31 research outputs found
Levetiracetam modulates brain metabolic networks and transcriptomic signatures in the 5XFAD mouse model of Alzheimer’s disease
- Author
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/01/2024
- Field of study
IntroductionSubcritical epileptiform activity is associated with impaired cognitive function and is commonly seen in patients with Alzheimer’s disease (AD). The anti-convulsant, levetiracetam (LEV), is currently being evaluated in clinical trials for its ability to reduce epileptiform activity and improve cognitive function in AD. The purpose of the current study was to apply pharmacokinetics (PK), network analysis of medical imaging, gene transcriptomics, and PK/PD modeling to a cohort of amyloidogenic mice to establish how LEV restores or drives alterations in the brain networks of mice in a dose-dependent basis using the rigorous preclinical pipeline of the MODEL-AD Preclinical Testing Core.MethodsChronic LEV was administered to 5XFAD mice of both sexes for 3 months based on allometrically scaled clinical dose levels from PK models. Data collection and analysis consisted of a multi-modal approach utilizing 18F-FDG PET/MRI imaging and analysis, transcriptomic analyses, and PK/PD modeling.ResultsPharmacokinetics of LEV showed a sex and dose dependence in Cmax, CL/F, and AUC0-∞, with simulations used to estimate dose regimens. Chronic dosing at 10, 30, and 56 mg/kg, showed 18F-FDG specific regional differences in brain uptake, and in whole brain covariance measures such as clustering coefficient, degree, network density, and connection strength (i.e., positive and negative). In addition, transcriptomic analysis via nanoString showed dose-dependent changes in gene expression in pathways consistent 18F-FDG uptake and network changes, and PK/PD modeling showed a concentration dependence for key genes, but not for network covariance modeling.DiscussionThis study represents the first report detailing the relationships of metabolic covariance and transcriptomic network changes resulting from LEV administration in 5XFAD mice. Overall, our results highlight non-linear kinetics based on dose and sex, where gene expression analysis demonstrated LEV dose- and concentration-dependent changes, along with cerebral metabolism, and/or cerebral homeostatic mechanisms relevant to human AD, which aligned closely with network covariance analysis of 18F-FDG images. Collectively, this study show cases the value of a multimodal connectomic, transcriptomic, and pharmacokinetic approach to further investigate dose dependent relationships in preclinical studies, with translational value toward informing clinical study design
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdullah Kanaan Hamagharib
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abosetugn Akine Eshete
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas Guimaraes
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz Khalid
- Abu-Gharbieh Eman
- Abu-Raddad Laith Jamal
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed Mohammad Kazem
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar Beshir
- Aji Budi
- Akalu Temesgen Yihunie
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akombi Blessing
- Akunna Chisom Joyqueenet
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad Mashhour
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline Elizabeth
- Alema Niguse Meles
- Alemu Biresaw Wassihun
- Alemu Yihun Mulugeta
- Alhabib Khalid F.
- Alhassan Robert Kaba
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed Mohamed
- Alla Francois
- Allebeck Peter
- Almadi Majid Abdulrahman Hamad
- Almasi Ali
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Almulhim Abdulaziz M.
- Alonso Jordi
- Altirkawi Khalid A.
- Alumran Arwa Khalid
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
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- Amini-Rarani Mostafa
- Aminorroaya Arya
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- Amul Gianna Gayle Herrera
- Anbesu Etsay Woldu
- Ancuceanu Robert
- Anderlini Deanna
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- Andrei Tudorel
- Androudi Sofia
- Angus Colin
- Anjomshoa Mina
- Ansari Fereshteh
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- Anvari Davood
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- Arba Aseb Arba Kinfe
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- Kurmi Om P.
- Kusuma Dian
- Kyu Hmwe Hmwe
- La Vecchia Carlo
- Lacey Ben
- Lal Dharmesh Kumar
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir H.
- Abolhassani Hassan
- Abosetugn Akine E.
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas G.
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz K.
- Abu-Gharbieh Eman
- Abu-Raddad Laith J.
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac A.
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun M.
- Adetokunboh Olatunji O.
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- Mosapour Abbas
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- Mueller Ulrich O.
- Mukhopadhyay Satinath
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- Musa Kamarul I.
- Mustafa Ghulam
- Muthupandian Saravanan
- Nabavizadeh Behnam
- Nabhan Ashraf F.
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- Nagarajan Ahamarshan J.
- Nagel Gabriele
- Naghavi Mohsen
- Naghshtabrizi Behshad
- Naik Gurudatta
- Naimzada Mukhammad D.
- Nair Sanjeev
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- Nandi Anita K.
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- Naserbakht Morteza
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- Ndejjo Rawlance
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- Negoi Ruxandra I.
- Netsere Henok B.
- Neupane Subas
- Ngari Kiirithio N.
- Nguefack-Tsague Georges
- Ngunjiri Josephine W.
- Nguyen Cuong T.
- Nguyen Diep N.
- Nguyen Huong L.
- Nguyen Jason Q.
- Nguyen Michele
- Nguyen Ming
- Nguyen Trang H.
- Nichols Emma
- Nigatu Dabere
- Nigatu Yeshambel T.
- Nikbakhsh Rajan
- Nikpoor Amin R.
- Nixon Molly R.
- Nnaji Chukwudi A.
- Nomura Shuhei
- Norheim Ole F.
- Norrving Bo
- Noubiap Jean J.
- Nouraei Motlagh Soraya
- Nowak Christoph
- Nsoesie Elaine
- Nunez-Samudio Virginia
- Oancea Bogdan
- Odell Christopher M.
- Ogbo Felix A. (R18978)
- Oghenetega Onome B.
- Oh In-Hwan
- Okunga Emmanuel W.
- Oladnabi Morteza
- Olagunju Andrew T.
- Olusanya Bolajoko O.
- Olusanya Jacob O.
- Oluwasanu Mojisola M.
- Omer Omer Muktar
- Ong Kanyin
- Ong Sokking
- Onwujekwe Obinna E.
- Oren Eyal
- Orji Aislyn U.
- Orpana Heather M.
- Ortega-Altamirano Doris V.
- Ortiz Alberto
- Osarenotor Osayomwanbo
- Osei Frank B.
- Ostojic Sergej M.
- Ostroff Samuel M.
- Otoiu Adrian
- Otstavnov Nikita
- Otstavnov Stanislav S.
- Owolabi Mayowa O.
- P. A. Mahesh
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- Pakhale Smita
- Pakhare Abhijit P.
- Pakshir Keyvan
- Palladino Raffaele
- Pana Adrian
- Panda-Jonas Songhomitra
- Pandey Anamika
- Pangaribuan Helena U.
- Park Eun-Kee
- Park James
- Parmar Priya
- Parry Charles D.
- Pasovic Maja
- Pasupula Deepak K.
- Patel Jenil R.
- Patel Sangram K.
- Paternina-Caicedo Angel J.
- Pathak Ashish
- Pathak Mona
- Patten Scott B.
- Patton George C.
- Paudel Deepak
- Paudel Sagun
- Paulson Katherine
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- Peden Amy E.
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- Pepito Veincent C.
- Peprah Emmanuel K.
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- Pereira David M.
- Pereira Jeevan
- Perico Norberto
- Pescarini Julia M.
- Pesudovs Konrad
- Pham Hai Q.
- Phillips Michael R.
- Piccinelli Cristiano
- Pierce Maxwell
- Pigott David M.
- Pilgrim Thomas
- Pilz Tessa M.
- Piradov Michael A.
- Pirsaheb Meghdad
- Pishgar Farhad
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- Pletche Martin
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- Postma Maarten J.
- Pottoo Faheem H.
- Pourjafar Hadi
- Pourmalek Farshad
- Pourmirza Kalhori Reza
- Pourshams Akram
- Poznanska Anna
- Prada Sergio I.
- Prakash Sanjay
- Prakash V.
- Prasad Narayan
- Preotescu Liliana
- Pribadi Dimas R.
- Pupillo Elisabetta
- Quazi Syed Zahiruddin
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafiee Ata
- Rafiei Alireza
- Raggi Alberto
- Rahim Fakher
- Rahimi-Movaghar Afarin
- Rahman Mohammad H.
- Rahman Muhammad A.
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Rakovac Ivo
- Ram Pradhum
- Ramezanzadeh Kiana
- Rana Saleem M.
- Ranabhat Chhabi L.
- Ranta Annemarei
- Rao Puja C.
- Rao Sowmya J.
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rath Goura K.
- Rathi Priya
- Rawaf David L.
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Rawat Ramu
- Razo Christian
- Redford Sofia B.
- Regassa Lemma D.
- Reiner Robert C.
- Reinig Nickolas
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N. (R17978)
- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.
Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. Global annual livebirths increased from 134·5 million (131·5–137·8) in 2000 to a peak of 139·6 million (133·0–146·9) in 2016. Global livebirths then declined to 135·3 million (127·2–144·1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2·1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27·1% (95% UI 26·4–27·8) of global livebirths. Global life expectancy at birth increased from 67·2 years (95% UI 66·8–67·6) in 2000 to 73·5 years (72·8–74·3) in 2019. The total number of deaths increased from 50·7 million (49·5–51·9) in 2000 to 56·5 million (53·7–59·2) in 2019. Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. Global population increased by 25·7%, from 6·2 billion (6·0–6·3) in 2000 to 7·7 billion (7·5–8·0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58·6 years (56·1–60·8) in 2000 to 63·5 years (60·8–66·1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
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- Angeslis Fragkiskos
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- Askar Aamal
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- Aslam Muhammad Nadeem
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- Asudo Felicia
- Atadag Yildiz Buyukdereli
- Atef Dina
- Athamneh Tayseer
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- Ather M Hammad
- Atherton Kristy
- Atia Ahmed
- Atici Semra Demirli
- Atilhan Ridvan
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- Atiq Tabish
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- Attiya Omar
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- Awadallah Safaa
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- Ayasrah Salem
- Aydin Cemil
- Aydoğdu Erhan Onur
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- Babalola Olakunle
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- Bakeer Hibah Bileid
- Bakeer Mohammed
- Balciscueta Zutoia
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- Banaga Essam Eldien Abuobaida
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- Bataineh Saad
- Bature Stephen Bodam
- Bayram Cigdem
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- Benamor Oumayma
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- Elgindy Yara
- Elhadi Muhammed
- Elhadi Muhammed
- Elhadi Muhammed
- Elhadi Rawan Elnoman Hamadelniel
- Elhassan Baraa
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- Elieyioğlu Güşta
- Elizabeth
- Elkenawi Karim
- Elkharaz Omar A
- Elkheshebi Ahlam
- Elkhodary Ahmed
- Ellepola Hasthika
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- Elmaghrabey Abdallah
- Elmehdawi Haitham
- Elmubark Abdelhadi
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- Trotta Georgina
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
- Tun Than
- Tung Melody
- Tuzuner Filiz
- Tynan Dominic
- Ugool Mahmoud
- Uğurlu Mustafa Ümit
- Ukrani Ronika Devi
- Ukwuoma Ohia Ernest
- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
- Uyanık Mustafa Safa
- Uzair Ahmad
- Uzel Kadir
- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
- Valverde-Vazquez Rocio
- Vance Lucille
- Vanguardia Kristina
- Vanguardia Maria Kristina
- Vanzuylekom Katie
- Varesano Marco
- Varghese Chris
- Varghese Chris
- Velenciuc Natalia
- Vermeulen Wikus
- Vidanagama Sasini
- Vimalan Vineeth
- Virani Sehar Salim
- Vollenhoven Beverley
- Vong Crystal
- Vrakopoulou Gavriella Zoi
- Vu Jennifer
- Vu Jennifer
- Waaka Nicholas
- Wadhwa Sanya
- Wagaarachchi Prabhath
- Waheed Ayesha Akbar
- Waldin Lucy
- Walsh Eamon
- Walters Chris
- Wang Bill
- Wang Christine
- Wang Erica
- Wang Grace
- Wang Katie
- Wang Nicole Qiwen
- Wang Pengnan
- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
- Author
- Abbasalizad-Farhangi Mahdieh
- Abbasi Masoumeh
- Abbastabar Hedayat
- Abdelalim Ahmed
- Abdoli Amir
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abebe Nebiyu Dereje
- Abebo Teshome Abuka
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abreu Lucas Guimarães
- Abrigo Michael R. M.
- Abushouk Abdelrahman I.
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Adabi Maryam
- Adebiyi Akindele Olupelumi
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adema Bereket Duko
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Aduroja Posi Emmanuel
- Advani Shailesh M.
- Afarideh Mohsen
- Afshin Ashkan
- Aghaali Mohammad
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadi Sepideh
- Ahmed Muktar Beshir
- Ahmed Rushdia
- Ajumobi Olufemi
- Akal Chalachew Genet
- Akalu Temesgen Yihunie
- Akinyemiju Tomi
- Akombi Blessing
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alam Samiah
- Alamene Genet Melak
- Alanzi Turki M.
- Alema Niguse Meles
- Ali Beriwan Abdulqadir
- Ali Muhammad
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed Mohamed
- Almasi Afshin
- Almasi-Hashiani Amir
- Altirkawi Khalid
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
- Amegah Adeladza Kofi
- Amini Saeed
- Amiri Fatemeh
- Amit Arianna Maever Loreche
- Anber Nahla Hamed
- Andrei Catalina Liliana
- Ansari Fereshteh
- Ansari-Moghaddam Alireza
- Anteneh Zelalem Alamrew
- Antonio Carl Abelardo T.
- Antriyandarti Ernoiz
- Anvari Davood
- Anwer Razique
- Appiah Seth Christopher Yaw
- Arab-Zozani Morteza
- Arabloo Jalal
- Araya Ephrem Mebrahtu
- Arefi Zohreh
- Aremu Olatunde
- Arnedo Carlos Alberto Marrugo
- Arzani Afsaneh
- Asadi-Aliabadi Mehran
- Asadi-Pooya Ali A.
- Asante Kwaku Oppong
- Asgari Samaneh
- Asghari Babak
- Ashagre Alebachew Fasil
- Asrat Anemaw A.
- Ataeinia Bahar
- Atalay Hagos Tasew
- Atnafu Desta Debalkie
- Atout Maha Moh’d Wahbi
- Ausloos Marcel
- Avokpaho Euripide F. G. A.
- Awasthi Ashish
- Ayanore Martin Amogre
- Aynalem Yared A. Asmare
- Azadmehr Abbas
- Azari Samad
- Azarian Ghasem
- Azene Zelalem Nigussie
- Babaee Ebrahim
- Badawi Alaa
- Badiye Ashish D.
- Bahrami Mohamad Amin
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- Bakhtiari Ahad
- Bakkannavar Shankar M.
- Balakrishnan Senthilkumar
- Balalami Nader Jafari
- Bali Ayele Geleto
- Banach Maciej
- Banik Palash Chandra
- Baradaran-Seyed Zahra
- Baraki Adhanom Gebreegziabher
- Barboza Miguel A.
- Barua Lingkan
- Basaleem Huda
- Basu Sanjay
- Bayati Mohsen
- Bayih Mulat Tirfie
- Baynes Habtamu Wondifraw
- Bedi Neeraj
- Behzadifar Masoud
- Behzadifar Meysam
- Bekele Yibeltal Alemu
- Bennett Derrick A.
- Berbada Dessalegn Ajema
- Berhe Abadi Kidanemariam
- Berhe Kidanemaryam
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- Bernstein Robert S.
- Bhageerathy Reshmi
- Bhandari Dinesh
- Bharadwaj Pankaj
- Bhattacharjee Natalia V.
- Bhattacharyya Krittika
- Bijani Ali
- Bikbov Boris
- Bilano Ver
- Bililign Nigus
- Birara Setognal
- Birhane Minuye Biniam Biniam
- Birhanu Minyichil
- Biswas Raaj Kishore
- Bitew Zebenay Workneh
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- Chatterjee Pranab
- Chattu Vijay Kumar
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- Deribe Kebede
- Desai Rupak
- Desalegn Beruk Berhanu
- Desalew Assefa
- Deshpande Aniruddha
- Dey Sagnik
- Dharmaratne Samath Dhamminda
- Dhillon Preeti
- Dhimal Meghnath
- Dhungana Govinda Prasad
- Diaz Daniel
- Dinsa Girmaye Deye
- Dipeolu Isaac Oluwafemi
- Djalalinia Shirin
- Do Hoa Thi
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- Doku Paul Narh
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- Durães Andre R.
- Dávila-Cervantes Claudio
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- El Sayed Zaki Maysaa
- El Sayed Iman
- El Tantawi Maha
- El-Jaafary Shaimaa I.
- El-Khatib Ziad
- El-Sherbiny Yasser Mohamed
- Elbarazi Iffat
- Elemineh Demelash Abewa
- Elsharkawy Aisha
- Elyazar Iqbal R. F.
- Emamian Mohammad Hassan
- Enany Shymaa
- Endalew Daniel Adane
- Endalifer Melese Linger
- Eskandari Khalil
- Eskandarieh Sharareh
- Esmaeilnejad Saman
- Esteghamati Alireza
- Etemadi Arash
- Etisso Atkilt Esaiyas
- Fanzo Jessica
- Farahmand Mohammad
- Faraj Anwar
- Farashi Sajjad
- Fareed Mohammad
- Farioli Andrea
- Faro Andre
- Farzadfar Farshad
- Farzam Hossein
- Fatima Syeda Sadia
- Fattahi Nazir
- Fauk Nelsensius Klau
- Fazaeli Ali Akbar
- Fentahun Netsanet
- Ferede Tomas Y.
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Fernandes João C.
- Feyissa Garumma Tolu
- Filip Irina
- Fischer Florian
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- Foigt Nataliya A.
- Folayan Morenike Oluwatoyin
- Fomenkov Artem Alekseevich
- Forooshani Zahra Sadat Dibaji
- Foroutan Masoud
- Francis Joel Msafiri
- Fukumoto Takeshi
- Förster Jana
- Gayesa Reta Tsegaye
- Geberemariyam Biniyam Sahiledengle
- Gebrehiwot Tsegaye Tewelde
- Gebremariam Hadush
- Gebremariam Kidane Tadesse
- Gebremedhin Ketema Bizuwork Bizuwork
- Gebremeskel Gebreamlak Gebremedhn
- Gebreslassie Assefa Ayalew Ayalew
- Gebretsadik Gebretsadkan G. G.
- Gedefaw Getnet Azeze
- Geramo Yilma Chisha Dea
- Gesesew Hailay Abrha
- Geta Birhanu
- Getenet Agegnehu Bante
- Gezae Kebede Embaye
- Ghaffarifar Fatemeh
- Ghafourifard Mansour
- Ghajar Alireza
- Ghajarzadeh Mahsa
- Ghashghaee Ahmad
- Ghiasvand Hesam
- Gholamian Asadollah
- Gilani Syed Amir
- Gill Tiffany K.
- Ginawi Ibrahim Abdelmageed
- Goli Srinivas
- Gomes Nelson G. M.
- Gopalani Sameer Vali
- Goudarzi Houman
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- Govindakarnavar Arunkumar
- Grada Ayman
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- Guimarães Rafael Alves
- Guled Rashid Abdi
- Guo Yuming
- Gupta Rahul
- Gupta Rajat Das
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- Hafezi-Nejad Nima
- Haile Michael Tamene
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- Hamadeh Randah R.
- Hamidi Yadollah
- Handiso Demelash Woldeyohannes
- Hankey Graeme J.
- Haririan Hamidreza
- Hariyani Ninuk
- Hasaballah Ahmed I.
- Hasan Md. Mehedi
- Hasankhani Milad
- Hasanpoor Edris
- Hasanzadeh Amir
- Hashemian Maryam
- Hassanipour Soheil
- Hassen Hamid Yimam
- Havmoeller Rasmus
- Hawkes Corinna
- Hay Simon I.
- Hayat Khezar
- Hayelom Desta Haftu
- Heidari Behnam
- Heidari-Soureshjani Reza
- Hendrie Delia
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- Herrero Mario
- Herteliu Claudiu
- Heydarpour Fatemeh
- Hoang Chi Linh
- Hoek Hans W.
- Hole Michael K.
- Holla Ramesh
- Hollerich Gillian
- Hong Sung Hwi
- Hoogar Praveen
- Horino Masako
- Hossain Naznin
- Hosseini Mostafa
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Househ Mowafa
- Hsairi Mohamed
- Hu Guoqing
- Huda Tanvir M.
- Humayun Ayesha
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Ilesanmi Olayinka Stephen
- Ilic Milena D.
- Imani-Nasab Mohammad Hasan
- Inbaraj Leeberk Raja
- Iqbal Usman
- Irvani Seyed Sina Naghibi
- Islam Sheikh Mohammed Shariful
- Iwu Chidozie C. D.
- Iwu Chinwe Juliana
- Izadi Neda
- Jaafari Jalil
- Jabbari Seyed Hossein Yahyazadeh
- Jaca Anelisa
- Jadidi-Niaragh Farhad
- Jafarinia Morteza
- Jahani Mohammad Ali
- Jakovljevic Mihajlo
- Jalali Amir
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- Jürisson Mikk
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- Moradzadeh Rahmatollah
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- Narayan K. M. Venkat
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- Ngunjiri Josephine W.
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- Orisakwe Orish Ebere
- Ortiz Alberto
- Osarenotor Osayomwanbo
- Osgood-Zimmerman Aaron E.
- Owolabi Mayowa Ojo
- P. A. Mahesh
- Padubidri Jagadish Rao
- Pakshir Keyvan
- Pana Adrian
- Panda-Jonas Songhomitra
- Parsian Hadi
- Pashaei Tahereh
- Pasupula Deepak Kumar
- Patel Sangram Kishor
- Pathak Ashish
- Pathak Mona
- Pati Sanghamitra
- Patle Ajay
- Patton George C.
- Paulos Kebreab
- Pepito Veincent Christian Filipino
- Perico Norberto
- Petri William A.
- Pickering Brandon V.
- Pigott David M.
- Pirestani Majid
- Piroozi Bakhtiar
- Pirsaheb Meghdad
- Pokhrel Khem Narayan
- Postma Maarten J.
- Pourjafar Hadi
- Pourmalek Farshad
- Pourshams Akram
- Poustchi Hossein
- Prada Sergio I.
- Preotescu Liliana
- Pribadi Dimas Ria Angga
- Quintanilla Beatriz Paulina Ayala
- Rabanal Jacqueline Elizabeth Alcalde
- Rabiee Mohammad
- Rabiee Navid
- Rad Enayatollah Homaie
- Radfar Amir
- Rafiei Alireza
- Rahim Fakher
- Rahimi-Movaghar Vafa
- Rahman Muhammad Aziz
- Rahman Sajjad ur
- Rai Rajesh Kumar
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Ramezanzadeh Kiana
- Rana Saleem Muhammad
- Ranabhat Chhabi Lal
- Rao Sowmya J.
- Rarani Mostafa Amini
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rathi Priya
- Rawaf David Laith
- Rawaf Salman
- Rawal Lal
- Ray Sarah E.
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N.
- Resnikoff Serge
- Rezaei Nima
- Rezaeian Shahab
- Rezai Mohammad Sadegh
- Rezapour Aziz
- Riahi Seyed Mohammad
- Ribeiro Ana Isabel
- Rickard Jennifer
- Rodriguez Alina
- Roever Leonardo
- Roro Elias Merdassa
- Roshandel Gholamreza
- Ross Jennifer M.
- Rostami Ali
- Rubagotti Enrico
- Saad Anas M.
- Saadatagah Seyedmohammad
- Sabde Yogesh Damodar
- Sabour Siamak
- Sadeghi Ehsan
- Sadeghi Masoumeh
- Safari Saeed
- Safari Yahya
- Safarpour Hamid
- Sagar Rajesh
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sajadi S. Mohammad
- Salahshoor Mohammad Reza
- Salam Nasir
- Salehi Farkhonde
- Salem Hosni
- Salem Marwa R. Rashad
- Salimi Yahya
- Salimzadeh Hamideh
- Sambala Evanson Zondani
- Samy Abdallah M.
- Santos Itamar S.
- Saraswathy Sivan Yegnanarayana Iyer
- Sarker Abdur Razzaque
- Sartorius Benn
- Sarveazad Arash
- Sathian Brijesh
- Satpathy Maheswar
- Saxena Sonia
- Sayeed Muhammad Shahdaat Bin
- Sayyah Mehdi
- Sbarra Alyssa N.
- Schaeffer Lauren E.
- Schipp Megan F.
- Schmidt Maria Inês
- Schutte Aletta Elisabeth
- Schwebel David C.
- Senbeta Anbissa Muleta
- Senthilkumaran Subramanian
- Seyedmousavi Seyedmojtaba
- Shaahmadi Faramarz
- Shafaat Omid
- Shahabi Saeed
- Shaikh Masood Ali
- Shalash Ali S.
- Shams-Beyranvand Mehran
- Shamshirian Amir
- Shamsizadeh Morteza
- Shannawaz Mohammed
- Sharafi Kiomars
- Sharif Mehdi
- Sharma Rajesh
- Shehata Hatem Samir
- Sheikhtaheri Abbas
- Shibuya Kenji
- Shiferaw Wondimeneh Shibabaw
- Shigematsu Mika
- Shin Jae Il
- Shiri Rahman
- Shirkoohi Reza
- Shiue Ivy
- Shuval Kerem
- Siabani Soraya
- Siddiqi Tariq J.
- Sigfusdottir Inga Dora
- Silva Diego Augusto Santos
- Simonetti Biagio
- Singh Ambrish
- Singh Jasvinder A.
- Singh Pankaj Kumar
- Singh Pushpendra
- Singh Virendra
- Sinha Dhirendra Narain
- Sintayehu Yitagesu
- Sisay Malede Mequanent M.
- Soheili Amin
- Soleymani Bija
- Soltani Farzaneh
- Soltani Shahin
- Soriano Joan B.
- Sorrie Muluken Bekele
- Soshnikov Sergey
- Soyiri Ireneous N.
- Spotin Adel
- Sreeramareddy Chandrashekhar T.
- Srivastava Rajni Kant Kant
- Starodubova Antonina
- Sudaryanto Agus
- Sufiyan Mu’awiyyah Babale
- Suleria Hafiz Ansar Rasul
- Sulo Gerhard
- Sunguya Bruno F.
- Syed Zahiruddin Quazi
- Sykes Bryan L.
- Tabarés-Seisdedos Rafael
- Tabuchi Takahiro
- Tadesse Birkneh Tilahun
- Taherkhani Amir
- Tamirat Koku Sisay
- Tassew Segen Gebremeskel
- Taveira Nuno
- Teklehaimanot Berhane Fseha
- Tekulu Gebretsadkan Hintsa
- Temsah Mohamad-Hani
- Terkawi Abdullah Sulieman
- Tessema Zemenu Tadesse
- Thomas Nihal
- Titova Mariya Vladimirovna
- Tlaye Kenean Getaneh
- Tohidinik Hamid Reza
- Tonelli Marcello
- Toroudi Hamidreza Pazoki
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Khanh Bao
- Tripathi Manjari
- Uddin Riaz
- Ullah Irfan
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Useh Ushotanefe
- Usman Muhammad Shariq
- Uthman Olalekan A.
- Vacante Marco
- Vaezghasemi Masoud
- Valdez Pascual R.
- VanderHeide John
- Varavikova Elena
- Varughese Santosh
- Vasankari Tommi Juhani
- Vasseghian Yasser
- Vecchia Carlo La
- Veisani Yousef
- Venkatesh Srinivasaraghavan
- Venketasubramanian Narayanaswamy
- Verma Madhur
- Vidale Simone
- Violante Francesco S.
- Vlassov Vasily
- Vollmer Sebastian
- Vukovic Rade
- Waheed Yasir
- Wang Haidong
- Wang Yafeng
- Wang Yuan-Pang
- Weldesamuel Girmay Teklay
- Werdecker Andrea
- Wiangkham Taweewat
- Wiens Kirsten E.
- Wijeratne Tissa
- Wolde Haileab Fekadu
- Wondafrash Dawit Zewdu
- Wonde Tewodros Eshete
- Wondmieneh Adam Belay
- Wu Ai-Min
- Xu Gelin
- Yadegar Abbas
- Yadollahpour Ali
- Yamada Tomohide
- Yano Yuichiro
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yeshaneh Alex
- Yeshaw Yigizie
- Yeshitila Yordanos Gizachew
- Yilma Mekdes Tigistu
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Youm Yoosik
- Younis Mustafa Z.
- Yousefi Zabihollah
- Yousof Hebat-Allah Salah A.
- Yu Chuanhua
- Yusefzadeh Hasan
- Zahabi Saleh Salehi
- Zaki Leila
- Zaman Sojib Bin
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zarafshan Hadi
- Zepro Nejimu Biza
- Zerfu Taddese Alemu
- Zewale Taye Abuhay
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Xiu-Ju
- Zodpey Sanjay
- Zomorodian Kamiar
- Zotor Francis Bruno
- Ärnlöv Johan
- Publication venue
- Nature Research
- Publication date
- 01/01/2020
- Field of study
A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic
In silico lineage tracing through single cell transcriptomics identifies a neural stem cell population in planarians
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- A Sanchez Alvarado
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- Alyssa M. Molinaro
- B Langmead
- BJ Pearson
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- C Blanpain
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- EM Hill
- F Cebria
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- J Pellettieri
- J Shin
- JB Skeath
- JC Rink
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- JC Wolfswinkel van
- JJ Collins 3rd
- JM Martin-Duran
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- JR Tollervey
- K Agata
- K Currie
- KG Ross
- KM Betke
- KW Currie
- L Maaten van der
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- ML Scimone
- MW Cowles
- O Wurtzel
- PA Newmark
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- PV Kharchenko
- PW Reddien
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- RM Labbe
- S Anders
- S Casarosa
- S Fraguas
- S Higuchi
- S Picelli
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- SJ Zhu
- SW Lapan
- T Guo
- T Hayashi
- Team RC
- Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo
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- Aguilar Danielle
- Alencar Michelle
- Allen Nina O
- Andre M.
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- Lowery Lonnie
- Lowery Ryan P
- Lu Hocheng
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- Martinez Nic
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- McCallum Ryley
- McFadden B.
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- McKinley Sarah
- Meers Grace M
- Meinking M.
- Mena Mauricio
- Mendel Ronald
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- Micensky Ashley
- Miller Michael E
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- Monsalves-Alvarez Matias
- Moon Jordan R
- Morales Elisa
- Moriarty Terence
- Mullen Katie A
- Mumford Petey W
- Murano P.
- Murano P. S
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- Norton Layne
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- Olivencia Alyssa
- Oliver J.
- Oliver J. M
- Oliver Jonathan M
- Ordway C.
- Ordway Chris E
- Oyharçabal Sebastian
- O’Connor A.
- Parker Kimberly
- Pascoe David D
- Patel Romil K
- Pawela Michael
- Peacock Corey
- Peacock Corey A
- Pellegrino J.
- Pellegrino Joseph K
- Perry Ross
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- Pollock Adam
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- Rasmussen C.
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- Rodriguez Winter
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- Romer Braden
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- Sanders David J
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- Sandler David
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- Silver Tobin
- Silver Tobin A
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- Smith Bridget
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- Sowinski R.
- Spillane Mike
- Sprow Kyle
- Stecker R.
- Stepp Stephanie
- Stone Jason D
- Stratton Matthew
- Szymanski David
- Tamayo Armando
- Taylor Lem
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- Tok Ozlem
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- Trexler Eric
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- Vargas Andres
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- BioMed Central
- Publication date
- 12/09/2016
- Field of study
Meeting Abstracts: Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo Clearwater Beach, FL, USA. 9-11 June 201
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
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- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
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- Barreau Amelie
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- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-Hélène
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ève
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Érin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
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- Cook Tim
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- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
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- Depuydt Pieter
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- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
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- Estcourt Lise J.
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- Gladas Kirsty
- Glasby Kathleen
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- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
- Goligher Ewan
- Gomez Keith
- Gommans Frank
- Goodwin Jayne
- Goossens Herman
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- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
- Grady Bart
- Graham Cheryl
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- Haider Nafeesah
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- Hajdu Bence
- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
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- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
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- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
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- Harvey Daniel
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- Hashmi Madhia
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- Headdon William
- Headlam Evie
- Healey Gail
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- Henry Joanne
- Henry Lavinia
- Hensley Joseph
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- Hernandez Erik
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- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
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- Hilldrith Anette
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- Hin Lui Lok
- Hindle Grace
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- Hodge Christopher
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- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
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- Kim Edy Y.
- Kimpton Sarah
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- Kolovou Angeliki
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- Kong Jing
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- Kosa Alma
- Kremling Julius
- Kreß Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
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- L?Hotellier Sylvie
- Labbe Vincent
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- Landais Michaël
- Landoni Giovanni
- Landsiedel-Mechenbier Elke
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- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen Lenaïg
- Le Loup Guillaume
- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
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- Lewis Roger J.
- Lewis Sarah
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- Liao Angela
- Lim Rosario
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- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
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- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
- Martin Elise
- Martin Emma
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- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
- McClintock Declan
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- McCracken Phoebe
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- McCullagh Liz
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- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
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- McKee Madeleine
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- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
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- Meermeier Werner
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- Mouncey Paul R.
- Mowery Brent
- Mrad Aymen
- Mtuwa Shelia
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- Nemeth-Roszpopa Karolina
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- Newman Tabitha
- Ng Anthony
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- Nguyen-Valat Thi-My-Hue
- Nichol Alistair D.
- Nicholier Tiphaine
- Nicholson Andrew
- Nicholson Anne
- Nicholson Sarah
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- O Rourke Kate
- O'Connell Martin
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- O?Brien Neale
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- Osagie Rawlings
- Osborne Alexander
- Osborne Jason
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- Ottens Thomas
- Owen David R. J.
- Oza Deepali
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- Page Shannon
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- Paneru Hem
- Panjwani Ashok
- Panwar Rakshit
- Pappa Evita
- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
- Parker Lorraine
- Parker Natasha
- Parmar Dinesh
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- Pletz Mathias
- Plummer Bethany
- Plummer Mark
- Pogreban Tatiana
- Pogson David
- Polfliet Margot
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- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
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- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
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- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
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- Bischoff Helge
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- Bommareddy Praveen K
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- Booth Jamie
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- Boyer Jean
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- Brockstedt Dirk G
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- Bullock Kim
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- Butterfield Lisa H
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- Clavijo Paul E
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- El Alaoui Meddy
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- Eles Klara
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- Emerling Daniel
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- English Jessie
- Enstrom Amanda
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- Facciabene Andrea
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- Facciponte John
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- Falchook Gerald
- Fantini Massimo
- Fantini Massimo
- Fantini Massimo
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- Fa’ak Faisal
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- Freimark Bruce
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- Frey Alan
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- Hu Yangyang
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- Metchette Ken
- Metelli Alessandra
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- Niederfellner Gerhard
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- Noessner Elfriede
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- Ogasawara Masahiro
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- Papachristofilou Alexandros
- Papadopoulos Kyriakos P
- Papot Sébastien
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- Pena Rhoneil
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- Peoples George E
- Perez Myra
- Perna Serena
- Perry Kyle
- Persaud Krishnadatt
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- Ponichtera Holly
- Ponte Jose
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- Qiu Xiaohong
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- Ramachandra Murali
- Ramachandra Raghuveer
- Ramalingam Suresh
- Ramchandren Radhakrishnan
- Ramos Kimberly
- Ranki Tuuli
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- Rao Tharak
- Rapisuwon Suthee
- Ravindranathan Roshni
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- Shabanowitz Jeffrey
- Shabanowitz Jeffrey
- Shafren Darren
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- Shakya Reena
- Shamalov Katerina
- Shanker Anil
- Shanker Anil
- Sharma Manish
- Sharma Meenu
- Sharma Naveen
- Sharma Padmanee
- Shayan Gulidanna
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- Shi Feng
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- Spada Filomena
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- Stein Paul L
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- Stewart Al
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- Straub Tobias
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- Ståhle Magnus
- Su Yu-Lin
- Sudarshan Naremaddepalli
- Sugarbaker David
- Sukari Ammar
- Sultan Hussein
- Sun Shaoli
- Sundararaman Srividya
- Sung Leonard
- Suresh Rahul
- Surguladze David
- Suryawanshi Satyendra
- Suryawanshi Satyendra
- Suzuki Akiko
- Suzuki Ryuji
- Sweis Randy F
- Taback Bret
- Tagliaferri Mary
- Talbert Erin
- Tallarico John
- Tan Joanne B
- Tan Joanne B L
- Tan Wei
- Tan Yann C
- Tanaka Maki
- Tang Chad
- Tannir Nizar M
- Tannir Nizar M
- Taylor Allison
- Taylor Matthew
- Tcherepanova Irina
- ter Meulen Jan
- ter Meulen Jan
- Terabe Masaki
- Terabe Masaki
- Termini James
- Tetzlaff Michael
- Tewary Poonam
- Thakurta Anjan
- Thayer Matt
- Theodoraki Marie-Nicole
- Thimme Robert
- Thomas Portia
- Thomas Remy
- Thomas Vincent
- Thompson John A
- Thounaojam Menaka
- Thounaojam Menaka
- Thurston Gavin
- Tighe Rober
- Tilahun Ashenafi
- Tillé Laure
- Timmerman John
- Tipton Kimberly A
- Tipton Kimberly A
- Tognon Christina E
- Tomai Mark A
- Toms Anne
- Torno Sebold
- Torrey Heather
- Torti Vince
- Toth Laszlo
- Trager James B
- Trappey Alfred F
- Trivedi Sumita
- Truesdell Peter
- Tsang Kwong
- Tsang Kwong
- Tsang Kwong Y
- Tsaparikos Konstantinos
- Tsouko Efrosini
- Tsujikawa Takahiro
- Tsujikawa Takahiro
- Tsujikawa Takahiro
- Tuck David
- Tumang Joseph
- Tumang Joseph
- Turbitt William J
- Turk Andrew T
- Tyner Jeffery W
- Tähtinen Siri
- Tähtinen Siri
- Uecker Darrin
- Uecker Darrin
- Uecker Darrin
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- Ugel Stefano
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- van Vugt Marianne
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- VanderVeen Laurie
- Vanpouille-Box Claire I
- VanVlasselaer Peter
- Varhegyi Nikole
- Vasilakos John P
- Vaske Charles
- Vassilev Lotta
- Velcheti Vamsidhar
- Velculescu Victor
- Verma Amita
- Verma Amita
- Vetto John
- Vianden Christina
- Vietsch Eveline E
- Vignali Dario
- Vignali Dario
- Vogel Katharina
- Volkmuth Wayne
- Volz Barbara
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- Vu Tuyen
- Wada Hiroshi
- Wagtmann Nicolai
- Waldman Michelle
- Waldman Scott A
- Waller John
- Wallraven Gladice
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- Wang Ena
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- Wang Hongjie
- Wang Ping
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- Wang Ximi K
- Wang Yi
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- Ward Stephen T
- Waugh Katherine
- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R
- Weiner David
- Weiner Louis M
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
- Wenthe Jessica
- Wenthe Jessica
- Werner Lauryn R
- West Brian
- West James
- West James
- Wheatley Courtney
- Whetstone Ryan
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C
- Whiting Chan C
- Wicha Max S
- Wicha Max S
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W
- Wilkinson Robert W
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Chihunt
- Wong Deborah J
- Wong Gabriel
- Wong Kenneth R
- Wong Kenneth R
- Wong Michael K
- Wood Laura
- Woodside Darren G
- Workman Creg
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- Wu Jennifer
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- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Ylösmäki Erkko
- Young Gregory
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W
- Young Steve W
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis
- Author
- A Aleman
- A Alonso
- A Britton
- A Cherubini
- A Cherubini
- A Garcia
- A Karp
- A Lobo
- A Marengoni
- A Nordberg
- A Ogunniyi
- A Ott
- A Ott
- A Ott
- A Ott
- AB Ford
- AB Mendelsohn
- AC Nooyens
- AF Jorm
- AF van Raamt
- AH Ford
- AH Ford
- AJ Schuit
- AK Campbell
- AL Gross
- Alan B Zonderman
- Alison Teel
- Alyssa A Gamaldo
- AP Smith
- AS Buchman
- B Rodgers
- B Schmand
- B Schmand
- BE Alvarado
- BM van Gelder
- BM van Gelder
- C Behl
- C Crecelius
- C Dufouil
- C Dufouil
- C Dullemeijer
- C Qiu
- C Reitz
- C Reitz
- C Reitz
- C Samieri
- C Samieri
- C Santos
- CB Begg
- CB Wright
- CC Wang
- CE Teunissen
- CG Lyketsos
- CJ Maxwell
- CM Callahan
- CQ Huang
- CW Cotman
- D Carmelli
- D De Ronchi
- D Galasko
- D Gavrila
- D Juan
- D Krahn
- D Laurin
- D Laurin
- D Zekry
- DA Evans
- DA Evans
- DB Petitti
- DE Barnes
- DE Zylberstein
- DF Zhou
- DJ Galanis
- DJ Moritz
- DM Kado
- DR Taaffe
- E Albanese
- E Castro-Costa
- E Herrera Jr
- E Kesse-Guyot
- E Kroger
- E Nurk
- E Ronnemaa
- EB Larson
- EE Devore
- EE Devore
- ES Paykel
- F Gomez-Pinilla
- F Grodstein
- F Landi
- F Lin
- F Pignatti
- F Zanjani
- G Li
- G McKhann
- G McNeill
- G Ravaglia
- G Ravaglia
- G Ravaglia
- G Ravaglia
- G Xu
- G Zuccala
- GA Broe
- GC Roman
- GE Bond
- GE Bond
- GE Bond
- GG Fillenbaum
- GM McKhann
- H Christensen
- H Christensen
- H Refsum
- H Zhou
- HC Hendrie
- HC Liu
- Hind A Beydoun
- HJ Wengreen
- I Leroi
- IG McKeith
- II Kruman
- J Ankri
- J Corley
- J Corley
- J de Champlain
- J Kim
- J Selhub
- J Verghese
- J Weuve
- JA Cervilla
- JA Luchsinger
- JA Luchsinger
- JE Dunn
- JE James
- JH Schafer
- JL Cobb
- JM Kim
- JM Kim
- JM Peacock
- JR Cerhan
- JS Vidal
- JW Jama
- JW Miller
- K Battig
- K Koivisto
- K Ritchie
- K Yaffe
- K Yaffe
- KA Cagney
- KH Masaki
- KK Chan
- KL Tucker
- KS Bjerve
- L Arab
- L Arab
- L Feng
- L Feng
- L Feng
- L Kilander
- L Letenneur
- L Letenneur
- L Letenneur
- L Li
- L White
- L Zhang
- LB Zahodne
- LE Herbert
- LE Middleton
- LJ Podewils
- M Andreassi
- M Chang
- M Egger
- M Egger
- M Egger
- M Fotuhi
- M Gallucci
- M Ganguli
- M Grundman
- M Haag
- M Hildebrandt
- M Johnson-Kozlow
- M Richards
- M Richards
- M Rusanen
- M Rusanen
- M Scazufca
- MA Beydoun
- MA Beydoun
- May A Beydoun
- MC de Wilde
- MC Morris
- MC Morris
- MC Morris
- MC Morris
- MC Morris
- MC Morris
- MC Norton
- MC Reid
- MC Stewart
- ME Farmer
- ME Lytle
- MF Elias
- MF Elias
- MF Elias
- MF Muldoon
- MF Shadlen
- MH Eskelinen
- MH Eskelinen
- MI Ramos
- MJ Dealberto
- MJ Engelhart
- MJ Engelhart
- MJ Engelhart
- MJ Jarvis
- MJ Stampfer
- MM Fichter
- MN Haan
- MN Vercambre
- MP van Boxtel
- MS Albert
- MT Sturman
- MY Zhang
- N Collins
- N Scarmeas
- ND Prins
- NT Akbaraly
- O Aevarsson
- O van de Rest
- P Barberger-Gateau
- P Quadri
- P Verhaeghen
- PB Gorelick
- PB Gorelick
- PC Elwood
- PE Wainwright
- PK Elias
- PP Zandi
- PS Mathuranath
- PS Sachdev
- Q Gao
- R Clarke
- R Doll
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- R Peters
- R Schmidt
- RA Whitmer
- RB Parsons
- RD Abbott
- RE Dustman
- RF Gillum
- RG Wight
- RL Rogers
- RP Gelber
- RS Wilson
- RS Wilson
- RT Lin
- S Ariogul
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- S Cerolini
- S Gonzalez
- S Kalmijn
- S Kalmijn
- S Kalmijn
- S Kalmijn
- S Kalmijn
- S Kalmijn
- S Kuriyama
- S Lee
- S Lee
- S Mejia-Arango
- S Redeen
- S Rovio
- S Sabia
- S Sabia
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- S Seshadri
- SA van Hooren
- SC Ho
- SJ Duthie
- SL Au Yeung
- SL Edelstein
- SL Gray
- SL Gray
- SL Tyas
- SP Mooijaart
- STATA
- T Anttila
- T Bottiglieri
- T den Heijer
- T Etgen
- T Hanninen
- T Ngandu
- T Psaltopoulou
- TA Hamid
- TE Seeman
- The Lund and Manchester Groups
- TM Scott
- TM Thomson
- TN van den Kommer
- TP Ng
- V Solfrizzi
- V Solfrizzi
- VC Hachinski
- VM Dotson
- VS Laitala
- W Freidl
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- WR Markesbery
- WT Chen
- WW Spirduso
- Y Christen
- Youfa Wang
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study