Never Quit: The Complexities of Promoting Social and Academic Excellence at a Single-Gender School for Urban African American Males

This study explores the experiences of urban African American males at a first year single-gender charter school in the Southern region of the United States. The present case study was based on interviews and focus groups with parents, teachers, students, and the school administrator, and a participant observation of Excel Academy [pseudonym]. The findings of this study suggest that there were four critical instructional complexities that emerged: expectations dissonance, disguised engagement, differential engagement, and expectations overload. Remarkably, these issues were being addressed by a school value created by students and institutionalized by teachers--To Never Quit. Recommendations to address each instructional complexity are explored

Ecologies of Hope: Understanding Educational Success Among Black Males in an Urban Midwestern City

The American Psychological Association\u27s Task Force on Resilience and Strength in Black Children and Adolescents (2008) called for resilience frameworks particularly designed to understand African American development. Thus, the present study explores the lives of seven academically successful Black males in an urban midwestern city. Using a Critical Race Theory framework, the researchers center the counterstories of men of color who matriculated through college from a failing high school in a challenging urban community. Using constant comparative analysis, two critical themes emerged: extended family and extended kinship support networks. A synthesis of these themes resulted in an emergent framework entitled Ecology of Hope, which advances resilience theory (APA, 2008) through centering the strengths vested within African American families, community organizations, and social networks

Education no longer deferred: the possibilities of educating urban african american males in a single gender school.

The purpose of this study is to investigate the emerging school culture of Excel Academy for Boys [Pseudonym] located in the Southwestern region of the United States, and how it contributes to the social and academic development of urban African American male students. This case study was based on interviews and focus groups with parents, teachers, students, and the school administrator. Additionally, the researcher conducted participant observations of school meetings, new parent orientations, new teacher interviews, and reviewed student academic and behavioral records. This exploratory analysis consisted of two separate; but interrelated, qualitative studies relevant to educating urban African American males. The first inquiry featured a case study of Excel Academy for Boys, a singlegender middle school serving urban African American males. This detailed examination of Excel Academy’s organizational habitus yielded the Building African American Males Model. This organizational process was characterized by four essential factors that included: (1) educational justice; (2) expectations monitoring; (3) expectations casting; and (4) a culture of Effort. Particular attention was given to how each factor promoted community-school synergy or organizational synergy. These processes were essential for creating a school culture and climate that promoted the emotional, social, and academic maturation of students. Implications for protecting and strengthening the organizational habitus of Excel Academy were offered and broader implications for the emerging African American males’ school movement were discussed. The second study of Excel Academy uncovered four complexities that teachers, parents, and the school leader encountered as they sought to meet the social, emotional, and academic needs of urban African American males. These four critical complexities emerged through observations of the educational processes at Excel Academy, and were labeled: 1) expectations dissonance; 2) disguised engagement; 3) differential engagement, and 4) expectations overload. The emergence of each factor was detailed, and recommendations were offered to address each complexity

Total Marginality: Cumulative Marginality among African American Students at a Predominantly White Institution

This study examines the cumulative nature of marginality felt by African American undergraduates attending a Predominantly White institution (PWI). In-depth semi-structured interviews with ten African American college upperclassmen revealed the need for conceptualization of student marginality at PWIs. The participants detailed their exposure to varying levels of marginality in campus spaces, classrooms, course curriculum, residence halls, the community surrounding the institution, elements of their home environment, and interracial and intraracial interactions with students. This study moves beyond descriptive analyses (Feagin, Vera, & Imani 1996; Davis, Dias-Bowie, Greenberg, Klukken, Pollio, Thomas, & Thompson, 2004; Lewis, Ginsberg, Davis, & Smith, 2004) and offers total marginality as an emergent theory affirming the collective weight of marginality on student development. Recommendations for redressing total marginality are provided

Optimizing sequencing protocols for leaderboard metagenomics by combining long and short reads.

As metagenomic studies move to increasing numbers of samples, communities like the human gut may benefit more from the assembly of abundant microbes in many samples, rather than the exhaustive assembly of fewer samples. We term this approach leaderboard metagenome sequencing. To explore protocol optimization for leaderboard metagenomics in real samples, we introduce a benchmark of library prep and sequencing using internal references generated by synthetic long-read technology, allowing us to evaluate high-throughput library preparation methods against gold-standard reference genomes derived from the samples themselves. We introduce a low-cost protocol for high-throughput library preparation and sequencing

Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes

Background Rare variants ingenecodingregions likely have agreater impactondisease-relatedphenotypes than common variants through disruption of their encoded protein. We searched for rare variants associated with onset of ESKD in individuals with type 1 diabetes at advanced kidney disease stage. Methods Gene-basedexome array analyses of15,449genes infivelarge incidence cohortsof individualswith type 1diabetes andproteinuriawere analyzedfor survival time toESKD, testing the top gene in a sixth cohort (n52372/1115 events all cohorts) and replicating in two retrospective case-control studies (n51072 cases, 752 controls). Deep resequencing of the top associated gene in five cohorts confirmed the findings. We performed immunohistochemistry and gene expression experiments in human control and diseased cells, and in mouse ischemia reperfusion and aristolochic acid nephropathy models. Results Protein coding variants in the hydroxysteroid 17- b dehydrogenase 14 gene (HSD17B14), predicted to affect protein structure, had a net protective effect against development of ESKD at exome-wide significance (n54196; P value53.331027). The HSD17B14 gene and encoded enzyme were robustly expressed in healthy human kidney, maximally in proximal tubular cells. Paradoxically, gene and protein expression were attenuated in human diabetic proximal tubules and in mouse kidney injury models. Expressed HSD17B14 gene and protein levels remained low without recovery after 21 days in a murine ischemic reperfusion injury model. Decreased gene expression was found in other CKD-associated renal pathologies. Conclusions HSD17B14 gene ismechanistically involved in diabetic kidney disease. The encoded sex steroid enzyme is a druggable target, potentially opening a new avenue for therapeutic development.Peer reviewe

Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm

Purpose: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm. Methods: A retrospective study was performed including patients from 17 centers in 5 countries. Adults diagnosed with DTC stage T1b-T3 N0-1a M0 who all underwent a total thyroidectomy were included. The primary endpoint was the presence of a contralateral carcinoma. Results: A total of 1

The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The ISLETS FOR US Collaborative

Islet allotransplantation in the United States (US) is facing an imminent demise. Despite nearly three decades of progress in the field, an archaic regulatory framework has stymied US clinical practice. Current regulations do not reflect the state-of-the-art in clinical or technical practices. In the US, islets are considered biologic drugs and more than minimally manipulated human cell and tissue products (HCT/Ps). Across the world, human islets are appropriately defined as minimally manipulated tissue which has led to islet transplantation becoming a standard-of-care procedure for patients with type 1 diabetes mellitus and problematic hypoglycemia. As a result of the outdated US regulations, only eleven patients underwent allo-ITx in the US between 2011-2016 and all in the setting of a clinical trial. Herein, we describe the current regulations pertaining to islet transplantation in the United States. We explore the progress which has been made in the field and demonstrate why the regulatory framework must be updated to both, better reflect our current clinical practice and to deal with upcoming challenges. We propose specific updates to current regulations which are required for the renaissance of ethical, safe, effective, and affordable allo-ITx in the United States

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead