152 research outputs found
Heavy and light roles: myosin in the morphogenesis of the heart
- Author
- A Abu-Daya
- A Du
- A Horowitz
- A Houmeida
- A Wessels
- AA Lagrutta
- AE Chambers
- AN Tullio
- AS Warkman
- AV Postma
- B Brenner
- BA Danowski
- BG Bruneau
- BN Davis
- BR Cullen
- BS Budde
- BS Pan
- BV Latinkic
- C Gove
- C Huang
- C Rutland
- C Wang
- CR Bagshaw
- CS Rutland
- CT Basson
- D Franco
- D Franco
- D Hailstones
- D Jin
- D Linde van der
- D Maughan
- D Mornet
- D Rhee
- D Yelon
- DJ Timson
- DM Alvarado
- DO FĂŒrst
- E Berdougo
- E Carniel
- E Eisenberg
- E Flashman
- E Rooij van
- E Rooij van
- EM Small
- EP Kirk
- F Charron
- G Bonne
- GE Lyons
- H Huxley
- H Niimura
- H Pannu
- H Suzuki
- H Wada
- HJ Auman
- HJ Li
- HL Sweeney
- HM Warrick
- I Morano
- I Morano
- I Rayment
- J Chen
- J Fewell
- J Flavigny
- J Gulick
- J Stull
- JD Molkentin
- Jennifer England
- JGF Cleland
- JJ Schott
- JM Miano
- JP Sluijter
- JS Davis
- JS Park
- JT Granados-Riveron
- JY Chan
- K Imanaka-Yoshida
- K Poetter
- K Takeda
- K Trybus
- KD Wilson
- KK Turnacioglu
- KM Price
- KN Ivey
- KT Tokuyasu
- L Khait
- L Zhu
- L Zhu
- LD Sacks
- LM Auckland
- M Arad
- M Chandra
- M Goujon
- M Maitra
- M Morano
- M Xin
- MA Geeves
- MA Larkin
- MC Schaub
- MG Posch
- MJ Macera
- ML Bell
- MS Parmacek
- N Liu
- ND Epstein
- ND Moncrief
- O Ogut
- O Ritter
- P Andersen
- P Richard
- P VanBuren
- P Vibert
- PFM Ven Van Der
- PJ Barton
- PJ Barton
- PJ Reiser
- PS Andersen
- Q Shi
- QY Li
- R Nishigaki
- R Walsh
- RE Cheney
- RE Hershberger
- RJ Garriock
- RL Moss
- RM Toydemir
- S Ghatpande
- S Goswami
- S Lu
- S Machida
- S Somi
- Siobhan Loughna
- SJ Smith
- SS Lehrer
- SW Kubalak
- T Boettger
- T Takaya
- TE Callis
- TM Olson
- TQP Uyeda
- TX OâBrien
- V Garg
- VJ Ferrans
- W Barillot
- W Dillmann
- W Lehman
- W Lu
- W Rottbauer
- W-H Lee
- WF Harrington
- WF Harrington
- WK Jones
- WL Fodor
- X Ma
- X Ma
- Y Hiroi
- Y Ishikawa
- Y Nakajima
- Y Taneda
- Y Yang
- YH Ching
- Z Chen
- Z Wang
- ZT Kabaeva
- ZZ Bao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies
suggest that both myosin heavy-chain and myosin lightchain
proteins are required for a correctly formed heart.
Myosins are structural proteins that are not only expressed
from early stages of heart development, but when mutated
in humans they may give rise to congenital heart defects.
This review will discuss the roles of myosin, specifically
with regards to the developing heart. The expression of
each myosin protein will be described, and the effects that
altering expression has on the heart in embryogenesis in
different animal models will be discussed. The human
molecular genetics of the myosins will also be reviewed
Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells)
- Author
- A Blesch
- A Segerman
- A Segerman
- A Sharma
- AA Lemckert
- AC Bakker
- AC Logan
- AD Frankel
- AJ Bett
- AL Epstein
- AL Pacchia
- AL Parker
- AL Peel
- AP Byrnes
- AT Power
- B Georgievska
- B Salone
- BC Schnepp
- BL Davidson
- BL Davidson
- C Delenda
- C Fleischli
- CA Pacak
- CN Cearley
- CP Glover
- CP Glover
- D Bouard
- D Cuchet
- D Rea
- D Stone
- D Terzi
- DA Muruve
- DA Sanders
- DC Farley
- DJ Palmer
- DJ Watson
- DM McCarty
- DM Nettelbeck
- DS Bangari
- DT Saenz
- DY Ho
- DY Ho
- E Davison
- E Li
- E Vigna
- E Wu
- EM Poeschla
- F Kreppel
- F Sakurai
- FJ Koczot
- FJ Staal
- FL Graham
- G Ferrari
- G Sailaja
- G Schiedner
- G Schiedner
- G Wadell
- GP Gao
- GP Kobinger
- GR Nemerow
- GS Arnold
- GS Ralph
- GS Yang
- H Buning
- H Fu
- H Miletic
- H Miyoshi
- H Mizuguchi
- H Mochizuki
- I Dmitriev
- IM Verma
- J Barquinero
- J Cronin
- J Jakobsson
- J Morrison
- J Reiser
- J Rijck De
- J Schaack
- JA Wolff
- James B. Uney
- JC Glorioso
- JC Johnston
- JC Olsen
- JE Phillips
- JF Dedieu
- JF Engelhardt
- JF Wright
- JJ Short
- JJ Song
- JL Howarth
- JL Howarth
- JL Nathanson
- JM Bergelson
- JM Markert
- JM Spergel
- JM Spergel
- JM Wilson
- Joanna L. Howarth
- JP O'Rourke
- JR Nevins
- JS Bartlett
- K Mitrophanous
- K Morizono
- K Sims
- K Stieger
- K Wang
- K Xu
- KK Conzelmann
- KN Leppard
- L Naldini
- L Zou
- LD Stein
- LF Wong
- LF Wong
- M Azzouz
- M Azzouz
- M Marttila
- M Poznansky
- MA Croyle
- MA Curran
- MA Kay
- MB Mathews
- MB Parrott
- MD Kofron
- MD Stachler
- MJ Havenga
- MJ Staba
- MM Burcin
- MS Horwitz
- N Arnberg
- N Larochelle
- N Morral
- N Muzyczka
- N Okada
- N Somia
- N Tatsis
- ND Mazarakis
- NJ DePolo
- NJ Horwood
- NK Heinzinger
- P Gallay
- P Manilla
- PE Monahan
- PF Lewis
- PK Buch
- PL Hermonat
- PL Leopold
- PL Sinn
- PL Stewart
- PL Stewart
- PN Reynolds
- PR Dormitzer
- PW Roelvink
- R Alba
- R Cattaneo
- R Mentel
- R Vogel
- R Zufferey
- R Zufferey
- RJ Parks
- RJ Yanez-Munoz
- RM Blaese
- RS Coura
- S Akli
- S Daya
- S Hacein-Bey-Abina
- S Knaan-Shanzer
- S Tuve
- S Virta
- SA Afione
- SA Nicklin
- SC Barry
- SJ White
- SN Waddington
- SP Cregan
- T Dull
- T Kafri
- T Kafri
- T Mebatsion
- T Roe
- T Shimada
- T Stehle
- T Todo
- TC Harding
- TC Harding
- TC He
- TC MacKenzie
- TH Ni
- TJ Wickham
- TJ Wickham
- U Blomer
- UF Greber
- VN Kim
- W Shi
- W Weis
- WC Russell
- WT Hermens
- X Lu
- Y Kang
- Y Yang
- Y Yang
- Y Yang
- YB Lee
- Youn Bok Lee
- Z Qian
- Z Shevtsova
- Z Wang
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2009
- Field of study
In recent years, the development of powerful viral gene transfer techniques has greatly facilitated the study of gene function. This review summarises some of the viral delivery systems routinely used to mediate gene transfer into cell lines, primary cell cultures and in whole animal models. The systems described were originally discussed at a 1-day European Tissue Culture Society (ETCS-UK) workshop that was held at University College London on 1st April 2009. Recombinant-deficient viral vectors (viruses that are no longer able to replicate) are used to transduce dividing and post-mitotic cells, and they have been optimised to mediate regulatable, powerful, long-term and cell-specific expression. Hence, viral systems have become very widely used, especially in the field of neurobiology. This review introduces the main categories of viral vectors, focusing on their initial development and highlighting modifications and improvements made since their introduction. In particular, the use of specific promoters to restrict expression, translational enhancers and regulatory elements to boost expression from a single virion and the development of regulatable systems is described
Measurement of the W±Z boson pair-production cross section in pp collisions at âs=13TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Aben R
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- AlconadaVerzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alstaty M
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amako K
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Anger P
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- Anghinolfi F
- Anisenkov AV
- Anjos CN
- Annovi A
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- Arai Y
- Araque JP
- Arce ATH
- Arduh FA
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- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
- Armitage LJ
- Arnaez O
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- Atkinson M
- Atlay NB
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- Baca MJ
- Bachacou H
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- Backes M
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- Bagiacchi P
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- Baines JT
- Baker OK
- Baldin EM
- Balek P
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- Bannoura AAE
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- Beacham JB
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- Youssef S
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- Zalieckas J
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- Zanzi D
- Zeitnitz C
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- Zenin O
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- Zerwas D
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- Zhemchugov A
- Zhong J
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zu Theenhausen HM
- zur Nedden M
- Zwalinski L
- Publication venue
- Netherlands
- Publication date
- 01/01/2016
- Field of study
published_or_final_versio
Charged-particle distributions at low transverse momentum in âs=13 13 TeV pp interactions measured with the ATLAS detector at the LHC
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Aben R
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Alberich LC
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
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- Alviggi MG
- Amadio BT
- Amako K
- Amelung C
- Amidei D
- Amorim A
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
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- Angelidakis S
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- Anghinolfi F
- Anisenkov AV
- Anjos N
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- Antel C
- Antonelli M
- Antonov A
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Aranda CP
- Araque JP
- Araya ST
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
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- Ashkenazi A
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baak MA
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Bagiacchi P
- Bagnaia P
- Bai Y
- Baines JT
- Baker OK
- Baldin EM
- Balek P
- Balestri T
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- Balunas WK
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- Boumediene D
- Bourdarios C
- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
- Bracinik J
- Brandt A
- Brandt G
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- Bratzler U
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- Braun HM
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- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang R
- Zhang R
- Zhang X
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
- Zhou L
- Zhou L
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Measurements of distributions of charged particles produced in protonâproton collisions with a centre-of-mass energy of 13 TeV are presented. The data were recorded by the ATLAS detector at the LHC and correspond to an integrated luminosity of 151 ÎŒb â1 ÎŒbâ1 . The particles are required to have a transverse momentum greater than 100 MeV and an absolute pseudorapidity less than 2.5. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the dependence of the mean transverse momentum on multiplicity are measured in events containing at least two charged particles satisfying the above kinematic criteria. The results are corrected for detector effects and compared to the predictions from several Monte Carlo event generators
Measurement of the inelastic proton-proton cross section at âs=13 TeV with the ATLAS detector at the LHC
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Aben R
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- Ilchenko Y
- Iliadis D
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2015
- Field of study
This Letter presents a measurement of the inelastic proton-proton cross section using 60ââÎŒb â1 of pp collisions at a center-of-mass energy âs of 13 TeV with the ATLAS detector at the LHC. Inelastic interactions are selected using rings of plastic scintillators in the forward region (2.0710 â6 , where M X is the larger invariant mass of the two hadronic systems separated by the largest rapidity gap in the event. In this Ο range the scintillators are highly efficient. For diffractive events this corresponds to cases where at least one proton dissociates to a system with M X >13ââGeV . The measured cross section is compared with a range of theoretical predictions. When extrapolated to the full phase space, a cross section of 78.1±2.9ââmb is measured, consistent with the inelastic cross section increasing with center-of-mass energy
Search for pair production of Higgs bosons in the bbÂŻbbÂŻ final state using proton-proton collisions at âs=13ââTeV with the ATLAS detector
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- Yildirim E
- Yildiz HD
- Yorita K
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- Yoshihara K
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- Young CJS
- Youssef S
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- Yuen SPY
- Yusuff I
- Zabinski B
- Zaidan R
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- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zengel K
- Zenin O
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- Zerwas D
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- Zhang R
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- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
- Zhou L
- Zhou L
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zu Theenhausen HM
- Zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2016
- Field of study
A search for Higgs-boson pair production in the bb ÂŻ bb ÂŻ final state is carried out with 3.2ââfb â1 of proton-proton collision data collected at s â =13ââTeV with the ATLAS detector. The data are consistent with the estimated background and are used to set upper limits on the production cross section of Higgs-boson pairs times branching ratio to bb ÂŻ bb ÂŻ for both nonresonant and resonant production. In the case of resonant production of Kaluza-Klein gravitons within the Randall-Sundrum model, upper limits in the 24 to 91 fb range are obtained for masses between 600 and 3000 GeV, at the 95% confidence level. The production cross section times branching ratio for nonresonant Higgs-boson pairs is also constrained to be less than 1.22 pb, at the 95% confidence level
Search for anomalous couplings in the W tb vertex from the measurement of double differential angular decay rates of single top quarks produced in the t-channel with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Alkire SP
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amako K
- Amaral Coutinho Y
- Amelung C
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- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
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- Andari N
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- Anders JK
- Anderson KJ
- Andreazza A
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- Angelidakis S
- Angelozzi I
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- Arabidze G
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- Artamonov A
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/10/2015
- Field of study
The electroweak production and subsequent decay of single top quarks is determined by the properties of the Wtb vertex. This vertex can be described by the complex parameters of an effective Lagrangian. An analysis of angular distributions of the decay products of single top quarks produced in the t -channel constrains these parameters simultaneously. The analysis described in this paper uses 4.6 fbâ1 of proton-proton collision data at âs =7 TeV collected with the ATLAS detector at the LHC. Two parameters are measured simultaneously in this analysis. The fraction f 1 of decays containing transversely polarised W bosons is measured to be 0.37 ± 0.07 (stat.âsyst.). The phase ÎŽ â between amplitudes for transversely and longitudinally polarised W bosons recoiling against left-handed b-quarks is measured to be â0.014Ï Â± 0.036Ï (stat.âsyst.). The correlation in the measurement of these parameters is 0.15. These values result in two-dimensional limits at the 95% confidence level on the ratio of the complex coupling parameters g R and V L, yielding Re[g R /V L] â [â0.36, 0.10] and Im[g R /V L] â [â0.17, 0.23] with a correlation of 0.11. The results are in good agreement with the predictions of the Standard Model
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44Â 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Measurement of the photon identification efficiencies with the ATLAS detector using LHC Run-1 data
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- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
© 2016, CERN for the benefit of the ATLAS collaboration.The algorithms used by the ATLAS Collaboration to reconstruct and identify prompt photons are described. Measurements of the photon identification efficiencies are reported, using 4.9 fb- 1 of pp collision data collected at the LHC at s=7 TeV and 20.3 fb- 1 at s=8 TeV. The efficiencies are measured separately for converted and unconverted photons, in four different pseudorapidity regions, for transverse momenta between 10 GeV and 1.5 TeV. The results from the combination of three data-driven techniques are compared to the predictions from a simulation of the detector response, after correcting the electromagnetic shower momenta in the simulation for the average differences observed with respect to data. Data-to-simulation efficiency ratios used as correction factors in physics measurements are determined to account for the small residual efficiency differences. These factors are measured with uncertainties between 0.5% and 10% in 7 TeV data and between 0.5% and 5.6% in 8 TeV data, depending on the photon transverse momentum and pseudorapidity
Modelling Z â ÏÏ processes in ATLAS with Ï-embedded Z â ΌΌ data
- Author
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- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2015
- Field of study
This paper describes the concept, technical realisation and validation of a largely data-driven method to model events with ZâÏÏ decays. In ZâΌΌ events selected from proton-proton collision data recorded at âs=8 TeV with the ATLAS experiment at the LHC in 2012, the Z decay muons are replaced by Ï leptons from simulated ZâÏÏ decays at the level of reconstructed tracks and calorimeter cells. The Ï lepton kinematics are derived from the kinematics of the original muons. Thus, only the well-understood decays of the Z boson and Ï leptons as well as the detector response to the Ï decay products are obtained from simulation. All other aspects of the event, such as the Z boson and jet kinematics as well as effects from multiple interactions, are given by the actual data. This so-called Ï-embedding method is particularly relevant for Higgs boson searches and analyses in ÏÏ final states, where ZarrowÏÏ decays constitute a large irreducible background that cannot be obtained directly from data control samples. In this paper, the relevant concepts are discussed based on the implementation used in the ATLAS Standard Model HâÏÏ analysis of the full datataset recorded during 2011 and 2012
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