Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution

Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement HH(98,y2) 0.95. Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.European Commission (EUROfusion 633053

Efecto de la preinmunización sobre la eficacia terapéutica y toxicidad de la terapia génica antitumoral

“Efecto de la preinmunización con adenovirus sobre la eficacia terapéutica y toxicidad de la terapia gé- nica antitumoral” Objetivo: Determinar si la inyección intratumoral de adenovirus portadores de genes reporteros indu- ce, o no, la producción de anticuerpos en contra del vector, y establecer si la presencia de éstos influye en la efectividad terapéutica y toxicidad de la terapia génica del cáncer mediada por vectores adenovira- les. Resultados y conclusiones: En los animales no inmunizados, la diseminación de los vectores ade- novirales desde el sitio de la inyección es homogé- nea y de carácter sistémico. La preinmunización ocasiona una significativa reducción en el nivel y dura- ción de la expresión de luciferasa. Esta disminución es más importante en el hígado, comparada con la expresión dentro del tumor. El uso de dosis elevadas de vectores virales en animales con inmunidad pre- existente, restituye los niveles de expresión intratumoral a niveles comparables con los observados en animales controles. Sin embargo, los fenómenos de toxicidad hepática observados en los animales pre- inmunizados necesitan ser estudiados con más deta- lle, debido a las enormes implicaciones terapéuticas que los vectores adenovirales tienen en el tratamien- to del cáncer

Association of single and joint metals with albuminuria and estimated glomerular filtration longitudinal change in middle-aged adults from Spain: The Aragon workers health study

The nephrotoxicity of low-chronic metal exposures is unclear, especially considering several metals simultaneously. We assessed the individual and joint association of metals with longitudinal change in renal endpoints in Aragon Workers Health Study participants with available measures of essential (cobalt [Co], copper [Cu], molybdenum [Mo] and zinc [Zn]) and non-essential (As, barium [Ba], Cd, chromium [Cr], antimony [Sb], titanium [Ti], uranium [U], vanadium [V] and tungsten [W]) urine metals and albumin-to-creatinine ratio (ACR) (N = 707) and estimated glomerular filtration rate (eGFR) (N = 1493) change. Median levels were 0.24, 7.0, 18.6, 295, 3.1, 1.9, 0.28, 1.16, 9.7, 0.66, 0.22 μg/g for Co, Cu, Mo, Zn, As, Ba, Cd, Cr, Sb, Ti, V and W, respectively, and 52.5 and 27.2 ng/g for Sb and U, respectively. In single metal analysis, higher As, Cr and W concentrations were associated with increasing ACR annual change. Higher Zn, As and Cr concentrations were associated with decreasing eGFR annual change. The shape of the longitudinal dose-responses, however, was compatible with a nephrotoxic role for all metals, both in ACR and eGFR models. In joint metal analysis, both higher mixtures of Cu–Zn–As–Ba–Ti–U–V–W and Co–Cd–Cr–Sb–V–W showed associations with increasing ACR and decreasing eGFR annual change. As and Cr were main drivers of the ACR change joint metal association. For the eGFR change joint metal association, while Zn and Cr were main drivers, other metals also contributed substantially. We identified potential interactions for As, Zn and W by other metals with ACR change, but not with eGFR change. Our findings support that Zn, As, Cr and W and suggestively other metals, are nephrotoxic at relatively low exposure levels. Metal exposure reduction and mitigation interventions may improve prevention and decrease the burden of renal disease in the population

A complex scenario of glacial survival in Mediterranean and continental refugia of a temperate continental vole species (Microtus arvalis) in Europe

Los autores de la UAM pertenecen al grupo Terrestrial Ecology Group (TEG)"This is the peer reviewed version of the following article: Journal of Zoological Systematics and Evolutionary Research 58.1 (2020): 459-474, which has been published in final form at https://doi.org/10.1111/jzs.12323. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions"The role of glacial refugia in shaping contemporary species distribution is a long-standing question in phylogeography and evolutionary ecology. Recent studies are questioning previous paradigms on glacial refugia and postglacial recolonization pathways in Europe, and more flexible phylogeographic scenarios have been proposed. We used the widespread common vole Microtus arvalis as a model to investigate the origin, locations of glacial refugia, and dispersal pathways, in the group of “Continental” species in Europe. We used a Bayesian spatiotemporal diffusion analysis (relaxed random walk model) of cytochrome b sequences across the species range, including newly collected individuals from 10 Iberian localities and published sequences from 68 localities across 22 European countries. Our data suggest that the species originated in Central Europe, and we revealed the location of multiple refugia (in both southern peninsulas and continental regions) for this continental model species. Our results confirm the monophyly of Iberian voles and the pre-LGM divergence between Iberian and European voles. We found evidence of restricted postglacial dispersal from refugia in Mediterranean peninsulas. We inferred a complex evolutionary and demographic history of M. arvalis in Europe over the last 50,000 years that does not adequately fit previous glacial refugial scenarios. The phylogeography of M. arvalis provides a paradigm of ice-age survival of a temperate continental species in western and eastern Mediterranean peninsulas (sources of endemism) and multiple continental regions (sources of postglacial spread). Our findings also provide support for a major role of large European river systems in shaping geographic boundaries of M. arvalis in Europ

Stellar kinematics across the Hubble sequence in the CALIFA survey: general properties and aperture corrections

We would like to thank the anonymous referee for constructive comments that helped improve some aspects of the original manuscript. We are also grateful to the DiskMass survey team for sharing their data with us for the spectral resolution tests, and to Marc Verheijen and Kyle Westfall in particular for in-depth discussions on the topic. This study makes use of the data provided by the Calar Alto Legacy Integral Field Area (CALIFA) survey (http://califa.caha.es). Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck-Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC). CALIFA is the first legacy survey being performed at Calar Alto. The CALIFA collaboration would like to thank the IAA-CSIC and MPIA-MPG as major partners of the observatory, and CAHA itself, for the unique access to telescope time and support in manpower and infrastructures. The CALIFA collaboration thanks also the CAHA staff for the dedication to this project.We present the stellar kinematic maps of a large sample of galaxies from the integral-field spectroscopic survey CALIFA. The sample comprises 300 galaxies displaying a wide range of morphologies across the Hubble sequence, from ellipticals to late-type spirals. This dataset allows us to homogeneously extract stellar kinematics up to several effective radii. In this paper, we describe the level of completeness of this subset of galaxies with respect to the full CALIFA sample, as well as the virtues and limitations of the kinematic extraction compared to other well-known integral-field surveys. In addition, we provide averaged integrated velocity dispersion radial profiles for different galaxy types, which are particularly useful to apply aperture corrections for single aperture measurements or poorly resolved stellar kinematics of high-redshift sources. The work presented in this paper sets the basis for the study of more general properties of galaxies that will be explored in subsequent papers of the survey.J. F.-B. from grant AYA2013- 48226-C3-1-P from the Spanish Ministry of Economy and Competitiveness (MINECO). J.F.-B. and G.v.d.V. from the FP7 Marie Curie Actions of the European Commission, via the Initial Training Network DAGAL under REA grant agreement number 289313. J.M.-A. and V.W. acknowledge support from the European Research Council Starting Grant (SEDMorph P.I. V. Wild). P.S.-B. acknowledge financial support from the BASAL CATA Center for Astrophysics and Associated Technologies through grant PFB-06. R.M.G.D. from grant AYA2014-57490-P. R.G.-B, R.M.G.D. and E.P. acknowledge support from the project JA-FQM-2828. C.J.W. acknowledges support through the Marie Curie Career Integration Grant 303912. L.G. from the Ministry of Economy, Development, and Tourism’s Millennium Science Initiative through grant IC120009 awarded to The Millennium Institute of Astrophysics (MAS), and CONICYT through FONDECYT grant 3140566. I.M. from grant AYA2013-42227-P

Pipe3d, a pipeline to analyze integral field spectroscopy data: II Analysis sequence and califa dataproducts

Presentamos una version mejorada de FIT3D, una herramienta de ajuste para el analisis de las poblaciones estelares y el gas ionizado en espectros de galaxias de resolucion intermedia. La misma se desarrollo para el análisis de datos de espectroscopía de campo integral y es la base de Pipe3D, un dataducto usado en el analisis de datos de los muestreos CALIFA, MaNGA y SAMI. Describimos la filosof´ıa y los pasos seguidos en el ajuste, presentando un conjunto amplio de simulaciones con el fin de estimar la precisión de los parametros derivados, mostrando el resultado de dichas simulaciones. Finalmente, comparamos el resultado del analisis con FIT3D y el obtenido mediante otros paquetes de uso frecuente, encontrando que los parametros derivados son totalmente compatibles.We present Pipe3D, an analysis pipeline based on the FIT3D fitting tool, developed to explore the properties of the stellar populations and ionized gas of integral field spectroscopy (IFS) data. Pipe3D was created to provide coherent, simple to distribute, and comparable dataproducts, independently of the origin of the data, focused on the data of the most recent IFU surveys (e.g., CALIFA, MaNGA, and SAMI), and the last generation IFS instruments (e.g., MUSE). In this article we describe the di fferent steps involved in the analysis of the data, illustrating them by showing the dataproducts derived for NGC 2916, observed by CALIFA and P-MaNGA. As a practical example of the pipeline we present the complete set of dataproducts derived for the 200 datacubes that comprises the V500 setup of the CALIFA Data Release 2 (DR2), making them freely available through the network. Finally, we explore the hypothesis that the properties of the stellar populations and ionized gas of galaxies at the e ffective radius are representative of the overall average ones, finding that this is indeed the case.Fil: Sánchez, S. F.. Universidad Nacional Autonoma de Mexico. Instituto de Astronomia; MéxicoFil: Pérez, E.. Instituto de Astrofísica de Andalucía; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Sanchez Blazquez, P.. Departamento de Fisica Teorica ; Facultad de Ciencias ; Universidad Autonoma de Madrid;Fil: García Benito, Rubén. Instituto de Astrofísica de Andalucía; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Ibarra Mede, H. J.. Space Telescope Science Institute; Estados UnidosFil: González, J. J.. Universidad Nacional Autonoma de Mexico. Instituto de Astronomia; MéxicoFil: Rosales Ortega, F. F.. Instituto Nacional de Astrofísica, Optica y Electrónica ; MéxicoFil: Sánchez Menguiano, L.. Instituto de Astrofísica de Andalucía; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Ascasibar, Y.. Universidad Autónoma de Barcelona. Facultad de Física. Departamento Astronomía y Meteorología; EspañaFil: Bitsakis, T.. Universidad Nacional Autonoma de Mexico. Instituto de Astronomia; MéxicoFil: Law, D.. Space Telescope Science Institute; Estados UnidosFil: Cano Díaz, M.. Universidad Nacional Autonoma de Mexico. Instituto de Astronomia; MéxicoFil: López Cobá, C.. Universidad Nacional Autonoma de Mexico. Instituto de Astronomia; MéxicoFil: Marino, R. A.. Universidad Complutense de Madrid; EspañaFil: Gil de Paz, A.. Australian Astronomical Observatory; AustraliaFil: López Sánchez, A.. Instituto de Astrofísica de Canarias (iac); EspañaFil: Barrera Ballesteros, Jorge K.. Instituto de Astrofísica de Canarias; EspañaFil: Galbany, Lluís. Millennium Institute Of Astrophysics; Chile. Universidad de Chile; ChileFil: Mast, Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Abril Malgarejo, V.. Universidad Nacional Autonoma de Mexico. Instituto de Astronomia; MéxicoFil: Roman Lopes, A.. Universidad de La Serena; Chil

A geometrical similarity pattern as an experimental model for shapes in architectural heritage: a case study of the base of the pillars in the Cathedral of Seville and the Church of Santiago in Jerez, Spain

This paper proposes a procedure for the search of a geometrical similarity pattern in architectural heritage by means of calculating probability indexes to support hypotheses initially endorsed by documentary sources. The buildings analysed are the Cathedral of Seville and the Church of Santiago, in Jerez, Spain. The 3D models of their selected pillars are obtained by means of Terrestrial Laser Scanning (TLS), Optical Scanning (OS) and photogrammetry through image-based modelling software (SFM-IBM). To this end, a procedure for the comparison of shapes is established. It is based on similarity statistics, the determination of homologous points and the agreement of characteristic sections. Here, two key aspects are considered: on the one hand, the metric standpoint; on the other hand, historical-graphical features of the 3D models: composition, techniques, styles, and historical-graphical documentary sources. Thus, putting aside the mere dimensional analysis, the sections are compared with graphical patterns and models of which the same authorship – stonemasons working in that age – is accurately known. As a result, the outcomes of this research reveal the geometrical similarity between the elements of the pillars of the Cathedral of Seville and the Church of Santiago

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured