295 research outputs found
Economic models for sustainable interprofessional education
Limited information exists on funding models for interprofessional education (IPE) course delivery, even though potential savings from IPE could be gained in healthcare delivery efficiencies and patient safety. Unanticipated economic barriers to implementing an IPE curriculum across programs and schools in University settings can stymie or even end movement toward collaboration and sustainable culture change. Clarity among stakeholders, including institutional leadership, faculty, and students, is necessary to avoid confusion about IPE tuition costs and funds flow, given that IPE involves multiple schools and programs sharing space, time, faculty, and tuition dollars. In this paper, we consider three funding models for IPE: (a) Centralized (b) Blended, and (c) Decentralized. The strengths and challenges associated with each of these models are discussed. Beginning such a discussion will move us toward understanding the return on investment of IPE
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Variation in Antibiotic Susceptibility of Uropathogens by Age among Ambulatory Pediatric Patients
We compared uropathogen antibiotic susceptibility across age groups of ambulatory
pediatric patients. For Escherichia coli (n=5,099) and other Gram-negative rods (n=626), significant
differences (p<0.05) existed across age groups for ampicillin, cefazolin, and
trimethoprim/sulfamethoxazole susceptibility. In E. coli, differences in
trimethoprim/sulfamethoxazole susceptibility varied from 79% in children under 2 to 88% in ages 16-18 (p<0.001) while ampicillin susceptibility varied from 30% in children under 2 to 53% in ages 2-5 (p=0.015). Uropathogen susceptibility to common urinary anti-infectives may be lower in the
youngest children. Further investigation into these differences is needed to facilitate appropriate and prudent treatment of urinary tract infections.This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at: http://www.sciencedirect.com/science/journal/08825963
Two-Proton Correlations from 14.6A GeV/c Si+Pb and 11.5A GeV/c Au+Au Central Collisions
Two-proton correlation functions have been measured in Si+Pb collisions at
14.6A GeV/c and Au+Au collisions at 11.5A GeV/c by the E814/E877 collaboration.
Data are compared with predictions of the transport model RQMD and the source
size is inferred from this comparison. Our analysis shows that, for both
reactions, the characteristic size of the system at freeze-out exceeds the size
of the projectile, suggesting that the fireball created in the collision has
expanded. For Au+Au reactions, the observed centrality dependence of the
two-proton correlation function implies that more central collisions lead to a
larger source sizes.Comment: RevTex, 12 pages, 5 figure
Neurocognitive and Neuroimaging Predictors of Clinical Outcome in Bipolar Disorder
Historically, bipolar disorder has been conceptualized as a disease involving episodic rather than chronic dysfunction. However, increasing evidence indicates that bipolar disorder is associated with substantial inter-episode psychosocial and vocational impairment. Here we review the contributions of neurocognitive deficits and structural and functional neuroanatomic alterations to the observed functional impairments. In particular, compelling evidence now suggests that neurocognitive impairments, particularly in the areas of attention, processing speed, and memory, are associated with functional outcome. Although investigation of the neural correlates of functional disability in bipolar disorder is only in its nascent stages, preliminary evidence suggests that white matter abnormalities may be predictive of poor outcome. A better understanding of the relationship between neurocognitive and neuroimaging assays and functional outcome has the potential to improve current treatment options and provide targets for new treatment strategies in bipolar disorder
Centrality dependence of pi^[+/-], K^[+/-], p and p-bar production from sqrt(s_NN)=130 GeV Au + Au collisions at RHIC
Identified pi^[+/-] K^[+/-], p and p-bar transverse momentum spectra at
mid-rapidity in sqrt(s_NN)=130 GeV Au-Au collisions were measured by the PHENIX
experiment at RHIC as a function of collision centrality. Average transverse
momenta increase with the number of participating nucleons in a similar way for
all particle species. The multiplicity densities scale faster than the number
of participating nucleons. Kaon and nucleon yields per participant increase
faster than the pion yields. In central collisions at high transverse momenta
(p_T greater than 2 GeV/c), anti-proton and proton yields are comparable to the
pion yields.Comment: 6 pages, 3 figures, 1 table, 307 authors, accepted by Phys. Rev.
Lett. on 9 April 2002. This version has minor changes made in response to
referee Comments. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are publicly available at
http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm
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Frequency of Outpatient Antibiotic Prescription on Discharge to Hospice Care
The use of antibiotics is common in hospice care despite limited evidence that it improves symptoms or quality of life. Patients
receiving antibiotics upon discharge from a hospital may be more likely to continue use following transition to hospice care despite
a shift in the goals of care. We quantified the frequency and characteristics for receiving a prescription for antibiotics on
discharge from acute care to hospice care. This was a cross-sectional study among adult inpatients (≥18 years old) discharged to
hospice care from Oregon Health & Science University (OHSU) from 1 January 2010 to 31 December 2012. Data were collected
from an electronic data repository and from the Department of Care Management. Among 62,792 discharges, 845 (1.3%) patients
were discharged directly to hospice care (60.0% home and 40.0% inpatient). Most patients discharged to hospice were >65
years old (50.9%) and male (54.6%) and had stayed in the hospital for ≤7 days (56.6%). The prevalence of antibiotic prescription
upon discharge to hospice was 21.1%. Among patients discharged with an antibiotic prescription, 70.8% had a documented infection
during their index admission. Among documented infections, 40.3% were bloodstream infections, septicemia, or endocarditis,
and 38.9% were pneumonia. Independent risk factors for receiving an antibiotic prescription were documented infection
during the index admission (adjusted odds ratio [AOR]=7.00; 95% confidence interval [95% CI]=4.68 to 10.46),
discharge to home hospice care (AOR=2.86; 95% CI=1.92 to 4.28), and having a cancer diagnosis (AOR=2.19; 95% CI=1.48
to 3.23). These data suggest that a high proportion of patients discharged from acute care to hospice care receive an antibiotic
prescription upon discharge
RHIC physics overview
The results from data taken during the last several years at the Relativistic
Heavy-Ion Collider (RHIC) will be reviewed in the paper. Several selected
topics that further our understanding of constituent quark scaling, jet
quenching and color screening effect of heavy quarkonia in the hot dense medium
will be presented. Detector upgrades will further probe the properties of Quark
Gluon Plasma. Future measurements with upgraded detectors will be presented.
The discovery perspectives from future measurements will also be discussed.Comment: 9 pages, 4 figures, invited review article, published by Frontier of
Physics in Chin
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ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors
Formation of dense partonic matter in relativistic nucleus-nucleus collisions at RHIC: Experimental evaluation by the PHENIX collaboration
Extensive experimental data from high-energy nucleus-nucleus collisions were
recorded using the PHENIX detector at the Relativistic Heavy Ion Collider
(RHIC). The comprehensive set of measurements from the first three years of
RHIC operation includes charged particle multiplicities, transverse energy,
yield ratios and spectra of identified hadrons in a wide range of transverse
momenta (p_T), elliptic flow, two-particle correlations, non-statistical
fluctuations, and suppression of particle production at high p_T. The results
are examined with an emphasis on implications for the formation of a new state
of dense matter. We find that the state of matter created at RHIC cannot be
described in terms of ordinary color neutral hadrons.Comment: 510 authors, 127 pages text, 56 figures, 1 tables, LaTeX. Submitted
to Nuclear Physics A as a regular article; v3 has minor changes in response
to referee comments. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are (or will be) publicly available
at http://www.phenix.bnl.gov/papers.htm
Measurement of charm production at central rapidity in proton-proton collisions at TeV
The -differential production cross sections of the prompt (B
feed-down subtracted) charmed mesons D, D, and D in the rapidity
range , and for transverse momentum GeV/, were
measured in proton-proton collisions at TeV with the ALICE
detector at the Large Hadron Collider. The analysis exploited the hadronic
decays DK, DK, DD, and their charge conjugates, and was performed on a
nb event sample collected in 2011 with a
minimum-bias trigger. The total charm production cross section at TeV and at 7 TeV was evaluated by extrapolating to the full phase space
the -differential production cross sections at TeV
and our previous measurements at TeV. The results were compared
to existing measurements and to perturbative-QCD calculations. The fraction of
cdbar D mesons produced in a vector state was also determined.Comment: 20 pages, 5 captioned figures, 4 tables, authors from page 15,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/307
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