466 research outputs found
Competencia internacional durante la primera globalización: El mercado de maquinaria en España (1877-1913)
Màster Oficial d'Història Econòmica, Facultat d'Economia i Empresa, Universitat de Barcelona, Curs: 2015-2016, Tutor: Ramon Ramon-MuñozDurante la Primera Globalización las importaciones de maquinaria crecieron de manera muy intensa en España. En aquellos países, que como el mencionado, se encontraban en los primeros estadios expansivos de la industrialización generaron externalidades especialmente positivas. Mediante el estudio del caso de España analizaré los mercados internacionales de maquinaria y su evolución competitiva, entre 1877 y 1913. Para ello he realizado una reconstrucción de la importación de maquinaria entre dichas fechas, extrayendo los datos necesarios de las Estadísticas Oficiales de Comercio Exterior. Estas estadísticas serán la base cuantitativa del trabajo, y a través de su análisis, y del de otras fuentes adicionales, trataré de aportar nuevos datos al debate en torno a las posibles variaciones competitivas acaecidas en un contexto de globalización y cambio
Heritage as a source of studies into industrial history: using digital tools to explore the geography of the industrialization
The main objective of this article is to explore the possibility of combining two very different sources in order to study the distribution of industrial activity throughout history. The traditional primary sources to use for this purpose are the official censuses on population and economic activity that have been conducted in the majority of countries since the mid-nineteenth century. However, the majority of these lack detail at the regional level and also with respect to the types of professional occupations that they quantify. In order to complement and profile these census data, we propose the use of another type of information which can also be quantified, but whose characteristics are very different. We refer to the industrial heritage sites identified in digital format in a given territory, which in this case is Catalonia, Spain. This innovative dataset was obtained using digital tools such as web scraping and data mining techniques. This type of historical information was used to check whether it is reliable and valid for interpreting the spatial impact of the introduction of industrial activity. The article also shows that the systematic identification of elements of industrial heritage offers a new and very useful source of information for interpreting the history of industrial geography.This research has been financed by the Ministerio de Economía y Competitividad (Spanish Ministry for the Economy and Competitiveness—CSO2015-65733-P), ICREA-Academia and also supported by RecerCaixa, and the EU (Jean Monnet 586912-EPP-1-2017-1-ES-EPPJMO-PROJEC)
El Comercio entre España y Latino América
Buscamos conocer cuál es la situación del comercio español y en especial del sector exportador. Nos centraremos en el caso de Latino América a través de una serie retrospectiva, para conocer cómo ha evolucionado el comercio entre las regiones. Focalizaré la atención en los cambios que la crisis económica de 2008 pueda haber ocasionado en el comercio con la región. Qué países eran y cuales son ahora más importantes, cuales poseen mayor crecimiento, etc… nos fijaremos en los casos de éxito y en los fracasos y estableceremos una radiografía precisa de esta evolución para comprender las relaciones comerciales actuales. Un mercado de más de 500 millones de habitantes en su mayor parte hispano hablantes y con un enorme potencial, no es nada desdeñable a pesar de encontrarse a miles de kilómetros
Measuring cocircularity in a point set
In a given set S of n points in the plane, how close are four points of S to be cocircular? We define several
measures to study this question, and present bounds on this almost-cocircularity in a point set. Algorithms
for cocircularity are presented as well.Peer ReviewedPostprint (published version
Measurement of the cosmic ray spectrum above eV using inclined events detected with the Pierre Auger Observatory
A measurement of the cosmic-ray spectrum for energies exceeding
eV is presented, which is based on the analysis of showers
with zenith angles greater than detected with the Pierre Auger
Observatory between 1 January 2004 and 31 December 2013. The measured spectrum
confirms a flux suppression at the highest energies. Above
eV, the "ankle", the flux can be described by a power law with
index followed by
a smooth suppression region. For the energy () at which the
spectral flux has fallen to one-half of its extrapolated value in the absence
of suppression, we find
eV.Comment: Replaced with published version. Added journal reference and DO
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences
The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported
by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on
18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based
researchers who signed it in the short time span from 20 September to 6 October 2016
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
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