1,053 research outputs found
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context
The aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands. Isoflavones are part of a family which include some well characterised endogenous AhR ligands. This paper analysed a novel family of these compounds, based on the structure of 2-amino-isoflavone. Initially two luciferase-based cell models, mouse H1L6.1c2 and human HG2L6.1c3, were used to identify whether the compounds had AhR agonistic and/or antagonistic properties. This analysis showed that some of the compounds were weak agonists in mouse and antagonists in human. Further analysis of two of the compounds, Chr-13 and Chr-19, was conducted using quantitative real-time PCR in rat H4IIE and human MCF-7 cells. The results indicated that Chr-13 was an agonist in rat but an antagonist in human cells. Chr-19 was shown to be an agonist in rat but more interestingly, a partial agonist in human. Luciferase induction results not only revealed that subtle differences in the structure of the compound could produce species-specific differences in response but also dictated the ability of the compound to be an AhR agonist or antagonist. Substituted 2-amino-isoflavones represent a novel group of AhR ligands that must differentially interact with the AhR ligand binding domain to produce their species-specific agonist or antagonist activity and future ligand binding analysis and docking studies with these compounds may provide insights into the differential mechanisms of action of structurally similar compounds
Low acoustic transmittance through a holey structure
J. S. Bell, I. R. Summers, A. R. J. Murray, Euan Hendry, J. Roy Sambles, and Alastair P. Hibbins, Physical Review B, Vol. 85, article 214305 (2012). Copyright © 2012 by the American Physical Society.The “acoustic double fishnet” is a structure with holes running from its front to back faces, yet at a characteristic frequency it transmits very little sound. The transmittance of this structure, which is comprised of a pair of closely spaced, periodically perforated plates, is determined experimentally and analytically. The surprising acoustic properties are due to hybridization between a two-dimensional resonance within the gap between the plates, and pipe modes within the holes. At the center of the stop band the input impedance is imaginary, interpreted as a negative product of effective bulk modulus and density
On the multiplicity of the O-star Cyg OB2 #8A and its contribution to the gamma-ray source 3EG J2033+4118
We present the results of an intensive spectroscopic campaign in the optical
waveband revealing that Cyg OB2 #8A is an O6 + O5.5 binary system with a period
of about 21.9 d. Cyg OB2 #8A is a bright X-ray source, as well as a non-thermal
radio emitter. We discuss the binarity of this star in the framework of a
campaign devoted to the study of non-thermal emitters, from the radio waveband
to gamma-rays. In this context, we attribute the non-thermal radio emission
from this star to a population of relativistic electrons, accelerated by the
shock of the wind-wind collision. These relativistic electrons could also be
responsible for a putative gamma-ray emission through inverse Compton
scattering of photospheric UV photons, thus contributing to the yet
unidentified EGRET source 3EG J2033+4118.Comment: 8 pages, 4 figures, conference on "The Multiwavelength Approach to
Gamma-Ray Sources", to appear in Ap&S
The mass-to-light ratio of rich star clusters
We point out a strong time-evolution of the mass-to-light conversion factor
eta commonly used to estimate masses of unresolved star clusters from observed
cluster spectro-photometric measures. We present a series of gas-dynamical
models coupled with the Cambridge stellar evolution tracks to compute
line-of-sight velocity dispersions and half-light radii weighted by the
luminosity. We explore a range of initial conditions, varying in turn the
cluster mass and/or density, and the stellar population's IMF. We find that
eta, and hence the estimated cluster mass, may increase by factors as large as
3 over time-scales of 50 million years. We apply these results to an hypothetic
cluster mass distribution function (d.f.) and show that the d.f. shape may be
strongly affected at the low-mass end by this effect. Fitting truncated
isothermal (Michie-King) models to the projected light profile leads to
over-estimates of the concentration parameter c of delta c ~ 0.3 compared to
the same functional fit applied to the projected mass density.Comment: 6 pages, 2 figures, to appear in the proceedings of the "Young
massive star clusters", Granada, Spain, September 200
A spatially-VSL gravity model with 1-PN limit of GRT
A scalar gravity model is developed according the 'geometric conventionalist'
approach introduced by Poincare (Einstein 1921, Poincare 1905, Reichenbach
1957, Gruenbaum1973). In principle this approach allows an alternative
interpretation and formulation of General Relativity Theory (GRT), with
distinct i) physical congruence standard, and ii) gravitation dynamics
according Hamilton-Lagrange mechanics, while iii) retaining empirical
indistinguishability with GRT. In this scalar model the congruence standards
have been expressed as gravitationally modified Lorentz Transformations
(Broekaert 2002). The first type of these transformations relate quantities
observed by gravitationally 'affected' (natural geometry) and 'unaffected'
(coordinate geometry) observers and explicitly reveal a spatially variable
speed of light (VSL). The second type shunts the unaffected perspective and
relates affected observers, recovering i) the invariance of the locally
observed velocity of light, and ii) the local Minkowski metric (Broekaert
2003). In the case of a static gravitation field the model retrieves the
phenomenology implied by the Schwarzschild metric. The case with proper source
kinematics is now described by introduction of a 'sweep velocity' field w: The
model then provides a hamiltonian description for particles and photons in full
accordance with the first Post-Newtonian approximation of GRT (Weinberg 1972,
Will 1993).Comment: v1: 11 pages, GR17 conf. paper, Dublin 2004, v2: WEP issue solved,
section on acceleration transformation added, text improved, more references,
same results, v3: typos removed, footnotes, added and references updated, v4:
appendix added, improved tex
Charged-Particle Multiplicities in Charged-Current Neutrino-- and Anti-Neutrino--Nucleus Interactions
The CHORUS experiment, designed to search for
oscillations, consists of a nuclear emulsion target and electronic detectors.
In this paper, results on the production of charged particles in a small sample
of charged-current neutrino-- and anti-neutrino--nucleus interactions at high
energy are presented. For each event, the emission angle and the ionization
features of the charged particles produced in the interaction are recorded,
while the standard kinematic variables are reconstructed using the electronic
detectors. The average multiplicities for charged tracks, the pseudo-rapidity
distributions, the dispersion in the multiplicity of charged particles and the
KNO scaling are studied in different kinematical regions. A study of
quasi-elastic topologies performed for the first time in nuclear emulsions is
also reported. The results are presented in a form suitable for use in the
validation of Monte Carlo generators of neutrino--nucleus interactions.Comment: 17 pages, 5 figure
The Fueling and Evolution of AGN: Internal and External Triggers
In this chapter, I review the fueling and evolution of active galactic nuclei
(AGN) under the influence of internal and external triggers, namely intrinsic
properties of host galaxies (morphological or Hubble type, color, presence of
bars and other non-axisymmetric features, etc) and external factors such as
environment and interactions. The most daunting challenge in fueling AGN is
arguably the angular momentum problem as even matter located at a radius of a
few hundred pc must lose more than 99.99 % of its specific angular momentum
before it is fit for consumption by a BH. I review mass accretion rates,
angular momentum requirements, the effectiveness of different fueling
mechanisms, and the growth and mass density of black BHs at different epochs. I
discuss connections between the nuclear and larger-scale properties of AGN,
both locally and at intermediate redshifts, outlining some recent results from
the GEMS and GOODS HST surveys.Comment: Invited Review Chapter to appear in LNP Volume on "AGN Physics on All
Scales", Chapter 6, in press. 40 pages, 12 figures. Typo in Eq 5 correcte
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC
Measurements of inclusive jet suppression in heavy ion collisions at the LHC
provide direct sensitivity to the physics of jet quenching. In a sample of
lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated
luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with
a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the
transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the
anti-kt algorithm with values for the distance parameter that determines the
nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of
the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp.
Jet production is found to be suppressed by approximately a factor of two in
the 10% most central collisions relative to peripheral collisions. Rcp varies
smoothly with centrality as characterized by the number of participating
nucleons. The observed suppression is only weakly dependent on jet radius and
transverse momentum. These results provide the first direct measurement of
inclusive jet suppression in heavy ion collisions and complement previous
measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables,
submitted to Physics Letters B. All figures including auxiliary figures are
available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02
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