Surgery for recurrent inflammatory pseudotumor of the lung

<p>Abstract</p> <p>Background</p> <p>Cases of recurrent inflammatory pseudotumor have only rarely been reported. The treatment for recurrent pseudotumor is surgery. Patients not eligible for surgery require different treatment, and the optimal type of the treatment is controversial.</p> <p>Case Presentation</p> <p>A 54-year-old woman was noted to have an abnormal shadow in the right middle lung field on chest X-ray. Computed tomography of the chest revealed an infiltrative lesion in the right segment 4 and a nodule in the right segment 8. She underwent right middle lobectomy and partial resection of the right segment 8. Histopathology revealed non-atypical lymphocytes and plasma cells infiltrates, leading to the diagnosis of the lymphoplasmacytic type of inflammatory pseudotumor. During postoperative follow-up, chest computed tomography revealed a nodular lesion in the left segment 3 and an infiltrative lesion in the right segment 2. Left segment 3 segmentectomy and right segment 2 wedge resection were performed. The histopathological findings were similar to those of the first surgical specimen, leading to the diagnosis of recurrent lymphoplasmacytic type of inflammatory pseudotumor.</p> <p>Conclusion</p> <p>Surgical cases of recurrent inflammatory pseudotumor of the lung have been reported only very rarely. We believe that surgery is the best treatment for recurrent inflammatory pseudotumor of the lung when patients are eligible.</p

DINÂMICA DA COBERTURA DO SOLO NA MICROBACIA E ZONA RIPÁRIA DO RIO JOANINHA (1984 A 2022), AMAZÔNIA OCIDENTAL, BRASIL

The development of human activities has an impact on natural resources and may compromise sustainable development. In this context, the objective of this study was to analyze the spatial and temporal dynamics of soil cover in the watershed and riparian zone of the Joaninha River, in order to know the impacts caused by anthropic activities and to select management practices to mitigate these impacts. Images of Landsat 5 and Landsat 8 satellites and geotechnologies were used to perform this work. In 38 years of colonization (1984 to 2022), the native forest area was reduced from 4.55 to 0.82 km2 in the watershed and from 0.23 to 0.14 km2 in the riparian zone. On the other hand, the agricultural area increased from 1.95 to 5.67 km2 in the watershed and from 0.26 to 0.34 km2 in the riparian zone. In 2022, soil cover was mainly composed of agriculture, reaching 87.23% and 69.39% of the total areas of the watershed and riparian zone, respectively. It is concluded that the excessive suppression of the native forest in the watershed and the advance of agriculture in the riparian zone compromise the sustainable development of the region, because they negatively impact the quality of the soil and the availability of water resources. It is recommended in an integrated way, the maintenance of the remaining native vegetation, the recovery of native vegetation in the areas protected by law that currently have agriculture, the inclusion of the forest component in productive activities.El desarrollo de las actividades humanas tiene un impacto en los recursos naturales y puede comprometer el desarrollo sostenible. En este contexto, el objetivo de este estudio fue analizar la dinámica espacial y temporal de la cobertura del suelo en la cuenca y zona ribereña del río Joaninha, con el fin de conocer los impactos causados por las actividades antrópicas y seleccionar prácticas de manejo para mitigar estos impactos. Se utilizaron imágenes de los satélites Landsat 5 y Landsat 8 y geotecnologías para realizar este trabajo. En 38 años de colonización (1984 a 2022), el área de bosque nativo se redujo de 4,55 a 0,82 km2 en la cuenca y de 0,23 a 0,14 km2 en la zona ribereña. Por otro lado, el área agrícola aumentó de 1,95 a 5,67 km2 en la cuenca y de 0,26 a 0,34 km2 en la zona ribereña. En 2022, la cobertura del suelo estuvo compuesta principalmente por la agricultura, alcanzando el 87,23% y el 69,39% de las áreas totales de la cuenca y la zona ribereña, respectivamente. Se concluye que la supresión excesiva del bosque nativo en la cuenca hidrográfica y el avance de la agricultura en la zona ribereña comprometen el desarrollo sostenible de la región, porque impactan negativamente en la calidad del suelo y la disponibilidad de recursos hídricos. Se recomienda de manera integrada, el mantenimiento de la vegetación nativa restante, la recuperación de la vegetación nativa en las áreas protegidas por ley que actualmente.O desenvolvimento das atividades humanas ocasiona impactos aos recursos naturais podendo comprometer o desenvolvimento sustentável. Nesse contexto, objetivou-se com o presente trabalho analisar a dinâmica espacial e temporal da cobertura do solo na microbacia e zona ripária do rio Joaninha, com a finalidade de conhecer os impactos provocados pelas atividades antrópicas e selecionar práticas de manejo para mitigar esses impactos. Para realização deste trabalho foram utilizadas imagens dos satélites Landsat 5 e Landsat 8, e geotecnologias. Em 38 anos de colonização (1984 a 2022), a área de floresta nativa foi reduzida de 4,55 para 0,82 km2 na microbacia e de 0,23 para 0,14 km2 na zona ripária. Em contrapartida, a área de agropecuária aumentou de 1,95 para 5,67 km2 na microbacia e de 0,26 para 0,34 km2 na zona ripária. No ano de 2022, a cobertura do solo era composta principalmente de agropecuária, chegando a ocupar 87,23% e 69,39% das áreas totais da microbacia e zona ripária, respectivamente. Conclui-se que a supressão excessiva da floresta nativa na microbacia e o avanço da agropecuária na zona ripária comprometem o desenvolvimento sustentável da região, por impactarem negativamente a qualidade do solo e a disponibilidade de recursos hídricos. Recomenda-se de forma integrada, a manutenção da vegetação nativa remanescente, recuperação da vegetação nativa nas áreas protegidas por lei que atualmente estão com agropecuária, a inclusão do componente florestal nas atividades produtivas (ex: sistema agroflorestal) e a adoção de práticas conservacionistas nos sistemas agropecuários.O desenvolvimento das atividades humanas ocasiona impactos aos recursos naturais podendo comprometer o desenvolvimento sustentável. Nesse contexto, objetivou-se com o presente trabalho analisar a dinâmica espacial e temporal da cobertura do solo na microbacia e zona ripária do rio Joaninha, com a finalidade de conhecer os impactos provocados pelas atividades antrópicas e selecionar práticas de manejo para mitigar esses impactos. Para realização deste trabalho foram utilizadas imagens dos satélites Landsat 5 e Landsat 8, e geotecnologias. Em 38 anos de colonização (1984 a 2022), a área de floresta nativa foi reduzida de 4,55 para 0,82 km2 na microbacia e de 0,23 para 0,14 km2 na zona ripária. Em contrapartida, a área de agropecuária aumentou de 1,95 para 5,67 km2 na microbacia e de 0,26 para 0,34 km2 na zona ripária. No ano de 2022, a cobertura do solo era composta principalmente de agropecuária, chegando a ocupar 87,23% e 69,39% das áreas totais da microbacia e zona ripária, respectivamente. Conclui-se que a supressão excessiva da floresta nativa na microbacia e o avanço da agropecuária na zona ripária comprometem o desenvolvimento sustentável da região, por impactarem negativamente a qualidade do solo e a disponibilidade de recursos hídricos. Recomenda-se de forma integrada, a manutenção da vegetação nativa remanescente, recuperação da vegetação nativa nas áreas protegidas por lei que atualmente estão com agropecuária, a inclusão do componente florestal nas atividades produtivas (ex: sistema agroflorestal) e a adoção de práticas conservacionistas nos sistemas agropecuários

Fabrication and Characterisation of the Cytotoxic and Antibacterial Properties of Chitosan-Cerium Oxide Porous Scaffolds

Bone damage arising from fractures or trauma frequently results in infection, impeding the healing process and leading to complications. To overcome this challenge, we engineered highly porous chitosan scaffolds (S1, S2, and S3) by incorporating 30 (wt)% iron-doped dicalcium phosphate dihydrate (Fe-DCPD) minerals and different concentrations of cerium oxide nanoparticles (CeO2) (10 (wt)%, 20 (wt)%, and 30 (wt)%) using the lyophilisation technique. The scaffolds were specifically designed for the controlled release of antibacterial agents and were systematically characterised by utilising Raman spectroscopy, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy methodologies. Alterations in the physicochemical properties, encompassing pore size, swelling behaviour, degradation kinetics, and antibacterial characteristics, were observed with the escalating CeO2 concentrations. Scaffold cytotoxicity and its impact on human bone marrow mesenchymal stem cell (BM-MSCs) proliferation were assessed employing the 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay. The synthesised scaffolds represent a promising approach for addressing complications associated with bone damage by fostering tissue regeneration and mitigating infection risks. All scaffold variants exhibited inhibitory effects on bacterial growth against Staphylococcus aureus and Escherichia coli strains. The scaffolds manifested negligible cytotoxic effects while enhancing antibacterial properties, indicating their potential for reducing infection risks in the context of bone injuries

New Approach of QuEChERS and GC-MS Triple-Quadrupole for the Determination of Ethyl Carbamate Content in Brazilian cachaças

Cachaça is a popular spirit produced in Brazil, obtained by distillation of fermented sugar cane. Among the contaminants arising from production, ethyl carbamate is a carcinogenic compound that occurs naturally in fermented foods and beverages; in Brazil, the maximum limit established by current legislation is 150 µg L−1. Quality control is usually performed using gas chromatography; however, robustness and reproducibility of quantitative results may be severely impaired, as the addition of 6–30 g L−1 of sucrose is a common procedure for taste standardization, directly interfering in the results. This work describes the development of a novel method to improve ethyl carbamate quantification in cachaças using a new approach of QuEChERS extraction based on salting-out phenomenon, to effectively separate ethanol from sugar-containing water. Eighteen different brands of cachaça were analyzed. The proposed methodology was able to eliminate components that contaminate the sample flow path in the gas chromatography system, while improving precision and accuracy by using a triple-quadrupole approach, in comparison with the methodology usually employed: direct analysis of cachaça samples with no sample prep. Results indicate that this approach is more effective due to the removal of sugar content, with no impact in costs per analysis