122 research outputs found

    Solar Panels for Scientific Missions Using CubeSat Platforms for LEO, MEO and GTO

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    DHV Technology is a company specialized on the designing, manufacturing and testing of solar panels for CubeSats and Small Satellites. In this presentation is discussed about solar panels of CubeSat missions developed for Scientific missions with Space Agencies involved as CNES, ESA and NASA Goddard. DHV Technology have developed the solar panels for Angels mission developed by HEMERIA and CNES based on a 12U platform, the solar panels for GTOSat mission developed by NASA Goddard based on a 3U CubeSat and the solar panels of TRISAT-R mission developed by Maribor University and funded by ESA using a 3U CubeSat. Angels mission is a LEO mission for Earth Observation with a payload developed by Syrlinksand Thales Alenia Space to analyze the state of the oceans, GTOSat mission is a GTO mission to acquire new data about high energy particles and TRISAT-R mission is a MEO mission for in-orbit demonstration. The requirements on solar panels for LEO, MEO and GTO missions will be analyzed in this presentation and other subjects as qualification process and the quality assurance will be discussed. There are some key points that are analyzed in this presentation as the features of the solar panels for high radiation environment, the resistance torque analysis and the harness design, the electrical losses analysis and the ATOX degradation analysis

    Performance and Operation of the CMS Electromagnetic Calorimeter

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    The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented

    Phytochemicals in Cancer Prevention and Therapy: Truth or Dare?

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    A voluminous literature suggests that an increase in consumption of fruit and vegetables is a relatively easy and practical strategy to reduce significantly the incidence of cancer. The beneficial effect is mostly associated with the presence of phytochemicals in the diet. This review focuses on a group of them, namely isothiocyanate, curcumin, genistein, epigallocatechin gallate, lycopene and resveratrol, largely studied as chemopreventive agents and with potential clinical applications. Cellular and animal studies suggest that these molecules induce apoptosis and arrest cell growth by pleiotropic mechanisms. The anticancer efficacy of these compounds may result from their use in monotherapy or in association with chemotherapeutic drugs. This latter approach may represent a new pharmacological strategy against several types of cancers. However, despite the promising results from experimental studies, only a limited number of clinical trials are ongoing to assess the therapeutic efficacy of these molecules. Nevertheless, the preliminary results are promising and raise solid foundations for future investigations

    NutriciĂłn en Salud PĂşblica

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    Este libro es fruto de una revisiĂłn y actualizaciĂłn ampliadas de los manuales docentes de ÂŤNutriciĂłn en Salud PĂşblicaÂť y ÂŤLa alimentaciĂłn y el consumidorÂť, editados en 2007 y 2013 respectivamente por la Escuela Nacional de Sanidad del Instituto de Salud Carlos III.La salud pĂşblica es el arte y la ciencia de prevenir la enfermedad, prolongar la vida y promover la salud a travĂŠs de los esfuerzos organizados de la sociedad. La nutriciĂłn es la ciencia que estudia la forma en que el organismo utiliza la energĂ­a de los alimentos para mantenerse y crecer, mediante el anĂĄlisis de los procesos por los cuales ingiere, digiere, absorbe, transporta, utiliza y extrae los nutrientes esenciales para la vida, y su interacciĂłn con la salud y la enfermedad. Por tanto, la nutriciĂłn en salud pĂşblica (public health nutrition) es la ciencia que estudia la relaciĂłn entre dieta y salud y sienta las bases para el diseĂąo, ejecuciĂłn y evaluaciĂłn de intervenciones nutricionales a nivel comunitario y poblacional con el objeto de mejorar el estado de salud de las poblaciones. La pandemia de obesidad, una enfermedad estrechamente relacionada con la nutriciĂłn, es uno de ejemplos paradigmĂĄticos del carĂĄcter multidisciplinar e intersectorial de la salud pĂşblica. Hace dĂŠcadas, la obesidad era considerada una enfermedad endocrina, de tipo glandular, dentro del dominio biomĂŠdico del especialista en endocrinologĂ­a. DespuĂŠs se pasĂł a considerar algunos factores personales de riesgo, como los hĂĄbitos alimentarios y de actividad fĂ­sica, entrando en el dominio de la medicina preventiva, que centra sus esfuerzos en los factores biomĂŠdicos individuales, como la ingesta de calorĂ­as o el sedentarismo, y del entorno familiar. La salud pĂşblica va mĂĄs allĂĄ, considerando factores ambientales, sociales y culturales que afectan a las preferencias alimentarias y los hĂĄbitos de vida, como los sistemas de producciĂłn de alimentos y fijaciĂłn del precio de los mismos, el uso de subsidios y tasas, la publicidad alimentaria, el nivel socioeconĂłmico de las familias, el diseĂąo urbanĂ­stico (cantidad de espacios verdes, parques, carriles bici) o los sistemas de transporte urbano, entre otros muchos. El abordaje de elementos tan variados requiere del concurso de especialistas en mĂşltiples disciplinas: profesionales sanitarios, abogados, economistas, periodistas, urbanistas, sociĂłlogos, etc. Aunque ningĂşn individuo puede ser experto en todas las especialidades relacionadas con la salud pĂşblica, el profesional bien formado debe conocer el rol de cada una de esas disciplinas en la formulaciĂłn de una intervenciĂłn de salud pĂşblica, estar familiarizado con el lenguaje y los postulados bĂĄsicos de dichas disciplinas, y haber practicado la implementaciĂłn de intervenciones a cargo de equipos multidisciplinarios

    NutriciĂłn en Salud PĂşblica

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    La salud pĂşblica es uno de los esfuerzos colectivos organizados de la sociedad para prevenir la muerte prematura, la enfermedad, las lesiones y la discapacidad, y para promover la salud de las poblaciones. La NutriciĂłn es la ciencia que estudia el conjunto de procesos por los cuales un organismo utiliza la energĂ­a de los alimentos para mantenerse y crecer; o, expresado de forma mĂĄs operativa, la ciencia que estudia los alimentos, nutrientes y otras sustancias relacionadas, su interacciĂłn y balance en relaciĂłn con la salud y la enfermedad y los procesos por los cuales el organismo ingiere, digiere, absorbe, transporta, utiliza y extrae las sustancias alimenticias. A partir de estas definiciones, podemos conceptualizar la nutriciĂłn en salud pĂşblica o la salud pĂşblica nutricional (public health nutrition) como la ciencia que estudia la relaciĂłn entre dieta y salud a nivel poblacional y el desarrollo de intervenciones nutricionales a nivel comunitario con el objeto de mejorar el estado de salud de las poblaciones

    Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: a study from the RelevarEM registry

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    We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75-2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, p = 0.002) and higher disability score (HR = 2.30, p < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients

    Assessing attacks and treatment response rates among adult patients with NMOSD and MOGAD: data from a nationwide registry in Argentina

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    We aimed to examine treatment interventions implemented in patients experiencing neuromyelitis optica spectrum disorders (NMOSD) attacks (frequency, types, and response). METHODS: Retrospective study. Data on patient demographic, clinical and radiological findings, and administered treatments were collected. Remission status (complete [CR], partial [PR], no remission [NR]), based on changes in the EDSS score was evaluated before treatment, during attack, and at 6 months. CR was analyzed with a generalized estimating equations (GEEs) model. RESULTS: A total of 131 patients (120 NMOSD and 11 myelin oligodendrocyte glycoprotein-antibody-associated diseases [MOGAD]), experiencing 262 NMOSD-related attacks and receiving 270 treatments were included. High-dose steroids (81.4%) was the most frequent treatment followed by plasmapheresis (15.5%). CR from attacks was observed in 47% (105/223) of all treated patients. During the first attack, we observed CR:71.2%, PR:16.3% and NR:12.5% after the first course of treatment. For second, third, fourth, and fifth attacks, CR was observed in 31.1%, 10.7%, 27.3%, and 33.3%, respectively. Remission rates were higher for optic neuritis vs. myelitis (p < 0.001). Predictor of CR in multivariate GEE analysis was age in both NMOSD (OR = 2.27, p = 0.002) and MOGAD (OR = 1.53, p = 0.03). CONCLUSIONS: This study suggests individualization of treatment according to age and attack manifestation. The outcome of attacks was generally poor

    Calibration of the CMS Drift Tube Chambers and Measurement of the Drift Velocity with Cosmic Rays

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    Peer reviewe

    CMS physics technical design report : Addendum on high density QCD with heavy ions

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    Peer reviewe

    Alignment of the CMS muon system with cosmic-ray and beam-halo muons

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    This is the Pre-print version of the Article. The official published version of the Paper can be accessed from the link below - Copyright @ 2010 IOPThe CMS muon system has been aligned using cosmic-ray muons collected in 2008 and beam-halo muons from the 2008 LHC circulating beam tests. After alignment, the resolution of the most sensitive coordinate is 80 microns for the relative positions of superlayers in the same barrel chamber and 270 microns for the relative positions of endcap chambers in the same ring structure. The resolution on the position of the central barrel chambers relative to the tracker is comprised between two extreme estimates, 200 and 700 microns, provided by two complementary studies. With minor modifications, the alignment procedures can be applied using muons from LHC collisions, leading to additional significant improvements.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia); Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR(Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
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