Intraosseous foreign-body granuloma in the mandible subsequent to a 20-year-old work-related accident

The purpose of this article was to describe the clinical and microscopic features of an intraosseous foreign-body granuloma in the mandible that developed after the traumatic implantation of metal fragments during a work-related accident. A 65-year-old male patient had a severe pain in the body of mandible. Clinical examination showed facial asymmetry and a scar, extending to the left mental region. Intraoral examination revealed a soft mass involving the left alveolar bone with normal appearance of the mucosa surface. Panoramic radiographs showed a radiolucent lesion along the mandible extending from the central incisive to the first molar. Computed tomography revealed an osteolytic mass in the same area. His medical history included a work-related accident twenty years prior to evaluation. During the biopsy an important amount of bright metal-like pieces surrounded by soft tissue were found. A microscopic examination showed a foreign body associated with an aggregation of multinucleated giant cells. The final diagnosis was a foreign body granuloma. Even though foreign-body granulomas in the mandible are rare lesions, dentists should be familiar with their features and include them in the differential diagnosis of tissue masses

Intraosseous foreign-body granuloma in the mandible subsequent to a 20-year-old work-related accident

Abstract The purpose of this article was to describe the clinical and microscopic features of an intraosseous foreign-body granuloma in the mandible that developed after the traumatic implantation of metal fragments during a work-related accident. A 65-year-old male patient had a severe pain in the body of mandible. Clinical examination showed facial asymmetry and a scar, extending to the left mental region. Intraoral examination revealed a soft mass involving the left alveolar bone with normal appearance of the mucosa surface. Panoramic radiographs showed a radiolucent lesion along the mandible extending from the central incisive to the first molar. Computed tomography revealed an osteolytic mass in the same area. His medical history included a work-related accident twenty years prior to evaluation. During the biopsy an important amount of bright metal-like pieces surrounded by soft tissue were found. A microscopic examination showed a foreign body associated with an aggregation of multinucleated giant cells. The final diagnosis was a foreign body granuloma. Even though foreign-body granulomas in the mandible are rare lesions, dentists should be familiar with their features and include them in the differential diagnosis of tissue masses

Pain impact on life of patients with temporomandibular disorder

A study on the impact of pain in patients with temporomandibular joint disorder (TMD) was carried out. Twenty two patients (20 women, two men, 28 years of age on average) with TMD who looked for specialized physiotherapy care were submitted to a brazilian version of McGill Pain Questionnaire (Br-MPQ), which includes questions about life quality, as follows: 1) social loss; 2) daily life activities; 3) third party?s perception; 4) pain tolerance; 5) sensation of being sick; 6) sensation of being useless; 7) life satisfaction. The results showed that pain related to the TMD significantly affected work activities (59.09%), school activities (59.09%), sleeping (68.18%) and appetite/feeding (63.64%). The authors conclude that pain from TMD has a negative impact on the patients? life quality and that, although unspecific, the questionnaire used allowed for an adequate evaluation of the impact.Foi realizado um estudo do impacto da dor na vida de indivíduos portadores de disfunção da articulação temporomandibular (DTM). Foram estudados 22 pacientes (20 mulheres e dois homens, com idade média de 28 anos) portadores de DTM que procuraram atendimento fisioterapêutico especializado, submetidos a uma versão brasileira do Questionário McGill de Dor (Br-MPQ), que inclui questões específicas sobre a qualidade de vida, como: 1) prejuízo social; 2) atividades da vida diária; 3) percepção do outro; 4) tolerância à dor; 5) sensação de estar doente; 6) sensação de utilidade; 7) satisfação com a vida. Os resultados mostraram que a dor da DTM prejudicou as atividades do trabalho (59,09%), da escola (59,09%), o sono (68,18%) e o apetite/alimentação (63,64%). Os autores concluíram que a dor da DTM tem um impacto negativo na qualidade de vida do paciente e que o questionário empregado, embora não específico, permitiu avalia-lo adequadamente.138143Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Impacto da dor na vida de portadores de disfunção temporomandibular

Foi realizado um estudo do impacto da dor na vida de indivíduos portadores de disfunção da articulação temporomandibular (DTM). Foram estudados 22 pacientes (20 mulheres e dois homens, com idade média de 28 anos) portadores de DTM que procuraram atendimento fisioterapêutico especializado, submetidos a uma versão brasileira do Questionário McGill de Dor (Br-MPQ), que inclui questões específicas sobre a qualidade de vida, como: 1) prejuízo social; 2) atividades da vida diária; 3) percepção do outro; 4) tolerância à dor; 5) sensação de estar doente; 6) sensação de utilidade; 7) satisfação com a vida. Os resultados mostraram que a dor da DTM prejudicou as atividades do trabalho (59,09%), da escola (59,09%), o sono (68,18%) e o apetite/alimentação (63,64%). Os autores concluíram que a dor da DTM tem um impacto negativo na qualidade de vida do paciente e que o questionário empregado, embora não específico, permitiu avalia-lo adequadamente.A study on the impact of pain in patients with temporomandibular joint disorder (TMD) was carried out. Twenty two patients (20 women, two men, 28 years of age on average) with TMD who looked for specialized physiotherapy care were submitted to a brazilian version of McGill Pain Questionnaire (Br-MPQ), which includes questions about life quality, as follows: 1) social loss; 2) daily life activities; 3) third partys perception; 4) pain tolerance; 5) sensation of being sick; 6) sensation of being useless; 7) life satisfaction. The results showed that pain related to the TMD significantly affected work activities (59.09%), school activities (59.09%), sleeping (68.18%) and appetite/feeding (63.64%). The authors conclude that pain from TMD has a negative impact on the patients life quality and that, although unspecific, the questionnaire used allowed for an adequate evaluation of the impact

Dynamics of biofilm formation and the interaction between Candida albicans and methicillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA)

Polymicrobial biofilms are an understudied and a clinically relevant problem. This study evaluates the interaction between C. albicans, and methicillin- susceptible (MSSA) and resistant (MRSA) S. aureus growing in single- and dual-species biofilms. Single and dual species adhesion (90 min) and biofilms (12, 24, and 48 h) were evaluated by complementary methods: counting colony-forming units (CFU mL-1), XTT-reduction, and crystal violet staining (CV). The secretion of hydrolytic enzymes by the 48 h biofilms was also evaluated using fluorimetric kits. Scanning electron microscopy (SEM) was used to assess biofilm structure. The results from quantification assays were compared using two-way ANOVAs with Tukey post-hoc tests, while data from enzymatic activities were analyzed by one-way Welch-ANOVA followed by Games-Howell post hoc test ( = 0.05). C. albicans, MSSA and MRSA were able to adhere and to form biofilm in both single or mixed cultures. In general, all microorganisms in both growth conditions showed a gradual increase in the number of cells and metabolic activity over time, reaching peak values between 12 h and 48 h (<0.05). C. albicans single- and dual-biofilms had significantly higher total biomass values (<0.05) than single biofilms of bacteria. Except for single MRSA biofilms, all microorganisms in both growth conditions secreted proteinase and phospholipase-C. SEM images revealed extensive adherence of bacteria to hyphal elements of C. albicans. C. albicans, MSSA, and MRSA can co-exist in biofilms without antagonism and in an apparent synergistic effect, with bacteria cells preferentially associated to C. albicans hyphal forms.CNPq (Council for Technical and Scientific Development) (Grant 400658/2012-7)Fundação para a Ciência e Tecnologia (FCT), Portugal (SFRH/BPD/71076/2010)CAPES(Coordination for the Improvement of Higher Level Personnel

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030