Peace at the Lily. The De Franceschi section in the stockbook of Bernardino Giunti

This contribution investigates the catalogue of publications by Francesco De Franceschi, printer, publisher and bookseller between 1561 and 1599, and his heirs, who took over his business until 1624, as recorded in the stockbook of Bernardino Giunti (Los Angeles, University of California Library, Department of Special Collections, call number 170/622), also a printer, publisher and bookseller in Venice at the beginning of the seventeenth century. Each entry of this De Franceschi section has been matched with the edition it was meant to describe, in order to analyse the price of each book according to the Giunti stockbook as the result of material features and book marketing strategies

Per un indice condiviso di possessori e provenienze in SBN: una prospettiva concreta

Partendo dall’analisi di punti di forza e criticità di cataloghi e banche dati nazionali e internazionali su possessori e provenienze, l’articolo presenta un progetto dell’ICCU, attualmente allo studio di fattibilità, per la realizzazione di un indice condiviso di possessori nell’ambito del Servizio bibliotecario nazionale (SBN)

Una base dati speciale per i libri animati

This paper describes the project to build and develop a specific website for an accurate description of pop-up books as an independent database yet sharing data with the collective catalogue of Italian libraries SBN. As a result of an agreement between the Sapienza University of Rome, the Fondazione Tancredi di Barolo and the Central Institute for the Union Catalogue of Italian Libraries and for Bibliographic Information, the database will comprise at its core some hundreds of extraordinary pop-up books of the collection of the Fondazione Tancredi di Barolo. The description of books from collections which have not joined the SBN network, including libraries abroad, will be allowed as well. Records will be based on SBN guidelines for bibliographic description, but will also be intended to encourage a more detailed description for pop-up books and to develop a tailored vocabulary for their peculiar features, which has been lacking to date. Additional information and resources, such as links to external references and digital images, will be a further improvement in order to support users in retrieving, accessing and studying these wonderfully rare and special materials

IFLA Library Reference Model (LRM) : Un modello concettuale per le informazioni bibliografiche

IFLA Library Reference Model (LRM) is a high-level conceptual reference model developed within an entity-relationship modelling framework. It is the consolidation of the separately developed IFLA conceptual models: FRBR, FRAD, FRSAD. IFLA LRM was developed to resolve inconsistencies between the three separate models. Every user task, entity, attribute and relationship from the original three models was examined, definitions had to be revised, but also some remodelling was required in order to develop a meaningful consolidation. The result is a single, streamlined, and logically consistent model that covers all aspects of bibliographic data and that at the same time brings the modelling up-to-date with current conceptual modelling practices. IFLA LRM was designed to be used in linked data environments and to support and promote the use of bibliographic data in linked data environments

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for coronavirus pathogenesis and is thus an attractive target for drug development. This macrodomain is thought to counteract the host interferon (IFN) response, an important antiviral signalling cascade, via the reversal of protein ADP-ribosylation, a posttranslational modification catalyzed by host poly(ADP-ribose) polymerases (PARPs). However, the main cellular targets of the coronavirus macrodomain that mediate this effect are currently unknown. Here, we use a robust immunofluorescence-based assay to show that activation of the IFN response induces ADP-ribosylation of host proteins and that ectopic expression of the SARSCoV- 2 Nsp3 macrodomain reverses this modification in human cells. We further demonstrate that this assay can be used to screen for on-target and cell-active macrodomain inhibitors. This IFN-induced ADP-ribosylation is dependent on PARP9 and its binding partner DTX3L, but surprisingly the expression of the Nsp3 macrodomain or the deletion of either PARP9 or DTX3L does not impair IFN signaling or the induction of IFNresponsive genes. Our results suggest that PARP9/DTX3Ldependent ADP-ribosylation is a downstream effector of the host IFN response and that the cellular function of the SARSCoV- 2 Nsp3 macrodomain is to hydrolyze this end product of IFN signaling, rather than to suppress the IFN response itself

Italian Guidelines in diagnosis and treatment of alopecia areata

Alopecia areata (AA) is an organ-specific autoimmune disorder that targets anagen phase hair follicles. The course is unpredictable and current available treatments have variable efficacy. Nowadays, there is relatively little evidence on treatment of AA from well-designed clinical trials. Moreover, none of the treatments or devices commonly used to treat AA are specifically approved by the Food and Drug Administration. The Italian Study Group for Cutaneous Annexial Disease of the Italian Society of dermatology proposes these Italian guidelines for diagnosis and treatment of Alopecia Areata deeming useful for the daily management of the disease. This article summarizes evidence-based treatment associated with expert-based recommendations

Physical properties of the trans-Neptunian binary 2000 YW₁₃₄

The study of trans-Neptunian binaries (TNBs) remains one of the most active areas of progress in understanding the solar system beyond Neptune. TNBs have been found in every dynamical population of the trans-Neptunian region (Noll et al. 2020), with proportions ranging from 29 % in the cold classical population to 5.5 % for the remaining classes combined (Brunini 2020). The formation of the contact TNB Arrokoth is one of the challenges that formation models face nowadays. The current angular momentum of Arrokoth is too low and the current binary formation scenarios, by either rotational fission or streaming instability (Nesvorný et al. 2019), require also loss of angular momentum (McKinnon et al. 2020). Additionally, formation mechanisms of close binaries may be distinct from those for the wider pairs. As the angular momentum of a system approaches that of an object spinning near its critical rotation period, rotational fission is the most likely explanation for their formation (Descamps et al. 2008), which is thought to be the case for the proposed satellites of Varuna and 2002 TC302 systems (Fernández-Valenzuela et al. 2019; Ortiz et al. 2020). If close TNBs turn out to be common for objects rotating close to the breakup limit, that could reveal important clues about angular momentum evolution during accretion for TNOs (Petit et al. 2011). However, characterizing binary systems at such distances is challenging. From the ~120 known TNBs, only around 40 have their mutual orbit fully determined, let alone physical characterization. 2000 YW134 is a TNB in a 3:8 resonance with an orbital semi-major axis of 57.4 au (a rare occurrence). On February 23rd, 2022, it occulted the Gaia EDR3 star 627356458358636544 (V = 17.1 mag). The stellar occultation was initially predicted using the JPL orbit solution #24, and updated using data from the 1.5-m and 1.23-m telescopes at Sierra Nevada and Calar Alto Observatories, using the same methodology as explained in Ortiz et al (2020). From the 17 observatories involved, seven reported positive chords, with five of them corresponding to the main body and the other two chords corresponding to its satellite. We are currently working on the analysis of these data in order to obtain the physical properties that characterize the system. Preliminary results show that the lower limit for the equivalent projected diameter of the satellite is twice the previously estimated size from HST observations (Stephens et al. 2006). We will also compare our results with the area-equivalent diameter and albedo obtained using thermal data from Herschel and Spitzer observations (Farkas-Takács et al. 2020)

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements