354 research outputs found
Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts
- Author
- A Bergman
- A Brouwer
- A Rivas
- A Sjodin
- A Smeds
- AC Layton
- AM Soto
- AM Soto
- AM Soto
- B Fangstrom
- C Dees
- C Sonnenschein
- E Silva
- ESP Bouvier
- Flemming Nielsen
- Helle Raun Andersen
- HR Andersen
- HT Jansen
- J Bitman
- J Legler
- JB Nielsen
- Jesper Bo Nielsen
- JW Brock
- K Nesaretnam
- K Nesaretnam
- K Ramamoorthy
- L Hovander
- MG Wade
- N Rajapakse
- P Grandjean
- Pal Weihe
- Philippe Grandjean
- R Steinmetz
- SD Stellman
- SH Safe
- TH Rasmussen
- Thomas Høj Rasmussen
- U Steuerwald
- V Vihma
- VJ Kramer
- WJ Rogan
- Publication venue
- BioMed Central
- Publication date
- 01/01/2003
- Field of study
BACKGROUND: Epidemiological documentation of endocrine disruption is complicated by imprecise exposure assessment, especially when exposures are mixed. Even if the estrogenic activity of all compounds were known, the combined effect of possible additive and/or inhibiting interaction of xenoestrogens in a biological sample may be difficult to predict from chemical analysis of single compounds alone. Thus, analysis of mixtures allows evaluation of combined effects of chemicals each present at low concentrations. METHODS: We have developed an optimized in vitro E-Screen test to assess the combined functional estrogenic response of human serum. The xenoestrogens in serum were separated from endogenous steroids and pharmaceuticals by solid-phase extraction followed by fractionation by high-performance liquid chromatography. After dissolution of the isolated fraction in ethanol-DMSO, the reconstituted extract was added with estrogen-depleted fetal calf serum to MCF-7 cells, the growth of which is stimulated by estrogen. After a 6-day incubation on a microwell plate, cell proliferation was assessed and compared with the effect of a 17-beta-estradiol standard. RESULTS AND CONCLUSIONS: To determine the applicability of this approach, we assessed the estrogenicity of serum samples from 30 pregnant and 60 non-pregnant Danish women thought to be exposed only to low levels of endocrine disruptors. We also studied 211 serum samples from pregnant Faroese women, whose marine diet included whale blubber that contain a high concentration of persistent halogenated pollutants. The estrogenicity of the serum from Danish controls exceeded the background in 22.7 % of the cases, while the same was true for 68.1 % of the Faroese samples. The increased estrogenicity response did not correlate with the lipid-based concentrations of individual suspected endocrine disruptors in the Faroese samples. When added along with the estradiol standard, an indication of an enhanced estrogenic response was found in most cases. Thus, the in vitro estrogenicity response offers a promising and feasible approach for an aggregated exposure assessment for xenoestrogens in serum
Modeling complex ecological economic systems: toward an evolutionary, dynamic understanding of people and nature
- Author
- A Banerjee
- B Hannon
- BB Mandelbrot
- BB Mandelbrot
- BG Norton
- BT Milne
- CS Holling
- CS Holling
- CS Holling
- CW Clark
- CW Clark
- CW Clark
- CW Clark
- EB Rastetter
- F Duchin
- F Duchin
- F Wulff
- FB Taub
- FB Taub
- G Debreu
- G Nicolis
- G Nicolis
- G Sugihara
- GC Gallopin
- GM Brown
- GM Brown
- H Sonnenschein
- HH Shugart
- HH Shugart
- I Prigogine
- J Maynard-Smith
- J Maynard-Smith
- J Maynard-Smith
- J Neuman von
- J Neuman von
- JA Schumpeter
- JB Robinson
- JB Rosser
- JB Rosser
- JH Holland
- JJ Kay
- JM Keynes
- JS Wroblewski
- K Arrow
- K Lindgren
- K-E Eriksson
- K-G Mäler
- KE Boulding
- L Bertalanffy von
- LF Olsen
- LR Klein
- M Lines
- M Lines
- MG Turner
- P Bak
- P Vitousek
- R Axelrod
- R Cabe
- R Costanza
- R Costanza
- R Costanza
- R Levins
- R Selten
- RB Norgaard
- RE Lucas
- RK Colwell
- RM Solow
- RV O’Neill
- RV O’Neill
- RV O’Neill
- SA Kauffman
- TFH Allen
- V Kaitala
- WB Arthur
- Publication venue
- PDXScholar
- Publication date
- 01/01/1993
- Field of study
Recent understanding about system dynamics and predictability that has emerged from the study of complex systems is creating new tools for modeling interactions between anthropogenic and natural systems. A range of techniques has become available through advances in computer speed and accessibility and by implementing a broad, interdisciplinary systems view
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alexander J
- Aliev T
- Allfrey P
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Asaadi J
- Asghar MI
- Askew A
- Ata M
- Atac M
- Atramentov O
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avery P
- Avetisyan A
- Awad A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Ball AH
- Ball G
- Ballin J
- Ban Y
- Bandurin D
- Banerjee S
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- Banzuzi K
- Barbagli G
- Barberis E
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- Barge D
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- Baumgartel D
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- Beaupere N
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- Wood JS
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- Yilmaz Y
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- Yumiceva F
- Yun JC
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- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
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- Zhukov V
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- Ziebarth EB
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- Zoeller MH
- Zorbilmez C
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Compressed representation of a partially defined integer function over multiple arguments
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta MV
- Adair A
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agram J-L
- Aguilar-Benitez M
- Ahmad M
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
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- Wiglesworth C.
- Wigmans R
- Wiik L. A. M.
- Wildauer A.
- Wildish T
- Wildt M. A.
- Wilke L
- Wilken R
- Wilkens H. G.
- Wilkinson R
- Williams E.
- Williams G
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- Williams JC
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- Wingerter-Seez I.
- Wingham M
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- Wlochal M
- Wohri HK
- Wolf R
- Wolter M. W.
- Wolters H.
- Womersley WJ
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- Wood JS
- Worm SD
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- Wrochna G
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- Wu X.
- Wulf E.
- Wulz CE
- Wurthwein F
- Wynne B. M.
- Wyslouch B
- Xaplanteris L.
- Xella S.
- Xie S
- Xie S.
- Xie Z
- Xu D.
- Xu N.
- Xue Z
- Yagil A
- Yamada M.
- Yamamoto A
- Yan M
- Yang X
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- Yang ZC
- Yarba J
- Yaselli I
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
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- Yumiceva F
- Yun JC
- Yuste C
- Zabi A
- Zabolotny W
- Zachariadou A
- Zalewski P
- Zampieri A
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyany A
- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
- Zhang J
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- Zhiltsov V
- Zhokin A
- Zhu B
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- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Zielinski M
- Zilizi G
- Zinonos Z
- Zito G
- Zoeller MH
- Zotto P
- Zub S
- Zumerle G
- Zuranski A
- Zuyeuski R
- Zych P
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Feedback within the Inter-Cellular Communication and Tumorigenesis in Carcinomas
- Author
- A Arlt
- A Mantovani
- A Wullaert
- AB Lowenfels
- B Farrow
- B Gyorffy
- B Vogelstein
- BB Friday
- C Guerra
- C Sonnenschein
- CC Park
- Christian Pilarsky
- CJ Lee
- CJ Magee
- D Hanahan
- D Radisky
- D Shibata
- D Tarin
- DF Parsons
- F Balkwill
- F Colotta
- F Ruckert
- F Ruckert
- F Rückert
- Felix Rückert
- G Bergers
- G Sethi
- GN Naumov
- H Goecke
- H Kurahara
- HF Dvorak
- J Ewing
- J Ling
- JB Greer
- JG Shelton
- JP McGrath
- JPt Morris
- KP Olive
- KR Cho
- L Jackson
- LA Liotta
- Laszlo Buday
- LM Coussens
- M Arvanitakis
- M Guarino
- M Karin
- MB Sporn
- MG Bachem
- MJ Bissell
- MJ Bissell
- MJ Hendrix
- MJ Renan
- MM Bilimoria
- MR Stratton
- N Bardeesy
- N Fausto
- P Monti
- P Savagner
- PA Kenny
- PC Nowell
- R Axelrod
- R Kalluri
- R Talar-Wojnarowska
- RA Weinberg
- Robert Grützmann
- RR Langley
- S Ghosh
- S Paget
- SA Eccles
- SG Hymowitz
- SM Pupa
- ST Dergham
- T Reya
- V Fendrich
- YT Lee
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
The classical somatic mutation theory (SMT) of carcinogenesis and metastasis postulates that malignant transformation occurs in cells that accumulate a sufficient amount of mutations in the appropriate oncogenes and/or tumor suppressor genes. These mutations result in cell-autonomous activation of the mutated cell and a growth advantage relative to neighboring cells. However, the SMT cannot completely explain many characteristics of carcinomas. Contrary to the cell-centered view of the SMT with respect to carcinogenesis, recent research has revealed evidence that the tumor microenvironment plays a role in carcinogenesis as well. In this review, we present a new model that accommodates the role of the tumor microenvironment in carcinogenesis and complements the classical SMT. Our “feedback” model emphasizes the role of an altered spatiotemporal communication between epithelial and stromal cells during carcinogenesis: a dysfunctional intracellular signaling in tumorigenic epithelial cells leads to inappropriate cellular responses to stimuli from associated stromal or inflammatory cells. Thus, a positive feedback loop of the information flow between parenchymal and stromal cells results. This constant communication between the stromal cells and the tumor cells causes a perpetually activated state of tumor cells analogous to resonance disaster
Observation of the diphoton decay of the Higgs boson and measurement of its properties
- Author
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- Abbiendi G
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agapitos A
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s=8 Tev
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agram J-L
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alderweireldt S
- Alexander J
- Aliev T
- Alimena J
- Alvarez JDR
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Androsov K
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
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- Arfaei H
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- Auzinger G
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
- Author
- Abbadie F
- Achkar A
- Ackroyd A
- Adamczyk A
- Adarraga Cansino Md
- Addala A
- Adnet F
- Agarwal G
- Ageno W
- Agnelli G
- Agnelli G
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- Allameddine A
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- Amado Fernández C
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- Angelini E
- Antignani Pl
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- Arden C
- Arellano Rodrigo E
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- Axthelm C
- Axthelm P
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- Cancellieri E
- Cannavacciuolo F
- Caprioli C
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- Rivera Gallego A
- Rodríguez Beltrán Em
- Roldán Schilling V
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- Sonnenschein K
- Sorvillo S
- Stachowitz J
- Staub D
- Stephan D
- Stoshikj S
- Strafino C
- Stücker M
- Sultanzadeh Sj
- Suriñach Caralt Jm
- Sánchez Fuentes D
- Sánchez Muñoz-Torrero Jf
- Sánchez Álvarez J
- Talerico A
- Testa S
- Thachil J
- Thieme M
- Tiefenbacher C
- Tirado Miranda R
- Tissot A
- Todolí Parra Ja
- Tonello C
- Tosi F
- Tropeano P
- Tsantilas D
- Tufano A
- Usandizaga de Antonio E
- Vallarelli S
- Vaquero de Sedas M
- Venton T
- Verdecchia P
- Vetrano V
- Vieth P
- Viganò S
- Villalta Blanch J
- Villalta S
- Villanueva Montes Ma
- Villaverde Álvarez I
- Vincentelli Gm
- Violo C
- Vital-Durand D
- Vodoungnon H
- Voigts B
- vom Dahl J
- von Bilderling P
- von Maltik T
- Wakeling J
- Walby C
- Waldron M
- Watt S
- Weber H
- Weinmann S
- Weinrich K
- Werner N
- Werno Hs
- Werth S
- Weyer M
- Willcock W
- Willich Sn
- Wirtz P
- Wittig I
- Wittig K
- Wucherpfennig P
- Zafar A.
- Zanatta N
- Zierock P
- Zingaretti O
- Zorzi F
- zur Nieden T
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- 01/01/2017
- Field of study
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
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