The use of developed mushroom compost in crop cultivation technology

The scientific work analyzes experimental data on the cultivation of potatoes and rapeseed using elements of biologization in conditions of Ryazan region. Two-year studies have been carried out to study the effect of developed mushroom compost on the yield of potato tubers and rape of various varieties cultivated on dark gray forest soils of Ryazan region. The use of spent mushroom compost is a promising technique that allows to increase the productivity of crops and obtain environmentally friendly products. When cultivating potatoes and spring rape, first, bare fallow was used as a precursor, and then the introduction of 84 t/ha of fresh mushroom compost for the main processing of potatoes and 80 t/ha for spring rape, immediately after harvesting mushrooms in the form of developed blocks. In the second option, 95 t/ha of mushroom compost was used for potatoes and 89 t/ha was used for spring rape, after a year of storage of spent mushroom blocks. As a result of the use of two types of mushroom compost, the foliage of plants improved: on average, the largest increase in leaves was obtained in the option with fresh compost. Its use immediately after harvesting mushrooms exceeded the control by 12.8%, and the use of compost after a year of storage caused 7.6% increase. The highest average marketability of tubers for all varieties was noted in the option with fresh mushroom compost and averaged 80.8% for all varieties, which was 9.1% more than the control. The productivity of spring rape seeds increased when using mushroom compost as a fertilizer. The introduction of fresh compost under the main tillage increased the rape productivity by 2.9 dt/ha, and rotted compost by 1.9 dt/ha compared with the control. For all varieties of potatoes, the yield with fresh mushroom compost increased by 37.8 dt/ha or 20.1% compared to the control, and for the variant after a year storage of mushroom compost, the yield increased by 23.8 dt/ha or 11.3 %

Surface impedance of copper MOB depending on the annealing temperature and deformation degree

Results of researches of influence of annealing temperature and deformation degree on mechanical features of copper MOB are presented. It is shown that minimal surface resistance is observed in copper samples that were subject to pre-deformation and were annealed in the range of temperatures 873…923K.Представлены результаты исследований влияния температуры отжига и степени деформации на электромеханические характеристики меди марки МОБ. Показано, что минимальное поверхностное сопротивление наблюдается у меди, деформированной и отожженной в интервале температур 873…923К.Представлені результати досліджень впливу температури відпалу та степені деформації на електромеханічні характеристики міді марки МОБ. Показано, що мінімальний поверхневий опір спостерігається у зразків міді, підверненої деформації і відпаленої в інтервалі температур 873…923К

NGS-based identification of druggable alterations and signaling pathways – hepatocellular carcinoma case report

Aim. To identify potential cancer driving or clinically relevant molecular events for a patient with hepatocellular carcinoma. Methods. In order to achieve this goal, we performed RNA-seq and exome sequencing for the tumor tissue and its matched control. We annotated the alterations found using several publicly available databases and bioinformatics tools. Results. We identified several differentially expressed genes linked to the classical sorafenib treatment as well as additional pathways potentially druggable by therapies studied in clinical trials (Erlotinib, Lapatinib and Temsirolimus). Several germline mutations, found in XRCC1, TP53 and DPYD, according to the data from other clinical trials, could be related to the increased sensitivity to platinum therapies and reduced sensitivity to 5-Fluorouracil. We also identified several potentially driving mutations that could not be currently linked to therapies, like deletion in CIRBP, SNVs in BTG1, ERBB3, TCF7L2 et al. Conclusions. The presented study shows the potential usefulness of the integrated approach to the NGS data analysis, including the analysis of germline mutations and transcriptome in addition to the cancer panel or the exome sequencing data.Мета. Ідентифікувати потенційно онкодрайверні або клінічно значущі молекулярні події у пацієнта з гепатоклітинною карциномою. Методи. РНК- та екзомне секвенування пухлинної тканини та відповідного контролю. Анотування знайдених змін, використовуючи декілька загальнодоступних баз даних та біоінформатичних програм. Ми також порівняли транскрипційний профіль досліджуваної пухлини з транскриптомами клітинних ліній з бази даних Genomics of Drug Sensitivity in Cancer. Результати. Ідентифіковано кілька генів, що дифференційно експресуються, і пов’язані як з класичною терапією сорафенібом, так і з додатковими сигнальними шляхами, що потенційно вразливі до терапії препаратами, які досліджувались у клініческих випробуваннях (ерлотініб, лапатініб та темсіролімус). Декілька гермінативних мутацій, знайдених в XRCC1, TP53 та DPYD, згідно з даними інших клінічних випробувань, можуть бути пов’язані з підвищеною чутливістю до платинових терапій та зменшеною чутливістю до 5-фторурацилу. Ми також ідентифікували декілька потенційно драйверних мутацій, які на цей час не можуть бути пов’язані з терапіями, наприклад делеції у CIRBP, заміни в BTG1, ERBB3, TCF7L2 тощо. Висновки. Запропоноване дослідження демонструє потенційну корисність інтегрованого підходу до NGS аналізу даних, в тому числі аналізу гермінативних мутацій та транскриптому у додаток до використання онкологічних генних панелей або даних секвенування екзому.Цель. Выявлении ключевых или клинически значимых молекулярных событий для пациента с гепатоцеллюлярной карциномой. Методы. РНК- и экзомное секвенирования опухолевой и нормальной ткани. Мы проаннотировали найденные генетические нарушения, используя несколько общедоступных баз данных и биоинформатических инструментов. Результаты. Мы определили несколько дифференциально экспрессированных генов, связанных с классической схемой лечения препаратом сорафениб, а также дополнительные пути потенциально поддающиеся терапии препаратами, включенными в клинические испытания (Эрлотиниб, Лапатиниб и Темсиролимус). Несколько герминативных мутаций, найденных в XRCC1, TP53 и DPYD, по данным из других клинических испытаний, могут быть связаны с повышенной чувствительностью к препаратам платины и пониженной чувствительностью к 5-фторурацилу. Мы также определили несколько потенциально драйверных мутаций в генах CIRBP, замены в BTG1, ErbB3, TCF7L2 и др., которые в настоящее время не связаны с тера­пией. Выводы. Данное исследование показывает потенциальную значимость комплексного подхода к анализу данных NGS, в том числе анализа герминативных мутаций и транскриптома в дополнение к данным из генных панелей или секвенирования экзома

Hadron Energy Reconstruction for the ATLAS Calorimetry in the Framework of the Non-parametrical Method

This paper discusses hadron energy reconstruction for the ATLAS barrel prototype combined calorimeter (consisting of a lead-liquid argon electromagnetic part and an iron-scintillator hadronic part) in the framework of the non-parametrical method. The non-parametrical method utilizes only the known $e/h$ ratios and the electron calibration constants and does not require the determination of any parameters by a minimization technique. Thus, this technique lends itself to an easy use in a first level trigger. The reconstructed mean values of the hadron energies are within $\pm 1$ of the true values and the fractional energy resolution is $[(58\pm3)/\sqrt{E}+(2.5\pm0.3)$. The value of the $e/h$ ratio obtained for the electromagnetic compartment of the combined calorimeter is $1.74\pm0.04$ and agrees with the prediction that $e/h > 1.7$ for this electromagnetic calorimeter. Results of a study of the longitudinal hadronic shower development are also presented. The data have been taken in the H8 beam line of the CERN SPS using pions of energies from 10 to 300 GeV.Comment: 33 pages, 13 figures, Will be published in NIM

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

Reducing heterotic M-theory to five dimensional supergravity on a manifold with boundary

This paper constructs the reduction of heterotic $M$-theory in eleven dimensions to a supergravity model on a manifold with boundary in five dimensions using a Calabi-Yau three-fold. New results are presented for the boundary terms in the action and for the boundary conditions on the bulk fields. Some general features of dualisation on a manifold with boundary are used to explain the origin of some topological terms in the action. The effect of gaugino condensation on the fermion boundary conditions leads to a `twist' in the chirality of the gravitino which can provide an uplifting mechanism in the vacuum energy to cancel the cosmological constant after moduli stabilisation.Comment: 16 pages, RevTe

Measurement of the inclusive isolated prompt photon cross-section in pp collisions at sqrt(s)= 7 TeV using 35 pb-1 of ATLAS data

A measurement of the differential cross-section for the inclusive production of isolated prompt photons in pp collisions at a center-of-mass energy sqrt(s) = 7 TeV is presented. The measurement covers the pseudorapidity ranges |eta|<1.37 and 1.52<=|eta|<2.37 in the transverse energy range 45<=E_T<400GeV. The results are based on an integrated luminosity of 35 pb-1, collected with the ATLAS detector at the LHC. The yields of the signal photons are measured using a data-driven technique, based on the observed distribution of the hadronic energy in a narrow cone around the photon candidate and the photon selection criteria. The results are compared with next-to-leading order perturbative QCD calculations and found to be in good agreement over four orders of magnitude in cross-section.Comment: 7 pages plus author list (18 pages total), 2 figures, 4 tables, final version published in Physics Letters