103 research outputs found
An in situ toxicity identification and evaluation water analysis system: Laboratory validation
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/06/2017
- Field of study
It is difficult to assess the toxicity of a single stressor and establish a strong stressor–causality link when multiple stressors coexist. Toxicity identification evaluation (TIE) methodology uses a series of chemical and physical manipulations to fractionate compounds within a matrix and systematically identify potential toxicants. The current US Environmental Protection Agency application of TIE can provide valuable information but often lacks ecological realism and is subject to laboratory‐related artifacts. An in situ TIE device (iTIED) was designed to assess the sources of toxicity in aquatic ecosystems. For this laboratory validation, each unit was equipped with a sorbent resin chamber, an organism exposure chamber, a water collection container, and a peristaltic pump. Chemical analyses of water processed by each iTIED unit were compared with both lethal and sublethal molecular responses of the organisms. The compound removal effectiveness of different sorbent resins was also compared. In addition to successfully fractionating diverse chemical mixtures, the iTIED demonstrated a potential for early detection of molecular biomarkers, which could identify chronic toxicity that may go unnoticed in traditional TIE assays. Utilizing this novel in situ system will reduce the uncertainty associated with laboratory‐based simulations and aid management efforts in targeting compounds that pose the greatest threat. Environ Toxicol Chem 2017;36:1636–1643. © 2016 SETACPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137342/1/etc3696.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137342/2/etc3696_am.pd
Distribuição de Escherichia coli nos órgãos do sistema mononuclear fagocitário após esplenectomia total isolada ou combinada com auto-implante esplênico em rato
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Overactive bladder – 18 years – part I
- Author
- Abrams P
- Alexandre Fornari
- Anibal Salazar
- Antunes-Lopes T
- Arlandis Guzmán S
- Arturo Dell'Oro
- Arya LA
- Berghmans B
- Borello-France D
- Bosch JL
- Botelho MG
- Brocklehurst JC
- Brown JS
- Bryant CM
- Burgio KL
- Caio Cintra
- Carlos A. Bezerra
- Carlos Alberto Ricetto Sacomani
- Caruso DJ
- Cheng Y
- Chung SD
- Coyne KS
- Creighton SM
- Cristiano Mendes Gomes
- de Sèze M
- Digesu GA
- Dmochowski RR
- Dobbs RW
- Dávila HA
- Eduardo Brambila
- Emilio Miguel Longo
- Fantl JA
- Fantl JA
- Farag FF
- Fernando G. Almeida
- Fitzgerald MP
- Flavio Trigo Rocha
- Francisco Coutinho
- Frankel SJ
- Franzén K
- Gabriel Favre
- Garcia Salord J
- Ghezzi A
- Ghoniem G
- Goldman HB
- Gordon D
- Gustavo Luis Garrido
- Hashim H
- Hashim H
- Haylen BT
- Holroyd-Leduc JM
- Hsiao SM
- Irwin DE
- Ivan Mauricio Plata
- Jackson S
- Jose Campos
- Jose Carlos Truzzi
- José Antonio Garcia
- Juan Castaño
- Juan Pablo Tapia
- Kafri R
- KEGEL AH
- Kelleher C
- Khalili aa
- Kim JC
- Kuo HC
- Lamb SE
- Liu HT
- Liu HT
- Liu HT
- Mamik MM
- Marcio Augusto Averbeck
- Miguel Reyes
- Milsom I
- Milsom I
- Nishijima S
- O'Reilly BA
- Oh SJ
- Onukwugha E
- Ouslander JG
- Ozdedeli S
- Palleschi G
- Qu HC
- Rai BP
- Ricardo Reges
- Rodrigo Eugenio Leyton
- Rovner ES
- Ruiter Silva Ferreira
- Scarpero H
- Seki S
- Sergio Duran
- Silva-Ramos M
- Stewart WF
- Sun Y
- Swithinbank L
- Teloken C
- Temml C
- Tikkinen KA
- Tomlinson BU
- Truzzi JC
- Tyagi P
- Vanda López
- Wein A
- Wells MJ
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
- Abuajaila A
- Abuattaya AA
- Abubakar AM
- Abueideh A
- Abuhayyeh HA
- Abuhlega MA
- Abukhalaf S
- Abumunshar AA
- Acuna G
- Adams S
- Adamu S
- Adanan MFSBM
- Adawi I
- Adawi S
- Adawy A
- Ade-Ajayi N
- Adegboyega R
- Ademuyiwa A
- Adesanya O
- Adhiwidjaja CF
- Adofo-Ansong N
- Agboola TH
- Agelebe E
- Aguiar AA
- Aguilar FA
- Aguirre-Lopez P
- Agulham MA
- Ahmad H
- Ahmad ZAH
- Ahmed H
- Ahmed MA
- Ajai OT
- Ajao EA
- Ajiboye OS
- Ajrami Y
- Akan ME
- Akhbari M
- Akhter N
- Akova F
- Al Dammagh NM
- Al Hussein S
- Al Massry NA
- Al Quran TM
- Al-Attar HM
- Al-Halbouni L
- Al-Mamun A
- Al-Mayoof AF
- Al-Momani HM
- Al-Mouakeh A
- Al-Rayyes M
- Al-Salhi AA
- Al-Shwaikh SH
- Al-Slaibi I
- Al-Taher RN
- Al-Taher RN
- Al-Tammam H
- Alakaloko F
- Alattas K
- Alberto C
- Albozidi A
- Alcantara E
- Aldirawi MAM
- Alebbini MM
- Alfoghi M
- Algabri HNO
- Alglaib MM
- Alhamid A
- Alhamid A
- Alhassan P
- Ali H
- Ali KO
- Ali L
- Ali M
- Alijla S
- Alijla SS
- Aliwisat AH
- Aljaboo H
- Aljadidi WOFS
- Aljarad Z
- Alkali YS
- Alkareem RMA
- Almada SA
- Almadhoun W
- Almasri M
- Almeida G
- Almengar I
- Almohamady H
- Almosaibli M
- Almusleh TFH
- Alnaeri A
- Alnahhal K
- Alonso V
- Alosta HM
- Alqarajeh F
- Alqor MOI
- Alsaadi NN
- Alsaggaf A
- Alsaied A
- Alser M
- Alser OH
- Alshaikhkhalil HAA
- Alshehri A
- Altamirano PR
- Altaweel A
- Altin M
- Altokhais T
- Altomi M
- Alturki F
- Alva LRC
- Alvarez JR
- Alwadia SMS
- Alwaggaa NA
- Alzamari AAM
- Alzeer AMS
- Alzerei ST
- Alzraikat SH
- Alzubair A
- Alzughayyar TZ
- Amad M
- Amado F
- Amaechi C
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- Amarin JZ
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- Ambriz-Gonzalez G
- Ameh E
- Amoabin AA
- Anatole N
- Anatole NK
- Anaya F
- Anaya WB
- Andrade J
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- Anyomih TTK
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- Appeadu-Mensah W
- Arabiat E
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- Arafat H
- Aragao L
- Arancibia JAC
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- Argomedo MRO
- Arnadottir H
- Arnaud AP
- Arnold M
- Arnoletto LB
- Arrmali S
- Arrmalli LA
- Arshad M
- Arthur F
- Arul S
- Ashour DA
- Ashour YS
- Aslan Y
- Aspirot A
- Assi A
- Assi MAF
- Astudillo M
- Atatri YYM
- Atta A
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- Aucatoma FC
- Augusto MLDS
- Avila DC
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- Avolio L
- Awad H
- Aydin E
- Aykut M
- Aziz DAA
- Ba'baa' B
- Badr H
- Baertschiger R
- Bagbio D
- Bah A
- Bai Q
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- Baistrocchi V
- Baker W
- Ballah AM
- Ballouhey Q
- Balousha AG
- Bamanga A
- Baniowda MAM
- Bao X
- Barauskas V
- Barbosa PR
- Barcelos FZ
- Baron JDJC
- Barreto JJS
- Barros BS
- Baseggio N
- Bashir F
- Bashir MK
- Bataineh ZA
- Batal MM
- Bazozi HM
- Beasley S
- Becker K
- Belesa FDA
- Beloy IC
- Beltran NS
- Ben Enbaya M
- Benaskeur Y-I
- Benavente CM
- Beres A
- Berkova K
- Bernaus M
- Berzanskis M
- Beshtawi DMS
- Besir A
- Bianchin E
- Bibas F
- Biber E
- bin Abdullah MY
- Bin Amjad M
- bin Bujarimin AS
- bin Hassan MR
- Bin Othman MY
- bin Zahari Z
- bin Zarwawi AZ
- Bischoff C
- Blain OE
- Blanc T
- Blanchet EB
- Blazquez-Gomez E
- Blom MD
- Bode C
- Bonnard A
- Boonthai A
- Borbonet D
- Borges CG
- Bouhadiba N
- Bowder A
- Bradshaw K
- Bragagnini P
- Brahmamdam P
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- Broch A
- Brunero M
- Bruxel CL
- Bsisu I
- Bucaram E
- Burgos CM
- Burks SS
- Burns K
- Butler M
- Bvulani B
- Caamal LJ
- Cai D
- Calancea C
- Calderon LO
- Calistus N
- Calle CS
- Cama J
- Camacho FRC
- Camamra K
- Cameron F
- Camp L
- Canozer A
- Caouette-Laberge L
- Carbajal LF
- Carloni ICS
- Carrasco AL
- Carrasco-Ortega C
- Carrillo I
- Casado FT
- Caseb P
- Casquero V
- Castaneda FDMD
- Castillo MN
- Cavaiuolo S
- Cekic B
- Celik M
- Centen SV
- Cepeda R
- Cesur IB
- Chan J
- Chang J
- Charras MD
- Chaudary AR
- Chaudhry MA
- Chauhan N
- Chen J
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- Chen R
- Cheung M
- Chipalavela RF
- Chipana CLA
- Chiriboga E
- Chiroque CM
- Chitiavi SW
- Chitnis M
- Cho SH
- Choo CSC
- Chukwu I
- Chukwuemeka AL-J
- Chung JH
- Cino EL
- Cletus C
- Coghill G
- Collins N
- Comert HSY
- Contreras CS
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- Cordonnier A
- Cordova KH
- Cornelli F
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- Corona MQ
- Correa A
- Correa C
- Cortez LFG
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- Cruzado GJS
- Cunningham A
- Cury EK
- Czauderna P
- da Cunha AG
- da Silva EAD
- da Silva JAN
- da Silva KI
- Dagilyte R
- Daher AP
- Dahman NBH
- Dalek NFRA
- Dallegre MB
- Dalloul H
- Damiani A
- Dania B
- Darras OM
- Darwish A
- Darwish AS
- Dass A
- Dassonville M
- Davenport K
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- Davies J
- Davis JK
- de Almeida TL
- de Andrade SO
- de Fernandez y Alcazar FR
- de Fraga JCS
- de Guzman J
- de Holanda FC
- De La Cruz RR
- de Oliveira DF
- de Oliveira DP
- de Souza RF
- de Vos C
- Dedeke F
- Defago VH
- Defert C
- Delefortrie T
- Delforge X
- Dendusic N
- Derbew M
- Derks T
- Deya C
- Deyab A
- Deyl RT
- Di Siervi O
- Dias AIBDS
- Dieudonne L
- Dimatatac DM
- Djordjevic I
- do Nascimento SD
- Dogar S
- Doheim MF
- Dominguez D
- Dominguez MA
- dos Santos CS
- dos Santos MSF
- Dosselman LJ
- Douiri A
- Drah W
- Dube AM
- Duchesne C
- Duggan E
- Dure C
- Ebeido A
- Echegaray MD
- Egbuchulem IK
- Ejinkeonye EC
- Ekenze SO
- Ekwunife OH
- El Tallaa MA
- El-Ghazaly M
- Elassall GMH
- Elayeb A
- Elebute OA
- Elewaily M
- Elfiky M
- Elgammudi M
- Elghazaly SM
- Elhadi A
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- Elhajjaji YA
- Elhattab A
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- Elkaloush AA
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- Elrais SA
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- Espineda B
- Espinosa SC
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- Essa TM
- Essamilghi KAM
- Ezidiegwu US
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- Fachin C
- Fadhle MJ
- Fajardo GYP
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- Falah EH
- Farag EM
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- Fawzy OM
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- Fernandez JY
- Ferreira JL
- Ferreira MDSS
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- Flores IMR
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- Fory GO
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- Fouly MAN
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- Greenberg J
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- Guerin F
- Guimaraes P
- Guinsburg R
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- Guo X
- Gurgel do Amaral AC
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- Gutierrez EA
- Gutierrez NT
- Guzman NJT
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- Haidari SA
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- Hajajreh MS
- Hakan N
- Halabi YA
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- Hamidi N
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- Hammato AY
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- Hammouri AG
- Hamzah SNABH
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- Hanifah NABM
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- Hasanain DK
- Hashim HHB
- Hashim I
- Hashim S
- Hassan MA
- Hassan MYM
- Hassan ZBM
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- Hwang IJ
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- Ibukunolu O
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- Ismail EM
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- Nkunzimana E
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- Nour IR
- Novotny N
- Nuntasunti W
- Nwangwu EI
- Nwankwo EP
- Nwosu DC
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- O'Connor Z
- Obeso AS
- Obianyo NE
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- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
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- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
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- Abdelhady S
- Abdelhamed R
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- Abdelkader M
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- Kong V
- Konstantina K
- Kontos M
- Kordorwu HEK
- Korkolis D
- Kosai NR
- Kosai NR
- Kose E
- Koskenvuo L
- Kostov E
- Kotb AHE-B
- Kotecha D
- Koto MZ
- Kotobi H
- Koumpa F
- Kouraklis G
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- Lam FY
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- Laurie K
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- Lawal A
- Lawal AO
- Lawal T
- Lawal TA
- Lawani I
- Lawther R
- Lazzari G
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- Le VTH
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- Lecompte J-F
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- Machaca M
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- Madiba T
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- Madrid Barrientos LA
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- Mirza A
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- Mohamed I
- Mohamed M
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- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
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- Mohammad A
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- Palomino Castillo VD
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- Papaskarlatos I-A
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- Samaraweera DI
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- Sanz S
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- Semeda N
- Semiz A
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- Senanayake KJ
- Senanayake WSMKJ
- Setiawan J
- Seto DM
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- Sfougaris D
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- Shahbaz AR
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- Shillito S
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- Silvani P
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- Smedley A
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- Snyder E
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
- Solar Garcia L
- Soldevila-Verdeguer C
- Soley R
- Soley R
- Soliman A
- Soliman A
- Soliman AR
- Soliman N
- Soliman NA
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
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- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
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- Truelsen TC
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- Umeokonkwo CD
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- Wickramasinghe ND
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- Wijeratne T
- Wilner LB
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- Wiysonge CS
- Wojtyniak B
- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
- Baye BA
- Bazmandegan G
- Becker JS
- Bedi N
- Beghi E
- Behzadifar M
- Bejot Y
- Bekuma TTT
- Bell ML
- Bello AK
- Ben L
- Bender RG
- Bennett DA
- Bennitt FB
- Bensenor IM
- Benziger CP
- Berhe K
- Berman AE
- Bernabe E
- Bernstein RS
- Bertolacci GJ
- Bhagavathula AS
- Bhageerathy R
- Bhala N
- Bhandari D
- Bhardwaj P
- Bhat AG
- Bhattacharyya K
- Bhattarai S
- Bhutta ZA
- Bibi S
- Bicer BK
- Biehl MH
- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
- Bitew H
- Bjorge T
- Bockarie MJ
- Bohlouli S
- Bohluli M
- Bojia HA
- Bolla SR
- Boloor A
- Boon-Dooley AS
- Borges G
- Borzi AM
- Borzouei S
- Bose D
- Bosetti C
- Boston S
- Boufous S
- Bourne R
- Brady OJ
- Braithwaite D
- Brauer M
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017
- Author
- Abate Degu
- Abate Lkidan Hassen
- Abay Solomon M
- Abbafati Cristiana
- Abbasi Nooshin
- Abbastabar Hcdayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdel-Rahman Omar
- Abdela Jeinal
- Abdelalim Ahmed
- Abdi Alireza
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdurahman Ahmed Abdulahi
- Abebe Haftom Temesgen
- Abebe Molla
- Abebe Zegeye
- Abebo Teshome Abuka
- Aboyans Victor
- Abraha Haftom Niguse
- Abrham Aklilu Roba
- Abu-Raddad Laith Jamal
- Abu-Rmeileh Niveen Ml
- Acharya Pawan
- Adebayo Oladimeji M
- Adedeji Isaac Akinkimmi
- Adedoyin Rufus Adesoji
- Adekanmbi Victor
- Adetokunboh Olatunji O
- Adhena Beyene Meressa
- Adhikari Tara Banal
- Adib Mina G
- Adou Arsene Kouablan
- Adsuar Jose C
- Afaridern Mohsen
- Afshin Ashkan
- Agarwal Gina
- Aggarwal Rakesh
- Aghayan Sargis Agbasi
- Agrawal Anurag
- Agrawal Sutapa
- Ahmadi Alireza
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmed Mohamed Lemine Cheikh Brahim
- Ahmed Muktar Beshir
- Ahmed Sayem
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Akanda Ali S
- Akbari Mohammad Esmaeil
- Akibu Mohammed
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akseer Nadia
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Raddadi Rajaa M
- Alam Khurshid
- Alandab Fares
- Alebel Animut
- Aleman Alicia V
- Alene Kefyalew Addis
- Ali Raghib
- Alijanzadely Mehran
- Alizadeh-Navaei Reza
- Aljunid Syed Mohamed
- Alkerwi Ala'a
- Alla Francois
- Allebeck Peter
- Allen Christine A
- Alonso Jordi
- Alsharif Ubai
- Altirkawi Khalid
- Alvis-Cituman Nelson
- Amare Azmeraw T
- Amini Erfan
- Ammar Walid
- Amoako Yaw Ampem
- Anber Nahla Hamed
- Andrei Catalina Liliana
- Androudi Sofia
- Animut Megbani Debalkie
- Anjomshoa Mina
- Anlay Degefaye Zelalem
- Ansari Hossein
- Ansariadi Ansariadi
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T
- Appiah Seth Christopher Yaw
- Aremu Olatunde
- Areri Habtarnu Abera
- Arnlov Johan
- Aroma Megha
- Artaman Al
- Aryal Krishna K
- Asadi-Lari Mohsen
- Asayesh Hamid
- Asfaw Ephrem Tsegay
- Asgedom Solomon Weldegebreal
- Assadi Reza
- Ataro Zerihun
- Atey Tesfay Mehan Mehari
- Athari Seyyed Shamsadin
- Atique Suleman
- Atre Sachin R
- Atteraya Madhu Sudhan
- Attia Engi F
- Ausloos Marcel
- Avila-Burgos Leticia
- Avokpaho Euripide FGA
- Awasthi Ash Ish
- Awuah Baffour
- Ayele Henok Tadesse
- Ayele Yohanes
- Ayer Rakesh
- Ayuk Tam Be B
- Azzopardi Peter S
- Azzopardi-Muscat Natasha
- Badali Hamid
- Badawi Alaa
- Balakrishnan Kalpana
- Bali Ayele Geleto
- Banach Maciej
- Banstola Armit
- Barac Aleksandra
- Barboza Miguel A
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- Basaleem Huda
- Basara Berrak Bora
- Bassat Quique
- Basu Arindam
- Basu Sanjay
- Baune Bernhard T
- Bazargan-Hejazi Shahrzad
- Bedi Neeraj
- Beghi Ettore
- Behzadifar Masoud
- Behzadifar Meysam
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- Bekele Bayu Begashaw
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- Bernabe Eduardo
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- Beuran Mircea
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- Bhatia Eesh
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- Bhutta Zulfiqar A
- Biadgo Belete
- Bicer Burcu Kucuk
- Bijani Ali
- Bikbov Boris
- Bililign Nigus
- Bin Sayeed Muhammad Shandaat
- Bin Zaman Sojib
- Birlik Sait Mentes
- Birungi Charles
- Bisanzio Donal
- Biswas Tuhin
- Bjorge Tone
- Bleyer Archie
- Bose Dipan
- Bosetti Cristina
- Boufous Soufiane
- Bourne Rupert
- Brady Oliver J
- Bragazzi Nicola Luigi
- Brant Luisa C
- Brazinova Alexandra
- Breitborde Nicholas JK
- Brenner Hermann
- Britton Gabrielle
- Brugha Traolach
- Burke Kristin E
- Busse Reinhard
- Butt Zahid A
- Cahuana-Hurtado Lucero
- Callender Charlton SKH
- Campos-Nonato Ismael R
- Caneras Giulia
- Canero Juan J
- Cano Jorge
- Car Lorainne Tudor
- Car Mate
- Cardenas Rosario
- Carter Austin
- Carvalho Felix
- Casaneda-Orjuela Carlos A
- Castro Franz
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- Cavlin Alanur
- Cerin Ester
- Chaiah Yazan
- Champs Ana Paula
- Chang Hsing-Yi
- Chang Jung-Chen
- Chattopadhyay Aparajita
- Chaturvedi Pankaj
- Chen Wanqing
- Chiang Peggy Pei-Chia
- Chimed-Ochir Odgerel
- Chin Ken Lee
- Chisumpa Vesper Hichilombwe
- Chitheer Abchilaal
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- Christensen Hanne
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- Chung Sheng-Chia
- Cicuttini Flavia M
- Ciobanu Liliana G
- Cirillo Massimo
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- Cohen Aaron J
- Coll Srinivas
- Collaborators GBD 2017 Mortality
- Collado-Mateo Daniel
- Constantin Maria-Magdalena
- Conti Sara
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- Cortesi Paolo Angelo
- Cortinovis Monica
- Cousin Ewerton
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- Cucu Alexandra
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- Dargan Paul I
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- Das Gupta Rajat
- das Neves Jose
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- Dasa Tamirat Tesfaye
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- Davitoiu Dragos Virgil
- Davletov Kairat
- Dayama Anand
- de Courten Barbora
- De la Hoz Fernando Pio
- De Leo Diego
- De Neve Jan-Walter
- Defo Barthelemy Kuate
- Degefa Meaza Ginna
- Degenhardt Louisa
- Degfie Tizta T
- Deiparine Selina
- Dellavalle Robert P
- Demoz Gebre Teklemariam
- Demtsu Balem Betsu
- Denova-Gutierrez Edgar
- Deribe Kebede
- Dervenis Nikolaos
- Des Jarlais Don C
- Dessie Getenet Ayalew
- Dey Subhojit
- Dharmaratne Samath Dhamminda
- Dhimal Meghnath
- Dicker Daniel
- Ding Eric L
- Djalalinia Shirin
- Doku David Teye
- Dolan Kate A
- Donnelly Christi A
- Dorsey E Ray
- Douwes-Schultz Dirk
- Doyle Kerrie E
- Drake Thomas M
- Driscoll Tim Robert
- Dubey Manisha
- Dubljanin Eleonora
- Duken Eyasu Ejeta
- Duncan Bruce B
- Duraes Andre R
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- Ebrahimpour Soheil
- Edessa Dumessa
- Edvardsson David
- Eggen Anne Elise
- El Bcheraoui Charbel
- El-Khatib Ziad
- Elfaramawi Mohammed
- Ellingsen Christian Lycke
- Elyazar Iqbal RF
- Enayati Ahmadali
- Endries Aman Yesuf Yesuf
- Er Benjamin
- Ermakov Sergey Petrovich
- Eshrati Babak
- Eskandarieff Sharareh
- Esmaeili Reza
- Esteghamati Alireza
- Esteghamati Sadaf
- Fakhar Matadi
- Fakhim Named
- Falavarjani Khalil Ghasemi
- Farag Tamer
- Faramarzi Mahbobelh
- Fareed Mohammad
- Farhadi Farzaneh
- Farid Talha A
- Farinha Carla Sofia E Sa
- Farioli Andrea
- Faro Andre
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- Farzadfar Farshad
- Farzaei Mohammad Hosein
- Farzeli Mir Sohail
- Feigin Valery L
- Feigl Andrea B
- Feizy Fariba
- Fentahum Netsanet
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Fernandes Joao C
- Feyissa Garumma Tolu
- Fijabi Daniel Obadare
- Filip Irina
- Finegold Samuel
- Fischer Florian
- Flor Luisa Sorio
- Foigt Nataliya A
- Ford John A
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- Fullman Nancy
- Furst Thomas
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- Gebregergs Gebremedhin Berne
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- Gelaw Yalemzewod Assefa
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- Genova-Maleras Ricard
- Gessner Bradford D
- Getachew Sefonias
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- Goto Atsushi
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- Goulart Barbara Niegia Garcia
- Grada Ayman
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- Gupta Rahul
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- Hafezi-Nejad Nima
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- Hailegiyorgis Tewodros Tesfa
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- Hay Simon I
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- Heredia-Pi Ileana
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- Hoek Hans W
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- Hoogar Praveen
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- Htet Aung Sae
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- Hutfless Susan
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- Igumbor Elliman U
- Ikeda Chad Thomas
- Illesanmi Olayinka Stephen
- Iqbal Usman
- Irvani Seyed Sina Naghibi
- Isehunwa Oluwaseyi Oluwakemi
- Islam Farhad
- Islam Sheikh Mohammed Shariful
- Jahangiry Leila
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- Jain Rajesh
- Jain Sudhir Kumar
- Jakovljevic Mihail
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- Jayanbakht Mehdi
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- Jonas Jost B
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- Olusanya Bolajoko Olubuktmola
- Olusanya Jacob Olusegun
- Ong Sok King
- Opio John Nelson
- Oren Eyal
- Ortiz Alberto
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- Ota Erika
- Otstavnov Stanislav S
- Overland Simon
- Owolabi Mayowa Ojo
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- Pacella Rosana
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- Pandey Achyut Raj
- Pandian Jeyaraj Durai
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- Pereira Alexandre
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- Prakash KC
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- Qorbani Mostafa
- Quintanilla Beatriz Paulina Ayala
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- Rahman Mahfuzar
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- Rawaf Salman
- Ray Sarah E
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- Rego Maria Albertina Santiago
- Rehm Juergen
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- Reinig Nickolas
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- Resnikoff Serge
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- Rezai Mohammad Sadegh
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- Ribeiro Antonio Luiz P
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- Rivas Jacqueline Castillo
- Roba Kedir Teji
- Robinson Stephen R
- Roever Leonardo
- Ronfani Luca
- Roshandel Gholargreza
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- Rostami Ali
- Rothenbacher Dietrich
- Rubagotti Enrico
- Ruhago George Mugambage
- Saadat Soheil
- Sabde Yogesh Damodar
- Sachder Perminder S
- Sacker Abdur Razzaque
- Saddik Basema
- Sadeghi Ehsan
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- Safdarian Mandi
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- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sajadi Haniye Sadat
- Salahshoor Mohamadreza
- Salam Nasir
- Salama Joseph S
- Salamati Payman
- Saldanha Raphael de Freitas
- Salimi Yahya
- Salimzadeh Hamideh
- Salz Inbal
- Sambala Evanson Zondani
- Samy Abdallah M
- Sanabria Juan
- Santos Itarnar S
- Santos Joao Vasco
- Sardana Mayank
- Sarrafzadegan Nizal
- Sartorius Benn
- Sarvi Shahabeddin
- Sathian Brijesh
- Satpathy Maheswar
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- Sawant Artmdhati R
- Sawhney Monika
- Saxena Sonia
- Sayyah Mehdi
- Scaria Vinod
- Schadffner Fake
- Schelonka Kathryn
- Schmidt Maria Ines
- Schneider Ione JC
- Schottker Ben
- Schutte Aletta Elisabeth
- Schwebel David C
- Schwendicke Falk
- Scott James G
- Sekerija Mario
- Sepanlou Sadaf G
- Servan-Mori Edson
- Shabaninejad Hosein
- Shackelford Katya Anne
- Shafieesabet Azadeh
- Shaheen Andra A
- Shaikh Masood Ali
- Shakir Raad A
- Shams-Beyranvand Mehran
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- Sharif-Alhoseini Mahdi
- Sharit Mehdi
- Sharma Jayendra
- Sharma Meenakshi
- Sharma Rajesh
- She Jun
- Sheikh Aziz
- Sheth Kevin N
- Shi Peilin
- Shiadeh Malihe Nourollahpour
- Shibuya Kenji
- Shifa Gimia Temam
- Shiferaw Mekonnen Sissy
- Shigematsu Mika
- Shiri Rahman
- Shirkoohi Reza
- Shiue Ivy
- Shokraneh Farhad
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- Shukla Sharvari Rahul
- Si Si
- Siabani Soraya
- Siddiqi Tariq J
- Sigfusdottir Inga Dora
- Sigurvinsdottir Rannveig
- Silpakit Nazis
- Silva Diego Augusto Santos
- Silva Joao Pedro
- Silveira Dayane Gabriele Alves
- Singam Narayana Sarma Venkata
- Singh Jasvinder A
- Singh Virendra
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- Sinha Dhirendra Narain
- Sitas Freddy
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- Sliwa Karen
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- Soriano Joan B
- Soyiri Ireneous N
- Sposato Luciano A
- Sreeramareddy Chandrashekhar T
- Srinivasan Vinay
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- Tabares-Seisdedos Rafael
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- Tadakamadla Santosh Kumar
- Takahashi Ken
- Tandon Nikhil
- Tassew Aberash Abay
- Tassew Segen Gebremeskel
- Tavakkoli Mohammad
- Taveira Nuno
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- Temesgen Habtamu
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- Temsah Omar
- Terkawi Abdullah Sulieman
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- Tessema Belay
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- Thankappan Kavumpurathu Raman
- Thinmavukkarasu Sathish
- Thomas Laura Anne
- Thomas Nihal
- Thou Maigeng
- Thrift Amanda G
- TIavani-Palone Marcos Roberto
- Tilahun Binyam
- To Quyen G
- Tobe-Gai Ruoyan
- Tonelli Marcello
- Topor-Madry Roman
- Topouzis Fotis
- Torisky Sonia
- Torre Anna E
- Tortajada-Girbes Miguel
- Towbin Jeffrey A
- Tran Bach Xuan
- Tran Khanh Ban
- Tripathi Suryakant
- Tripathy Srikanth Prasad
- Truelsen Thomas Clement
- Truong Nu Thi
- Tsadik Afewerki Gehremeskel
- Tsilimparis Nikolaos
- Tuzcu E Murat
- Tyrovolas Stefanos
- Ukwaja Kingsley Nnanna
- Ullah Irfan
- Usman Muhammad Shaniq
- Uthman Olalekan A
- Uzun Selen Begun
- Vaduganathan Muthiah
- Vaezi Afsane
- Vaidya Gaurang
- Valdez Pascual R
- Varavikova Elena
- Varughese Santosh
- Vasankari Tommi Juhani
- Vasconcelos Ana Maria Nogales
- Velasquez This Moreno
- Venketasubramanian Narayanaswamy
- Vidavalur Ramesh
- Villafaina Santos
- Violante Francesco S
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Vollset Stein Emil
- Vos Theo
- Vosoughi Kia
- Vujcic Isidora S
- Wagner Gregory R
- Wagnew Fasil Shiferaw Wagnew
- Waheed Yasir
- Wang Yanping
- Wang Yuan-Pang
- Wassie Molla Mesele
- Weaver Nicole Davis
- Weiderpass Elisabete
- Weintraub Robert G
- Weiss Daniel J
- Weiss Jordan
- Weldegebreal Fitsum
- Weldegwergs Kidu Gidey
- Werdecker Andrea
- Westerman Ronny
- Whiteford Harvey A
- Widecka Justyna
- Widecka Katarzyna
- Wijeratne Tissa
- Winkler Andrea Sylvia
- Wiysonge Charles Shey
- Wolfe Charles DA
- Wondemagegn Sintayehu Ambachew
- Wu Shouling
- Wyper Grant MA
- Xu Gelin
- Yadav Rajaram
- Yakob Bereket
- Yamada Tomohide
- Yan Lijing L
- Yano Yuichiro
- Yaseri Mehdi
- Yasin Jemal Yasin
- Ye Pengpeng
- Yearwood Jamal A
- Yentur Gokalp Kadri
- Yeshaneh Alex
- Yimer Ebrahim M
- Yip Paul
- Yisma Engida
- Yonemoto Naohiro
- Yoon Seok-Jun
- York Hunter W
- Yotebieng Marcel
- Younis Mustafa Z
- Yousefifard Mahmoud
- Yu Chuanhua
- Zachariah Geevar
- Zadnik Vesna
- Zafar Shamsa
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zamani Mohammad
- Zare Zohreh
- Zeeb Hajo
- Zeleke Mulugeta Molla
- Zenebe Zerihun Menlkalew
- Zerfu Taddese Alemu
- Zhang Kai
- Zhang Xueying
- Zhu Jun
- Zodpey Sanjay
- Zucker Inbar
- Zuhlke Liesl Joanna J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1-4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0-8·4) while the total sum of global YLDs increased from 562 million (421-723) to 853 million (642-1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6-9·2) for males and 6·5% (5·4-7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782-3252] per 100 000 in males vs 1400 [1279-1524] per 100 000 in females), transport injuries (3322 [3082-3583] vs 2336 [2154-2535]), and self-harm and interpersonal violence (3265 [2943-3630] vs 5643 [5057-6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
- Anestiadou Elissavet
- Angelis Fragkiskos
- Angeslis Fragkiskos
- Aqeel Syed Talha Bin
- Aral Canan
- Arebi Jaber
- Arnaoutoglou Eleni
- Arslangilay Mert
- Arvanitaki Alexandra
- Asadyari-Lupo Shadie
- Ashar Nur Ayuni Khirul
- Ashour Amira
- Ashraf Hamza
- Ashur Abir Ben
- Asjad Imran
- Askar Aamal
- Askin Abdullah Emre
- Aslam Muhammad Nadeem
- Aslan Merve
- Aslangilay Mert
- Astal Mohammed
- Asudo Felicia
- Atadag Yildiz Buyukdereli
- Atef Dina
- Athamneh Tayseer
- Athanasiadis Apostolos
- Ather M Hammad
- Atherton Kristy
- Atia Ahmed
- Atici Semra Demirli
- Atilhan Ridvan
- Atim Terkaa
- Atiq Tabish
- Atta Raneem
- Attia Mohamed
- Attiya Omar
- Awad Hasan
- Awadallah Safaa
- Awoyinka Babatunde
- Ayasrah Salem
- Aydin Cemil
- Aydoğdu Erhan Onur
- Ayogu Emeka
- Ayoub Kerillos
- Ayyad Alaa
- Azboy Ibrahim
- Azer Armia
- Azhari Malaz
- Aziz Aliya Begum
- Babalola Olakunle
- Babar Daniyal
- Babekir Enas Mohammedtom Abdulhameed
- Babiker Afra
- Bacariza Loreto
- Baccar Marwen
- Badawy Asmaa
- Badi Hussameddin
- Badr Karim
- Badri Danniel
- Bagazi Doaa
- Bailey Ashley
- Bakare Adewumi
- Bakari Maisaratu A
- Bakeer Hibah Bileid
- Bakeer Mohammed
- Balciscueta Zutoia
- Ballah Shirahn
- Balogh Zsolt
- Baltacı Zeynep Hazal
- Banaga Essam Eldien Abuobaida
- Banerjee Arnab
- Banihani Farah
- Barbara Silvia Jasmine
- Barbaro Antonio
- Bareka Metaxia
- Bariun Yara
- Barka Sharf
- Barker John
- Barker Sally
- Barsoum Fady
- Basam Aya
- Basam Aya
- Bassam Ahmad
- Bassey Asi-oqua
- Bataineh Saad
- Bature Stephen Bodam
- Bayram Cigdem
- Baysallar Duygu
- Baziotis-Kalfas Kristian
- Beatson Nicholas
- Bei Michael
- Bektas Sebnem
- Bell David
- Benamor Oumayma
- Benek Duygu Ece
- Benham Emily
- Benismai Israa
- Bensalem Marya
- Bensalem Serien Hossain
- Benyani Simran Vinod
- Bernabei Massimiliano
- Betts Aisling
- Bezweek Adel
- Bhikha Jainey
- Bindra Randipsingh
- Binnawara Muhannud
- Bird Katie
- Bisgin Tayfun
- Bitsianis Stefanos
- Blake Jessica
- Bland Laura
- Blassey Aneel
- Blundell Jian
- Bobba Sriya
- Bockxmeer John Van
- Bolam Scott Matthew
- Bolton Damien
- Bosi Simone
- Bouaoud Souad
- Bouchenak Kamel
- Boussahel Ikram Fatima Zohra
- Bowman Sarah
- Boyd Theresa
- Boyes Hamish
- Boyley Jessica
- Bozhko Maxim
- Bozkir Haktan Ovul
- Bozkurt Mehmet Abdussamet
- Bresadola Vittorio
- Brewster Dani
- Brooke Kenya
- Brown Georgia
- Brown Matthew
- Buari Taiwo
- Buhavac Milos
- Bunjo Zachary
- Burrows Emalee
- Burruso Luca
- Busaidi Ibrahim S Al
- Bushaala Hassan
- Butterworth Yasmine
- Butyrskii Aleksandr
- Cabalag Carlos
- Cade Richard
- Cakcak Ibrahim Ethem
- Cakir Niyazi
- Calini Giacomo
- Calini Giacomo
- Camkıran Elifsu
- Canavese Anna
- Candan Mert
- Canny Mitch
- Canton Joshua
- Capar Mehmet Ali
- Cardelli Stefano
- Carlos Angela
- Carnuccio Emma
- Carre Xenia
- Casciola Francesca
- Castagnini Francesco
- Catalioto Caterina
- Cepe Hale
- Cerinic Pietro Matucci
- Certel Alperen Taha
- Cetınkaya Zeynep Sahan
- Chakroun Sawssen
- Chambers Jessica
- Champipis Apostolos
- Chan Alex
- Chan Ashley
- Chan Juliet
- Chan Justin
- Chan Nicholas
- Chand Namisha
- Chandiok Karan
- Chandler Callum
- Chandra Pooja
- Chang Jared
- Chang Kelvin
- Changati Varun
- Chao Phoebe
- Chau Michelle
- Chau Michelle
- Chauhan Karanjeet
- Chawla Tabish
- Chen Andrew
- Chen Brian
- Chen Paul
- Chen Yan
- Chene Danielle
- Cheng Felicity
- Cheng Felicity
- Cheung Aiden
- Cheung King Tung
- Chiappe Caterina
- Chidambaram Seevakan
- Chilaka Lalitya
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- Sherif Yara
- Sheriff Arfaan
- Shetwan Sundes
- Shipa Ahmed
- Shiru Mariam Motunrayo
- Shrestha Pallavi
- Shuaibu Ibrahim Shaphat
- Shui Amanda
- Sibic Osman
- Sierra Oscar Alonso Verduzco
- Silem Yousra Othman Reham
- Silva Yannick De
- Silverii Julia
- Simiona Levi
- Simonetti Marta
- Singer David
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- Singhal Megan
- Sinha Akansha
- Siribaddana Venesa
- Sivakumar Gananadha
- Sivakumar Seiyon
- Sivasuthan Goutham
- Sivrikaya Ramazan Kemal
- Skalidou Smaragda
- Skoufias Spyridon
- Slavec Mark
- Smadi Rayyan
- Smith Corinne
- Smith Nicolas
- Smith Quintin
- Smitham Peter
- Snider Ruth
- Sobhy George
- Soek Jenny
- Sofian Ahmad Anuar
- Soh Isabel
- Soh Jien Yen
- Soh Qi Rui
- Soh Rachel TingQian
- Sok Rumnea
- Sokmen Selman
- Solagbade Remi Sanyaolu
- Solanki Krisha
- Solar Caitlin Del
- Soliman Keroles
- Soliman Mahmoud Ayman
- Soliman Nisha Bianca
- Soliman Randa
- Soltan Hatem
- Songden Zumnan
- Soni Akshay
- Soula Enas
- Soytas Mustafa
- Sriranjan Roshni
- Sritharan Mithra
- Srivastava Shambhavi
- Standish Lucy
- Stavratis Fotios
- Stevens Sean
- Stewart Peter
- Stokes Andrew
- Struthers Jamie
- Studd Rod
- Sulaiman Bilal
- Suleiman Khadijah Richifa
- Suliman Hozifa Mohamed Abdalla
- Suliman Merna Ezz
- Sun Kexin
- Sun Phoebe
- Sun Selena
- Sung Nakjun
- Surkitt Amy
- Suttor Sean
- Swalem Aisha
- Swan Daniel
- Swansson Will
- Sweetapple Amie
- Syed Saifulla
- Syllaios Athanasios
- Symeonidis Savvas
- Şen Eminenur
- Şenödeyici Eylül
- Tabak Elif Zeynep
- Taha Hala Abdelhalim Mohamed
- Taha Ibrahim
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- Tahir Farah
- Tahir Izza
- Taingson Mathew Chum
- Talaat Omnia
- Talavera Elena
- Taman Mohamed
- Tan Kevin
- Tan Sarah
- Tan Sarah
- Tan Suqi
- Tan Wen Po Jonathan
- Tandogan Yusuf Iskender
- Tang Howard
- Tang Patrick
- Tang-Ieam Pattarapan
- Tao Steve
- Tarek Yousef
- Tariq
- Tarmidi Jazmina
- Tasi Zoya
- Taşcı Muhammed Enes
- Taufiq Maliha
- Tay Kai Yun Jodene
- Taylor Emily
- Taylor Isobel
- Teema Eman
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- Temerik Abdallah Rashad
- Teng Cherilyn
- Tepe Mustafa Deniz
- Tepe Mustafa Deniz
- Terrosu Giovanni
- Theophilus Mary
- Thompson Nasya
- Thornton-Hume David
- Tiffany Lea
- Ting Clarissa
- Tiras Hale Nur
- Titan Ashley
- Toft Alexandra
- Traina Francesco
- Tran Anthony
- Tran Quang
- Tran Tam
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- Tsakiridis Ioannis
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- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
- Tun Than
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- Tuzuner Filiz
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- Ugool Mahmoud
- Uğurlu Mustafa Ümit
- Ukrani Ronika Devi
- Ukwuoma Ohia Ernest
- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
- Uyanık Mustafa Safa
- Uzair Ahmad
- Uzel Kadir
- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
- Valverde-Vazquez Rocio
- Vance Lucille
- Vanguardia Kristina
- Vanguardia Maria Kristina
- Vanzuylekom Katie
- Varesano Marco
- Varghese Chris
- Varghese Chris
- Velenciuc Natalia
- Vermeulen Wikus
- Vidanagama Sasini
- Vimalan Vineeth
- Virani Sehar Salim
- Vollenhoven Beverley
- Vong Crystal
- Vrakopoulou Gavriella Zoi
- Vu Jennifer
- Vu Jennifer
- Waaka Nicholas
- Wadhwa Sanya
- Wagaarachchi Prabhath
- Waheed Ayesha Akbar
- Waldin Lucy
- Walsh Eamon
- Walters Chris
- Wang Bill
- Wang Christine
- Wang Erica
- Wang Grace
- Wang Katie
- Wang Nicole Qiwen
- Wang Pengnan
- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
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- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
SARS-CoV-2 Infection Is at Herd Immunity in the Majority Segment of the Population of Qatar.
- Author
- Abdeen Sami
- Abdelkarim Ashraf
- Abdul Rahim Hanan F
- Abu-Raddad Laith J
- Agsalog Meynard JA
- Akkarathodiyil Bassam K
- Al Kanaani Zaina
- Al Khal Abdullatif
- Al Kuwari Einas
- Al Kuwari Mohamed Ghaith
- Al Romaihi Hamad Eid
- Al-Qahtani Abdulsalam Ali AH
- Al-Shedifat Monther HA
- Al-Thani Mohamed H
- Alakshar Mohamed Morhaf MH
- Alkhalaf Ayat A
- Ansari Anas
- Ataalla Ahmad Ali
- Bertollini Roberto
- Butt Adeel A
- Chaghoury Odette
- Chemaitelly Hiam
- Chougule Sandeep
- Coyle Peter
- Craft and Manual Workers Seroprevalence Study Group
- Craft and Manual Workers Seroprevalence Study Group
- Daraan Faisal
- Elhaj Ismail Ahmed Ibrahim Hashim
- Farag Elmoubasher
- Gopinathan Abhilash KKV
- Jeremijenko Andrew
- Kaleeckal Anvar Hassan
- Kasem Hasan Ali
- Latif Ali Nizar
- Mostafa Nahid
- Nasrallah Gheyath K
- Poolakundan Feroz J
- Ranbhise Sanjay U
- Saefan Saed MA
- Sahl Mohamed
- Shaik Riyazuddin Mohammad
- Suliman Jinan
- Tayar Elias
- Thaivalappil Mohamed M
- Thoyalil Abubacker S
- Umar Inayath M
- Yassine Hadi M
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/08/2021
- Field of study
BACKGROUND: Qatar experienced a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic that disproportionately affected the craft and manual worker (CMW) population, who comprise 60% of the total population. This study aimed to assess ever and/or current infection prevalence in this population. METHODS: A cross-sectional population-based survey was conducted during July 26 to September 09, 2020, to assess both anti-SARS-CoV-2 positivity through serological testing and current infection positivity through polymerase chain reaction (PCR) testing. Associations with antibody and PCR positivity were identified through regression analyses. RESULTS: The study included 2641 participants, 69.3% of whom were <40 years of age. Anti-SARS-CoV-2 positivity was 55.3% (95% CI, 53.3%-57.3%) and was significantly associated with nationality, geographic location, educational attainment, occupation, and previous infection diagnosis. PCR positivity was 11.3% (95% CI, 9.9%-12.8%) and was significantly associated with nationality, geographic location, occupation, contact with an infected person, and reporting 2 or more symptoms. Infection positivity (antibody and/or PCR positive) was 60.6% (95% CI, 58.6%-62.5%). The proportion of antibody-positive CMWs who had a prior SARS-CoV-2 diagnosis was 9.3% (95% CI, 7.9%-11.0%). Only seven infections were ever severe, and only 1 was ever critical-an infection severity rate of 0.5% (95% CI, 0.2%-1.0%). CONCLUSIONS: Six in every 10 CMWs in Qatar have been infected, suggestive of reaching the herd immunity threshold. Infection severity was low, with only 1 in every 200 infections progressing to be severe or critical. Only 1 in every 10 infections had been previously diagnosed, which is suggestive of mostly asymptomatic or mild infections
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