107 research outputs found
Radiologic Characteristics of Spinal Hemangioblastomas in von Hippel Lindau Disease as Guidance in Clinical Interventions
Objective: Hemangioblastomas in the central nervous system are the most common manifestation of von Hippel-Lindau (VHL) disease. Because the growth rate of hemangioblastomas is unpredictable, regular follow-up is mandatory, focusing on clinical symptoms and imaging of the central nervous system. However, clinical symptoms may be subtle and nonspecific, and data about the relationship between the radiologic findings and clinical symptoms are sparse. This study aims to evaluate if and how findings of magnetic resonance imaging (MRI) regarding spinal hemangioblastomas are associated with symptoms of VHL disease, with special attention to peritumoral edema and spinal cysts. Methods: Serial spinal MRI scans of 43 genetically or clinically established VHL patients with at least 2 years of follow-up were reevaluated to examine the volume, growth rate, and location of spinal hemangioblastomas and the presence, size, and growth rate of peritumoral edema and cysts. Findings were compared with clinical symptoms using the Fisher exact test. Results: We observed a total of 77 spinal hemangioblastomas in 28 patients. Eight of the 28 patients showed peritumoral edema and spinal cysts, and 1 patient showed peritumoral edema without cyst formation; 6 of these 9 patients showed clinical symptoms. Both peritumoral edema and spinal cysts were associated with clinical symptoms (P = 0.023 and P = 0.011, respectively). Conclusions: The presence of peritumoral edema and/or spinal cysts shown on MRI in VHL patients with spinal hemangioblastomas is associated with symptoms in more than half of the patients and may alert the clinician to intensify clinical and radiologic surveillance.</p
A Measurement of Psi(2S) Resonance Parameters
Cross sections for e+e- to hadons, pi+pi- J/Psi, and mu+mu- have been
measured in the vicinity of the Psi(2S) resonance using the BESII detector
operated at the BEPC. The Psi(2S) total width; partial widths to hadrons,
pi+pi- J/Psi, muons; and corresponding branching fractions have been determined
to be Gamma(total)= (264+-27) keV; Gamma(hadron)= (258+-26) keV, Gamma(mu)=
(2.44+-0.21) keV, and Gamma(pi+pi- J/Psi)= (85+-8.7) keV; and Br(hadron)=
(97.79+-0.15)%, Br(pi+pi- J/Psi)= (32+-1.4)%, Br(mu)= (0.93+-0.08)%,
respectively.Comment: 8 pages, 6 figure
Time-integrated luminosity recorded by the BABAR detector at the PEP-II e+e- collider
This article is the Preprint version of the final published artcile which can be accessed at the link below.We describe a measurement of the time-integrated luminosity of the data collected by the BABAR experiment at the PEP-II asymmetric-energy e+e- collider at the ϒ(4S), ϒ(3S), and ϒ(2S) resonances and in a continuum region below each resonance. We measure the time-integrated luminosity by counting e+e-→e+e- and (for the ϒ(4S) only) e+e-→μ+μ- candidate events, allowing additional photons in the final state. We use data-corrected simulation to determine the cross-sections and reconstruction efficiencies for these processes, as well as the major backgrounds. Due to the large cross-sections of e+e-→e+e- and e+e-→μ+μ-, the statistical uncertainties of the measurement are substantially smaller than the systematic uncertainties. The dominant systematic uncertainties are due to observed differences between data and simulation, as well as uncertainties on the cross-sections. For data collected on the ϒ(3S) and ϒ(2S) resonances, an additional uncertainty arises due to ϒ→e+e-X background. For data collected off the ϒ resonances, we estimate an additional uncertainty due to time dependent efficiency variations, which can affect the short off-resonance runs. The relative uncertainties on the luminosities of the on-resonance (off-resonance) samples are 0.43% (0.43%) for the ϒ(4S), 0.58% (0.72%) for the ϒ(3S), and 0.68% (0.88%) for the ϒ(2S).This work is supported by the US Department of Energy and National Science Foundation, the Natural Sciences and Engineering Research Council (Canada), the Commissariat à l’Energie Atomique and Institut National de Physique Nucléaire et de Physiquedes Particules (France), the Bundesministerium für Bildung und Forschung and Deutsche Forschungsgemeinschaft (Germany), the Istituto Nazionale di Fisica Nucleare (Italy), the Foundation for Fundamental Research on Matter (The Netherlands), the Research Council of Norway, the Ministry of Education and Science of the Russian Federation, Ministerio de Ciencia e Innovación (Spain), and the Science and Technology Facilities Council (United Kingdom). Individuals have received support from the Marie-Curie IEF program (European Union) and the A.P. Sloan Foundation (USA)
WW Production Cross Section and W Branching Fractions in e+e- Collisions at 189 GeV
From a data sample of 183 pb^-1 recorded at a center-of-mass energy of roots
= 189 GeV with the OPAL detector at LEP, 3068 W-pair candidate events are
selected. Assuming Standard Model W boson decay branching fractions, the W-pair
production cross section is measured to be sigmaWW = 16.30 +- 0.34(stat.) +-
0.18(syst.) pb. When combined with previous OPAL measurements, the W boson
branching fraction to hadrons is determined to be 68.32 +- 0.61(stat.) +-
0.28(syst.) % assuming lepton universality. These results are consistent with
Standard Model expectations.Comment: 22 pages, 5 figures, submitted to Phys. Lett.
Search for charginos in e+e- interactions at sqrt(s) = 189 GeV
An update of the searches for charginos and gravitinos is presented, based on
a data sample corresponding to the 158 pb^{-1} recorded by the DELPHI detector
in 1998, at a centre-of-mass energy of 189 GeV. No evidence for a signal was
found. The lower mass limits are 4-5 GeV/c^2 higher than those obtained at a
centre-of-mass energy of 183 GeV. The (\mu,M_2) MSSM domain excluded by
combining the chargino searches with neutralino searches at the Z resonance
implies a limit on the mass of the lightest neutralino which, for a heavy
sneutrino, is constrained to be above 31.0 GeV/c^2 for tan(beta) \geq 1.Comment: 22 pages, 8 figure
Genotype-phenotype associations in a large PTEN Hamartoma Tumor Syndrome (PHTS) patient cohort
Background: Pathogenic PTEN germline variants cause PTEN Hamartoma Tumor Syndrome (PHTS), a rare disease with a variable genotype and phenotype. Knowledge about these spectra and genotype-phenotype associations could help diagnostics and potentially lead to personalized care. Therefore, we assessed the PHTS genotype and phenotype spectrum in a large cohort study. Methods: Information was collected of 510 index patients with pathogenic or likely pathogenic (LP/P) PTEN variants (n = 467) or variants of uncertain significance. Genotype-phenotype associations were assessed using logistic regression analyses adjusted for sex and age.Results: At time of genetic testing, the majority of children (n = 229) had macrocephaly (81%) or developmental delay (DD, 61%), and about half of the adults (n = 238) had cancer (51%), macrocephaly (61%), or cutaneous pathology (49%). Across PTEN, 268 LP/P variants were identified, with exon 5 as hotspot. Missense variants (n = 161) were mainly located in the phosphatase domain (PD, 90%) and truncating variants (n = 306) across all domains. A trend towards 2 times more often truncating variants was observed in adults (OR = 2.3, 95%CI = 1.5-3.4) and patients with cutaneous pathology (OR = 1.6, 95%CI = 1.1-2.5) or benign thyroid pathology (OR = 2.0, 95%CI = 1.1-3.5), with trends up to 2-4 times more variants in PD. Whereas patients with DD (OR = 0.5, 95%CI = 0.3-0.9) or macrocephaly (OR = 0.6, 95%CI = 0.4-0.9) had about 2 times less often truncating variants compared to missense variants. In DD patients these missense variants were often located in domain C2.Conclusion: The PHTS phenotypic diversity may partly be explained by the PTEN variant coding effect and the combination of coding effect and domain. PHTS patients with early-onset disease often had missense variants, and those with later-onset disease often truncating variants
Measurements of the cross sections for at 3.650, 3.6648, 3.773 GeV and the branching fraction for
Using the BES-II detector at the BEPC Collider, we measured the lowest order
cross sections and the values () for inclusive hadronic event
production at the center-of-mass energies of 3.650 GeV, 3.6648 GeV and 3.773
GeV. The results lead to which is the
average of these measured at 3.650 GeV and 3.6648 GeV, and at GeV. We determined the lowest order cross
section for production to be at 3.773 GeV, the branching fractions for
decays to be , and , which result in the total non-
branching fraction of decay to be .Comment: 11 pages, 5 figure
Mulit-Photon Events with Large Missing energy in e+e- collisions at sqrt(s)=192-209 GeV
Events with a final state consisting of two or more photons and large missing
transverse energy have been observed in e+e- collisions at centre-of-mass
energies in the range 192 - 209 GeV using the OPAL detector at LEP.
Cross-section measurements are performed within the kinematic acceptance of the
selection and compared with the expectation from the Standard Model process
e+e- -> nu nu gamma gamma(gamma). No evidence for new physics contributions to
this final state is observed. Upper limits on sigma (e+e- -> XX) BR^2(X ->
Ygamma) are derived for the case of stable and invisible Y. In the case of
massive Y the combined limits obtained from all the data range from 10 fb to 60
fb, while for the special case of massless Y the range is 20 fb to 40 fb. The
limits apply to pair production of excited neutrions (X=nu^*,Y=nu), to
neutralino production (X=~chi^0_2, Y=~chi^0_1) and to supersymmetric models in
which X=~chi^0_1 and Y=~G is a light gravitino.Comment: 18 pages, 4 figures, Submitted to Phys. Letts
Measurement of \chi_{c2} Production in Two-Photon Collisions
The production of the \chi_{c2} charmonium state in two-photon collisions has
been measured with the Belle detector at the KEKB e^+e^- collider. A clear
signal for \chi_{c2} --> \gamma J/\psi, J/\psi --> l^+l^- is observed in a
32.6fb^{-1} data sample accumulated at center-of-mass energies near 10.6GeV,
and the product of its two-photon decay width and branching fraction is
determined to be \Gamma_{\gamma\gamma}(\chi_{c2})B(\chi_{c2} --> \gamma J/\psi)
B(J/\psi --> l^+l^-)= 13.5 +/- 1.3(stat.) +/- 1.1(syst.)eV.Comment: 16 pages, 5 figures, to be submitted to Phys. Lett.
Precison Measurements of the Mass, the Widths of Resonance and the Cross Section at GeV
By analyzing the values measured at 68 energy points in the energy region
between 3.650 and 3.872 GeV reported in our previous paper, we have precisely
measured the mass, the total width, the leptonic width and the leptonic decay
branching fraction of the to be MeV, MeV,
eV and , respectively, which result in
the observed cross section nb at MeV. We have also measured for the continuum light hadron production in the
region from 3.650 to 3.872 GeV.Comment: 5 pages, 2 figure
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