Energy end-use flexibility of the next generation of decision-makers in a smart grid setting: an exploratory study

Demand Response (DR) mechanisms have been developed to reshape consumption patterns in face of price signals, enabling to deal with the increasing penetration of intermittent renewable resources and balance electricity demand and supply. Although DR mechanisms have been in place for some time, it is still unclear to what extent end-users are ready, or willing, to embrace DR programs that can be complex and imply adjustments of daily routines. This work aims to understand how the next generation of Portuguese decision makers, namely young adults in higher education, are prepared to deal with energy decisions in the context of the challenges brought by the smart grids. Results demonstrate that cost savings and the contribution to environmental protection are found to be important motivating factors to enroll into DR programs, which should be further exploited in future actions for the promotion of end-user engagement. Moreover, DR solutions are well-accepted by higher education students, although with limited flexibility levels. In addition, there is room to exploit the willingness to adopt time-differentiated tariffs, yet savings should be clearer and more attractive to end-users. Also, the framing effect should be considered when promoting this type of time-differentiated tariffs.This work was partially supported by project grants UID/MULTI/00308/2013 and UID/CEC/00319/2013 and by the European Regional Development Fund through the COMPETE 2020 Programme, FCT—Portuguese Foundation for Science and Technology with in projects ESGRIDS (POCI-01-0145-FEDER-016434), Learn2Behave (02/SAICT/2016-023651), MAnAGER (POCI-01-0145-FEDER-028040), and POCI-01-0145-FEDER-007043, as well as by the Energy for Sustainability Initiative of the University of Coimbra

Transketolase-Like 1 Expression Is Modulated during Colorectal Cancer Progression and Metastasis Formation

Background Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, even in presence of oxygen, favoring the malignant aerobic glycolytic phenotype characteristic of tumor cells. As TKTL1 appears to be a valid biomarker for cancer prognosis, the aim of the current study was to correlate its expression with tumor stage, probability of tumor recurrence and survival, in a series of colorectal cancer patients. Methodolody/Principal Findings Tumor tissues from 63 patients diagnosed with colorectal cancer at different stages of progression were analyzed for TKTL1 by immunohistochemistry. Staining was quantified by computational image analysis, and correlations between enzyme expression, local growth, lymph-node involvement and metastasis were assessed. The highest values for TKTL1 expression were detected in the group of stage III tumors, which showed significant differences from the other groups (Kruskal-Wallis test, P = 0.000008). Deeper analyses of T, N and M classifications revealed a weak correlation between local tumor growth and enzyme expression (Mann-Whitney test, P = 0.029), a significant association of the enzyme expression with lymph-node involvement (Mann-Whitney test, P = 0.0014) and a significant decrease in TKTL1 expression associated with metastasis (Mann-Whitney test, P = 0.0004). Conclusions/Significance To our knowledge, few studies have explored the association between variations in TKTL1 expression in the primary tumor and metastasis formation. Here we report downregulation of enzyme expression when metastasis appears, and a correlation between enzyme expression and regional lymph-node involvement in colon cancer. This finding may improve our understanding of metastasis and lead to new and more efficient therapies against cancer

conditions for re deployment and energy development

Irrespective of technical abundancy, RE potential per se does not imply a structural and inclusive expansion of energy access and an overall sustainable energy development of EA. Proper technological, economic, institutional, and policy considerations must be made to assess which are the best ways and most apt policies to sustain the exploitation of such potential in the regional context in relation to other energy sources, as well as which roadblocks and challenges are faced. A first meaningful consideration in this sense is that EA is characterised by a strong rural-urban imbalance: the majority of the population lives in poorly interconnected rural communities away from the electricity grid, which serves predominantly densely populated urban centres. While plans to tackle the imbalance are in place in virtually every country (both Kenya and South Africa have achieved notable results in this sense), the issue is not going to be structurally overcome rapidly. Thus, as highlighted by the least-cost electrification scenarios in Chap. 4, when discussing the case for renewables to increase and improve access, a distinction must be made between national grid expansion to reach additional shares of the population, and specific decentralised solutions

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Making energy surveys more impactful: Testing material and non-monetary response strategies

© 2019 Elsevier Ltd Recent years have seen a growth in energy research that integrates social and behavioural sciences. A core component of this work involves collecting human data, commonly via surveys and field experiments. But there are often barriers to recruiting large and representative samples of participants, with sampling bias and non-response error posing threats to validity. Identifying cost-effective ways to increase participation in energy research is therefore important for strengthening the rigor, utility and generalisability of studies in this area. To this end, the current study harnesses an experimental design to test pathways for making energy surveys more impactful – specifically by improving response rates and times, lowering sampling bias, and enhancing overall cost-effectiveness. As part of a postal survey on household energy use in Australia, a set of randomised controlled trials were conducted to test the impact of four strategies: incentives, an envelope message, a handwritten sticky note, and a reminder postcard. A 3 x 2 x 2 x 2 factorial design was applied to assess both individual and interactive effects. While material incentives in the form of an upfront token gift and prize draw were ineffective in improving response relative to the control survey, results revealed that a handwritten sticky note expressing upfront thanks for participating – designed to serve as an intrinsically motivating attentional cue – improved both the rate and timeliness of response. Three combinations of strategies yielded significantly higher response rates than the control, but they were more expensive on a ‘dollar cost per response’ basis. Implications for research and practice are discussed