Monitoring Cognitive and Emotional Processes Through Pupil and Cardiac Response During Dynamic Versus Logical Task

The paper deals with the links between physiological measurements and cognitive and emotional functioning. As long as the operator is a key agent in charge of complex systems, the definition of metrics able to predict his performance is a great challenge. The measurement of the physiological state is a very promising way but a very acute comprehension is required; in particular few studies compare autonomous nervous system reactivity according to specific cognitive processes during task performance and task related psychological stress is often ignored. We compared physiological parameters recorded on 24 healthy subjects facing two neuropsychological tasks: a dynamic task that require problem solving in a world that continually evolves over time and a logical task representative of cognitive processes performed by operators facing everyday problem solving. Results showed that the mean pupil diameter change was higher during the dynamic task; conversely, the heart rate was more elevated during the logical task. Finally, the systolic blood pressure seemed to be strongly sensitive to psychological stress. A better taking into account of the precise influence of a given cognitive activity and both workload and related task-induced psychological stress during task performance is a promising way to better monitor operators in complex working situations to detect mental overload or pejorative stress factor of error

The Incremental Cooperative Design of Preventive Healthcare Networks

This document is the Accepted Manuscript version of the following article: Soheil Davari, 'The incremental cooperative design of preventive healthcare networks', Annals of Operations Research, first published online 27 June 2017. Under embargo. Embargo end date: 27 June 2018. The final publication is available at Springer via http://dx.doi.org/10.1007/s10479-017-2569-1.In the Preventive Healthcare Network Design Problem (PHNDP), one seeks to locate facilities in a way that the uptake of services is maximised given certain constraints such as congestion considerations. We introduce the incremental and cooperative version of the problem, IC-PHNDP for short, in which facilities are added incrementally to the network (one at a time), contributing to the service levels. We first develop a general non-linear model of this problem and then present a method to make it linear. As the problem is of a combinatorial nature, an efficient Variable Neighbourhood Search (VNS) algorithm is proposed to solve it. In order to gain insight into the problem, the computational studies were performed with randomly generated instances of different settings. Results clearly show that VNS performs well in solving IC-PHNDP with errors not more than 1.54%.Peer reviewe

Capability driven development: an approach to designing digital enterprises

The final publication is available at Springer via http://dx.doi.org/10.1007/s12599-014-0362-0[EN] The need for organizations to operate in changing environments is addressed by proposing an approach that integrates organizational development with information system (IS) development taking into account changes in the application context of the solution. This is referred to as Capability Driven Development (CDD). A meta-model representing business and IS designs consisting of goals, key performance indicators, capabilities, context and capability delivery patterns, is being proposed. The use of the meta-model is validated in three industrial case studies as part of an ongoing collaboration project, whereas one case is presented in the paper. Issues related to the use of the CDD approach, namely, CDD methodology and tool support are also discussed.This work has been partially supported by the EU-FP7 funded project no: 611351 CaaS - Capability as a Service in Digital Enterprises.Berzisa, S.; Bravos, G.; Cardona Gonzalez, T.; Czubayko, U.; España, S.; Grabis, J.; Henkel, M.... (2015). Capability driven development: an approach to designing digital enterprises. Business and Information Systems Engineering. 57(1):15-25. https://doi.org/10.1007/s12599-014-0362-0S1525571ArchiMate (2013) An enterprise modeling language from the Open Group. http://www.opengroup.org/archimate/ . Accessed 3 Dec 2014Asadi M, Ramsin R (2008) MDA-based methodologies: an analytical survey. In: Proceedings Model driven architecture – foundations and applications (ECMDA-FA 2008), LNCS 5095, pp 419–431Barney JB (1991) Firm resources and sustained competitive advantage. J Manag 17(1):99–120Bērziša S, Bravos G, Gonzalez Cardona T, Czubayko U, España S, Grabis J, Henke lM, Jokste L, Kampars J, Koc H, Kuhr J, Llorca C, Loucopoulos P, Juanes Pascua lR, Sandkuh lK, Simic H, Stirna J, Zdravkovic J (2014) Deliverable 1.4: Requirements specification for CDD, CaaS – capability as a service for digital enterprises. FP7 project no 611351, Riga Technical University, Latvia. Submitted for reviewBubenko JA Jr, Persson A, Stirna J (2001) User guide of the knowledge management approach using enterprise knowledge patterns. Deliverable D3, IST programme project hypermedia and pattern based knowledge management for smart organisations. project no. IST-2000-28401, Royal Institute of Technology, SwedenBriand LC, Yue T, Labiche Y (2011) A systematic review of transformation approaches between user requirements and analysis models. Requir Eng 16:75–99De Kinderen S, Gordijn J, Akkermans H (2009) Reasoning about customer needs in multi-supplier ICT service bundles using decision models. In: Proceedings 11th international conference on enterprise information systems (ICEIS 2009), pp 131–136Deloitte (2009) Cloud computing: forecasting change. Deloitte Consulting, New York. http://public.deloitte.no/dokumenter/2_Cloud_Computing%5B1%5D.pdf . Accessed 3 Dec 2014Dey A (2001) Understanding and using context. Pers Ubiquitous Comput 5(1):4–7Gamma E, Helm R, Johnson R, Vlissides J (1995) Design patterns: elements of reusable object-oriented software architecture. Addison-Wesley, BostonGomes D, Gonçalves JM, Santos R, Aguiar R (2010) XMPP based context management architecture. In: Proceedings GLOBECOM workshop, IEEE, pp 1372–1377González A, España S, Ruiz M, Pastor Ó (2011) Systematic derivation of class diagrams from communication-oriented business process models. In: 12th working conference on business process modeling, development, and support (BPMDS’11). Springer LNBIP 81, pp 246–260Henkel M, Stirna J (2010) Pondering on the key functionality of model driven development tools: the case of mendix. In: Forbrig P, Günther H (eds) Proceedings business informatics research (BIR 2010), Springer LNBIP 64, pp 146–160Hervas R, Bravo J, Fontecha J (2010) A context model based on ontological languages – a proposal for information visualisation. J Univers Comput Sci 16(12):1539–1555Jarke M, Loucopoulos P, Lyytinen K, Mylopoulos J, Robinson W (2011) The brave new world of design requirements. Information Syst 36(7):992–1008Kaplan RS, Norton DP (2004) Strategy maps: converting intangible assets into tangible outcomes. Harvard Business School Press, BostonKleppe A, Warmer J, Bast W (2013) MDA explained. Addison-Wesley, BostonLoniewski G, Insfran E, Abrahao L (2010) A systematic review of the use of requirements engineering techniques in model-driven development. In: Proceedings model driven engineering languages and systems (MODELS 2010), Part II, LNCS 6395, pp 213–227Mohagheghi P, Dehlen V (2008) Where is the proof? - a review of experiences from applying MDE in industry. In: Proceedings model driven architecture – foundations and applications (ECMDA-FA 2008). LNCS 5095. Springer, Heidelberg, pp 432–443Nilsson AG, Tolis C, Nellborn C (eds) (1999) Perspectives on business modelling: understanding and changing organisations. Springer, HeidelbergOASIS (2011) Reference architecture foundation for service oriented architecture version 1.0, committee specification draft 03/public review draft 02 06 July 2011. http://docs.oasis-open.org/soa-rm/soa-ra/v1.0/soa-ra.pdf . Accessed 3 Dec 2014OMG (2011a) UML superstructure. http://www.omg.org/spec/UML/2.4.1/ . Accessed 3 Dec 2014OMG (2011b) Business process model and notation. http://www.omg.org/spec/BPMN/2.0/ . Accessed 3 Dec 2014Osterwalder A, Pigneur Y (2003) Modeling value propositions in e-business. Proc 5th international conference on electronic commerce (ICEC 2003). ACM Conference Proceedings Series 50Papazoglou MP, Yang J (2002) Design methodology for web services and business processes. In: Proceedings 3rd international workshop on technologies for e-services (TES 03). LNCS 2444. Springer, Heidelberg, pp 54–64Pastor O, Giachetti G (2010) Linking goal-oriented requirements and model-driven development. In: Intentional perspectives on information systems engineering. Springer, Heidelberg, pp 257–276Porter ME (1985) Competitive advantage: creating and sustaining superior performance. Free Press, New YorkRuiz M, Costal D, España S, Franch X, Pastor Ó (2014) Integrating the goal and business process perspectives in information system analysis. In: 26th International Conference on Advanced Information Systems Engineering (CAiSE 2014). LNCS 8484. Springer, Heidelberg, pp 332–346Sheng Q, Yu J, Dustar S (eds) (2010) Enabling context-aware web services: methods, architectures, and technologies. Chapman & Hall/CRC, Boca RatonSmanchat S, Ling S, Indrawan M (2008) A survey on context-aware workflow adaptations. In: Proceedings 6th international conference on advances in mobile computing and multimedia (MoMM 2008), New York, pp 414–417Stirna J, Grabis J, Henkel M, Zdravkovic J (2012) Capability driven development – an approach to support evolving organizations. In: The practice of enterprise modeling (PoEM 2012). LNBIP 134. Springer, Heidelberg, pp 117–131Vale S, Hammoudi S (2009) COMODE: a framework for the development of context-aware applications in the context of MDE. In: Proceedings 4th international conference on internet and web applications and services (ICIW 2009). IEEE, Venice, pp 261–266Wesenberg H (2011) Enterprise modeling in an agile world. In: Johannesson P, Krogstie J, Opdahl AL (eds) The practice of enterprise modeling (PoEM 2011). LNBIP 92. Springer, Heidelberg, pp 126–130Zdravkovic J, Stirna J, Henkel M, Grabis J (2013) Modeling business capabilities and context dependent delivery by cloud services. In: Proceedings advanced information systems engineering (CAiSE 2013). LNCS 7908. Springer, Heidelberg, pp 369–38

A General Model of Dynamics on Networks with Graph Automorphism Lumping

In this paper we introduce a general Markov chain model of dynamical processes on networks. In this model, nodes in the network can adopt a finite number of states and transitions can occur that involve multiple nodes changing state at once. The rules that govern transitions only depend on measures related to the state and structure of the network and not on the particular nodes involved. We prove that symmetries of the network can be used to lump equivalent states in state-space. We illustrate how several examples of well-known dynamical processes on networks correspond to particular cases of our general model. This work connects a wide range of models specified in terms of node-based dynamical rules to their exact continuous-time Markov chain formulation

The effects of patient characteristics on ADHD diagnosis and treatment: a factorial study of family physicians

<p>Abstract</p> <p>Background</p> <p>Attention Deficit Hyperactivity Disorder (ADHD) is a costly and prevalent disorder in the U.S., especially among youth. However, significant disparities in diagnosis and treatment appear to be predicted by the race and insurance status of patients.</p> <p>Methods</p> <p>This study employed a web-based factorial survey with four ADHD cases derived from an ADHD clinic, two diagnosed with ADHD in actual evaluation, and two not. Randomized measures included race and insurance status of the patients. Participants N = (187) included clinician members of regional and national practice-based research networks and the U.S. clinical membership of the Society of Teachers of Family Medicine. The main outcomes were decisions to 1) diagnose and 2) treat the cases, based upon the information presented, analyzed via binary logistic regression of the randomized factors and case indicators on diagnosis and treatment.</p> <p>Results</p> <p>ADHD-positive cases were 8 times more likely to be diagnosed and 12 times more likely to be treated, and the male ADHD positive case was more likely to be diagnosed and treated than the female ADHD positive case. Uninsured cases were significantly more likely to be treated overall, but male cases that were uninsured were about half as likely to be diagnosed and treated with ADHD. Additionally, African-American race appears to increase the likelihood of medicinal treatment for ADHD and being both African-American and uninsured appears to cut the odds of medicinal treatment in half, but not significantly.</p> <p>Conclusions</p> <p>Family physicians were competent at discerning between near-threshold ADHD-negative and ADHD positive cases. However, insurance status and race, as well as gender, appear to affect the likelihood of diagnosis and treatment for ADHD in Family Medicine settings.</p

Location of Immunization and Interferon-γ Are Central to Induction of Salivary Gland Dysfunction in Ro60 Peptide Immunized Model of Sjögren's Syndrome

INTRODUCTION: Anti-Ro antibodies can be found in the serum of the majority of patients with Sjögren's syndrome (SS). Immunization with a 60-kDa Ro peptide has been shown to induce SS-like symptoms in mice. The aim of this study was to investigate factors involved in salivary gland (SG) dysfunction after immunization and to test whether the induction of SS could be improved. METHODS: Ro60 peptide immunization was tested in Balb/c mice, multiple antigenic peptide (MAP)-Ro60 and Pertussis toxin (PTX) were tested in SJL/J mice. In addition, two injection sites were compared in these two strains: the abdominal area and the tailbase. Each group of mice was tested for a loss of SG function, SG lymphocytic infiltration, anti-Ro and anti-La antibody formation, and cytokine production in cultured cells or homogenized SG extracts. RESULTS: Ro60 peptide immunization in the abdominal area of female Balb/c mice led to impaired SG function, which corresponded with increased Th1 cytokines (IFN-γ and IL-12) systemically and locally in the SG. Moreover, changing the immunization conditions to MAP-Ro60 in the abdominal area, and to lesser extend in the tailbase, also led to impaired SG function in SJL/J mice. As was seen in the Balb/c mice, increased IFN-γ in the SG draining lymph nodes accompanied the SG dysfunction. However, no correlation was observed with anti-MAP-Ro60 antibody titers, and there was no additional effect on disease onset or severity. CONCLUSIONS: Effective induction of salivary gland dysfunction after Ro60 peptide immunization depended on the site of injection. Disease induction was not affected by changing the immunization conditions. However, of interest is that the mechanism of action of Ro60 peptide immunization appears to involve an increase in Th1 cytokines, resulting in the induction of SG dysfunction

Time-Course Analysis of Cyanobacterium Transcriptome: Detecting Oscillatory Genes

The microarray technique allows the simultaneous measurements of the expression levels of thousands of mRNAs. By mining these data one can identify the dynamics of the gene expression time series. The detection of genes that are periodically expressed is an important step that allows us to study the regulatory mechanisms associated with the circadian cycle. The problem of finding periodicity in biological time series poses many challenges. Such challenge occurs due to the fact that the observed time series usually exhibit non-idealities, such as noise, short length, outliers and unevenly sampled time points. Consequently, the method for finding periodicity should preferably be robust against such anomalies in the data. In this paper, we propose a general and robust procedure for identifying genes with a periodic signature at a given significance level. This identification method is based on autoregressive models and the information theory. By using simulated data we show that the suggested method is capable of identifying rhythmic profiles even in the presence of noise and when the number of data points is small. By recourse of our analysis, we uncover the circadian rhythmic patterns underlying the gene expression profiles from Cyanobacterium Synechocystis

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT

Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector

This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}$and correspond to an integrated luminosity of$4.6\;{\rm f}{{{\rm b}}^{-1}}$. The measurement is performed by reconstructing the boosted W or Z bosons in single jets. The reconstructed jet mass is used to identify the W and Z bosons, and a jet substructure method based on energy cluster information in the jet centre-of-mass frame is used to suppress the large multi-jet background. The cross-section for events with a hadronically decaying W or Z boson, with transverse momentum${{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}$and pseudorapidity$|\eta |\lt 1.9$, is measured to be${{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques