Shell-Model Effective Operators for Muon Capture in ^{20}Ne

It has been proposed that the discrepancy between the partially-conserved axial-current prediction and the nuclear shell-model calculations of the ratio $C_P/C_A$ in the muon-capture reactions can be solved in the case of ^{28}Si by introducing effective transition operators. Recently there has been experimental interest in measuring the needed angular correlations also in ^{20}Ne. Inspired by this, we have performed a shell-model analysis employing effective transition operators in the shell-model formalism for the transition $^{20}Ne(0^+_{g.s.})+\mu^- \to ^{20}F(1^+; 1.057 MeV) + \nu_\mu$. Comparison of the calculated capture rates with existing data supports the use of effective transition operators. Based on our calculations, as soon as the experimental anisotropy data becomes available, the limits for the ratio $C_P/ C_A$ can be extracted.Comment: 9 pages, 3 figures include

Comparative bioavailability of a newly developed Irbesartan 300 mg containing preparation

Introduction: Irbesartan (CAS registry: 138402-11-6) is a potent, orally active, selective antagonist of the angiotensin II receptors (type AT1) indicated for the treatment of arterial hypertension and chronic heart failure. Aim: The objective of the present study was to demonstrate the bioequivalence of an oral test preparation (Irbesartan 300 mg film-coated tablets Tchaikapharma High Quality Medicines Inc., Bulgaria) and a reference (Aprovel 300 mg film-coated tablets, Sanofi Clir SNC, France), by comparing the rate and extent of absorption of both products upon a single oral administration of the tablets under fasting conditions in healthy volunteers. Methodology: The study was carried out as a single-center, open-label, randomised, twoperiod, single dose, crossover oral bioequivalence study in 40 healthy male and female subjects under fasting conditions. During each study period blood samples for analysis of irbesartan were taken prior to dosing and at 0.25, 0.5, 0.75, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 12, 24, 36, 48 and 72 hours after dosing. The separated plasma was analyzed in the bioanalytical division of Anapharm Europe with a validated method using reversed phase high performance liquid chromatography coupled to a tandem mass spectrometry detector (RP-LC/MS/MS). Results: The point estimates with 90% confidence intervals of the geometric mean ratios of test and reference (T/R) in the study were found to be 102.39% (95.55% - 109.71%) for Cmax and 98.56 % (92.72 % - 104.76 %) for AUC0-72. Thus, the corresponding ratios of Cmax and AUC0-72 met the predetermined criteria for bioequivalence (90% confidence intervals of the geometric mean ratios of test and reference within the 80.00% - 125.00%). Both products were generally very well tolerated. Conclusions: Irbesartan 300 mg film-coated tablets, Tchaikapharma High Quality Medicines Inc., Bulgaria) and Aprovel 300 mg film-coated tablets (Sanofi Clir SNC, France), are bioequivalent with regard to the rate and extent of absorption

Technical design and performance of the NEMO3 detector

The development of the NEMO3 detector, which is now running in the Frejus Underground Laboratory (L.S.M. Laboratoire Souterrain de Modane), was begun more than ten years ago. The NEMO3 detector uses a tracking-calorimeter technique in order to investigate double beta decay processes for several isotopes. The technical description of the detector is followed by the presentation of its performance.Comment: Preprint submitted to Nucl. Instrum. Methods A Corresponding author: Corinne Augier ([email protected]

Nurse managers' experience with ethical issues in six government hospitals in Malaysia: A cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Nurse managers have the burden of experiencing frequent ethical issues related to both their managerial and nursing care duties, according to previous international studies. However, no such study was published in Malaysia. The purpose of this study was to explore nurse managers' experience with ethical issues in six government hospitals in Malaysia including learning about the way they dealt with the issues.</p> <p>Methods</p> <p>A cross-sectional study was conducted in August-September, 2010 involving 417 (69.2%) of total 603 nurse managers in the six Malaysian government hospitals. Data were collected using three-part self-administered questionnaire. Part I was regarding participants' demographics. Part II was about the frequency and areas of management where ethical issues were experienced, and scoring of the importance of 11 pre-identified ethical issues. Part III asked how they dealt with ethical issues in general; ways to deal with the 11 pre-identified ethical issues, and perceived stress level. Data were analyzed using descriptive statistics, cross-tabulations and Pearson's Chi-square.</p> <p>Results</p> <p>A total of 397 (95.2%) participants experienced ethical issues and 47.2% experienced them on weekly to daily basis. Experiencing ethical issues were not associated with areas of practice. Top area of management where ethical issues were encountered was "staff management", but "patient care" related ethical issues were rated as most important. Majority would "discuss with other nurses" in dealing generally with the issues. For pre-identified ethical issues regarding "patient care", "discuss with doctors" was preferred. Only 18.1% referred issues to "ethics committees" and 53.0% to the code of ethics.</p> <p>Conclusions</p> <p>Nurse managers, regardless of their areas of practice, frequently experienced ethical issues. For dealing with these, team-approach needs to be emphasized. Proper understanding of the code of ethics is needed to provide basis for reasoning.</p

Adaptive Evolution in Zinc Finger Transcription Factors

The majority of human genes are conserved among mammals, but some gene families have undergone extensive expansion in particular lineages. Here, we present an evolutionary analysis of one such gene family, the poly–zinc-finger (poly-ZF) genes. The human genome encodes approximately 700 members of the poly-ZF family of putative transcriptional repressors, many of which have associated KRAB, SCAN, or BTB domains. Analysis of the gene family across the tree of life indicates that the gene family arose from a small ancestral group of eukaryotic zinc-finger transcription factors through many repeated gene duplications accompanied by functional divergence. The ancestral gene family has probably expanded independently in several lineages, including mammals and some fishes. Investigation of adaptive evolution among recent paralogs using dN/dS analysis indicates that a major component of the selective pressure acting on these genes has been positive selection to change their DNA-binding specificity. These results suggest that the poly-ZF genes are a major source of new transcriptional repression activity in humans and other primates

Broad targeting of resistance to apoptosis in cancer

Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminate malignant cells. However, in cancer, de-regulated apoptotic signaling, particularly the activation of an anti-apoptotic systems, allows cancer cells to escape this program leading to uncontrolled proliferation resulting in tumor survival, therapeutic resistance and recurrence of cancer. This resistance is a complicated phenomenon that emanates from the interactions of various molecules and signaling pathways. In this comprehensive review we discuss the various factors contributing to apoptosis resistance in cancers. The key resistance targets that are discussed include (1) Bcl-2 and Mcl-1 proteins; (2) autophagy processes; (3) necrosis and necroptosis; (4) heat shock protein signaling; (5) the proteasome pathway; (6) epigenetic mechanisms; and (7) aberrant nuclear export signaling. The shortcomings of current therapeutic modalities are highlighted and a broad spectrum strategy using approaches including (a) gossypol; (b) epigallocatechin-3-gallate; (c) UMI-77 (d) triptolide and (e) selinexor that can be used to overcome cell death resistance is presented. This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer

Patterns in recent and Holocene pollen accumulation rates across Europe - the Pollen Monitoring Programme Database as a tool for vegetation reconstruction

The collection of modern, spatially extensive pollen data is important for the interpretation of fossil pollen assemblages and the reconstruction of past vegetation communities in space and time. Modern datasets are readily available for percentage data but lacking for pollen accumulation rates (PARs). Filling this gap has been the motivation of the pollen monitoring network, whose contributors monitored pollen deposition in modified Tauber traps for several years or decades across Europe. Here we present this monitoring dataset consisting of 351 trap locations with a total of 2742 annual samples covering the period from 1981 to 2017. This dataset shows that total PAR is influenced by forest cover and climate parameters, which determine pollen productivity and correlate with latitude. Treeless vegetation produced PAR values of at least 140 grains cm(-2) yr(-1). Tree PAR increased by at least 400 grains cm(-2) yr(-1) with each 10% increase in forest cover. Pollen traps situated beyond 200 km of the distribution of a given tree species still collect occasional pollen grains of that species. The threshold of this long-distance transport differs for individual species and is generally below 60 grains cm(-2) yr(-1). Comparisons between modern and fossil PAR from the same regions show similar values. For temperate taxa, modern analogues for fossil PARs are generally found downslope or southward of the fossil sites. While we do not find modern situations comparable to fossil PAR values of some taxa (e.g. Corylus), CO2 fertilization and land use may cause high modern PARs that are not documented in the fossil record. The modern data are now publicly available in the Neotoma Paleoecology Database and aid interpretations of fossil PAR data.Peer reviewe

Моделирование рецептурных композиций для продуктов детского питания лечебно-профилактического назначения

1. У ході дослідження встановлено високу частоту аліментарно-залежних станів у дітей з алергічною патологією (49,00±5,75) % та функціональними розладами травної системи (56,00±5,79) %, а також виявлено значущість порушень принципів раціонального харчування у їх виникненні та перебігу. 2. Науково обґрунтовані рецептурні композиції теоретично забезпечують вимоги до принципів дієтотерапії дітей з харчовою алергією та функціональними розладами шлунково-кишкового тракту й можуть бути рекомендованими для подальшої апробації в умовах медичних закладів і промислових умовах.The article presents the results of the study of the compatibility of functional and technological and physico-chemical characteristics of the components of the developed formulations of products of the medical-preventive destination. The interrelation of the basic components of scientific modeling of products with the given properties — the principle of food combinatorics, production technology and the principle of diet therapy — have been analyzed. The performed researches indicate that the substantiation of the formulations of the products of the therapeutic and prophylactic purpose is based on a set of scientific data concerning the nature, depth and structure of micro- and macrodeficit deficiency in children with relevant disorders of health status, properties of raw materials and enrichment additives, including their chemical composition and function — technological properties and the degree of their conservation under the influence of technological factors.Приведены результаты изучения совместимости функционально-технологических и физикохимических характеристик составляющих разработанных рецептур продуктов лечебно-профилактического назначения. Проанализирована взаимосвязь основных составляющих продуктов с заданными свойствами на этапе научного моделирования в соответствии с принципами пищевой комбинаторики, технологии производства и диетотерапии. Выполненные исследования свидетельствуют, что обоснование рецептур продуктов лечебнопрофилактического назначения базируется на комплексе научных данных о характере, глубине и структуре дефицита микро- и макронутриентов у детей с соответствующими нарушениями состояния здоровья, особенностей сырья и обогатительных добавок, включая их химический состав и функционально-технологические свойства, а также степень сохранности под влиянием технологических факторов

Особенности суточного профиля артериального давления у больных гипертонической болезнью в сочетании с ишемической болезнью сердца и ишемической болезнью нижних конечностей

У статті аналізуються дані про особливості показників добового моніторингу артеріального тиску (АТ) у хворих на гіпертонічну хворобу (ГХ) поєднану з ішемічною хворобою серця (ІХС) та ішемічною хворобою нижніх кінцівок (ІХНК). Встановлено, що у хворих на ГХ, сполученої з ІХНК, більш високі рівні середньодобового, денного та нічного ДАТ, збільшення індексу часу та площі протягом доби. При поєднанні ГХ з ІХС індекс часу і площі САТ як вдень, так і вночі, а також рівень і швидкість ранкового підйому САТ, збільшилися порівняно до пацієнтів без поєднаної патології.Daily monitoring of blood pressure in the patients with essential hypertension (EH), contemporary in the with combined EH and coronary heart disease (CHD) and in a combination of EH with ischemic disease of extremities (IDE). Is has been established that at hypertensive patients in a combination with CHD an index of time and area systolic BP, the speed of its morning increasing was authentically more, than at the patients without CHD. At a combination IDE with EH the average of diastolic BP was more than in patients without IDE.Суточное мониторирование артериального давления (АД) проведено у 30 больных гипертонической болезнью (ГБ), 43 больных, у которых ГБ сочеталась в ишемической болезнью сердца (ИБС) и у 47 - в сочетании с ишемической болезнью нижних конечностей (ИБНК). Установлено, что у больных ГБ в сочетании с ИБС индекс времени и площади систолического АД, скорость повышения его в утернние часы была достоверно больше, чем у пациентов без ИБС. При сочетании ИБНК с ГБ отмечается достоверное увеличение среднесуточного дневного и ночного диастоличесого АД