Metodología Six Sigma en la mejora de la productividad de la empresa INVERFAEL SAC

La empresa INVERFAEL S.A.C, dedicada a la fabricación de estructuras metálicas, esta organización presento una baja productividad debido a una deficiente distribución de estaciones de trabajo, falta de capacitación a los trabajadores involucrados en el proceso de fabricación, ausencia de un plan de control y calidad para los materiales, todo esto porque la empresa no contaba con una metodología de mejora de calidad, la cual fue causa del bajo desempeño del personal y esto generaba baja calidad y productividad en la organización. Los resultados obtenidos por la implementación fueron un aumento de manera significativa en la productividad. Se concluye del presente informe que la implementación de la metodología Six sigma incrementa la productividad de las organizaciones

FORMULASI EMULGEL EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura Linn.) DAN EVALUASI AKTIVITASNYA SEBAGAI ANTIACNE TERHADAP Propionibacterium acnes

Preferensi penggunaan obat herbal meningkat sebagai antiacne untuk melengkapi terapi yang ada. Daun kersen (Muntingia calabura Linn.) berpotensi sebagai antiacne karena memiliki aktivitas antiinflamasi dan antibakteri. Penelitian ini bertujuan untuk optimasi formulasi emulgel ekstrak daun kersen dan pengujian aktivitasnya sebagai antiacne terhadap P. acnes. KHM dari ekstrak etanol daun kersen ditentukan dengan metode difusi padat. KHM digunakan untuk menentukan kekuatan sediaan emulgel. Optimasi formulasi emulgel dilakukan pada variasi penggunaan Carbopol 940 (0,5; 1,0; dan 1,5%) sebagai gelling agent dan variasi penggunaan konsentrasi ekstrak etanol daun kersen (3; 4,5; dan 6%). Evaluasi sediaan emulgel yang dilakukan meliputi pengamatan organoleptic, uji homogenitas, pengukuran pH, penentuan viskositas, uji sentrifugasi, uji freeze-thaw, uji daya sebar, dan uji iritasi. Pengujian aktivitas antiacne emulgel dilakukan menggunakan metode difusi agar. Nilai rata-rata zona hambat pertumbuhan bakteri dari sampel uji dibandingkan dengan zona hambat dari gel klindamisin sebagai pembanding. Hasil optimasi menunjukkan formula emulgel F3 dengan penggunaan Carbopol 940 1,5% dan kandungan ekstrak etanol daun kersen 6%. Hasil uji aktivitas antiacne emulgel yang mengandung ekstrak etanol daun kersen dengan konsentrasi 3; 4,5; dan 6% menghasilkan zona hambat pertumbuhan P. acnes dengan diameter 16,12 ± 0,13; 18,20 ± 0,35; dan 19,35 ± 0,28 mm. Kata kunci: Muntingia calabura Linn., Antiacne, Emulge

A Vacuum-driven Origami “Magic-ball” Soft Gripper

Soft robotics has yielded numerous examples of soft grippers that utilize compliance to achieve impressive grasping performances with great simplicity, adaptability, and robustness. Designing soft grippers with substantial grasping strength while remaining compliant and gentle is one of the most important challenges in this field. In this paper, we present a light-weight, vacuum-driven soft robotic gripper made of an origami “magic-ball” and a flexible thin membrane. We also describe the design and fabrication method to rapidly manufacture the gripper with different combinations of lowcost materials for diverse applications. Grasping experiments demonstrate that our gripper can lift a large variety of objects, including delicate foods, heavy bottles, and other miscellaneous items. The grasp force on 3D-printed objects is also characterized through mechanical load tests. The results reveal that our soft gripper can produce significant grasp force on various shapes using negative pneumatic pressure (vacuum). This new gripper holds the potential for many practical applications that require safe, strong, and simple graspingUnited States. Defense Advanced Research Projects Agency (award number FA8650-15-C-7548)National Science Foundation (U.S.) (award number 1830901)Wyss Institute for Biologically Inspired EngineeringJD.co

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Twist exome capture allows for lower average sequence coverage in clinical exome sequencing

Background Exome and genome sequencing are the predominant techniques in the diagnosis and research of genetic disorders. Sufficient, uniform and reproducible/consistent sequence coverage is a main determinant for the sensitivity to detect single-nucleotide (SNVs) and copy number variants (CNVs). Here we compared the ability to obtain comprehensive exome coverage for recent exome capture kits and genome sequencing techniques. Results We compared three different widely used enrichment kits (Agilent SureSelect Human All Exon V5, Agilent SureSelect Human All Exon V7 and Twist Bioscience) as well as short-read and long-read WGS. We show that the Twist exome capture significantly improves complete coverage and coverage uniformity across coding regions compared to other exome capture kits. Twist performance is comparable to that of both short- and long-read whole genome sequencing. Additionally, we show that even at a reduced average coverage of 70× there is only minimal loss in sensitivity for SNV and CNV detection. Conclusion We conclude that exome sequencing with Twist represents a significant improvement and could be performed at lower sequence coverage compared to other exome capture techniques

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.

Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development

A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing

Purpose Within the Solve-RD project (https://solve-rd.eu/), the European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies aimed to investigate whether a reanalysis of exomes from unsolved cases based on ClinVar annotations could establish additional diagnoses. We present the results of the “ClinVar low-hanging fruit” reanalysis, reasons for the failure of previous analyses, and lessons learned. Methods Data from the first 3576 exomes (1522 probands and 2054 relatives) collected from European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies was reanalyzed by the Solve-RD consortium by evaluating for the presence of single-nucleotide variant, and small insertions and deletions already reported as (likely) pathogenic in ClinVar. Variants were filtered according to frequency, genotype, and mode of inheritance and reinterpreted. Results We identified causal variants in 59 cases (3.9%), 50 of them also raised by other approaches and 9 leading to new diagnoses, highlighting interpretation challenges: variants in genes not known to be involved in human disease at the time of the first analysis, misleading genotypes, or variants undetected by local pipelines (variants in off-target regions, low quality filters, low allelic balance, or high frequency). Conclusion The “ClinVar low-hanging fruit” analysis represents an effective, fast, and easy approach to recover causal variants from exome sequencing data, herewith contributing to the reduction of the diagnostic deadlock