Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24

We conducted a genome-wide association study involving 224 cases and 383 controls of Central European origin to identify susceptibility loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P). A 640-kb region at chromosome 8q24.21 was found to contain multiple markers with highly significant evidence for association with the cleft phenotype, including three markers that reached genome-wide significance. The 640-kb cleft-associated region was saturated with 146 SNP markers and then analyzed in our entire NSCL/P sample of 462 unrelated cases and 954 controls. In the entire sample, the most significant SNP (rs987525) had a P value of 3.34 x 10(-24). The odds ratio was 2.57 (95% CI = 2.02-3.26) for the heterozygous genotype and 6.05 (95% CI = 3.88-9.43) for the homozygous genotype. The calculated population attributable risk for this marker is 0.41, suggesting that this study has identified a major susceptibility locus for NSCL/P

Curriculum corruption? : On the place of subjects in secondary school curriculum making

The production of a W boson in association with a single charm quark is studied using 4.6 fb-1 of pp collision data at 1as = 7TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96+-00.30 at Q2 = 1.9 GeV, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally the cross-section ratio \u3c3(W+ + c)/\u3c3(W- +c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s\u2013s quark asymmetry

Search for contact interactions and large extra dimensions in dilepton events from pppp collisions at s=7\sqrt{s} = 7 TeV with the ATLAS detector

A search for non-resonant new phenomena, originating from either contact interactions or large extra spatial dimensions, has been carried out using events with two isolated electrons or muons. These events, produced at the LHC in proton-proton collisions at sqrt(s) = 7 TeV, were recorded by the ATLAS detector. The data sample, collected throughout 2011, corresponds to an integrated luminosity of 4.9 and 5.0 fb-1 in the e+e- and mu+mu- channels, respectively. No significant deviations from the Standard Model expectation are observed. Using a Bayesian approach, 95% confidence limit lower limits ranging from 9.0 to 13.9 TeV are placed on the energy scale of llqq contact interactions in the left-left isoscalar model. Lower limits ranging from 2.4 to 3.9 TeV are also set on the string scale in large extra dimension models. After combination of these limits with results from a similar search in the diphoton channel, slightly more stringent limits are obtained.Comment: 12 pages plus author list (25 pages in total), 3 figures, 8 tables, published in Phys.Rev.D 87, 015010 (2013), all figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/EXOT-2012-17/; revision corresponds to published version and corrects units for M_S in the legend of Figs. 2 and 3, as well as M_S limit values in the main tex

Search for resonant top plus jet production in ttˉt\bar{t} + jets events with the ATLAS detector in pppp collisions at s=7\sqrt{s}=7 TeV

This paper presents a search for a new heavy particle produced in association with a top or antitop quark. Two models in which the new heavy particle is a color singlet or a color triplet are considered, decaying, respectively, to t̅ q or tq, leading to a resonance within the tt̅ +jets signature. The full 2011 ATLAS pp collision data set from the LHC (4.7  fb-1) is used to search for tt̅ events produced in association with jets, in which one of the W bosons from the top quarks decays leptonically and the other decays hadronically. The data are consistent with the Standard Model expectation, and a new particle with mass below 430 Gev for both W′ boson and color triplet models is excluded at 95% confidence level, assuming unit right-handed coupling.United States. Dept. of EnergyNational Science Foundation (U.S.

Light-quark and gluon jet discrimination in collisions at root s=7 TeV with the ATLAS detector

A likelihood-based discriminant for the identification of quark- and gluon-initiated jets is built and validated using 4.7 fb$^{-1}$ of proton-proton collision data at $\sqrt{s}$ = 7 TeV collected with the ATLAS detector at the LHC. Data samples with enriched quark or gluon content are used in the construction and validation of templates of jet properties that are the input to the likelihood-based discriminant. The discriminating power of the jet tagger is established in both data and Monte Carlo samples within a systematic uncertainty of 10-20%. In data, light-quark jets can be tagged with an efficiency of 50% while achieving a gluon-jet mis-tag rate of 25% in a $p_T$ range between 40 GeV and 360 GeV for jets in the acceptance of the tracker. The rejection of gluon-jets found in the data is significantly below what is attainable using a Pythia 6 Monte Carlo simulation, where gluon-jet mis-tag rates of 10% can be reached for a 50% selection efficiency of light-quark jets using the same jet properties.Comment: 19 pages plus author list (33 pages total), 8 figures, 1 table, submitted to Eur. Phys. J. C, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/PERF-2013-02