Increased Content Accessibility For Wikis And Blogs

This paper aims to introduce a useful approach on the combined use of template based publishing tools (i.e. for blogs and wikis) and content personalization services. The approach considers that the original developers of web content have limited awareness on accessibility issues, and they are facilitated and guided by the editing interface. The publishing mechanism is responsible for storing web content in a flexible representation, where structured content is separated from the formatting information. Intermediate brokering services (i.e aggregators, mediators or simply the portal software) produce multiple versions of the same content in order to increase content accessibility. Finally, end-users are able to set their preferences on how the content will be presented and get a homogeneous representation of the community content. The different versions may comprise multiple languages, audio and text representations etc and be based on a single version of the original content. The structured nature of content produced by template based tools allows intermediate services to intervene and reproduce the original content in various formats and client tools to filter and present information according to user needs and capabilities. The paper presents the focal points of the suggested approach, details on the underlying architecture and presents the required supporting infrastructure

Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans : a systematic review

BACKGROUND: Synthetic glucocorticoids are commonly used in reproductive medicine. Fetal organ systems are highly sensitive to changes in the intrauterine environment, including overexposure to glucocorticoids. Structural and functional alterations resulting from such changes may persist throughout life and have been associated with diverse diseases. One system that could be particularly sensitive to fetal glucocorticoid overexposure is the hypothalamic-pituitary-adrenal (hpa) axis. Many human studies have investigated this possibility, but a systematic review to identify consistent, emergent findings is lacking. METHODS: We systematically review 49 human studies, assessing the effects of intrauterine exposure to synthetic glucocorticoids on fetal, neonate, and infant hpa function. RESULTS: Study quality varied considerably, but the main findings held true after restricting the analyses to higher-quality studies: intrauterine exposure to synthetic glucocorticoids reduces offspring hpa activity under unstimulated conditions after pain but not pharmacological challenge. Although reduced unstimulated hpa function appears to recover within the first 2 wk postpartum, blunted hpa reactivity to pain is likely to persist throughout the first 4 months of life. There is some evidence that the magnitude of the effects is correlated with the total amount of glucocorticoids administered and varies with the time interval between glucocorticoid exposure and hpa assessment. CONCLUSIONS: This systematic review has allowed the demonstration of the way in which intrauterine exposure to various regimens of synthetic glucocorticoids affects various forms of hpa function. As such, it guides future studies in terms of which variables need to be focused on in order to further strengthen the understanding of such therapy, whilst continuing to profit from its clinical benefits

Pregnant women become insensitive to cold stress

BACKGROUND: The function of the hypothalamic-pituitary-adrenal (HPA) axis is known to be altered during pregnancy, but it has not been tested with a natural stressor. METHODS: A group of pregnant women (n = 10) were tested towards the end of pregnancy (mean 36.8 ± 2.5 weeks gestation) and about 8 weeks postpartum (mean 7.8 ± 1.5 weeks), together with a matched control group, with a one minute cold hand stressor test. Saliva samples were collected before and 10 and 20 minutes after the test, and stored for later radioimmunoassay of cortisol. RESULTS: The control group showed a highly significant response to the test. The pregnant group showed no response, and the postpartum group a variable but non significant one CONCLUSIONS: This shows that the HPA axis becomes hypofunctional to a natural stressor at the end of pregnancy. It is suggested that one possible evolutionary function for this is to protect the fetus from the stress responses of the mother

Associations between biological markers of prenatal stress and infant negative emotionality are specific to sex

Purpose Fetal programming is the idea that environmental stimuli can alter the development of the fetus, which may have a long-term effect on the child. We have recently reported that maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner: high prenatal cortisol was associated with increased negative emotionality in females, and decreased negative emotionality in males. This study aims to test for this sex-specific effect in a different cohort, and investigate whether sex differences in fetal programming may be specific to glucocorticoid mechanisms by also examining a maternal salivary alpha-amylase (sAA) by sex interaction. Methods 88 pregnant women (mean gestational age = 27.4 weeks, SD = 7.4) collected saliva samples at home over two working days to be assayed for the hormone cortisol (range = 0.13–88.22 nmol/l) and the enzyme alpha-amylase (range = 4.57–554.8 units/ml). Samples were collected at waking, 30-min post-waking and 12 h post-waking. Two months after birth participants reported infant negative emotionality using the distress to limits subscale of the Infant Behavior Questionnaire. Results The interaction between maternal prenatal cortisol and infant sex to predict distress to limits approached significance (p = 0.067). In line with our previous finding there was a positive association between prenatal cortisol and negative emotionality in females, and a negative association in males. The interaction between sAA and sex to predict distress was significant (p = 0.025), and the direction of effect was the same as for the cortisol data; high sAA associated with increased negative emotionality in females and reduced negative emotionality in males. Conclusions In line with our previous findings, this research adds to an emerging body of literature, which suggests that fetal programming mechanisms may be sex-dependent. This is the first study to demonstrate that maternal prenatal sAA may be an important biomarker for infant behavior, and the findings have implications for understanding sex differences in developmental psychopathology

Exploring the Dominance of the English Language on the Websites of EU Countries

The English language is the most dominant language in the Western world and its influence can be noticed in every aspect of human communication. It’s increasing diffusion, especially since the turn of the century, is hard to measure with conventional means. The present research studies the use of language in websites of European Union (EU) member states, in order to collect data about the prevalence of the English language in the different countries and regions of the European Union. To achieve a realistic representation of today’s landscape of the European Web, this study uses a vast population of websites and a representative sampling size and methodology. By analyzing and processing the findings from over 100,000 websites from every country in the EU, a solid foundation is set that is used to explore the dominance of the English language in the European World Wide Web in general. This is the first study that examines the presence of English content in the websites of all EU member countries and provides statistical evidence regarding the ratio of English content availability for each country. Conclusively, the results of the research demonstrate that the English language is available on more than one quarter of all websites of non-English speaking EU member states. Moreover, it is available in the vast majority of multilingual and bilingual websites, while at the same time being the only language that is available in a number of monolingual websites. In addition, it is shown preference over the national language in a significant number of cases. A moderate negative correlation is found between a member state’s population and the availability of English in these countries’ websites and the same holds true for a member state’s Gross Domestic Product (GDP). Both these correlations indicate that smaller countries tend to provide more content in English in order to establish a stronger presence in the international environment. Taking into account the role of language in the expression of national identity, this study provides data and insights which may contribute to the discussion about the changes underway in the national identity of EU member states

Developing a Civic Journalism Social Medium on the Web: Technological Methods and Constraints

1. Introduction Specific and carefully designed procedures, along with thoughtful economic planning and decision-making are essential in order for any newly developed social medium to be positioned in the online market-place. The launching of a new social medium, named Television without Frontiers, in November 2008, has been a risky attempt in an immature market like the Greek online media one. The attempt can be thought of as successful, in terms of visitors, participation and media coverage..