Impact of CKD Progression on Cardiovascular Disease Risk in a Contemporary UK Cohort of Individuals With Diabetes

Introduction: It remains unclear whether an increased progression rate of chronic kidney disease (CKD) adds predictive information regarding cardiovascular disease (CVD) risk. The aim of this study was to evaluate the association between CKD progression, based on estimated glomerular filtration rate (eGFR) slope estimates and the risk for CVD. Methods: We compared the updated eGFR slope calculated over multiple overlapping 2-year periods and the updated mean eGFR. Incident CKD subjects were selected from a prevalent population with diabetes (T2DM). Subjects from the UK Clinical Practice Research Data Link GOLD (CPRD) were followed from CKD diagnosis (n = 30,222) until heart failure (HF), myocardial infarction (MI), ischemic stroke (IS), or a composite end point including all 3 event types (MACE plus), mortality, database dropout, or end of study follow-up. Results: Both the updated eGFR slope and updated mean eGFR were associated with MACE plus and HF. Updated eGFR slope decline of > –3 ml/min/1.73 m2 increased the risk for MACE plus (adjusted hazard ratio [HR] = 1.45; 95% confidence interval [CI], 1.26–1.67), HF (HR = 1.50; 95% CI, 1.27–1.76), and MI (HR = 1.39; 95% CI, 1.01–1.91). Conclusions: This study strongly supports current evidence that CKD is an independent risk factor for CVD. From a clinical perspective, both rate of progression and cumulative status of CKD describe distinct aspects of the cardiorenal risk among persons with diabetes. This evidence is essential to enable more timely and improved use of treatments in this population

Crummer SunTrust Portfolio Recommendations: Crummer Investment Management [2015]

We approach the market this year with muffled optimism. The market’s growth rate will be softer than the last two years, based on our GDP forecast of 2.8% accompanied by steady unemployment and low interest rates. In this environment, stock selection is paramount and we have modified the portfolio to favor pro-cyclical sectors like Consume Discretionary and Industrials

Optimización del tratamiento térmico para la inducción al desove de Argopecten purpuratus (Mollusca: Bivalvia)

Based on methodologies currently used in commercial hatcheries, four thermic treatments were compared to induce the gametes expulsion of Argopecten purpuratus. The treatments evaluated included: 1) gradual increase in temperature, 2) gradual decrease, 3) 5 °C thermal-shock, 4) 10 °C thermal-shock and 5) control at constant temperature 16 °C. After induction, the number of fertilized oocytes in each treatment was estimated. The results show that a gradual increase in temperature between 16 and 26 °C causes a significantly higher proportion of fertilized oocytes compared to other treatments

Evaluación de Bioabonos caseros utilizando como indicadores plantas de lechuga y repollo en Tecnoacademia Túquerres

En Colombia se estima que entre 60% y 70% del volumen total de desechos generados son materia biodegradable, de la misma manera el 40% de los desechos que se generan en casa son de tipo orgánico; estos residuos son depositados como basura en los rellenos sanitarios lo que disminuyen la vida útil de estos y aumentan el impacto ambiental; sin embargo, estos residuos pueden ser aprovechados para generar productos biotecnológicos como el bioabono mediante el proceso convencional de compostaje.  [1,2]. Bajo este contexto desde el semillero de Ciencia para la Vida, inscrito a la línea de biotecnología de Tecnoacademia Túquerres se tuvo como objetivo evaluar un bioabono casero proveniente de residuos orgánicos caseros, utilizando plantas de repollo y lechuga. Se recolectaron residuos orgánicos generados en la casa de los aprendices de la línea de biotecnología de Tecnoacademia, se elaboraron composteras con botellas plásticas y se analizó el bioabono para determinar contenido de nutrientes. Se aplicará compost en dos etapas de cultivo como fertilizante. Se utilizará un diseño completamente al azar con tres tratamientos y tres repeticiones, T0: Testigo, sin abono; T1: bioano casero, y T2: compost químico. Se logró que los aprendices fabricaran compost a pequeña escala gracias a la aplicación de procesos biotecnológicos, se incentivó hábitos ecológicos en torno al empleo de abonos orgánicos y reducción del uso de fertilizantes químicos; actualmente se está realizando pruebas físico-químicas y microbiológicas del bioabono casero según lo estipulado en la norma NTC 516

Optimización de un protocolo de elaboración de jabón a partir de residuos de aceite de cocina usado.

Actualmente, existe inadecuada disposición de los residuos de aceite de cocina usado en muchos de nuestros hogares, dado que son eliminados por el sifón de la cocina, acción que se convierte en una mala práctica pues contribuye a aumentar la problemática mundial de contaminación del medio ambiente. Estos residuos de aceite llegan a los ecosistemas acuáticos y terrestres donde provocan pérdida de biodiversidad, causan infertilidad yerosión del suelo, daños y sobrecostes en las plantas de tratamiento de agua residuales, además, taponamiento de las tuberías de alcantarillado que causan inundaciones, pérdidas económicas y enfermedades en los seres humanos. Bajo este contexto, se presenta la actual propuesta de investigación que tiene como objetivo optimizar un protocolo de elaboración de jabón a partir de residuos de aceite de cocina. La metodología propuesta consisteen reciclar el aceite de cocina usado y realizar la evaluación fisicoquímica de este para posteriormente usarlo en la elaboración de jabón artesanal con agregado de ingredientes naturales, mediante el método de saponificación. Se aplicarán seis procedimientos experimentales (A, B, C, D, E y F), para saponificar los residuos de aceite usado.Con este estudio se busca mostrar una opción en el reciclado de estos aceites, disminuyendo con ello el impacto ambiental que provocan a la vez que se genera un nuevo producto y se fomentan hábitos ecológicos en casa

Estado actual da aquacultura na selva peruana: caso de Loreto / Current status of aquaculture in the Peruvian jungle: the case of Loreto

El propósito de la investigación fue determinar las características de la actividad acuícola del departamento de Loreto. Se aplicó un cuestionario a 141 acuicultores de los distritos de Nauta, San Juan Bautista e Indiana. Los resultados muestran que el 64% de los Centros Acuícolas son de tipo AREL y el 36% del tipo AMYPE. Además, el 83.69% de los centros acuícolas  tienen un nivel de producción baja (< 3,5 TM), predominando los Centros Acuícolas con 1-2 estanques de tierra, se evidencia su poca capacidad de gestión y escaso uso de tecnología, solo el  31.9% realizan análisis del agua en los estanques y una vez al mes(restándole eficacia a este dato), aplica baja densidad de carga, usa menos de la cuarta parte de cal de lo recomendado, usa alto nivel de alimento balanceado (por su alto costo) sustituyéndolo por alimento natural lo que alarga el periodo de cultivo con pesos menores a lo capturado en los ríos. Se concluye que en la Región Loreto predomina el policultivo de (sábalo y/o gamitana) con una producción acuícola con escasa tecnificación en el manejo del recurso hídrico y el cultivo propiamente dicho, teniendo como resultado cultivos con baja densidad de sembrado, inversión, etc

The outcome of peripheral t-cell lymphoma patients failing first-line therapy: A report from the prospective, international t-cell project

This analysis explored factors influencing survival of patients with primary refractory and relapsed peripheral T-cell lymphomas enrolled in the prospective International T-cell Project. We analyzed data from 1020 patients with newly diagnosed disease, enrolled between September 2006 and December 2015. Out of 937 patients who received first-line treatment, 436 (47%) were identified as refractory and 197 (21%) as relapsed. Median time from the end of treatment to relapse was 8 months (range 2-73). Overall, 75 patients (8%) were consolidated with bone marrow transplantation, including 12 refractory and 22 relapsed patients. After a median follow up of 38 months (range 1-96 months) from documentation of refractory/relapsed disease, 440 patients had died. The median overall survival (OS) was 5.8 months; 3-year overall survival rates were 21% and 28% for refractory and relapsed patients, respectively (P12 months, HR 0.57, P=0.001) and salvage therapy with transplantation (HR=0.36, P<0.001) were associated with a better OS. No difference was found in OS with respect to histology. This study accurately reflects outcomes for patients treated according to standards of care worldwide. Results confirm that peripheral T-cell lymphomas patients had dismal outcome after relapse or progression. Patients with chemotherapy sensitive disease who relapsed after more than 12 months might benefit from consolidation bone marrow transplantation. (Registered at clinicaltrials.gov identifier: 01142674)

Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb^-1. The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b-hadrons in jets are reconstructed using information from the tracking detectors, or a muon-based method where the presence of a muon is used to identify semileptonic decays of b-hadrons inside jets. The inclusive b-jet cross-section is measured as a function of transverse momentum in the range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet cross-section is measured as a function of the dijet invariant mass in the range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets and the angular variable chi in two dijet mass regions. The results are compared with next-to-leading-order QCD predictions. Good agreement is observed between the measured cross-sections and the predictions obtained using POWHEG + Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet cross-section. However, it does not reproduce the measured inclusive cross-section well, particularly for central b-jets with large transverse momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final version published in European Physical Journal

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum