adofo Koranteng
- Adou Arsène K
- Adsuar José C
- Afshin Ashkan
- Agardh Emilie E
- Al Khabouri Mazin J
- Al Lami Faris H
- Alam Sayed Saidul
- Alasfoor Deena
- Albittar Mohammed I
- Alegretti Miguel A
- Aleman Alicia V
- Alemu Zewdie A
- Alexander Lily
- Alfonso-Cristancho Rafael
- Alhabib Samia
- Ali Mohammed K
- Ali Raghib
- Alla François
- Allebeck Peter
- Allen Peter J
- Alsharif Ubai
- Alvarez Elena
- Alvis-Guzman Nelson
- Amankwaa Adansi A
- Amare Azmeraw T
- Ameh Emmanuel A
- Ameli Omid
- Amini Heresh
- Ammar Walid
- Anderson Benjamin O
- Anderson H Ross
- Antonio Carl Abelardo T
- Anwari Palwasha
- Argeseanu Cunningham Solveig
- Arnlöv Johan
- Arsenijevic Valentina S Arsic
- Artaman Al
- Asghar Rana J
- Assadi Reza
- Astha KC
- Atkins Lydia S
- Atkinson Charles
- Avila Marco A
- Awuah Baffour
- Bachman Victoria F
- Badawi Alaa
- Bahit Maria C
- Bakfalouni Talal
- Balakrishnan Kalpana
- Balalla Shivanthi
- Balu Ravi Kumar
- Banerjee Amitava
- Barber Ryan M
- Barker-Collo Suzanne L
- Barquera Simon
- Barregard Lars
- Barrero Lope H
- Barrientos-Gutierrez Tonatiuh
- Basto-Abreu Ana C
- Basu Arindam
- Basu Sanjay
- Basulaiman Mohammed O
- Batis Ruvalcaba Carolina
- Beardsley Justin
- Bedi Neeraj
- Bekele Tolesa
- Bell Michelle L
- Benjet Corina
- Bennett Derrick A
- Benzian Habib
- Bernabé Eduardo
- Beyene Tariku J
- Bhala Neeraj
- Bhalla Ashish
- Bhutta Zulfiqar A
- Bikbov Boris
- Bin Abdulhak Aref A
- Biryukov Stan
- Blore Jed D
- Blyth Fiona M
- Bohensky Megan A
- Bora Başara Berrak
- Borges Guilherme
- Bornstein Natan M
- Bose Dipan
- Boufous Soufiane
- Bourne Rupert R
- Brainin Michael
- Brauer Michael
- Brazinova Alexandra
- Breitborde Nicholas J
- Brenner Hermann
- Briggs Adam DM
- Broday David M
- Brooks Peter M
- Bruce Nigel G
- Brugha Traolach S
- Brunekreef Bert
- Buchbinder Rachelle
- Bui Linh N
- Bukhman Gene
- Bulloch Andrew G
- Burch Michael
- Burnett Richard
- Burney Peter GJ
- Campos-Nonato Ismael R
- Campuzano Julio C
- Cantoral Alejandra J
- Caravanos Jack
- Cardis Elisabeth
- Carpenter David O
- Casey Daniel
- Caso Valeria
- Castañeda-Orjuela Carlos A
- Castro Ruben E
- Catalá-López Ferrán
- Cavalleri Fiorella
- Chadha Vineet K
- Chang Jung-Chen
- Charlson Fiona J
- Chen Honglei
- Chen Wanqing
- Chen Zhengming
- Chiang Peggy P
- Chimed-Ochir Odgerel
- Chowdhury Rajiv
- Christophi Costas A
- Chuang Ting-Wu
- Chugh Sumeet S
- Cirillo Massimo
- Claßen Thomas KD
- Coates Matthew M
- Cohen Aaron
- Colistro Valentina
- Colomar Mercedes
- Colquhoun Samantha M
- Contreras Alejandra G
- Cooper Cyrus
- Cooper Leslie T
- Cooperrider Kimberly
- Coresh Josef
- Courville Karen J
- Criqui Michael H
- Cuevas-Nasu Lucia
- Cárdenas Rosario
- Damsere-Derry James
- Danawi Hadi
- Dandona Lalit
- Dandona Rakhi
- Dargan Paul I
- Davis Adrian
- Davitoiu Dragos V
- Dayama Anand
- de Castro E Filipa
- De la Cruz-Góngora Vanessa
- De Leo Diego
- de Lima Graça
- Degenhardt Louisa
- del Pozo-Cruz Borja
- Dellavalle Robert P
- Delwiche Kristen
- Deribe Kebede
- Derrett Sarah
- Des Jarlais Don C
- Dessalegn Muluken
- deVeber Gabrielle A
- Devries Karen M
- Dharmaratne Samath D
- Dherani Mukesh K
- Dicker Daniel
- Dimbuene Zacharie Tsala
- Ding Eric L
- Dokova Klara
- Dorsey E Ray
- Driscoll Tim R
- Duan Leilei
- Durrani Adnan M
- Ebel Beth E
- Ellenbogen Richard G
- Elshrek Yousef M
- Endres Matthias
- Ermakov Sergey P
- Erskine Holly E
- Eshrati Babak
- Esteghamati Alireza
- Estep Kara
- Fahimi Saman
- Faraon Emerito Jose A
- Farzadfar Farshad
- Fay Derek FJ
- Feigin Valery L
- Feigl Andrea B
- Fereshtehnejad Seyed-Mohammad
- Ferrari Alize J
- Ferri Cleusa P
- Flaxman Abraham D
- Fleming Thomas D
- Foigt Nataliya
- Foreman Kyle J
- Forouzanfar Mohammad H
- Franklin Richard C
- Frostad Joseph J
- Gabbe Belinda
- Gaffikin Lynne
- Gakidou Emmanuela
- Gamkrelidze Amiran
- Gankpé Fortuné G
- Gansevoort Ron T
- García-Guerra Francisco A
- Gasana Evariste
- GBD 2013 Risk Factors Collaborators
- Geleijnse Johanna M
- Gessner Bradford D
- Gething Pete
- Gibney Katherine B
- Gillum Richard F
- Ginawi Ibrahim AM
- Giroud Maurice
- Giussani Giorgia
- Goenka Shifalika
- Goginashvili Ketevan
- Gomez Dantes Hector
- Gona Philimon
- Gonzalez de Cosio Teresita
- González-Castell Dinorah
- Gotay Carolyn C
- Goto Atsushi
- Gouda Hebe N
- Guerrant Richard L
- Gugnani Harish C
- Guillemin Francis
- Gunnell David
- Gupta Rahul
- Gupta Rajeev
- Gutiérrez Reyna A
- Hafezi-Nejad Nima
- Hagan Holly
- Hagstromer Maria
- Halasa Yara A
- Hamadeh Randah R
- Hammami Mouhanad
- Hankey Graeme J
- Hao Yuantao
- Harb Hilda L
- Haregu Tilahun Nigatu
- Haro Josep Maria
- Havmoeller Rasmus
- Hay Simon I
- Hedayati Mohammad T
- Heredia-Pi Ileana B
- Hernandez Lucia
- Heuton Kyle R
- Heydarpour Pouria
- Hijar Martha
- Hoek Hans W
- Hoffman Howard J
- Hornberger John C
- Hosgood H Dean
- Hoy Damian G
- Hsairi Mohamed
- Hu Guoqing
- Hu Howard
- Huang Cheng
- Huang John J
- Hubbell Bryan J
- Huiart Laetitia
- Husseini Abdullatif
- Iannarone Marissa L
- Iburg Kim M
- Idrisov Bulat T
- Ikeda Nayu
- Innos Kaire
- Inoue Manami
- Islami Farhad
- Ismayilova Samaya
- Jacobsen Kathryn H
- Jansen Henrica A
- Jarvis Deborah L
- Jassal Simerjot K
- Jauregui Alejandra
- Jayaraman Sudha
- Jeemon Panniyammakal
- Jensen Paul N
- Jha Vivekanand
- Jiang Fan
- Jiang Guohong
- Jiang Ying
- Jonas Jost B
- Juel Knud
- Kan Haidong
- Kany Roseline Sidibe S
- Karam Nadim E
- Karch André
- Karema Corine K
- Karthikeyan Ganesan
- Kaul Anil
- Kawakami Norito
- Kazi Dhruv S
- Kemp Andrew H
- Kengne Andre P
- Keren Andre
- Khader Yousef S
- Khalifa Shams Eldin Ali Hassan
- Khan Ejaz A
- Khang Young-Ho
- Khatibzadeh Shahab
- Khonelidze Irma
- Kieling Christian
- Kim Daniel
- Kim Sungroul
- Kim Yunjin
- Kimokoti Ruth W
- Kinfu Yohannes
- Kinge Jonas M
- Kissela Brett M
- Kivipelto Miia
- Knibbs Luke D
- Knudsen Ann Kristin
- Kokubo Yoshihiro
- Kose M Rifat
- Kosen Soewarta
- Kraemer Alexander
- Kravchenko Michael
- Krishnaswami Sanjay
- Kromhout Hans
- Ku Tiffany
- Kuate Defo Barthelemy
- Kucuk Bicer Burcu
- Kuipers Ernst J
- Kulkarni Chanda
- Kulkarni Veena S
- Kumar G Anil
- Kwan Gene F
- Kyu Hmwe H
- Lai Taavi
- Lakshmana Balaji Arjun
- Lalloo Ratilal
- Lallukka Tea
- Lam Hilton
- Lan Qing
- Lansingh Van C
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- Larsson Anders
- Laryea Dennis O
- Lavados Pablo M
- Lawrynowicz Alicia E
- Leasher Janet L
- Lee Jong-Tae
- Leigh James
- Leung Ricky
- Levi Miriam
- Levy Teresa Shamah
- Li Yichong
- Li Yongmei
- Liang Juan
- Liang Xiaofeng
- Lim Stephen S
- Lindsay M Patrice
- Lipshultz Steven E
- Liu Shiwei
- Liu Yang
- Lloyd Belinda K
- Logroscino Giancarlo
- London Stephanie J
- Lopez Alan D
- Lopez Nancy
- Lortet-Tieulent Joannie
- Lotufo Paulo A
- Lozano Rafael
- Lunevicius Raimundas
- Ma Jixiang
- Ma Stefan
- Machado Vasco MP
- MacIntyre Michael F
- Magis-Rodriguez Carlos
- Mahdi Abbas A
- Majdan Marek
- Malekzadeh Reza
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- Marape Marape
- Marcenes Wagner
- Margolis David J
- Margono Christopher
- Marks Guy B
- Martin Randall V
- Marzan Melvin B
- Mashal Mohammad T
- Masiye Felix
- Mason-Jones Amanda J
- Matsushita Kunihiro
- Matzopoulos Richard
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- Mazorodze Tasara T
- McKay Abigail C
- McKee Martin
- McLain Abigail
- Meaney Peter A
- Medina Catalina
- Mehndiratta Man Mohan
- Mejia-Rodriguez Fabiola
- Mekonnen Wubegzier
- Melaku Yohannes A
- Meltzer Michele
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- Meretoja Atte
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- Mills Edward J
- Misganaw Awoke
- Mishra Santosh
- Mohamed Ibrahim Norlinah
- Mohammad Karzan A
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- Monasta Lorenzo
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- Mori Rintaro
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- Mukaigawara Mitsuru
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- Naghavi Mohsen
- Nahas Ziad
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- Ng Marie
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- Ngirabega Jean de Dieu
- Nguyen Grant
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- Nisar Muhammad I
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- Norrving Bo
- Nyakarahuka Luke
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- Rao Mayuree
- Razavi Homie
- Reddy K Srinath
- Refaat Amany H
- Rehm Jürgen
- Remuzzi Giuseppe
- Ribeiro Antonio L
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- Richardson Lee
- Riederer Anne
- Robinson Margaret
- Roca Anna
- Rodriguez Alina
- Rojas-Rueda David
- Romieu Isabelle
- Ronfani Luca
- Room Robin
- Roy Nobhojit
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- Rushton Lesley
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- Saha Sukanta
- Sahathevan Ramesh
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- Shangguan Siyi
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- Stapelberg Nicolas JC
- Stathopoulou Vasiliki
- Steckling Nadine
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- Stroumpoulis Konstantinos
- Sturua Lela
- Stöckl Heidi
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- Sánchez-Pimienta Tania G
- Søreide Kjetil
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- Thomson Blake
- Thorne-Lyman Andrew L
- Thrift Amanda G
- Thurston George D
- Tillmann Taavi
- Tobollik Myriam
- Tonelli Marcello
- Topouzis Fotis
- Towbin Jeffrey A
- Toyoshima Hideaki
- Traebert Jefferson
- Tran Bach X
- Trasande Leonardo
- Trillini Matias
- Trujillo Ulises
- Tsilimbaris Miltiadis
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- Van Dingenen Rita
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- Vavilala Monica S
- Veerman Lennert J
- Velasquez-Melendez Gustavo
- Venketasubramanian N
- Vijayakumar Lakshmi
- Villalpando Salvador
- Violante Francesco S
- Vlassov Vasiliy Victorovich
- Vollset Stein Emil
- Vos Theo
- Wagner Gregory R
- Wagner Joseph
- Waller Stephen G
- Wallin Mitchell T
- Wan Xia
- Wang Haidong
- Wang JianLi
- Wang Linhong
- Wang Wenzhi
- Wang Yanping
- Warouw Tati S
- Watts Charlotte H
- Weichenthal Scott
- Weiderpass Elisabete
- Weintraub Robert G
- Werdecker Andrea
- Wessells K Ryan
- Westerman Ronny
- Whiteford Harvey A
- Wilkinson James D
- Williams Hywel C
- Williams Thomas N
- Woldeyohannes Solomon M
- Wolfe Charles DA
- Wong John Q
- Woolf Anthony D
- Wright Jonathan L
- Wurtz Brittany
- Xu Gelin
- Yan Lijing L
- Yang Gonghuan
- Yano Yuichiro
- Ye Pengpeng
- Yenesew Muluken
- Yentür Gökalp K
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Younis Mustafa Z
- Younoussi Zourkaleini
- Yu Chuanhua
- Zaki Maysaa E
- Zhao Yong
- Zheng Yingfeng
- Zhou Maigeng
- Zhu Jun
- Zhu Shankuan
- Zou Xiaonong
- Zunt Joseph R
- Çavlin Alanur
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
International audienceThe Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development. We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time. Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs fell by 3·6% (0·3-7·4), and age-standardised DALY rates per 100 000 people fell by 26·7% (24·6-29·1). For communicable, maternal, neonatal, and nutritional disorders, global DALY numbers, crude rates, and age-standardised rates have all declined between 1990 and 2013, whereas for non-communicable diseases, global DALYs have been increasing, DALY rates have remained nearly constant, and age-standardised DALY rates declined during the same period. From 2005 to 2013, the number of DALYs increased for most specific non-communicable diseases, including cardiovascular diseases and neoplasms, in addition to dengue, food-borne trematodes, and leishmaniasis; DALYs decreased for nearly all other causes. By 2013, the five leading causes of DALYs were ischaemic heart disease, lower respiratory infections, cerebrovascular disease, low back and neck pain, and road injuries. Sociodemographic status explained more than 50% of the variance between countries and over time for diarrhoea, lower respiratory infections, and other common infectious diseases; maternal disorders; neonatal disorders; nutritional deficiencies; other communicable, maternal, neonatal, and nutritional diseases; musculoskeletal disorders; and other non-communicable diseases. However, sociodemographic status explained less than 10% of the variance in DALY rates for cardiovascular diseases; chronic respiratory diseases; cirrhosis; diabetes, urogenital, blood, and endocrine diseases; unintentional injuries; and self-harm and interpersonal violence. Predictably, increased sociodemographic status was associated with a shift in burden from YLLs to YLDs, driven by declines in YLLs and increases in YLDs from musculoskeletal disorders, neurological disorders, and mental and substance use disorders. In most country-specific estimates, the increase in life expectancy was greater than that in HALE. Leading causes of DALYs are highly variable across countries. Global health is improving. Population growth and ageing have driven up numbers of DALYs, but crude rates have remained relatively constant, showing that progress in health does not mean fewer demands on health systems. The notion of an epidemiological transition--in which increasing sociodemographic status brings structured change in disease burden--is useful, but there is tremendous variation in burden of disease that is not associated with sociodemographic status. This further underscores the need for country-specific assessments of DALYs and HALE to appropriately inform health policy decisions and attendant actions. Bill & Melinda Gates Foundation
Recommended from our members
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016
- Author
- Abassi Yama
- Abelin Jennifer G.
- Abolhalaj Milad
- Abraham Tara S.
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F.
- Adamus Tomasz
- Addepalli Murali
- Adjei Alex A.
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G.
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T.
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C.
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T.
- Alley Evan W.
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H. I.
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S.
- Antonia Scott J.
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F.
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M.
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B.
- Atkinson Victoria
- Au Katrina
- Autio Karen A.
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A.
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Barton Sunjay M.
- Barve Minal
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- Bauer Todd W.
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
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- Curti Brendan
- Da Costa Andre
- Dai Fu
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- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A.
- Daud Adil
- David Justin M.
- Davies Bronwyn
- de Boisferon Marc Hillairet
- de Groot Patricia
- de Gruijl Tanja
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- De Maeseneire Coraline
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- de Silva Suresh
- Deacon Donna
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- Declerck Paul
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
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- Demaria Sandra
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- Dunai Cordelia
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- Duvvuri Uma
- Dyson Mike
- D’Apuzzo Massimo
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- Eisenhower Mary
- El Alaoui Meddy
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- Elvecrog James
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- Emerling Daniel
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- English Jessie
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- Evans Elizabeth
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- Facciponte John
- Falchook Gerald
- Fantini Massimo
- Farkas Emil
- Farren Matthew
- Faustman Denise
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- Feng JunLi
- Feng Yan
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- Feola Sara
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- Field Jessica J.
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- Fogler William
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- Formenti Silvia C.
- Foster Cathie
- Foster Rosemary
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- Fox Bernard
- Francica Brian
- Francis Julie-Ann
- Frangou Costa
- Franklin Marilyn
- Franklin Wilbur
- Frascaro Federica
- Fraser Kathryn
- Frederix Kim
- Freimark Bruce
- Frey Alan
- Fridman Leticia
- Friedman Alan
- Friedman David
- Fromm George
- Früh Martin
- Fu Yang-Xin
- Fu Yichun
- Fuertes Marraco Silvia A.
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- Fukaya Satoshi
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- Ghamsari Lila
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- Grigsby Iwen
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- Guirado Elizabeth
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- Kleinerman Eugenie S.
- Kler Jasdeep
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- Kohanbash Gary
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- Kraus Manfred
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- Lindstedt Malin
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- Liszkay Gabriella
- Litton Jennifer
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- Liu Biao
- Liu Cailian
- Liu Glenn
- Liu Hao
- Liu Hongtao
- Liu Linying
- Liu Matt
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- Liu Xiu-fen
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- Lu Bo
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- Ludwig Dale
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- Luke Jason
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- Lundberg Kristina
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- MacDonald Cameron
- MacDonald Douglas
- Mace Thomas
- MacKinnon Andy
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- Magee Michael S.
- Magnani John L.
- Makarov Vladimir
- Makhanov Michael
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- Mallow Crystal
- Malnassy Gregory
- Mandloi Nitin
- Mangin Eric
- Mangrolia Drishty
- Manguso Robert
- Manieri Nicholas
- Manning Luisa
- Manning-Bog Amy
- Manoharan Malini
- Manro Jason
- Mansfield David
- Marabelle Aurelien
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- Marelli Bo
- Marguier Gisele
- Maric Dragan
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- Marincola Francesco
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- Martin Allison
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- Medina Daniel
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- Meier Roland
- Melcher Alan
- Melero Ignacio
- Melssen Marit
- Mendoza Daniel
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- Mennel Robert
- Mera Toshi
- Merghoub Taha
- Merrick Daniel
- Metchette Ken
- Metelli Alessandra
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- Meyers Michael L.
- Milenova Ioanna
- Millar David
- Miller Lance
- Miller Nichol
- Miller Peter
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- Mohr Ian
- Mohrs Markus
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- Morel Yannis
- Moreno Rafael
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- Morris Zachary S.
- Morrow Matthew
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- Morse Michael
- Mudan Satvinder
- Mueller Sabine
- Muir Lincoln
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- Mullins Stefanie
- Mulvey Matthew
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- Murphy William J.
- Murray Brion
- Muthuswamy Ravi
- Muthuswamy Ravikumar
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- Nagasaka Misako
- Nail Carmel
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- Nair Nitya
- Nakamura Yusuke
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- Nechaev Sergey
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- Nemunaitis John
- Neou Silinda
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- Neves Rogerio
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- Nguyen Ngan
- Niazi Kayvan
- Nicholas Courtney
- Nicolette Charles
- Niederfellner Gerhard
- Nielsen Michael
- Noessner Elfriede
- Normant Emmanuel
- Novosiadly Ruslan
- Nuccitelli Richard
- Nutakki Ravi
- Obalapur Palakshi
- Obeid Joseph M.
- Obermajer Nataša
- Ochyl Lukasz
- Odunsi Kunle
- Oft Martin
- Ogasawara Masahiro
- Ohr James
- Okada Hideho
- Okada Kaori
- Okeley Nicole M.
- Okubo Yoshiaki
- Olasz Judit
- Olson Walter
- Olson William
- Opyrchal Mateusz
- Ordentlich Peter
- Orecchioni Marco
- Ornatowski Wojciech
- Osada Toshihiro
- Ostrowski Michael C.
- Oswald Detlef
- Ota Shuichi
- Ott Patrick A.
- Ottoson Nadine
- Overwijk Willem W.
- Ovsepyan Armen
- Oyola Sandra
- O’Connor Rachel W.
- Pachynski Russell K.
- Pai Steven
- Pal Sumanta
- Palena Claudia
- Pall Georg
- Palmer Brent
- Palombella Vito J.
- Pan Alison
- Pan Wenjing
- Pandha Hardev
- Paneque Tomas
- Pant Shubham
- Papachristofilou Alexandros
- Papadopoulos Kyriakos P.
- Papot Sébastien
- Paramithiotis Eustache
- Paris Mark
- Paris Sébastien
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- Parsons Andrea J.
- Parviainen Suvi
- Pastan Ira
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- Patel Shashank
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- Patil Ashwini
- Patnaik Amita
- Patterson Troy D.
- Paul Kiran
- Paul-Wetterberg Gabriella
- Paustian Christopher
- Peace Kaitlin M.
- Pei Jerry
- Pellom Samuel
- Peltonen Karita
- Pena Rhoneil
- Penny Sarah A.
- Peoples George E.
- Perez Myra
- Perna Serena
- Perry Kyle
- Persaud Krishnadatt
- Pesonen Sari
- Peterson Nichole
- Petit Robert
- Petricoin Emanuel
- Petroni Gina
- Petrylak Daniel P.
- Pferdekamper Anne Marie
- Pierobon Mariaelena
- Pike Luke
- Pilon-Thomas Shari
- Pinczewski Joel
- Pirson Romain
- Plachco Ana
- Pless Miklos
- Pollack Ian F.
- Pollock Emily
- Ponichtera Holly
- Ponte Jose
- Pope Hans
- Posner Marshall
- Postow Michael
- Pottier Agnes
- Poueymirou William
- Pourchet Aldo
- Pourdehnad Michael
- Pourzia Alexandra
- Powers Jay P.
- Pramoonjago Patcharin
- Prantner Andrew M.
- Preillon Julie
- Presnell Scott
- Princiotta Michael
- Profusek Pam
- Puri Raj K.
- Qi Jin
- Qian Yingzhi
- Qiao Guanxi
- Qiao Na
- Qin Guozhong
- Qiu Xiaohong
- Quach Phi
- Quick Laura
- Quinn David I.
- Rabizadeh Shahrooz
- Rabolli Virginie
- Radfar Arash
- Radoja Sasa
- Radvanyi Laszlo
- Rae Chris S.
- Rafail Stavros
- Rafat Marjan
- Rahma Osama E.
- Rajopadhye Milind
- Rakhmilevich Alexander L.
- Ralph Christy
- Ramachandra Murali
- Ramachandra Raghuveer
- Ramalingam Suresh
- Ramchandren Radhakrishnan
- Ramos Kimberly
- Ranki Tuuli
- Rankin Erinn
- Rao Tharak
- Rapisuwon Suthee
- Ravindranathan Roshni
- Ray Chad
- Rebhun Robert
- Redchenko Irina
- Reeves Rebecca S.
- Reid-Schachter Gillian
- Reilley Matthew
- Reilly Christine
- Reiter Yoram
- Rekoske Brian
- Ren Xiubao
- Rennier Keith R.
- Renrick Ariana N.
- Repasky Elizabeth
- Reshef Ran
- Restifo Nicholas
- Ribas Antoni
- Richardson Jennifer H.
- Ridnour Lisa
- Rimoldi Donata
- Rinchai Darawan
- Rivas Sarai
- Rizell Magnus
- Roberts David D.
- Robinson William
- Rodriguez Anthony
- Rodriguez-Cruz Tania
- Roelands Jessica
- Roen Diana
- Rogers Connie J.
- Rose Jason
- Ross Merrick
- Rothwell William T.
- Rowlinson Scott
- Ruchko Sergey
- Ruth Nicola
- Ryan Kevin
- Saeed Abu Z.
- Saenger Yvonne M.
- Saims Dan
- Saito Takuro
- Salata Daria
- Salazar Rachel
- Saleh Rachidi
- Salerno Elise
- Samiulla Dodheri
- Sams Lillian
- Sanborn J. Zachary
- Sanborn Rachel E.
- Santo Gregg Espiritu
- Santos João
- Santos Patricia M.
- Sarnaik Amod A.
- Sasaki Eiji
- Saser Kate A.
- Sasikumar Pottayil
- Sathian Rekha
- Sato-Kaneko Fumi
- Saunthararajah Yogen
- Sausen Mark
- Savolt Akos
- Sawant Deepali
- Sayers Thomas J.
- Scales Stephanie
- Schad Sara
- Schaeffeler Elke
- Schaer David
- Scharping Nicole
- Scheel Birgit
- Schindler Ulrike
- Schlom Jeffrey
- Schlunegger Kyle
- Schluns Kimberly S.
- Schmidt Carl
- Schmidt Emmett
- Schmidt Manuel
- Schoenfeld Jonathan
- Schoenhals Jonathan
- Scholler Nathalie
- Scholz Alexander
- Schreiber Taylor H.
- Schroeder Andreas
- Schwab Matthias
- Schwartz Anthony L.
- Schwendeman Anna
- Scrivens Maria
- Sebastian Martin
- Sefrin Julian P.
- Segal Neil H.
- Seibel Tobias
- Senbabaoglu Yasin
- Senter Peter D.
- Senzer Neil
- Serpa Gregory
- Setiady Yulius
- Sette Alessandro
- Sevdali Maria
- Sexton Holly
- Seymour Len
- Sgarrella Francesco
- Shabanowitz Jeffrey
- Shafren Darren
- Shakya Reena
- Shamalov Katerina
- Shanker Anil
- Sharma Manish
- Sharma Meenu
- Sharma Naveen
- Sharma Padmanee
- Shayan Gulidanna
- Shea Sofia
- Shehade Hussein
- Sheikh Nadeem A.
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- Shepard Dale
- Sherry Lorcan
- Shi Feng
- Shi Jian
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- Shimizu Atsushi
- Shrestha Yashaswi
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- Shuman Stewart
- Shuster Alexandr
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- Sims Jennifer S.
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- Singson Victoria
- Siurala Mikko
- Sivado Eva
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- Sjöberg Madeleine
- Skaletskaya Anna
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- Slansky Jill
- Slingluff Craig L.
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- Smith Ernest
- Smith Jill
- Smith Kelly
- Smith Leia
- Smolkin Mark E.
- Snook Adam E.
- Snzol Mario
- Sokolove Jeremy
- Solowiej Jim
- Somanchi Srinivas
- Sondel Paul M.
- Soneson Charlotte
- Song Xiao-Tong
- Sotayo Alaba
- Sotirovska Natalija
- Spada Filomena
- Speers Ellen
- Speiser Daniel E.
- Spektor Alexander
- Spranger Stefani
- Spurgeon Stephen
- Squalls Olivia
- Srirangam Jay
- Srivastava Raghvendra
- Staab Mary Jane
- Stack Edward
- Staelens Ludovicus
- Starzynska Teresa
- Steadman Lora
- Stefano Pierini
- Steggerda Susanne
- Stein Paul L.
- Stelow Edward B.
- Sternby Malin
- SternJohn Julius
- Stewart Al
- Stock Wendy
- Stone Geoffrey W.
- Stosnach Claudia
- Straub Tobias
- Straus Jane
- Streiner Nicole
- Ståhle Magnus
- Su Yu-Lin
- Sudarshan Naremaddepalli
- Sugarbaker David
- Sukari Ammar
- Sultan Hussein
- Sun Shaoli
- Sundararaman Srividya
- Sung Leonard
- Suresh Rahul
- Surguladze David
- Suryawanshi Satyendra
- Suzuki Akiko
- Suzuki Ryuji
- Sweis Randy F.
- Taback Bret
- Tagliaferri Mary
- Talbert Erin
- Tallarico John
- Tan Joanne B. L.
- Tan Joanne BL
- Tan Wei
- Tan Yann Chong
- Tanaka Maki
- Tang Chad
- Tannir Nizar M.
- Taylor Allison
- Taylor Matthew
- Tcherepanova Irina
- ter Meulen Jan
- Terabe Masaki
- Termini James
- Tetzlaff Michael
- Tewary Poonam
- Thakurta Anjan
- Thayer Matt
- Theodoraki Marie-Nicole
- Thimme Robert
- Thomas Portia
- Thomas Remy
- Thomas Vincent
- Thompson John A.
- Thounaojam Menaka
- Thurston Gavin
- Tighe Rober
- Tilahun Ashenafi
- Tillé Laure
- Timmerman John
- Tipton Kimberly A.
- Tognon Christina E.
- Tomai Mark A.
- Toms Anne
- Torno Sebold
- Torrey Heather
- Torti Vince
- Toth Laszlo
- Trager James B.
- Trappey Alfred F.
- Trivedi Sumita
- Truesdell Peter
- Tsang Kwong
- Tsang Kwong Y.
- Tsaparikos Konstantinos
- Tsouko Efrosini
- Tsujikawa Takahiro
- Tuck David
- Tumang Joseph
- Turbitt William J.
- Turk Andrew T.
- Tyner Jeffery W.
- Tähtinen Siri
- Uecker Darrin
- Ugel Stefano
- Uhlik Mark
- Ujhelyi Mihaly
- Ullenhag Gustav
- Unfricht Darryn
- Ungerleider Richard
- Urban Julie
- Valsesia-Wittmann Sandrine
- Van der Meijs Pien
- van Vugt Marianne
- van Zutphen Mariëlle
- Vanamee Eva
- Vanderslice Peter
- VanderVeen Laurie
- Vanpouille-Box Claire I.
- VanVlasselaer Peter
- Varhegyi Nikole
- Vasilakos John P.
- Vaske Charles
- Vassilev Lotta
- Velcheti Vamsidhar
- Velculescu Victor
- Verma Amita
- Vetto John
- Vianden Christina
- Vietsch Eveline E.
- Vignali Dario
- Vogel Katharina
- Volkmuth Wayne
- Volz Barbara
- vonEbyen Rie
- Vreeland Timothy J.
- Vu Tuyen
- Wada Hiroshi
- Wagtmann Nicolai
- Waldman Michelle
- Waldman Scott A.
- Waller John
- Wallraven Gladice
- Walsh Richard
- Walters Ian B.
- Wang Ena
- Wang Hongjie
- Wang Ping
- Wang Shangzi
- Wang Weiyi
- Wang Ximi K.
- Wang Yi
- Wang Ziming
- Ward Stephen T.
- Waugh Katherine
- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R.
- Weiner David
- Weiner Louis M.
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
- Wenthe Jessica
- Werner Lauryn R.
- West Brian
- West James
- Wheatley Courtney
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C.
- Wicha Max S.
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W.
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M.
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D.
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Deborah J.
- Wong Gabriel
- Wong Kenneth R.
- Wong Michael KK
- Wood Laura
- Woodside Darren G.
- Workman Creg
- Wu Bill X.
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J.
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W.
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D.
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S.
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/01/2017
- Field of study