A cooperative-relational approach to digital libraries

Copyright @ 2007 Springer-Verlag, Berlin HeidelbergThis paper presents a novel approach to model-driven development of Digital Library (DL) systems. The overall idea is to allow Digital Library systems designers (e.g. information architects, librarians, domain experts) to easily design such systems by using a visual language. We designed a Domain Specific Visual Language for such a purpose and developed a framework supporting it; this framework helps designers by automatically generating code for the defined Digital Library system, so that they do not have to get involved into technical issues concerning its deployment. In our approach, both Human-Computer Interaction and Computer Supported Collaborative Work techniques are exploited when generating interfaces and services for the specific Digital Library domain

An annotated checklist of trees and relatives in tropical montane forests from southeast Peru: the importance of continue collecting

Los Andes están considerados como los puntos calientes más diversos de los trópicos, dentro de estos se encuentra el Parque Nacional del Manu, cuyas complejas condiciones climáticas y fisiográficas albergan una mega-diversidad y endemismo. En el presente trabajo se presenta una lista anotada de especies arbóreas y afines a lo largo de un gradiente de elevación desde los bosques submontanos a 800 m hasta la línea de bosque a 3625 m en la Reserva de Biosfera del Manu. En base a una red de 21 parcelas permanentes de una hectárea y exploraciones botánicas se sistematiza la información florística por rangos de elevación, distribución geográfica y endemismo. Estos resultados preliminares se traducen en 1108 especies de las cuales el 39.7% son morfoespecies, el 43% de las especies determinadas son registros nuevos para la región del Cusco, 15 especies son nuevos registros para la flora peruana, 40 especies son endémicas para Perú y 30 son potenciales especies nuevas para la ciencia. Adicionalmente, se resalta la expansión del rango altitudinal para el 45.2% de las especies determinadas (302 especies). Estos resultados son una muestra de la alta diversidad arbórea y afines en estos ecosistemas montañosos registrados en tan solo ~20 km de distancia geográfica, además muestra lo escasamente colectados y poco estudiados que se encuentran. Mas colecciones botánicas son necesarias - estos estudios básicos de florística son imperativos para un mejor entendimiento de la distribución de especies y la función del ecosistemas, además ayudará a responder una de las grandes preguntas en la ecología global moderna, ¿Cómo responderán los bosques tropicales al cambio climático global?The tropical Andes and adjacent Amazon are Earth’s highest biodiversity hotspot. Manu National Park in southeastern Peru encompasses an entire watershed, ranging from Andean highlands to Amazonian lowlands, and is a megadiverse landscape on the Andes to Amazon transition. Here we present an annotated checklist of trees and related species is along an elevation gradient in the Manu Biosphere Reserve that runs from sub-montane forests at 800 m elevation up to the tree line at 3625 m. Based on a network of 21 1-hectare permanent tree plots and botanical explorations, the floristic information is systematized by elevation ranges, geographical distribution and endemism. These preliminary results show 1108 species. Of these, 43% are new records for the region of Cusco, 15 species are new records for the Peruvian flora, 40 species are endemics for Peru, and 30 are potential new species for science. Another 39.7% are identified to genus or family level and remain morphospecies. Additionally, we show altitudinal range expansion for 45.2% of identified species (302 species). These results were found in a transect of plots spanning only 20 km of geographic distance, and are a sample of the high tree diversity in these mountainous ecosystems. The data show how poorly collected and understudied these ecosystems are. Basic floristic studies and collections are imperative for a better understanding of species distribution and function of ecosystems, and the basic biodiversity of the tropical Andes. They will also help to answer a major, unresolved question in modern global ecology of how tropical forests will respond to global climate change

Headache during pregnancy : an observational study

Introducción: Las cefaleas primarias (CP) tienen mayor prevalencia e incidencia a menor edad y en su mayoría afectan a mujeres. La predilección femenina puede ser explicada por la relación de la cefalea y las hormonas sexuales, en particular el estrógeno. La migraña es la CP más discapacitante. Diversos estudios demuestran que dicha cefalea mejora durante el embarazo, principalmente en cuanto a frecuencia e intensidad. Objetivo: Caracterizar las CP según su intensidad y frecuencia durante el embarazo, además de valorar aspectos demográficos y clínicos asociados en estas pacientes. Materiales y métodos: Estudio descriptivo, transversal que analizó al azar mujeres durante el embarazo o puerperio mediato y se investigó el padecimiento de cefalea antes o durante el curso de dicho estado, mediante un cuestionario realizado por médicos del Servicio de Neurología. Se emplearon criterios de la International Headache Society 2018 (IHS) para la clasificación de cefaleas. Se analizaron datos con EpiInfo 7. Resultados: Se incluyeron 102 pacientes obstétricas. La media de edad fue de 27,6 años (DS+/-7). El 47,1% cursaba puerperio, 40,2% tercer trimestre, 7,8% segundo trimestre, 4,9% primer trimestre. El 14% presentaba antecedentes patológicos previos. El 89,2% padecía CP previa al embarazo siendo mayor en frecuencia la cefalea tensional episódica (61,8%). Se observó que hubo mejoría durante el embarazo en el 71,4%.Además se vio que el 12,8% de las pacientes presentaron cefalea nueva durante el embarazo siendo más frecuente la secundaria (8,8%). Conclusión: Entre las pacientes que presentaban CP previa al embarazo se observó que la mayoría mejoró durante el mismo. Además se concluyó que ante la aparición de cefalea nueva durante el embarazo se deberían realizar estudios complementarios ya que la mayoría fue secundaria a patologías graves.Introduction: Primary headache disorders (PH) are pathologies with high prevalence and incidence in young people, affecting women predominantly. Female predilection is associated with the linkage between headache and sexual hormones, mainly estrogens. Migraine is the most disabling primary headache. Some studies have shown that intensity and frequency of migraine tend to improve during pregnancy. Objetive: Describe primary headaches during pregnancy, in terms of frequency and intensity, and assess demographic and clinical manifestations associated with this condition. Subjects and methods: Descriptive, transversal study that randomly analyzed women during pregnancy or mediate puerperium. Existence of headache before and after these conditions was investigated trough a questionary made by physicians of the Neurology Service. International Headache Society 2018 criteria (IHS) were used to classify headaches. Data were analyzed with EpiInfo 7. Results: One hundred and twoobstetric patients were included. Median agewas 27,6 (SD +/-7). 47,1% patientswere in puerperium, 40,2% in the third trimester, 7.8% in the second trimester and 4.9% in the first trimester. Previous medical history was reported in 14% cases. PH prior to pregnancy was reported in 89.2% patients, being episodic tension headache the most frequent (61.8%). Improvement of headache during pregnancy was detected in 71.4% of the cases. There was a 12,8% of new-onset headache during pregnancy, with the secondary etiology as the most frequent cause (8,8%). Conclusion: Most of the headaches previous to pregnancy improve during this condition. New-onset headache during pregnancy must induce to request complementary studies in order to rule out severe secondary etiologies.Fil: Peñalver, F.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Galiana, G.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Delfino, C.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Farfan Alé, F.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Sánchez, C.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Gonzalez, M.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Giner, F.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Rodríguez, N.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Martínez, M.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y NeurocirugíaFil: Ianardi, S.. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Neurología y Neurocirugí

Introductions of West Nile Virus Strains to Mexico

Complete genome sequencing of 22 West Nile virus isolates suggested 2 independent introductions into Mexico. A previously identified mouse-attenuated glycosylation variant was introduced into southern Mexico through the southeastern United States, while a common US genotype appears to have been introduced incrementally into northern Mexico through the southwestern United States

Interpreting long-term trends in bushmeat harvest in southeast Cameroon

Measuring hunting sustainability across West/Central African forests remains a challenge. Long-term assessment of trends is crucial. Via hunter-reported surveys we collected offtake data in three villages near the Dja Biosphere Reserve (southeast Cameroon). During four months (March–June) in 2003, 2009 and 2016, we gathered information on hunters, prey species and number of carcasses brought to the three settlements. Because it was not possible to record hunter effort i.e. the time a hunter spent pursuing animals or setting traps, to calculate catch per unit effort (CPUE), we used catch per hunter per day (CPHD) to document hunter returns. We then used the changes in the mean body mass indicator (MBMI) throughout the study period to test for defaunation in the three villages. Differences in CPHD and MBMI by month and year, between villages and hunting method, were investigated using Tweedie regression models. For all species pooled, we found that the mean CPHD remained relatively constant between 2003 and 2016. There was an observed shift from traps to firearms during the study period. CPHD for each of the seven most hunted species did not vary significantly during the entire study period, and a similar change from traps to firearms was observed. MBMI also remained stable for all species pooled, but significantly declined in the remotest village. Starting MBMI values for this village were higher than for the other two settlements perhaps because wildlife here is less depleted. Although hunter effort data may be difficult to obtain over long time periods, CPHD and MBMI may be useful tools as a measure of impact of hunters on prey populations

Sexual experience affects reproductive behavior and preoptic androgen receptors in male mice

Reproductive behavior in male rodents is made up of anticipatory and consummatory elements which are regulated in the brain by sensory systems, reward circuits and hormone signaling. Gonadal steroids play a key role in the regulation of male sexual behavior via steroid receptors in the hypothalamus and preoptic area. Typical patterns of male reproductive behavior have been characterized, however these are not fixed but are modulated by adult experience. We assessed the effects of repeated sexual experience on male reproductive behavior of C57BL/6 mice; including measures of olfactory investigation of females, mounting, intromission and ejaculation. The effects of sexual experience on the number of cells expressing either androgen receptor (AR) or estrogen receptor alpha (ERα) in the primary brain nuclei regulating male sexual behavior was also measured. Sexually experienced male mice engaged in less sniffing of females before initiating sexual behavior and exhibited shorter latencies to mount and intromit, increased frequency of intromission, and increased duration of intromission relative to mounting. No changes in numbers of ERα-positive cells were observed, however sexually experienced males had increased numbers of AR-positive cells in the medial preoptic area (MPOA); the primary regulatory nucleus for male sexual behavior. These results indicate that sexual experience results in a qualitative change in male reproductive behavior in mice that is associated with increased testosterone sensitivity in the MPOA and that this nucleus may play a key integrative role in mediating the effects of sexual experience on male behavior

Intranasal administration of mesenchymal stem cell secretome reduces hippocampal oxidative stress, neuroinflammation and cell death, improving the behavioral outcome following perinatal asphyxia

Indexación: Scopus.PerinatalAsphyxia (PA) is a leading cause ofmotor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global PA, we investigated the neuroprotective effect of intranasally administered secretome, derived from human adipose mesenchymal stem cells (MSC-S), preconditioned with either deferoxamine (an hypoxia-mimetic) or TNF-ff+IFN- (pro-inflammatory cytokines). PA was generated by immersing fetus-containing uterine horns in a water bath at 37 ffC for 21 min. Thereafter, 16 ffL of MSC-S (containing 6 ffg of protein derived from 2 ff 105 preconditioned-MSC), or vehicle, were intranasally administered 2 h after birth to asphyxia-exposed and control rats, evaluated at postnatal day (P) 7. Alternatively, pups received a dose of either preconditioned MSC-S or vehicle, both at 2 h and P7, and were evaluated at P14, P30, and P60. The preconditioned MSC-S treatment (i) reversed asphyxia-induced oxidative stress in the hippocampus (oxidized/reduced glutathione); (ii) increased antioxidative Nuclear Erythroid 2-Related Factor 2 (NRF2) translocation; (iii) increased NQO1 antioxidant protein; (iv) reduced neuroinflammation (decreasing nuclearNF-ffB/p65 levels and microglial reactivity); (v) decreased cleaved-caspase-3 cell-death; (vi) improved righting reflex, negative geotaxis, cliff aversion, locomotor activity, anxiety, motor coordination, and recognition memory. Overall, the study demonstrates that intranasal administration of preconditioned MSC-S is a novel therapeutic strategy that prevents the long-term effects of perinatal asphyxia. © 2020 by the authors.https://www.mdpi.com/1422-0067/21/20/780

Pantropical modelling of canopy functional traits using Sentinel-2 remote sensing data

Tropical forest ecosystems are undergoing rapid transformation as a result of changing environmental conditions and direct human impacts. However, we cannot adequately understand, monitor or simulate tropical ecosystem responses to environmental changes without capturing the high diversity of plant functional characteristics in the species-rich tropics. Failure to do so can oversimplify our understanding of ecosystems responses to environmental disturbances. Innovative methods and data products are needed to track changes in functional trait composition in tropical forest ecosystems through time and space. This study aimed to track key functional traits by coupling Sentinel-2 derived variables with a unique data set of precisely located in-situ measurements of canopy functional traits collected from 2434 individual trees across the tropics using a standardised methodology. The functional traits and vegetation censuses were collected from 47 field plots in the countries of Australia, Brazil, Peru, Gabon, Ghana, and Malaysia, which span the four tropical continents. The spatial positions of individual trees above 10 cm diameter at breast height (DBH) were mapped and their canopy size and shape recorded. Using geo-located tree canopy size and shape data, community-level trait values were estimated at the same spatial resolution as Sentinel-2 imagery (i.e. 10 m pixels). We then used the Geographic Random Forest (GRF) to model and predict functional traits across our plots. We demonstrate that key plant functional traits can be accurately predicted across the tropicsusing the high spatial and spectral resolution of Sentinel-2 imagery in conjunction with climatic and soil information. Image textural parameters were found to be key components of remote sensing information for predicting functional traits across tropical forests and woody savannas. Leaf thickness (R2 = 0.52) obtained the highest prediction accuracy among the morphological and structural traits and leaf carbon content (R2 = 0.70) and maximum rates of photosynthesis (R2 = 0.67) obtained the highest prediction accuracy for leaf chemistry and photosynthesis related traits, respectively. Overall, the highest prediction accuracy was obtained for leaf chemistry and photosynthetic traits in comparison to morphological and structural traits. Our approach offers new opportunities for mapping, monitoring and understanding biodiversity and ecosystem change in the most species-rich ecosystems on Earth

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London