330 research outputs found
IN-HOSPITAL USE OF POTENTIALLY HARMFUL DRUGS IN HEART FAILURE: IMPACT ON LENGTH OF STAY AND MORTALITY
Coral reef biofilm bacterial diversity and successional trajectories are structured by reef benthic organisms and shift under chronic nutrient enrichment
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Remple, K. L., Silbiger, N. J., Quinlan, Z. A., Fox, M. D., Kelly, L. W., Donahue, M. J., & Nelson, C. E. Coral reef biofilm bacterial diversity and successional trajectories are structured by reef benthic organisms and shift under chronic nutrient enrichment. Npj Biofilms and Microbiomes, 7(1), (2021): 84, https://doi.org/10.1038/s41522-021-00252-1.Work on marine biofilms has primarily focused on host-associated habitats for their roles in larval recruitment and disease dynamics; little is known about the factors regulating the composition of reef environmental biofilms. To contrast the roles of succession, benthic communities and nutrients in structuring marine biofilms, we surveyed bacteria communities in biofilms through a six-week succession in aquaria containing macroalgae, coral, or reef sand factorially crossed with three levels of continuous nutrient enrichment. Our findings demonstrate how biofilm successional trajectories diverge from temporal dynamics of the bacterioplankton and how biofilms are structured by the surrounding benthic organisms and nutrient enrichment. We identify a suite of biofilm-associated bacteria linked with the orthogonal influences of corals, algae and nutrients and distinct from the overlying water. Our results provide a comprehensive characterization of marine biofilm successional dynamics and contextualize the impact of widespread changes in reef community composition and nutrient pollution on biofilm community structure.This work was supported through grants from the National Science Foundation for Biological Oceanography (1923877 to C.E.N. and M.J.D., 1949033 to C.E.N. and 2118687 to L.W.K., and 1924281 to N.J.S.) and the National Fish and Wildlife Foundation (grant no. 44447 to C.E.N.). This paper is funded in part by the National Oceanic and Atmospheric Administration, Project A/AS-1, which is sponsored by the University of Hawaii Sea Grant College Program, SOEST, under Institutional Grant No. NA18OAR4170076 from NOAA Office of Sea Grant, Department of Commerce. This is CSUN marine biology contribution #365, UH Sea Grant contribution UNIHI-SEAGRANT-JC-21-06, and UH SOEST contribution 11435
An infrared survey of brightest cluster galaxies: Paper I
We report on an imaging survey with the Spitzer Space Telescope of 62
brightest cluster galaxies with optical line emission. These galaxies are
located in the cores of X-ray luminous clusters selected from the ROSAT All-Sky
Survey. We find that about half of these sources have a sign of excess infrared
emission; 22 objects out of 62 are detected at 70 microns, 18 have 8 to 5.8
micron flux ratios above 1.0 and 28 have 24 to 8 micron flux ratios above 1.0.
Altogether 35 of 62 objects in our survey exhibit at least one of these signs
of infrared excess. Four galaxies with infrared excesses have a 4.5/3.6 micron
flux ratio indicating the presence of hot dust, and/or an unresolved nucleus at
8 microns. Three of these have high measured [OIII](5007A)/Hbeta flux ratios
suggesting that these four, Abell 1068, Abell 2146, and Zwicky 2089, and
R0821+07, host dusty active galactic nuclei (AGNs). 9 objects (including the
four hosting dusty AGNs) have infrared luminosities greater than 10^11 L_sol
and so can be classified as luminous infrared galaxies (LIRGs). Excluding the
four systems hosting dusty AGNs, the excess mid-infrared emission in the
remaining brightest cluster galaxies is likely related to star formation.Comment: accepted for publication in ApJ
The Extended Blue Continuum and Line Emission around the Central Radio Galaxy in Abell 2597
We present results from detailed imaging of the centrally dominant radio
elliptical galaxy in the cooling flow cluster Abell 2597, using data obtained
with the Wide Field and Planetary Camera 2 (WFPC2) on the Hubble Space
Telescope (HST). This object is one of the archetypal "blue-lobed" cooling flow
radio elliptical galaxies, also displaying a luminous emission-line nebula, a
compact radio source, and a significant dust lane and evidence of molecular gas
in its center. We show that the radio source is surrounded by a complex network
of emission-line filaments, some of which display a close spatial association
with the outer boundary of the radio lobes. We present a detailed analysis of
the physical properties of ionized and neutral gas associated with the radio
lobes, and show that their properties are strongly suggestive of direct
interactions between the radio plasma and ambient gas. We resolve the blue
continuum emission into a series of knots and clumps, and present evidence that
these are most likely due to regions of recent star formation. We investigate
several possible triggering mechanisms for the star formation, including direct
interactions with the radio source, filaments condensing from the cooling flow,
or the result of an interaction with a gas-rich galaxy, which may also have
been responsible for fueling the active nucleus. We propose that the properties
of the source are plausibly explained in terms of accretion of gas by the cD
during an interaction with a gas-rich galaxy, which combined with the fact that
this object is located at the center of a dense, high-pressure ICM can account
for the high rates of star formation and the strong confinement of the radio
source.Comment: Astrophysical Journal, in press, 34 pages, includes 6 PostScript
figures. Latex format, uses aaspp4.sty and epsf.sty file
Galaxy Cluster Pressure Profiles as Determined by Sunyaev Zel’dovich Effect Observations with MUSTANG and Bolocam. II. Joint Analysis of 14 Clusters
We present pressure profiles of galaxy clusters determined from high
resolution Sunyaev-Zel'dovich (SZ) effect observations of fourteen clusters,
which span the redshift range . The procedure simultaneously
fits spherical cluster models to MUSTANG and Bolocam data. In this analysis, we
adopt the generalized NFW parameterization of pressure profiles to produce our
models. Our constraints on ensemble-average pressure profile parameters, in
this study , , and , are consistent with those in
previous studies, but for individual clusters we find discrepancies with the
X-ray derived pressure profiles from the ACCEPT2 database. We investigate
potential sources of these discrepancies, especially cluster geometry, electron
temperature of the intracluster medium, and substructure. We find that the
ensemble mean profile for all clusters in our sample is described by the
parameters: , for cool core clusters: , and for disturbed
clusters: . Four of the fourteen clusters have
clear substructure in our SZ observations, while an additional two clusters
exhibit potential substructure.Comment: 22 pages, 9 figures, accepted to Ap
Integration and continuity of primary care: polyclinics and alternatives - a patient-centred analysis of how organisation constrains care co-ordination
Background
An ageing population, the increasing specialisation of clinical services and diverse health-care provider ownership make the co-ordination and continuity of complex care increasingly problematic. The way in which the provision of complex health care is co-ordinated produces – or fails to produce – six forms of continuity of care (cross-sectional, longitudinal, flexible, access, informational and relational). Care co-ordination is accomplished by a combination of activities by patients themselves; provider organisations; care networks co-ordinating the separate provider organisations; and overall health-system governance. This research examines how far organisational integration might promote care co-ordination at the clinical level.
Objectives
To examine (1) what differences the organisational integration of primary care makes, compared with network governance, to horizontal and vertical co-ordination of care; (2) what difference provider ownership (corporate, partnership, public) makes; (3) how much scope either structure allows for managerial discretion and ‘performance’; (4) differences between networked and hierarchical governance regarding the continuity and integration of primary care; and (5) the implications of the above for managerial practice in primary care.
Methods
Multiple-methods design combining (1) the assembly of an analytic framework by non-systematic review; (2) a framework analysis of patients’ experiences of the continuities of care; (3) a systematic comparison of organisational case studies made in the same study sites; (4) a cross-country comparison of care co-ordination mechanisms found in our NHS study sites with those in publicly owned and managed Swedish polyclinics; and (5) the analysis and synthesis of data using an ‘inside-out’ analytic strategy. Study sites included professional partnership, corporate and publicly owned and managed primary care providers, and different configurations of organisational integration or separation of community health services, mental health services, social services and acute inpatient care.
Results
Starting from data about patients’ experiences of the co-ordination or under-co-ordination of care, we identified five care co-ordination mechanisms present in both the integrated organisations and the care networks; four main obstacles to care co-ordination within the integrated organisations, of which two were also present in the care networks; seven main obstacles to care co-ordination that were specific to the care networks; and nine care co-ordination mechanisms present in the integrated organisations. Taking everything into consideration, integrated organisations appeared more favourable to producing continuities of care than did care networks. Network structures demonstrated more flexibility in adding services for small care groups temporarily, but the expansion of integrated organisations had advantages when adding new services on a longer term and a larger scale. Ownership differences affected the range of services to which patients had direct access; primary care doctors’ managerial responsibilities (relevant to care co-ordination because of their impact on general practitioner workload); and the scope for doctors to develop special interests. We found little difference between integrated organisations and care networks in terms of managerial discretion and performance.
Conclusions
On balance, an integrated organisation seems more likely to favour the development of care co-ordination and, therefore, continuities of care than a system of care networks. At least four different variants of ownership and management of organisationally integrated primary care providers are practicable in NHS-like settings. Future research is therefore required, above all to evaluate comparatively the different techniques for coordinating patient discharge across the triple interface between hospitals, general practices and community health services; and to discover what effects increasing the scale and scope of general practice activities will have on continuity of care
HALT (Hernia Active Living Trial): protocol for a feasibility study of a randomised controlled trial of a physical activity intervention to improve quality of life in people with bowel stoma with a bulge/parastomal hernia
Background
Parastomal hernia (PSH) can be repaired surgically, but results to date have been disappointing, with reported recurrence rates of 30 to 76%. Other types of intervention are therefore needed to improve the quality of life of people with PSH. One potential intervention is physical activity. We hypothesise that the intervention will increase core activation and control across the abdominal wall at a site of potential weakness and thus reduce the risk of PSH progression. Increases in physical activity will improve body image and quality of life (QoL).
Methods
Subjects and sample
There were approximately 20 adults with a bowel stoma and PSH. People with previous PSH repair will be excluded as well as people who already do core training.
Study design
This is a feasibility study of a randomised controlled trial with 2 months follow-up, in 2 sites using mixed methods. Stage 1 involves intervention development and in stage 2, intervention and trial parameters will be assessed.
Intervention
A theoretically informed physical activity intervention was done, targeting people with PSH.
Main outcome of feasibility study
The main outcome is the decision by an independent Study Steering Committee whether to proceed to a full randomised controlled trial of the intervention.
Other outcomes
We will evaluate 4 intervention parameters—fidelity, adherence, acceptability and safety and 3 trial parameters (eligible patients’ consent rate, acceptability of study design and data availability rates for following endpoints):
I.
Diagnosis and classification of PSH
II.
Muscle activation
III.
Body composition (BMI, waist circumference)
IV.
Patient reported outcomes: QoL, body image and physical functioning
V.
Physical activity;
VI.
Psychological determinants of physical activity
Other data
Included are other data such as interviews with all participants about the intervention and trial procedures.
Data analysis and statistical power
As this is a feasibility study, the quantitative data will be analysed using descriptive statistics. Audio-recorded qualitative data from interviews will be transcribed verbatim and analysed thematically.
Discussion
The feasibility and acceptability of key intervention and trial parameters will be used to decide whether to proceed to a full trial of the intervention, which aims to improve body image, quality of life and PSH progression.
Trial registration
ISRCTN1520759
Provenance of Cretaceous through Eocene strata of the Four Corners region: Insights from detrital zircons in the San Juan Basin, New Mexico and Colorado
Cretaceous through Eocene strata of the Four Corners region provide an excellent record of changes in sediment provenance from Sevier thin-skinned thrusting through the formation of Laramide block uplifts and intra-foreland basins. During the ca. 125–50 Ma timespan, the San Juan Basin was flanked by the Sevier thrust belt to the west, the Mogollon highlands rift shoulder to the southwest, and was influenced by (ca. 75–50 Ma) Laramide tectonism, ultimately preserving a >6000 ft (>2000 m) sequence of continental, marginal-marine, and offshore marine sediments. In order to decipher the influences of these tectonic features on sediment delivery to the area, we evaluated 3228 U-Pb laser analyses from 32 detrital-zircon samples from across the entire San Juan Basin, of which 1520 analyses from 16 samples are newly reported herein. The detrital-zircon results indicate four stratigraphic intervals with internally consistent age peaks: (1) Lower Cretaceous Burro Canyon Formation, (2) Turonian (93.9–89.8 Ma) Gallup Sandstone through Campanian (83.6–72.1 Ma) Lewis Shale, (3) Campanian Pictured Cliffs Sandstone through Campanian Fruitland Formation, and (4) Campanian Kirtland Sandstone through Lower Eocene (56.0–47.8 Ma) San Jose Formation. Statistical analysis of the detrital-zircon results, in conjunction with paleocurrent data, reveals three distinct changes in sediment provenance. The first transition, between the Burro Canyon Formation and the Gallup Sandstone, reflects a change from predominantly reworked sediment from the Sevier thrust front, including uplifted Paleozoic sediments and Mesozoic eolian sandstones, to a mixed signature indicating both Sevier and Mogollon derivation. Deposition of the Pictured Cliffs Sandstone at ca. 75 Ma marks the beginning of the second transition and is indicated by the spate of near-depositional-age zircons, likely derived from the Laramide porphyry copper province of southern Arizona and southwestern New Mexico. Paleoflow indicators suggest the third change in provenance was complete by 65 Ma as recorded by the deposition of the Paleocene Ojo Alamo Sandstone. However, our new U-Pb detrital-zircon results indicate this transition initiated ∼8 m.y. earlier during deposition of the Campanian Kirtland Formation beginning ca. 73 Ma. This final change in provenance is interpreted to reflect the unroofing of surrounding Laramide basement blocks and a switch to local derivation. At this time, sediment entering the San Juan Basin was largely being generated from the nearby San Juan Mountains to the north-northwest, including uplift associated with early phases of Colorado mineral belt magmatism. Thus, the detrital-zircon spectra in the San Juan Basin document the transition from initial reworking of the Paleozoic and Mesozoic cratonal blanket to unroofing of distant basement-cored uplifts and Laramide plutonic rocks, then to more local Laramide uplifts.National Science Foundation (NSF grant EAR-1649254
Consultocracy and its discontents : A critical typology and a call for a research agenda
Peer reviewe
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