Conhecimento materno sobre aleitamento: um estudo piloto realizado em Salvador, Bahia visando à elaboração de uma cartilha educativa

Although breast milk is the best food for the infants, maternal misinformation about the importance of breastfeeding is remarkable. We aimed to evaluate the knowledge of mothers and pregnant women about breastfeeding and to elaborate an educative booklet addressing the most important doubts identified in this population. A qualitative study was idealized and developed by Medicine graduating students of UFBA, attending at Preventive and Social Paediatrics' discipline. We studied a convenience sample, not probabilistic, composed by 24 mothers and pregnant women, using a semi-structured questionnaire elaborated by the authors to personal interview. The studied group presented doubts and misinformation about the subject, chiefly those related to breast preparing and feeding position (70.8%), besides the correct moment to introduce new foods (67.0%). The use of tea, water and juices before the sixth month is very frequent (50.0%), while 25.0% of the participants were afraid to have insufficient breast milk. Based on these data, an educative booklet was elaborated. We verified that the level of mothers' information about breastfeeding remains rather low in spite of the campaigns and the progress on scientific knowledge about the topic. The construction of an informative booklet should contribute to the enlightenment of the most important doubts about breastfeeding.Embora o leite materno seja o melhor alimento para a criança, é notável o desconhecimento das mães sobre a importância da amamentação. Foram objetivos do estudo: (1) avaliar o conhecimento de mães e gestantes acerca da amamentação e (2) elaborar uma cartilha que contemplasse as principais dúvidas identificadas. Um estudo qualitativo foi idealizado e desenvolvido por alunos de graduação em Medicina da UFBA, no curso da disciplina de Pediatria Preventiva e Social. Estudou-se uma amostra de conveniência, não probabilística, composta por 24 mães e gestantes. Utilizou-se questionário semi-estruturado, elaborado pelos autores, para entrevista pessoal. O grupo estudado apresentou diversas dúvidas e desconhecimentos acerca do tema, destacando-se aqueles relacionados ao preparo da mama e posição de amamentar (70,8%), além do momento correto para introdução de novos alimentos (67,0%). O uso de chá, água e sucos antes do sexto mês é ainda muito freqüente (50,0%) entre os lactentes, e 25,0% das mulheres temiam não ter leite suficiente. A partir desses dados, elaborou-se a cartilha informativa. Verificou-se que o nível de informação das mães sobre a amamentação é insuficiente, apesar das campanhas veiculadas pela mídia e do avanço no conhecimento científico sobre o tema. A construção de uma cartilha informativa deve contribuir no esclarecimento das principais dúvidas acerca de amamentação

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin

A search for resonances decaying into a Higgs boson and a new particle X in the XH→qqbb final state with the ATLAS detector

A search for heavy resonances decaying into a Higgs boson ($H$) and a new particle ($X$) is reported, utilizing 36.1 fb$^{-1}$ of proton-proton collision data at $\sqrt{s} =$ 13 TeV collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle $X$ is assumed to decay to a pair of light quarks, and the fully hadronic final state $XH \rightarrow q\bar q'b\bar b$ is analysed. The search considers the regime of high $XH$ resonance masses, where the $X$ and $H$ bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of $XH$ mass versus $X$ mass is scanned for evidence of a signal, over a range of $XH$ resonance mass values between 1 TeV and 4 TeV, and for $X$ particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of $XH$ and $X$ masses, on the production cross-section of the $XH\rightarrow q\bar q'b\bar b$ resonance

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. Results: SVR24 rates were 46.1 % (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1,2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced ≥1 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with ≥1 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not ≥5. Conclusions: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginter-feron alfa-2a/ribavirin

Viscoelastic hydrodynamics and holography

We formulate the theory of nonlinear viscoelastic hydrodynamics of anisotropic crystals in terms of dynamical Goldstone scalars of spontaneously broken translational symmetries, under the assumption of homogeneous lattices and absence of plastic deformations. We reformulate classical elasticity effective field theory using surface calculus in which the Goldstone scalars naturally define the position of higher-dimensional crystal cores, covering both elastic and smectic crystal phases. We systematically incorporate all dissipative effects in viscoelastic hydrodynamics at first order in a long-wavelength expansion and study the resulting rheology equations. In the process, we find the necessary conditions for equilibrium states of viscoelastic materials. In the linear regime and for isotropic crystals, the theory includes the description of Kelvin-Voigt materials. Furthermore, we provide an entirely equivalent description of viscoelastic hydrodynamics as a novel theory of higher-form superfluids in arbitrary dimensions where the Goldstone scalars of partially broken generalised global symmetries play an essential role. An exact map between the two formulations of viscoelastic hydrodynamics is given. Finally, we study holographic models dual to both these formulations and map them one-to-one via a careful analysis of boundary conditions. We propose a new simple holographic model of viscoelastic hydrodynamics by adopting an alternative quantisation for the scalar fields