Social Work Towards a Quality of Life and Well Being Subjective

The quality of life understood as satisfaction related to resources, values, norms, expectations, perceptions and capabilities is a central issue in the public health agenda for sustainable local development (García, 2013). Some studies on quality of life provide significant gender differences regarding transportation, employment and recreation (Baldi & Garcia, 2010). Furthermore, when pondering as a perceptual system resources around the individual and in reference to the parent group, it is considered a style of personal well - being that is geared to social integration (Barranco, Delgado, Meli, & Quintana, 2010). But quality of life is correlated with anxiety and depression in medical situations of uncertainty and deteriorating health (Machado, Anarte, & Ruiz, 2010). That is, the quality of life is the result of the perception of scarcity of resources rather than the hopes generated from personal abilities. Opportunities seem to boil down to a minimum and thus the responsibility of self increases and an improvement in expectations is observed through the links between the members of a social, family or school group. Grimaldo (2010) found eight alluding to the quality of life dimensions. This is the economic well - being, interpersonal relationship, family situation, neighborhood context, social capital and health. Therefore, the quality of life is a web of expectations that are based on a figurative nucleus to influence the decisions of resource allocation (Carreon & Garcia, 2013).This work was proposed to establish a correlative model to discuss the importance of other variables in the investigation of the quality of life. Once the relationships between the factors derived from the literature review were specified, it conducted a cross sectional study with a non - probabilistic sample of 245 students. When the validity and reliability of the instrument measured was obtained: life satisfaction, expected capabilities, expectations of opportunity, trust relationships, perception of justice, assessment of the environment, standards of context and perceived resources, a structural model was tested [X 2 = 12,35 (12 gl); p = 0.000; GFI = 0.975; RMR = 0.000] in which the perceived availability of resources indirectly correlated to life satisfaction through standards context (γ = 0.52). The results were compared with findings reported in the state of knowledge

Social Work Towards a Quality of Life and Well Being Subjective

The quality of life understood as satisfaction related to resources, values, norms, expectations, perceptions and capabilities is a central issue in the public health agenda for sustainable local development (García, 2013). Some studies on quality of life provide significant gender differences regarding transportation, employment and recreation (Baldi & Garcia, 2010). Furthermore, when pondering as a perceptual system resources around the individual and in reference to the parent group, it is considered a style of personal well - being that is geared to social integration (Barranco, Delgado, Meli, & Quintana, 2010). But quality of life is correlated with anxiety and depression in medical situations of uncertainty and deteriorating health (Machado, Anarte, & Ruiz, 2010). That is, the quality of life is the result of the perception of scarcity of resources rather than the hopes generated from personal abilities. Opportunities seem to boil down to a minimum and thus the responsibility of self increases and an improvement in expectations is observed through the links between the members of a social, family or school group. Grimaldo (2010) found eight alluding to the quality of life dimensions. This is the economic well - being, interpersonal relationship, family situation, neighborhood context, social capital and health. Therefore, the quality of life is a web of expectations that are based on a figurative nucleus to influence the decisions of resource allocation (Carreon & Garcia, 2013).This work was proposed to establish a correlative model to discuss the importance of other variables in the investigation of the quality of life. Once the relationships between the factors derived from the literature review were specified, it conducted a cross sectional study with a non - probabilistic sample of 245 students. When the validity and reliability of the instrument measured was obtained: life satisfaction, expected capabilities, expectations of opportunity, trust relationships, perception of justice, assessment of the environment, standards of context and perceived resources, a structural model was tested [X 2 = 12,35 (12 gl); p = 0.000; GFI = 0.975; RMR = 0.000] in which the perceived availability of resources indirectly correlated to life satisfaction through standards context (γ = 0.52). The results were compared with findings reported in the state of knowledge

En la costa aún sin mar

Los trabajos que conforman este volumen son una muestra de la presencia y actualidad de la obra de César Vallejo. Su poesía aún da lugar a nuevas y diversas interpretaciones; también a ciertas reconsideraciones. Asimismo, la narrativa del escritor peruano, poco atendida, está presente y exige estudio además de revalorización. La persona y obra de César Vallejo, en fin, son actuales incluso como un fenómeno metapoético.César Vallejo es un escritor esencial en el ámbito de la literatura contemporánea. Su obra literaria, escrita a principios del siglo pasado, sigue vigente. En su poesía, en particular, captó la sensibilidad de toda una época. Asimismo, supo traducir lo que él llamaba “el ritmo interior y el espíritu que se desprende de la realidad actual”. En cuanto a su obra en prosa, los estudios recientes dan muestra de su importancia, valor social y artístico. A casi cien años de la publicación de libros como Trilce y Los heraldos negros, la obra de César Vallejo sigue siendo fuente de goce estético y, por su complejidad, de búsqueda de conocimiento profundo de la realidad social y humana

Planeación, gobernanza y sustentabilidad Retos y desafíos desde el enfoque territorial

Frente a la compleja realidad actual, resulta ineludible el desarrollo de la investigación científica de los fenómenos y procesos urbanos, territoriales y ambientales, que contribuya a su comprensión y la construcción de alternativas de solución a los retos y desafíos vigentes. En este contexto, el abordaje de las ciudades y regiones metropolitanas, el ordenamiento del territorio y la ocupación del espacio, así como la relación sociedad-naturaleza y la complejidad ambiental, precisa la generación de metodologías y procesos de investigación multi e inter disciplinarios que contribuyan a la comprensión de los procesos socioterritoriales, el mejoramiento de las condiciones de vida y la conservación ambiental.Programa de Fortalecimiento de la Calidad Educativa PFCE-2016 proyecto K0313101

Review of the late Quaternary stratigraphy of the northern Gulf of Cadiz continental margin:New insights into controlling factors and global implications

Over the past decades, the northern Gulf of Cadiz has been the focus of a wide range of late Quaternary seismic and sequence stratigraphic studies, either addressing the slope contourite depositional system (CDS), or the development of the continental shelf. Yet, high-resolution seismic data bridging between these domains and age information have remained sparse. This study, based on new high-resolution reflection seismic profiles calibrated to IODP Expedition 339 sites U1386/U1387, now presents an updated stratigraphic framework, that integrates (for the first time) the late Quaternary records of the northern Gulf of Cadiz middle slope to shelf off the Guadiana River. Seismic stratigraphic analysis of the stacking, depocenter distribution, stratal architecture and facies of the seismic (sub-)units reveals the influence of similar to 100 kyr sea-level variations paced by Milankovitch (eccentricity) cycles, tectonics (manifesting as two pulses of uplift and margin progradation), sediment supply and bottom current activity. This work furthermore contributes to the application and understanding of high-resolution, late Quaternary sequence stratigraphy. Firstly, the proposed sequence stratigraphic interpretation shows that adaptations to the basic models are required to integrate the shelf and slope record, and to account for the presence of a significant alongslope (bottom current-controlled) component. Secondly, the results confirm that the sequences are dominantly composed of regressive deposits, whereas the preservation of transgressive to highstand deposits is more irregular. Significantly, the common assumption that successive major glacial lowstands are consistently recorded as well-marked, shelf-wide erosional unconformities, is demonstrated to be occasionally invalid, as tectonics can obliterate this one-to-one relationship

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection