Multivariate data analysis as a discriminating method of the origin of wines

A data set of 178 wines from Piedmont (Barbera, Grignolino, Barolo) was evaluated by multivariate data analysis in order to both build the category models and single out anomalous samples. By feature selection (Fisher weights) only 8 variables, out of the 28 chemical and physico-chemical original variables of the data set, were selected on account of their high univariate discriminant ability. Classification methods (KNN, LDA, PCA) and modelling techniques (Bayesian analysis, SIMCA) were applied to the 8-dimension data set; classification ability was about 98 %

MEMS 411: Compact Sewing Pin Dispenser

Sewing pins are small and hard to handle, and managing the pins can be very distracting (or painful) for a sewist. Our goal was to design a simple and easy sewing pin dispenser for a home sewist that can dispense small headed dressmaker pins. For our design to be a viable product, it would have to dispense pins very quickly, accurately, and safely. Additionally, it has to handle many pins at the same time so it does not have to be reloaded during use. Based on the design of a toothpick dispenser, our prototype small, lightweight, and portable device that manually dispenses pins quickly and easily. The pins are loaded onto a ramp with the head of the pin placed into a rut that guides the pin as it rolls down the ramp. The pins sit at the bottom of the ramp until the user presses down on the lifting mechanism. The lifting mechanism is held up by a spring, but when pressed it drops down to the ramp and allows exactly one pin to roll into a pin-sized slot. The spring then raises the lifter back up for easy selection of the pin by the user

LIGURIA (Italia). Cartas náuticas (1855)

Contiene 24 cartas náuticas de las costas de Liguria, incluyendo también la rada de Niza. Presentan orografía detallada por normales, indican sondas batimétricas, veriles, fondeaderos y calidad de fondo. Señalan núcleos de población, caminos, fuertes, conventos y otros edificios aislados de la costaLa mención de responsabilidad consta en la cubierta y la firma del prólogo. La portada no contiene más que el título y el pie de imprentaDedicatoria : "A S.M. la Regia di Spagna. Per Omaggio Il Vice Amiraglio della Marina Sarda Albini"Según el prefacio, este portulano es complemento de otro publicado en 1842 por el autor sobre el MediterráneoEncuadernado en terciopelo granate con grabados en oroCopia digital. Madrid : Ministerio de Cultura. Dirección General del Libro, Archivos y Bibliotecas, 201

High-affinity neurotensin receptor is involved in phosphoinositide turnover increase by inhibition of sodium pump in neonatal rat brain

Phosphoinositide (PI) metabolism is enhanced in neonatal brain by activation of neurotransmitter receptors and by inhibition of the sodium pump with ouabain or endogenous inhibitor termed endobain E. Peptide neurotensin inhibits synaptosomal membrane Na+, K+-ATPase activity, an effect blocked by SR 48692, a selective antagonist for high-affinity neurotensin receptor (NTS1). The purpose of this study was to evaluate potential participation of NTS1 receptor on PI hydrolysis enhancement by sodium pump inhibition. Cerebral cortex miniprisms from neonatal Wistar rats were preloaded with [3H]myoinositol in buffer during 60 min and further preincubated for 0 min or 30 min in the absence or presence of SR 48692. Then, ouabain or endobain E were added and incubation proceeded during 20 or 60 min. Reaction was stopped with chloroform/methanol and [3H]inositol-phosphates (IPs) accumulation was quantified in the water phase. After 60-min incubation with ouabain, IPs accumulation values reached roughly 500% or 860% in comparison with basal values (100%), if the preincubation was omitted or lasted 30 min, respectively. Values were reduced 50% in the presence of SR 48692. In 20-min incubation experiments, IPs accumulation by ouabain versus basal was 300% or 410% if preincubation was 0 min or 30 min, respectively, an effect blocked 23% or 32% with SR 48692. PI hydrolysis enhancement by endobain E was similarly blocked by SR 48692, being this effect higher when sample incubation with the endogenous inhibitor lasted 60 min versus 20 min. Present results indicate that PI hydrolysis increase by sodium pump inhibition with ouabain or endobain E is partially diminished by SR 48692. It is therefore suggested that NTS1 receptor may be involved in cell signaling system mediated by PI turnover. © 2008 Springer Science+Business Media, LLC.Fil: Pereyra Alfonso, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Armanino, María del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Vázquez, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Peña, Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Rodriguez, Georgina Emma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentin