Treatment for Condyloma Acuminatum with Graves’ disease

SAS Publisher's journals are open access journals.A rare case of external genital condylomata acuminatum with Graves’ disease was reported. The cauliflower warts were observed on glans penis and foreskin of a 40-year-old man, who had typical Graves’ symptoms. After combining treatment of laser, intramuscular injection interferon, and orally administered Acyclovir or Tamciclovir tablets, Amoxicilline capsules or phenoxy mephyl penicillin potassium tablets, vitamin C and vitamin B1 of multiple courses (weeks), the condylomata acuminatum recurred, the warts grew again, and Graves’ disease worsened. However, after integrated treatment of laser, orally administered transfer factor, antibiotics and vitamins of three courses, the patient recovered fully and Graves’ symptoms alleviated. The venereal warts have not recurred within six months

Multiple Parton Scattering in Nuclei: Twist-Four Nuclear Matrix Elements and Off-Forward Parton Distributions

Multiple parton scatterings inside a large nucleus generally involve higher-twist nuclear parton matrix elements. The gluon bremsstrahlung induced by multiple scattering depends not only on direct parton matrix elements but also on momentum-crossed ones, due to the Landau-Pomeranchuk-Migdal interference effect. We show that both types of twist-four nuclear parton matrix elements can be factorized approximately into the product of twist-two nucleon matrix elements in the limit of extremely large nuclei, $A\to \infty$, as assumed in previous studies. Due to the correlative nature of the twist-four matrix elements under consideration, it is actually the off-forward parton distributions that appear naturally in this decomposition, rather than the ordinary diagonal distributions probed in deeply-inelastic scattering. However, we argue that the difference between these two distribution classes is small in certain kinematic regimes. In these regions, the twist-four nuclear parton matrix elements are evaluated numerically and compared to the factorized form for different nuclear sizes within a schematic model of the two-nucleon correlation function. The nuclear size dependence is found to be $A^{4/3}$ in the limit of large $A$, as expected. We find that the factorization is reasonably good when the momentum fraction carried by the gluon field is moderate. The deviation can be more than a factor of 2, however, for small gluon momentum fractions, where the gluon distribution is very large.Comment: 23 pages, 7 figures, minor correction

Multiple Parton Scattering in Nuclei: Parton Energy Loss

Multiple parton scattering and induced parton energy loss is studied in deeply inelastic scattering (DIS) off nuclei. The effect of multiple scattering of a highly off-shell quark and the induced parton energy loss is expressed in terms of the modification to the quark fragmentation functions. We derive such modified quark fragmentation functions and their QCD evolution equations in DIS using generalized factorization of higher twist parton distributions. We consider double-hard, hard-soft parton scattering as well as their interferences in the same framework. The final result, which depends on both the diagonal and off-diagonal twist-four parton distributions in nuclei, demonstrates clearly the Landau-Pomeranchuk-Migdal interference features and predicts a unique nuclear modification of the quark fragmentation functions.Comment: Final version published in Nucl. Phys. A. 40 pages in RevTex with 15 postscript figure

The association between comorbidities and the quality of life among colorectal cancer survivors in the People's Republic of China

BACKGROUND: Cancer survivors with certain comorbidities had lower quality of life (QOL). This study was performed to investigate the prevalence of comorbidities and the association between comorbidities and the QOL among Chinese colorectal cancer survivors (CCS). METHODS: A cross-sectional study was conducted among 1,398 CCS between April and July 2013 in Shanghai, People’s Republic of China. All the participants were asked to complete a simplified Chinese version of the European Organization for Research and Treatment quality of life version 3 questionnaire and questions on sociodemographic characteristics and comorbidities. In order to mitigate the bias caused by confounding factors, multiple linear regression models were employed to calculate the adjusted means of QOL scores. RESULTS: The proportion of participants without any comorbidity was only 20.2%. The CCS with comorbidities except hypertension scored significantly lower on the European Organization for Research and Treatment quality of life version 3 questionnaire global health and functioning scales and Functional Assessment of Cancer Therapy-General scales but higher on the European Organization for Research and Treatment quality of life version 3 questionnaire symptom scores, indicating that they had poorer QOL, particularly for cardiovascular, respiratory, digestive, and musculoskeletal diseases. CONCLUSION: There exists a significant association between comorbidities and QOL among Chinese CCS, and participants with comorbidities generally reported lower QOL scores. These findings suggested comprehensive care for CCS

Multiple parton scattering in nuclei: gauge invariance

Within the framework of a generalized collinear factorization for multiple parton scattering in nuclear medium, twist-4 contributions to DIS off a large nucleus can be factorized as a convolution of hard parts and two-parton correlation functions. The hard parts for the quark scattering in the light-cone gauge correspond to interaction with a transverse (physical) gluon in the target, while they are given by the second derivative of the cross section with a longitudinal gluon in the covariant gauge. We provide a general proof of the equivalence of the hard parts in the light-cone and covariant gauge. We further demonstrate the equivalence in calculations of twist-4 contributions to semi-inclusive cross section of DIS in both lowest order and next leading order. Calculations of the nuclear transverse momentum broadening of the struck quark in the light-cone and covariant gauge are also discussed.Comment: 23 pages with 4 figure

Worshipers and Warriors

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68415/2/10.1177_009770047600200102.pd

Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth. Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Krüppel-like factor 5 (KLF5) pathways. Aberrations in these processes in cancer cells involve mutations and thus the suppression of genes that prevent growth, as well as mutation and activation of genes involved in driving cell growth. Using these pathways as examples, we prioritize molecular targets that might be leveraged to promote anti-growth signaling in cancer cells. Interestingly, naturally-occurring phytochemicals found in human diets (either singly or as mixtures) may promote anti-growth signaling, and do so without the potentially adverse effects associated with synthetic chemicals. We review examples of naturally-occurring phytochemicals that may be applied to prevent cancer by antagonizing growth signaling, and propose one phytochemical for each pathway. These are: epigallocatechin-3-gallate (EGCG) for the Rb pathway, luteolin for p53, curcumin for PTEN, porphyrins for Hippo, genistein for GDF15, resveratrol for ARID1A, withaferin A for Notch and diguelin for the IGF1-receptor pathway. The coordination of anti-growth signaling and natural compound studies will provide insight into the future application of these compounds in the clinical setting

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

Genomic instability is a common feature of cancer etiology. This provides an avenue for therapeutic intervention, since cancer cells are more susceptible than normal cells to DNA damaging agents. However, there is growing evidence that the epigenetic mechanisms that impact DNA methylation and histone status also contribute to genomic instability. The DNA damage response, for example, is modulated by the acetylation status of histone and non-histone proteins, and by the opposing activities of histone acetyltransferase and histone deacetylase (HDAC) enzymes. Many HDACs overexpressed in cancer cells have been implicated in protecting such cells from genotoxic insults. Thus, HDAC inhibitors, in addition to unsilencing tumor suppressor genes, also can silence DNA repair pathways, inactivate non-histone proteins that are required for DNA stability, and induce reactive oxygen species and DNA double-strand breaks. This review summarizes how dietary phytochemicals that affect the epigenome also can trigger DNA damage and repair mechanisms. Where such data is available, examples are cited from studies in vitro and in vivo of polyphenols, organosulfur/organoselenium compounds, indoles, sesquiterpene lactones, and miscellaneous agents such as anacardic acid. Finally, by virtue of their genetic and epigenetic mechanisms, cancer chemopreventive agents are being redefined as chemo- or radio-sensitizers. A sustained DNA damage response coupled with insufficient repair may be a pivotal mechanism for apoptosis induction in cancer cells exposed to dietary phytochemicals. Future research, including appropriate clinical investigation, should clarify these emerging concepts in the context of both genetic and epigenetic mechanisms dysregulated in cancer, and the pros and cons of specific dietary intervention strategies