Allergenius, an expert system for the interpretation of allergen microarray results

BACKGROUND: An in vitro procedure based on a microarray containing many different allergen components has recently been introduced for use in allergy diagnosis. Recombinant and highly purified allergens belonging to different allergenic sources (inhalants, food, latex and hymenoptera) are present in the array. These components can either be genuine or cross-reactive, resistant or susceptible to heat and low pH, and innocuous or potentially dangerous. A large number of complex and heterogeneous relationships among these components has emerged, such that sometimes these interactions cannot be effectively managed by the allergist. In the 1960s, specialized languages and environments were developed to support the replacement of human experts with dedicated decision-making information systems. Currently, expert systems (ES) are advanced informatics tools that are widely used in medicine, engineering, finance and trading. METHODS: We developed an ES, named Allergenius ®, to support the interpretation of allergy tests based on microarray technology (ImmunoCAP ISAC ®). The ES was implemented using Flex, a LPA Win-Prolog shell. Rules representing the knowledge base (KB) were derived from the literature and specialized databases. The input data included the patient’s ID and disease(s), the results of either a skin prick test or specific IgE assays and ISAC results. The output was a medical report. RESULTS: The ES was first validated using artificial and real life cases and passed all in silico validations. Then, the opinions of allergists with experience in molecular diagnostics were compared with the ES reports. The Allergenius reports included all of the allergists’ opinions and considerations, as well as any additional information. CONCLUSIONS: Allergenius is a trustable ES dedicated to molecular tests for allergy. In the present version, it provides a powerful method to understand ISAC results and to obtain a comprehensive interpretation of the patient’s IgE profiling

Gothic Revival Architecture Before Horace Walpole's Strawberry Hill

The Gothic Revival is generally considered to have begun in eighteenth-century Britain with the construction of Horace Walpole’s villa, Strawberry Hill, Twickenham, in the late 1740s. As this chapter demonstrates, however, Strawberry Hill is in no way the first building, domestic or otherwise, to have recreated, even superficially, some aspect of the form and ornamental style of medieval architecture. Earlier architects who, albeit often combining it with Classicism, worked in the Gothic style include Sir Christopher Wren, Nicholas Hawksmoor, William Kent and Batty Langley, aspects of whose works are explored here. While not an exhaustive survey of pre-1750 Gothic Revival design, the examples considered in this chapter reveal how seventeenth- and eighteenth-century Gothic emerged and evolved over the course of different architects’ careers, and how, by the time that Walpole came to create his own Gothic ‘castle’, there was already in existence in Britain a sustained Gothic Revivalist tradition

Proceedings of the 2nd International Conference on the Practical Application of Prolog, London, United Kingdom, 26-29 April 1994

Edited proceedings of the 2nd International Conference on the Practical Application of Prolog, held at the Royal Society of Arts, London, United Kingdom, from 26 to 29 April 1994

Using Ethnography To Design a Mass Detection Tool(MDT) For The Early Discovery of Insurance Fraud.

We describe a Mass Detection Tool (MDT) for early detection of insurance fraud. Ethnography was used to specify needs and process, capture expertise, and design an interface for triggering fraud indicators while capturing unexpected anomalies detected by claims handlers. The MDT uses a dynamic Bayesian Belief Network of fraud indicators, whose weights are determined by how predictive each indicator is of specific types of fraud. The system uses automated knowledge updating to keep pace with dynamically changing fraud, adding new indicators that emerge from patterns of repeated anomalies

Hellish Falls: Faustus’s Dismemberment, Phaeton’s Limbs and Other Renaissance Aviation Disasters – Part I

With its aerial voyages and ominous allusions to the failed aviators Icarus, Lucifer and Simon Magus, Doctor Faustus presents an uncanny commentary on the Renaissance dream of flight. This article uncovers Marlowe’s infatuation with human flight as the ultimate act of physical, intellectual and spiritual trangression. So the grisly addition to the B-text, in which a group of scholars examine—like a forensics team at a crash site—the carnage of Faustus’s “mangled limbs”, is more than a lurid flourish. Mangled limbs are splattered all over the annals of pre-modern aviation. While implicating the play in Renaissance aeronautics, this study of Faustus also has some eye-opening implications for theatre history. Faustus was penned at a time when on-stage ascents and descents became increasingly feasible, and Marlowe’s Icarian muse may have spurred the Admiral’s Men to interpolate more spectacular flying effects, taking advantage of the throne, pulleys and dragons recorded in Henslowe’s Diary. The revisions to Faustus not only showcase the flight-simulation capabilities of the Admiral’s playhouses but also associate Marlowe’s conjuror with other presumptuous aeronauts in the company’s repertoire. In particular, Part II of this essay (to be published in a forthcoming issue of English Studies) will argue that Faustus’s “hellish fall” and dismemberment mirrors that of Phaeton, the titular protagonist of a lost play performed by the Admiral’s Men in 1598. While reading the fall of these characters as a literal enactment of de casibus tragedy, Part II concludes that the increasingly sophisticated aerial stunts reflect a technological optimism about transhuman flight that undercuts the Chorus’s warning not to “practice more than heavenly power permits”