84 research outputs found
Global economic burden of unmet surgical need for appendicitis
- Author
- Aahlin E. K.
- Aamer A.
- Aaniana K.
- Ababneh A.
- Abaliksta T.
- Abantanga F.
- Abbas M.
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- Zulkifli A.
- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A.
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R.
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O.
- Ademuyiwa Adesoji O.
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O.
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
- Ahmed Lopna Ahmed Mohamed
- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
- Ajah Jonathan
- Ajai Olalekan
- Ajao Akinlabi
- Ajiboye Anthony
- Akoto Elliot
- Akpenyi Onyinye
- Al Amin Shadid
- Al Attar Samaa Mahmoud
- Al Barraw Fayez Elian
- Al Bastawis Fatema
- Al Meligy Amgad
- Al Rafati Ahmad Abdel Razaq
- Al Raouf Eman Abd
- Al Saied Ghiath
- Al Subaie Norah
- Al-Bahrani Ahmed
- Al-Buhaisi Alaa
- Al-Dakka Emad
- Al-faqawi Maha
- Al-farram Hadeel
- Al-khatib Ahmed
- Al-Marakby Dina
- Al-saqqa Sara
- Al-Saqqa Sara W.
- Al-Slaibi Ibrahim
- Al-taher Taher
- AlaaelDein Shahinaz
- Alada Muslimat
- Alakaloko Felix
- Alaloul Enas
- Alamin Shadid
- Alamoudi Mohammed
- Albiety Adel
- Alcca Ticona Willy
- Alejos Bermudez Ysabel Esthefany
- Alexander Philip
- Alexander Philip
- Alexandre Challine
- Alghamdi Ahmed
- Alghamdi Mohammed Saleh A.
- Alhady Khaled
- Alhammali Tariq
- Alhassan Basmah
- Alhazmi Wedyan
- Alherz Mohammad
- Ali Ahmed
- Ali Citra Dewi Mohd
- Ali Elsayed
- Ali Safia
- Ali Syed Abdul Wahhab Eusoffee Wan
- Ali Tebian Hassanein Ahmed
- Ali Wadah
- Alihonou Thierry
- Alis Halil
- Aliyu Halima
- Aliyu Mohammad
- Aliyu Shamsudeen
- Aljboor Khaled
- Aljiffry Murad
- Alkaaki Aroub
- Alkelani Muhammad
- Allam Meran
- Allam Yomna
- Alnaby Mohamed Hassab
- Alnusairat Aseel
- Alqahtani Saleh
- Alsaggaf Mohammed Ubaid
- Alser Osaid H.
- Alshareef Reham
- Altaf Abdulmalik
- Altamimi Abdullah
- Altamimi Afnan
- Altamini Afnan
- Altarayra Marwa
- Altibi Ahmed
- Altinel Yuksel
- Altinel Yuksel
- Altwijri Abdulaziz
- Alvi Abdul Rehman
- Aly Mohammed Yahia Mohamed
- Alyacoubi Said
- Alyahya Reem
- Alzahrani Ahmed
- Aman Nowrin F.
- Amandito Radhian
- Amandito Radhian
- Ambrona-Zafra David
- Amin Hager Abdul Aziz
- Amjad Mohammadasim
- Amoah Michael
- Amoako Joachim
- Amoako Philip Taah
- Amoako-Boateng Mabel
- Amole Isaac
- Amreia Mahmoud
- Anderson Frank
- Andika Ferry Fitriya Ayu
- Andreotti Dario
- Andress Cedar
- Andriola Valeria
- Ang Yun Lin
- Angelieri Daniele
- Anis Echaieb
- Ansaloni Luca
- Ansaloni Luca
- Ansaloni Luca
- Antezana Diego
- Anthoulakis Christos
- Antoniozzi Angelo
- Anwar Nourhan
- Anyanwu Lofty-John
- Aonzo Paolo
- Appeadu-Mensah William
- Appiah Eric Kofi
- Aquilino Fabrizio
- Arafa Omar
- Arafa Sara
- Arango Maria Clara Mendoza
- Arcudi Claudio
- Armellini Andrea
- Arnaud Alexis
- Arnaud Alexis Pierre
- Arshad Mohammad Mohsin
- Arslan Ekin
- Arsyad Hasbi Maulana
- Arthur Tom
- Aruldas Neerav
- Asar Yomna Hosny
- Asare-Bediako Kwasi
- Ashour Ahmad
- Ashour Ahmad
- Ashour Khlood
- Ashtari Morvarid
- Asi Fatema
- Asilah Siti Mohd Desa
- Assal Abdelrahman
- Asturias Sabrina
- Asumah Hamza
- Ata Ahmed
- Ata Aya Yehia
- Atiyeh Anwar
- Atkins Ebenezer Takyi
- Attia Attia
- Augestad Knut Magne
- Aviles Susan
- Avoka Anthony
- Awad Israa
- Awad Sawsan Adel
- Awadallah Salwa
- Ayandipo Omobolaji
- Aydin Mehmet Can
- Aziz Dayang Nita Abdul
- Aziz Mohamed Rezal Abdul
- Aziz Nora Abdul
- Azizeldine Mohammed G.
- Azzie Georges
- Azzis Olivier
- Baba Suleiman
- Bachri Houda
- Badawy Mahmoud
- Badenjki Mohamed Adel
- Badicel Maria
- Badr Mohamed Fawzy Mahrous
- Badwi Nermin Mohamed
- Bahar Suraya
- Baillie Katie
- Baki Bahadir Emre
- Bakr Ahmad
- Bakry Hesham Mohammed
- Bala Miklosh
- Balalis Dimitrios
- Balducci Genoveffa
- Ballouhey Quentin
- Balmaceda Ruben
- Balmaceda Ruben
- Balogun Fatai
- Baltrunas Robertas
- Baluch Fatima
- Bamford Rebecca
- Bamicha Athanasia
- Banaitis Vincas Jonas
- Bandi Ashwath
- Bandoh Dickson
- Bani-Sadar Ahmad
- Banipal Gurpreet Singh
- Baquero Suarez Alibeth Andres
- Baraka Heba
- Barendegere Venerand
- Barkolias Christos
- Barmayehvar Behrad
- Barnabas Gandau Naa
- Barrios Emmanuel
- Basilico Silvia
- Basir Elissa Rifhan Mohd
- Bassem Monica
- Bassit Khalil Abdul
- Basso Stefano M. M.
- Bayram Sefa
- Beamon Mieshia
- Bedada Alemayehu Ginbo
- BediakoBowan Antoinette
- Bekhet Amira Hassan
- Bekhet Nada Mohamed
- Beleno Alvaro Enrique Mendoza
- Belkouchi Abdelkader
- Belli Andrea
- Bello Bashir
- Benammi Sarah
- Benevento Angelo
- Bennai Redouane Mammar
- Bentounsi Zineb
- Benyaiche Chaymae
- Berti Stefano
- Bertuello Isaac
- Beuran Mircea
- Bhangu Aneel
- Bhangu Aneel
- Bhangu Anna
- Bhatnagar Ankur
- Bhopal Kamran Faisal
- Bianco Federica
- Bigaran Annamaria
- Billy Matthew
- Bin Adnan Ahmad
- Bin Hasnan Muhammad
- Bin Ismail Mohamad Jeffrey
- Birindelli Arianna
- Bisset Carly
- Bjorklund Ida
- Blacker Sarah
- Blackwell James
- Blanco Ruth
- Blanco-Colino Ruth
- Blencowe Natalie
- Bliksoen Marte
- Bluelle Rafael
- Bocchetti Tommaso
- Bode Chris
- Bodur Selim
- Boggon Adam
- Bonavia Karl
- Bonavina Luigi
- Bond-Smith Giles
- Bondin John
- Bondurri Andrea
- Boni Silvia
- Bonney William
- Borda-Luque Giuliano
- Borg Elaine
- Borg Elaine
- Bortolasi Luca
- Bottini Corrado
- Bougard Heather
- Boukhal Khaoula
- Bowabsak Alaa
- Bowling Kirk
- Bradulskis Saulius
- Bratu Matei
- Bratu Matei Razvan
- Breaud Jean
- Breistrand Michaela
- Breslin Ryan
- Brincat Svetlana Doris
- Broch Aline
- Brunoni Beatrice
- Bsisu Isam
- Bucci Luigi
- Buisson Philippe
- Bunting David
- Burger Sule
- Burmistrovas Andrius
- Bustangi Nasir
- Bustangi Nasir
- Butt Muhammad Talha
- Cakaloglu Haluk Cem
- Caliman Celeste
- Callan Rory
- Camilleri Georgette Marie
- Camilleri-Brennan Julian
- Campagnaro Tommaso
- Canta Calua Alexander
- Capito Carmen
- Carabott Kurt
- Carmela Lapitan Marie
- Carmona Juan Manuel
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- Pardo Gabriel
- Park Esther H. G.
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- Vilcinskas Mantas
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- Widiastini T. Ariani
- Widmer Lukas Werner
- Wijayarathna L. S.
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Wilson Michael
- Wimalge P. M. S. N.
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- Elsevier
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
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- Publication venue
- J Clin Oncol
- Publication date
- 01/01/2020
- Field of study
PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
- Author
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abatini C.
- Abbadessa F.
- Abbas A. M.
- Abbassi-Ghadi N.
- Abbott D.
- Abbott T.
- Abd Elazeem H. A. S.
- Abdalla M.
- Abdallah M.
- Abdel Al S.
- Abdel Jalil R.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarem M. M.
- Abdelkarim M.
- Abdelmajeed A.
- Abdelrahman A.
- Abdelrahman S.
- Abdelsamed A.
- Abdou M.
- Abdulkareem A.
- Abdulwahed E.
- Abdur-Rahman L.
- Abel M. K.
- Abellan M.
- Aboelkassem Ibrahim A.
- Abosamak N. E.
- Abou Chaar M. K.
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- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2021
- Field of study
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
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- Elfil M
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- Elhusseiny AAE
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- Elzowawi F
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- Espin-Basany E
- Espinoza F
- Essam A
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- Major P
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- Mak T
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- Makama J
- Makinde M
- Makupe A
- Malaga B
- Malavenda M
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- Malik P
- Malik TAM
- Mamdouh E
- Mamdouh R
- Manatakis DK
- Manchego Bautista AC
- Manchego Bautista AC
- Manfreda S
- Mangan C
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- Mangiapane M
- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
- Manrique Sila G
- Manrique Sila GC
- Manriquez-Reyes M
- Manrrique Sila G
- Mansor EY
- Mansour B
- Mansour S
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- Marcelo Delgado J
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- Mariani A
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- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
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- Mas R
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- Mat TNT
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- Mathew SW
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- Mattar O
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- Menegussi J
- Mensah E
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- Merlo MS
- Mesbah N
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- Metwally MM
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- Minguez Garcia J
- Minguez G
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- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
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- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
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- Moaty M
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- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
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- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
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- Monteleone M
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- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
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- Morandi E
- Moreira G
- Moreno SC
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- Morton R
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- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
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- Mowafy B
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- Nanthakumaran S
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- Naranjo Aristizaibal FA
- Narayanan R
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- Negida A
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- Nevieraite V
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- Nnajiuba H
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- Nowers J
- Nsengimana VJP
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- Nurqistan HD
- Nwabuoku E
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- Nwokoro C
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- Perez Velasquez CI
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- Pertersen Servin GR
- Pesenti G
- Petrikenas S
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- Pinkney T
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- Qureshi AU
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- Ramarez Cabrera CC
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- Razi SAU
- Razmdjou S
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- Razzaque J
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- Salah OM
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- Samaraweera DI
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- Sandoval Barrantes AM
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- Semiz A
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- Senanayake KJ
- Senanayake WSMKJ
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- Shahbaz AR
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- Snyder E
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
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- Solar Garcia L
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- Soldevila-Verdeguer C
- Soley R
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- Soltani N
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- Stefanopoulos A
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- Sundstrom SM
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- Tackie E
- Taddei A
- Tade A
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- Taha EMS
- Tahboub H
- Taher AA
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- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
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- Tammam A
- Tan C
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- Tan CY
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- Tan YK
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- Tanase A
- Tang A
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- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
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- Tawfik BA
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- Tawfik G
- Taylor F
- Teasdale E
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- Teasdale E
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- Tedeschi U
- Tedjaatmadja C
- Telfah MM
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- Tennakoon A
- Teo SY
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- Thabet W
- Thalgaspitiya SPB
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- Thanusan V
- Tharmalingam S
- Theodosopoulos T
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- Turkustani S
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- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
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- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldana M
- Valente Laufer LA
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Celis JM
- Vergara Mejia AG
- Verjee A
- Vermaas M
- Veronese E
- Vianna JGP
- Vicario E
- Vicenta Collado M
- Vida LC
- Vida LC
- Vilcinskas M
- Villa R
- Villalobos S
- Vimalachandran D
- Vincent J
- Violi P
- Visinskas P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Wael N
- Wagener M
- Wakefield R
- Waledziak M
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward AE
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick AM
- Waterman A
- Watson NF
- Watson NF
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein MS
- Weiser TG
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini TA
- Widmer LW
- Wijayarathna LS
- Wild JRL
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson MSJ
- Wilson MSJ
- Wimalge PMSN
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold TB
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong CS
- Wong CY
- Wong F
- Wong HY
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright NJ
- Xerri T
- Xerri T
- Yahaya MT
- Yakubu M
- Yallop L
- Yam SY
- Yang J
- Yap S
- Yaseen T
- Yaseen TM
- Yau JD
- Yavuz MA
- Ye J
- Yeang LJ
- Yee J
- Yeo LS
- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abady GG
- Abbasi-Kangevari M
- Abbasifard M
- Abd-Allah F
- Abedi V
- Abu-Rmeileh NM
- Abualhasan A
- Abushouk A
- Adebayo OM
- Agarwal G
- Agasthi P
- Ahinkorah BO
- Ahmad S
- Ahmadi S
- Aji B
- Akbarpour S
- Akinyemi RO
- Al Hamad H
- Al Montasir A
- Al-Raddadi RM
- Alahdab F
- Alif SM
- Alipour V
- Aljunid SM
- Almustanyir S
- Alvis-Guzman N
- Ancuceanu R
- Anderlini D
- Anderson JA
- Ansar A
- Antonazzo IC
- Arabloo J
- Arnlov J
- Artanti KD
- Aryan Z
- Asgari S
- Ashraf T
- Athar M
- Atreya A
- Ausloos M
- Bach XT
- Baig AA
- Baltatu OC
- Banach M
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barone MTU
- Basu S
- Bazmandegan G
- Beghi E
- Beheshti M
- Bejot Y
- Bell AW
- Bennett DA
- Bensenor IM
- Bezabhe WM
- Bezabih YM
- Bhagavathula AS
- Bhardwaj P
- Bhattacharyya K
- Bijani A
- Bikbov B
- Bin Zaman S
- Birhanu MM
- Bisignano C
- Boloor A
- Bonny A
- Brauer M
- Brenner H
- Bryazka D
- Butt ZA
- Campos-Nonato IR
- Cantu-Brito C
- Carrero JJ
- Castaneda-Orjuela CA
- Catapano AL
- Chakraborty PA
- Charan J
- Choudhari SG
- Chowdhury EK
- Chu D-T
- Chung S-C
- Colozza D
- Costa VM
- Costanzo S
- Criqui MH
- D'Amico E
- Dadras O
- Dagnew B
- Dai X
- Dalal K
- Damasceno AAM
- Dandona L
- Dandona R
- Davletov K
- De La Cruz-Gongora V
- Desai R
- Dhamnetiya D
- Dharmaratne SD
- Dhimal M
- Dhimal ML
- Diaz D
- Dichgans M
- Dokova K
- dos Santos FLC
- Doshi R
- Douiri A
- Duncan BB
- Eftekharzadeh S
- Ekholuenetale M
- El Nahas N
- El-Jaafary S
- Elgendy IY
- Elhadi M
- Endres M
- Endries AY
- Erku DA
- Faraon EJA
- Farooque U
- Farzadfar F
- Feigin VL
- Feroze AH
- Filip I
- Fischer F
- Flood D
- Gad MM
- Gaidhane S
- Gela JD
- Ghashghaee A
- Gheshlagh RG
- Ghith N
- Ghozali G
- Ghozy S
- Gialluisi A
- Giampaoli S
- Giang TV
- Gilani SA
- Gill PS
- Gnedovskaya E
- Golechha M
- Goulart AC
- Guo Y
- Gupta R
- Gupta VB
- Gupta VK
- Gyanwali P
- Hafezi-Nejad N
- Hamidi S
- Hanif A
- Hankey GJ
- Hanson SW
- Hargono A
- Hashi A
- Hassan TS
- Hassen HY
- Havmoeller RJ
- Hay S
- Hayat K
- Hegazy M
- Herteliu C
- Holla R
- Hostiuc S
- Househ M
- Huang J
- Humayun A
- Hwang B-F
- Iacoviello L
- Iavicoli I
- Ibitoye SE
- Ilesanmi OS
- Ilic IM
- Ilic MD
- Iqbal U
- Irvani SSN
- Islam SMS
- Ismail NE
- Iso H
- Isola G
- Iwagami M
- Jabbari SHY
- Jacob L
- Jain V
- Jang S-I
- Jayapal SK
- Jayaram S
- Jayawardena R
- Jeemon P
- Jha RP
- Johnson CO
- Johnson WD
- Jonas JB
- Jonasson JM
- Joseph N
- Jozwiak JJ
- Jurisson M
- Kalani R
- Kalhor R
- Kalkonde Y
- Kamath A
- Kamiab Z
- Kan FP
- Kanchan T
- Kandel H
- Kandel SN
- Karch A
- Katoto PDMC
- Kayode GA
- Keshavarz P
- Khader YS
- Khan EA
- Khan IA
- Khan M
- Khan MAB
- Khatib MN
- Khubchandani J
- Kim GR
- Kim MS
- Kim YJ
- Kisa A
- Kisa S
- Kivimaki M
- Kolte D
- Koolivand A
- Koyanagi A
- Krishan K
- Krishnamoorthy V
- Krishnamurthi R
- Kumar GA
- Kusuma D
- La Vecchia C
- Lacey B
- Lak HM
- Lallukka T
- Lasrado S
- Lavados PM
- Laxminarayana SLK
- Leonardi M
- Li B
- Li S
- Lin H
- Lin R-T
- Linh GV
- Liu X
- Lo WD
- Lorkowski S
- Lucchetti G
- Magnani FG
- Mahajan PB
- Majeed A
- Makki A
- Malekzadeh R
- Malik AA
- Manafi N
- Mansournia MA
- Mantovani LG
- Martini S
- Mazzaglia G
- Mehndiratta MM
- Menezes RG
- Meretoja A
- Mersha AG
- Miazgowski B
- Miazgowski T
- Michalek IM
- Mirrakhimov EM
- Moghaddam SS
- Mohammad Y
- Mohammadian-Hafshejani A
- Mohammed S
- Mokdad AH
- Mokhayeri Y
- Molokhia M
- Moni MA
- Moradzadeh R
- Morawska L
- Morze J
- Murray CJL
- Muruet W
- Musa KI
- Nagarajan AJ
- Naghavi M
- Nascimento BR
- Negoi RI
- Norrving B
- Noubiap JJ
- Nwatah VE
- Oancea B
- Odukoya OO
- Olagunju AT
- Orru H
- Owolabi MO
- Padubidri JR
- Pana A
- Parekh T
- Park E-C
- Pathak M
- Peres MFP
- Perianayagam A
- Piradov MA
- Podder V
- Polinder S
- Postma MJ
- Pourshams A
- Radfar A
- Rafiei A
- Raggi A
- Rahim F
- Rahimi-Movaghar V
- Rahman M
- Rahman MA
- Rahmani AM
- Rajai N
- Ranasinghe P
- Rao CR
- Rao SJ
- Rathi P
- Rawaf DL
- Rawaf S
- Razek HMAE
- Reitsma MB
- Renjith V
- Renzaho AMN
- Rezapour A
- Rodriguez JAB
- Roever L
- Romoli M
- Roth GA
- Rynkiewicz A
- Sacco S
- Sadeghi M
- Sahebkar A
- Saif-Ur-Rahman K
- Salah R
- Salih YA
- Salman RA-S
- Samaei M
- Samy AM
- Santos IS
- Santric-Milicevic MM
- Sarrafzadegan N
- Sathian B
- Sattin D
- Saute RL
- Schiavolin S
- Schlaich MP
- Schmidt MI
- Schutte AE
- Sepanlou SG
- Seylani A
- Sha F
- Shahabi S
- Shaikh MA
- Shannawaz M
- Shawon MSR
- Sheikh A
- Sheikhbahaei S
- Shibuya K
- Siabani S
- Silva DAS
- Singh JA
- Singh JK
- Skryabin VY
- Skryabina AA
- Sobaih BH
- Stark BA
- Stortecky S
- Stranges S
- Swamy SN
- Tadesse EG
- Tahbaz SV
- Tarigan IU
- Temsah M-H
- Teuschl Y
- Thrift AG
- Tonelli M
- Tovani-Palone MR
- Trang HN
- Tripathi M
- Truong-Minh P
- Tsegaye GW
- Ullah A
- Unim B
- Unnikrishnan B
- Vakilian A
- Vasankari TJ
- Venketasubramanian N
- Vervoort D
- Vo B
- Volovici V
- Vosoughi K
- Wafa HA
- Waheed Y
- Wang Y
- Wijeratne T
- Winkler AS
- Wolfe CDA
- Woodward M
- Wu JH
- Xu X
- Yadav L
- Yadollahpour A
- Yamagishi K
- Yatsuya H
- Yonemoto N
- Yu C
- Yunusa I
- Zaman MS
- Zamanian M
- Zand R
- Zandifar A
- Zastrozhin MS
- Zastrozhina A
- Zhang Y
- Zhang Z-J
- Zhong C
- Zuniga YMH
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 01/10/2021
- Field of study
Background:
Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels.
Methods:
We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level.
Findings:
In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]).
Interpretation:
The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
Funding:
Bill & Melinda Gates Foundation
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
- Abuajaila A
- Abuattaya AA
- Abubakar AM
- Abueideh A
- Abuhayyeh HA
- Abuhlega MA
- Abukhalaf S
- Abumunshar AA
- Acuna G
- Adams S
- Adamu S
- Adanan MFSBM
- Adawi I
- Adawi S
- Adawy A
- Ade-Ajayi N
- Adegboyega R
- Ademuyiwa A
- Adesanya O
- Adhiwidjaja CF
- Adofo-Ansong N
- Agboola TH
- Agelebe E
- Aguiar AA
- Aguilar FA
- Aguirre-Lopez P
- Agulham MA
- Ahmad H
- Ahmad ZAH
- Ahmed H
- Ahmed MA
- Ajai OT
- Ajao EA
- Ajiboye OS
- Ajrami Y
- Akan ME
- Akhbari M
- Akhter N
- Akova F
- Al Dammagh NM
- Al Hussein S
- Al Massry NA
- Al Quran TM
- Al-Attar HM
- Al-Halbouni L
- Al-Mamun A
- Al-Mayoof AF
- Al-Momani HM
- Al-Mouakeh A
- Al-Rayyes M
- Al-Salhi AA
- Al-Shwaikh SH
- Al-Slaibi I
- Al-Taher RN
- Al-Taher RN
- Al-Tammam H
- Alakaloko F
- Alattas K
- Alberto C
- Albozidi A
- Alcantara E
- Aldirawi MAM
- Alebbini MM
- Alfoghi M
- Algabri HNO
- Alglaib MM
- Alhamid A
- Alhamid A
- Alhassan P
- Ali H
- Ali KO
- Ali L
- Ali M
- Alijla S
- Alijla SS
- Aliwisat AH
- Aljaboo H
- Aljadidi WOFS
- Aljarad Z
- Alkali YS
- Alkareem RMA
- Almada SA
- Almadhoun W
- Almasri M
- Almeida G
- Almengar I
- Almohamady H
- Almosaibli M
- Almusleh TFH
- Alnaeri A
- Alnahhal K
- Alonso V
- Alosta HM
- Alqarajeh F
- Alqor MOI
- Alsaadi NN
- Alsaggaf A
- Alsaied A
- Alser M
- Alser OH
- Alshaikhkhalil HAA
- Alshehri A
- Altamirano PR
- Altaweel A
- Altin M
- Altokhais T
- Altomi M
- Alturki F
- Alva LRC
- Alvarez JR
- Alwadia SMS
- Alwaggaa NA
- Alzamari AAM
- Alzeer AMS
- Alzerei ST
- Alzraikat SH
- Alzubair A
- Alzughayyar TZ
- Amad M
- Amado F
- Amaechi C
- Amah CC
- Amarin JZ
- Amarin M
- Ambriz-Gonzalez G
- Ameh E
- Amoabin AA
- Anatole N
- Anatole NK
- Anaya F
- Anaya WB
- Andrade J
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- Annajjar MH
- Anntinea J
- Antunes A
- Antunez-Mora A
- Anyomih TTK
- Anzelewicz S
- Appeadu-Mensah W
- Arabiat E
- Arafa MA
- Arafat H
- Aragao L
- Arancibia JAC
- Arar AS
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- Arboleda J
- Aremo A
- Argomedo MRO
- Arnadottir H
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- Arnoletto LB
- Arrmali S
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- Arshad M
- Arthur F
- Arul S
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- Ashour YS
- Aslan Y
- Aspirot A
- Assi A
- Assi MAF
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- Atatri YYM
- Atta A
- Attia AM
- Aucatoma FC
- Augusto MLDS
- Avila DC
- Avile R
- Avolio L
- Awad H
- Aydin E
- Aykut M
- Aziz DAA
- Ba'baa' B
- Badr H
- Baertschiger R
- Bagbio D
- Bah A
- Bai Q
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- Baistrocchi V
- Baker W
- Ballah AM
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- Bamanga A
- Baniowda MAM
- Bao X
- Barauskas V
- Barbosa PR
- Barcelos FZ
- Baron JDJC
- Barreto JJS
- Barros BS
- Baseggio N
- Bashir F
- Bashir MK
- Bataineh ZA
- Batal MM
- Bazozi HM
- Beasley S
- Becker K
- Belesa FDA
- Beloy IC
- Beltran NS
- Ben Enbaya M
- Benaskeur Y-I
- Benavente CM
- Beres A
- Berkova K
- Bernaus M
- Berzanskis M
- Beshtawi DMS
- Besir A
- Bianchin E
- Bibas F
- Biber E
- bin Abdullah MY
- Bin Amjad M
- bin Bujarimin AS
- bin Hassan MR
- Bin Othman MY
- bin Zahari Z
- bin Zarwawi AZ
- Bischoff C
- Blain OE
- Blanc T
- Blanchet EB
- Blazquez-Gomez E
- Blom MD
- Bode C
- Bonnard A
- Boonthai A
- Borbonet D
- Borges CG
- Bouhadiba N
- Bowder A
- Bradshaw K
- Bragagnini P
- Brahmamdam P
- Bravo MN
- Bravo MRDT
- Brenner NK
- Bright BP
- Broch A
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- Bruxel CL
- Bsisu I
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- Burgos CM
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- Bvulani B
- Caamal LJ
- Cai D
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- Camacho FRC
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- Canozer A
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- Carbajal LF
- Carloni ICS
- Carrasco AL
- Carrasco-Ortega C
- Carrillo I
- Casado FT
- Caseb P
- Casquero V
- Castaneda FDMD
- Castillo MN
- Cavaiuolo S
- Cekic B
- Celik M
- Centen SV
- Cepeda R
- Cesur IB
- Chan J
- Chang J
- Charras MD
- Chaudary AR
- Chaudhry MA
- Chauhan N
- Chen J
- Chen L
- Chen R
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- Chipalavela RF
- Chipana CLA
- Chiriboga E
- Chiroque CM
- Chitiavi SW
- Chitnis M
- Cho SH
- Choo CSC
- Chukwu I
- Chukwuemeka AL-J
- Chung JH
- Cino EL
- Cletus C
- Coghill G
- Collins N
- Comert HSY
- Contreras CS
- Coon J
- Cordonnier A
- Cordova KH
- Cornelli F
- Cornwall H
- Corona MQ
- Correa A
- Correa C
- Cortez LFG
- Cosoreanu V
- Costa EC
- Costas-Chavarri A
- Cripovich A
- Cruzado GJS
- Cunningham A
- Cury EK
- Czauderna P
- da Cunha AG
- da Silva EAD
- da Silva JAN
- da Silva KI
- Dagilyte R
- Daher AP
- Dahman NBH
- Dalek NFRA
- Dallegre MB
- Dalloul H
- Damiani A
- Dania B
- Darras OM
- Darwish A
- Darwish AS
- Dass A
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- Davis JK
- de Almeida TL
- de Andrade SO
- de Fernandez y Alcazar FR
- de Fraga JCS
- de Guzman J
- de Holanda FC
- De La Cruz RR
- de Oliveira DF
- de Oliveira DP
- de Souza RF
- de Vos C
- Dedeke F
- Defago VH
- Defert C
- Delefortrie T
- Delforge X
- Dendusic N
- Derbew M
- Derks T
- Deya C
- Deyab A
- Deyl RT
- Di Siervi O
- Dias AIBDS
- Dieudonne L
- Dimatatac DM
- Djordjevic I
- do Nascimento SD
- Dogar S
- Doheim MF
- Dominguez D
- Dominguez MA
- dos Santos CS
- dos Santos MSF
- Dosselman LJ
- Douiri A
- Drah W
- Dube AM
- Duchesne C
- Duggan E
- Dure C
- Ebeido A
- Echegaray MD
- Egbuchulem IK
- Ejinkeonye EC
- Ekenze SO
- Ekwunife OH
- El Tallaa MA
- El-Ghazaly M
- Elassall GMH
- Elayeb A
- Elebute OA
- Elewaily M
- Elfiky M
- Elgammudi M
- Elghazaly SM
- Elhadi A
- Elhadi M
- Elhajjaji YA
- Elhattab A
- Elias RA
- Elisante J
- Elkaloush AA
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- Elsiraffy OO
- Elstad M
- Elzohiri M
- Elzowawi F
- Emam OS
- Emil S
- Ensar N
- Ercin S
- Erdem M
- Eren E
- Ergenekon E
- Eroglu E
- Erturk N
- Eshkabilov S
- Espineda B
- Espinosa SC
- Espinoza PP
- Essa TM
- Essamilghi KAM
- Ezidiegwu US
- Ezomike UO
- Faboya OM
- Fachin C
- Fadhle MJ
- Fajardo GYP
- Faks V
- Falah EH
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- Feliz E
- Ferdinando DLT
- Ferdousi T
- Fernandez JY
- Ferreira JL
- Ferreira MDSS
- Ferrer MF
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- Fourcade L
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- Gadepalli S
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- Galvez PC
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- Garcia I
- Garcia M
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- Gargum SA
- Gargurevich PPA
- Garnier H
- Garrett-Cox R
- Gasana G
- Gashugi IS
- Gatzinsky V
- Gavrila B
- Gavrilovska-Brzanov A
- Gee O
- Gerus S
- Geze S
- Ghabayen ATS
- Ghallab A
- Ghaly KAE
- Ghanem WH
- Ghayth S
- Ghazzawi I
- Ghorab IA
- Ghosh D
- Gilardi J
- Giovanoni LS
- Goddard L
- Goebel P
- Gohil H
- Gomes AL
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- Gomez JMD
- Gomez O
- Goncalves PCB
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- Gonzalez CCP
- Gonzalez DE
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- Gosain A
- Grabowski A
- Graneli C
- Greenberg J
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- Grosos C
- Grottling E
- Grynberg L
- Guadagno E
- Guayelema M
- Guazzotti M
- Guerin F
- Guimaraes P
- Guinsburg R
- Guisse C
- Guo X
- Gurgel do Amaral AC
- Gurskas P
- Gutierrez EA
- Gutierrez NT
- Guzman NJT
- Habiba A
- Hagander L
- Hagander L
- Haidari SA
- Haider N
- Hajajreh MS
- Hakan N
- Halabi YA
- Hall N
- Hall T
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- Hamidi N
- Hamidovic A
- Hamill J
- Hamilton A
- Hammato AY
- Hammond P
- Hammouri AG
- Hamzah SNABH
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- Hanifah NABM
- Haraux E
- Harilal S
- Harper L
- Hasan S
- Hasan S
- Hasanain DK
- Hashim HHB
- Hashim I
- Hashim S
- Hassan MA
- Hassan MYM
- Hassan ZBM
- Herdan MO
- Herrera C
- Herrera L
- Hery G
- Hinojosa AS
- Hinostroza D
- Hisham I
- Hodgman E
- Honhar M
- Horacio B
- Horozic D
- Hospital SI
- Hossini SL
- Hu D
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- Huang S
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- Huespe E
- Hukic L
- Huq U
- Hussain SR
- Hussein OG
- Hussien M
- Hwang IJ
- Hyeon CS
- Hyman G
- Ibarra D
- Ibrahim EAA
- Ibrahim F
- Ibrahim MA
- Ibukunolu O
- Igoche M
- Ihediwa G
- Imamoglu M
- Ionescu S
- Iracelay S
- Iriondo M
- Ishak S
- Ismail EM
- Ismavel VA
- Isolan PMBS
- Itangishaka I
- Ivanov M
- Jabaiti MS
- Jabang JN
- Jaber D
- Jacobson J
- Jain S
- Jaiteh M
- Jallow CS
- Jalo I
- Jamal MU
- Jaramillo M
- Jauregui L
- Jauri C
- Jayaratnam S
- Jeremie N
- Jester I
- Joda AE
- Joharifard S
- Johnson S
- Jones B
- Jones C
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- Jonuzi A
- Jooma U
- Joubeh S
- Jovcheski L
- Juhasz L
- Julio L
- Junes MDC
- Juricic M
- Jusabani M
- Jyun KWY
- Kader S
- Kalicinsk P
- Kamel TM
- Kamilovski M
- Kannessan H
- Kano Y
- Kapihya C
- Karabulut R
- Karakus SC
- Karamustafic A
- Karavdic K
- Karim S
- Karim S
- Kaya H
- Kayed YIO
- Kayibanda E
- Kchiche N
- Kcomt SG
- Kelay A
- Keles E
- Keshtgar A
- Khaled A
- Khalel WIA
- Khalid HM
- Khamag O
- Khatatba LZA
- Khattak MAK
- Khlevner J
- Khorana J
- Kihiko D
- Kim H-Y
- King S
- Kist IN
- Kluppel EN
- Knorr C
- Knurowska A
- Kohaut J
- Koipapi S
- Korlacki W
- Koshy RM
- Kostic A
- Koszutski T
- Kowalewsk G
- Krause H
- Krayem Y
- Krisanova D
- Krishnaswami S
- Kufeji D
- Kukkady A
- Kumar V
- Kumolalo FO
- Kunfah SMP
- Kurian M
- Kurt G
- Kwasau H
- Laberge J-M
- Labonia C
- Ladino AMF
- Ladipo-Ajayi O
- Lahlooh RA
- Lakhoo K
- Lander T
- Langer M
- Langley J
- Lapouble F
- Lara S
- Latiff ZA
- Lawal T
- Lawalbarau A
- Layas T
- Laymouna MA
- Le Gall C
- Leal PO
- Leather AJM
- Lechmiannandan A
- Lee JY
- Lee S
- Leech M
- Leite MTC
- Leles KDDP
- Leon CD
- Leon JLA
- Leon NRM
- Lerma S
- Letic E
- Levard G
- Levitt M
- Leyba MF
- Li H
- Li S
- Li Z
- Liang L
- Liljesthrom K
- Lim F
- Lin N
- Lindert J
- Liu Y
- Liubsys A
- Liukitithara S
- Liyenzero PO
- Ljuhar D
- Lobos P
- Lodhia J
- Lofberg K
- Losa GN
- Losty P
- Lotfollahzadeh S
- Lu J
- Lubbad W
- Lucio P
- Lui Y
- Lukac M
- Lule J
- Luo W
- Lv J
- Lv Z
- Lyttle BD
- Mac C
- Macdonald A
- Machado ABS
- Machemedze S
- Madieh J
- Madziba S
- Magro NMH
- Mahmoud AM
- Mahmud K
- Mahmud R
- Mairami AB
- Maistry N
- Makepeace LM
- Makhmud A
- Malaga FPD
- Malcius D
- Maldonado JEG
- Malik J
- Malik S
- Mancera J
- Mangray H
- Manirambona E
- Manjira E
- Manni F
- Mansfield S
- Mansour I
- Mansour MA
- Manteola ER
- Marcos D
- Marianella D
- Marin AM
- Marmol M
- Marques GMN
- Marta O
- Martin AD
- Martin B
- Martinez HG
- Martinez-Leo B
- Martins BMR
- Matias MA
- Matos JPV
- Matour BM
- Mazzuca RB
- Mbonicura JC
- Mbonisweni A
- Mccluney S
- Medard P
- Meftah A
- Mellado DH
- Meloche-Dumas L
- Mena A
- Mendizabal DB
- Menin FA
- Mercado P
- Mert MK
- Mesic A
- Meyer KF
- Michael V
- Middlesworth W
- Middleton T
- Mieres C
- Mikneviciute A
- Milisic E
- Millan C
- Miranda CT
- Miriam A
- Mironescu A
- Mirza MB
- Misk RA
- Mitul A
- Mitul AR
- Modekwe V
- Modi V
- Mohammad MA
- Mohammed A
- Mohammed AA
- Mohammed HM
- Mohammed KA
- Mohammed MM
- Mohammed OAA
- Moitt N
- Molina M
- Molinelli M
- Monawar AB
- Montoya D
- Moore AC
- Mora M
- Moraes M
- Morales A
- Morales LB
- Morales O
- Morejon VJ
- Moreno ME
- Mori FT
- Moriya E
- Morjan M
- Mose M
- Motee J
- Motter SB
- Motter SB
- Mounira BNEI
- Mouti MB
- Mouttalib S
- Mshelbwala PM
- Msuya D
- Mugambi S
- Mugo R
- Muhic A
- Mulu J
- Mumtaz U
- Munoz G
- Muntean L
- Murad AMI
- Muradi T
- Muragijimana JDD
- Muraveji Q
- Murillo IVE
- Murshidi RM
- Murtadi HM
- Murzaie MY
- Muslimovich AM
- Mussein HM
- Mustufa H
- Mutlu M
- Mvukiyehe JP
- Mwai T
- Nageh M
- Nah SA
- Naidoo R
- Naim NABM
- Naim SRR
- Naranjo K
- Nassar I
- Nataraja RM
- Naumeri F
- Naunova VC
- Ndata A
- Ndayishimiye I
- Ndungu J
- Negash S
- Negida A
- Negrete A
- Nemer AA
- Nemer R
- Neyra MSL
- Nezerwa YC
- Ngerncham M
- Ngwenya S
- Nisar MU
- Niyukuri A
- Nkuliza D
- Nkunzimana E
- Nofal AH
- Noor WR
- Nor MTM
- Nour I
- Nour IR
- Nour IR
- Novotny N
- Nuntasunti W
- Nwangwu EI
- Nwankwo EP
- Nwosu DC
- O'Connor J
- O'Connor Z
- Obeso AS
- Obianyo NE
- Ochieng K
- Ochieng R
- Odi AA-NB
- Ogundoyin O
- Ojeda AG
- Olabisi OO
- Olanrewaju M
- Olayade K
- Olori S
- Olulana DI
- Omari RY
- Omling E
- Ortiz RS
- Osagie O
- Osazuwa M
- Oshiba AM
- Osman M
- Osowicka M
- Osuigwe AN
- Osuoji RI
- Otuneye AT
- Outani O
- Oviedo JJM
- Owiwi Y
- Owusu S
- Owusu-Sekyere F
- Oyebanji L
- Oyinloye A
- Ozcelik Z
- Ozen MA
- Pachl M
- Padilla CP
- Pajouhandeh F
- Palacios N
- Palomino AG
- Pandit GS
- Papa A
- Pardo L
- Pardo LM
- Pardy C
- Paredes ER
- Paredes VS
- Parigi GB
- Parker S
- Parmentier B
- Pasaoglu M
- Pasierbek M
- Pasqua N
- Patel A
- Patkowski D
- Patzer L
- Pauzi SFM
- Peraza JL
- Perez JO
- Perez MO
- Perez RD
- Pernik MN
- Pesara LMH
- Petel MR
- Peycelon M
- Phannua R
- Philipo GS
- Piche N
- Picon CMDJT
- Pigeolet M
- Pilkington M
- Pinar B
- Piotrowska A
- Planka L
- Poenaru D
- Poocharoen W
- Popovic N
- Porras JD
- Portilla EF
- Pos L
- Prabhu PS
- Prat J
- Puentes MC
- Puglia P
- Puig MG
- Puligandla P
- Putruele D
- Qabaja MM
- Qadomi AB
- Qawwash A
- Qi TTH
- Qudah HA
- Quevedo LMB
- Quinteros EFD
- Quiroz NH
- Qunaibi MAF
- Qureshi T
- Qutishat H
- Qwaider YZ
- Raboe E
- Rackova T
- Radwan AS
- Raffaele A
- Raicevic M
- Raj A
- Ramli NB
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- Rani Z
- Raposo JW
- Rasaki A
- Rashid S
- Rashwan H
- Ravetta P
- Ravi K
- Raymond KJ
- Raza R
- Reda A
- Rehman WU
- Rengura C
- Reuter C
- Rex D
- Reyes GY
- Rhodes H
- Ribas B
- Riboni C
- Rieth A
- Rincon LC
- Rissmann A
- Risteski T
- Rite S
- Rivarola NI
- Rivera AC
- Rivera JRCC
- Roberts CA
- Roberts K
- Roberts R
- Rojas N
- Rolle U
- Romano PG
- Rosa BR
- Rosas FA
- Roszkiewicz A
- Ruan W
- Rudolfson N
- Ruzgar N
- Rygl M
- Saad AM
- Saad MM
- Sabbatini S
- Sabic A
- Sabti S
- Sadagurschi M
- Sadek K
- Sadek M
- Safa N
- Safus A
- Sahnoun L
- Sahuanay VRC
- Salah M
- Salawu MM
- Salazar K
- Saldana L
- Saleem A
- Saleem M
- Saleh A
- Saleh M
- Salem HK
- Salha AAS
- Salim JM
- Salinas V
- Salo M
- Samad L
- Samadi AZ
- Samarah YA
- Samarakkody U
- Sambo YT
- Samy D
- San Miguel DO
- Sanchez A
- Sanchez B
- Sanchez CIA
- Sanchez J
- Sanchez JS
- Sanchez N
- Saousen B
- Sara N
- Saracevic A
- Sarhan OAK
- Sarihan H
- Sarkaz TL
- Sayeed F
- Sbaih MF
- Scalabre A
- Scherl H
- Schmedding A
- Schopf LF
- Sehic A
- Sehwiel AS
- Sekyere O
- Selak N
- Sempertegui D
- Serban AM
- Seref K
- Serezo B
- Sevdalis N
- Seyi-Olajide J
- Sferco CA
- Shabana OS
- Shahbal S
- Shaheen AA
- Shaheen N
- Shajin T
- Shaklawoon A
- Shalaby A
- Shalaby H
- Shalluf HA
- Shan CH
- Sharabati F
- Sharabati M
- Sharif M
- Sharif RAM
- Shaw K
- Shehada M
- Shehu I
- Sheir H
- Sherer K
- Sherzad A
- Shikha A
- Shinondo P
- Shnishah AE
- Shokri HA
- Shonubi A
- Shoubaki A
- Shu Q
- Siddiqui SM
- Sidler D
- Sigalet D
- Sihem B
- Sikwete G
- Silva E
- Silva J
- Silva MDA
- Silva RV
- Silva XG
- Silva Y
- Sim M
- Simeon T
- Simon S
- Sindi O
- Singer G
- Singh M
- Sivaraj J
- Sivasubramaniam M
- Siyotula T
- Skvaril J
- Slavkovi A
- Slavkovic M
- Smith ER
- Sobrero H
- Soccorso G
- Sokolovic E
- Sola J
- Solanki M
- Soldan CP
- Soliman NA
- Son J
- Song ES
- Sonmez K
- Soomro A
- Sotelo LO
- Souhem T
- Soula E
- Sowe B
- Sriniworn A
- St-Louis E
- St-Vil D
- Stark D
- Stichhauer R
- Stojanovic M
- Stringer M
- Strumila A
- Sueiras I
- Suleiman F
- Sultana S
- Sundeep PT
- Suradi HH
- Sutcliffe J
- Suzen A
- Svensson E
- Svirsky A
- Swessi H
- Syed S
- Syovata F
- Szklarz MT
- Tababa O
- Tabari AK
- Tabiri S
- Tadesse A
- Tahyneh AAA
- Takrouney MH
- Talat N
- Tamada H
- Tamaddun HFB
- Tang W
- Tanimola AG
- Tanming P
- Tanny ST
- Tantush SA
- Tarabishi AS
- Tarek A
- Tarmohamed M
- Tarniba SA
- Tarrado X
- Tasker D
- Tauffer MG
- Teague W
- Telles L
- Temilade BB
- Teo R
- Teran A
- Terzic S
- Testoni D
- Thaiwatcharamas K
- Thiessen J
- Thomas AH
- Thomas G
- Thomas MC
- Thompson H
- Till H
- Tillig B
- Tobor S
- Toczewski K
- Tom A
- Toplicic D
- Toral E
- Torres-Canchala L
- Toselli L
- Touabti S
- Toufik IA
- Trainba S
- Trein CS
- Trojanova B
- Trypens A
- Tumi M
- Turkyilmaz C
- Turkyilmaz Z
- Tuyishime E
- Ubhi H
- Ugwu JO
- Ugwunne CA
- Ulasi I
- Ullrich S
- Unchon GL
- Urquizo MML
- Vacek J
- Vaitkiene A
- Valencia S
- Valeria P
- Valerio-Vazquez R
- Valladares PS
- Vanis N
- Vaquila J
- Varela MF
- Vargas OP
- Vatta F
- Vazquez MEM
- vd Merwe E
- Velana J
- Velasco JJCR
- Vellusamy VMM
- Venant N
- Venkatraman SS
- Verdeata R
- Verduga L
- Vergara C
- Verkauskas G
- Veronica S
- Vervoort D
- Vianney BJM
- Vida L
- Vidal CRZ
- Vierboom L
- Villalba AV
- Vinskaite A
- von Bismarck S
- von Delft D
- Vosoughi A
- Wafa T
- Walker G
- Wang D
- Wang J
- Wang J
- Wang P
- Waseem B
- Weeratunga N
- Weiszewsk A
- Wen G
- Wester T
- Wijekoon N
- Wilke A
- Williams I
- Williams O
- Williams R
- Wilson MDF
- Win WSP
- Wishah BDM
- Wishah N
- Wissanji H
- Wolak P
- Wolny A
- Wong J
- Wong M
- Wright NJ
- Wu G
- Wyrzykowski D
- Xie H
- Yacoub MA
- Yaghi B
- Yaghi DH
- Yalcinkaya A
- Yang H-B
- Yanis AH
- Yao Y
- Yapo B
- Yeniay AO
- Yola MM
- Yong F
- Youn JK
- Yousuf H
- Yu M
- Yu R
- Yuen QS
- Yuldashev RZ
- Yunus A
- Zaghlol LY
- Zain M
- Zaman ASK
- Zanellato JB
- Zea-Salazar LE
- Zeinelabdeen A
- Zelada JA
- Zhao X
- Zhu J
- Zhu L
- Zidan M
- Zivanovic D
- Zreeg DAS
- Zurikat RO
- Zvizdic N
- Zvizdic Z
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18 : a modelling study
- Author
- Abbastabar Hedayat
- Abebo Zeleke H.
- Abosetugn Akine E.
- Abu-Gharbieh Eman
- Accrombessi Manfred M.
- Adebayo Oladimeji M.
- Adegbosin Adeyinka E.
- Adekanmbi Victor
- Adetokunboh Olatunji O.
- Adeyinka Daniel A.
- Ahinkorah Bright O.
- Ahmadi Keivan
- Ahmed Muktar B.
- Akalu Yonas
- Akinyemi Oluwaseun O.
- Akinyemi Rufus O.
- Aklilu Addis
- Akunna Chisom J.
- Al-Aly Ziyad
- Alahdab Fares
- Alam Noore
- Alamneh Alehegn A.
- Alanzi Turki M.
- Alemu Biresaw W.
- Alhassan Robert K.
- Ali Tilahun
- Alipour Vahid
- Amin Hawraz I.
- Amini Saeed
- Ancuceanu Robert
- Ansari Fereshteh
- Anteneh Zelalem A.
- Anvari Davood
- Anwer Razique
- Appiah Seth C.
- Arabloo Jalal
- Asemahagn Mulusew A.
- Asghari Mohammad A.
- Asmare Wondwossen N.
- Atnafu Desta D.
- Atout Maha M.
- Atreya Alok
- Ausloos Marcel
- Awedew Atalel F.
- Ayanore Martin A.
- Aynalem Yared A.
- Ayza Muluken A.
- Azari Samad
- Azene Zelalem N.
- Babar Zaheer-Ud-Din
- Baig Atif A.
- Balakrishnan Senthilkumar
- Banach Maciej
- Barnighausen Till W.
- Basu Sanjay
- Bayati Mohsen
- Bedi Neeraj
- Bekuma Tariku T.
- Bezabhe Woldesellassie M.
- Bhagavathula Akshaya S.
- Bhardwaj Pankaj
- Bhattacharyya Krittika
- Bhutta Zulfiqar A.
- Bibi Sadia
- Bikbov Boris
- Birhan Tsegaye A.
- Bitew Zebenay W.
- Bockarie Moses J.
- Boloor Archith
- Brady Oliver J.
- Bragazzi Nicola L.
- Briko Andrey N.
- Briko Nikolay I.
- Butt Zahid A.
- Cardenas Rosario
- Carvalho Felix
- Charan Jaykaran
- Chatterjee Souranshu
- Chattu Soosanna K.
- Chattu Vijay K.
- Chowdhury Mohiuddin A.
- Chu Dinh-Toi
- Cook Aubrey J.
- Cork Michael A.
- Cormier Natalie M.
- Cowden Richard G.
- Culquichicon Carlos
- Dagnew Baye
- Dahlawi Saad M.
- Damiani Giovanni
- Daneshpajouhnejad Parnaz
- Daoud Farah
- Daryani Ahmad
- das Neves Jose
- Defo Barthelemy K.
- Deribe Kebede
- Desta Abebaw A.
- Deuba Keshab
- Dharmaratne Samath D.
- Dhungana Govinda P.
- Diaz Daniel
- Djalalinia Shirin
- Doku Paul N.
- Dubljanin Eleonora
- Duko Bereket
- Eagan Arielle W.
- Earl Lucas
- Eaton Jeffrey W.
- Effiong Andem
- El-Jaafary Shaimaa I.
- Elayedath Rajesh
- Elsharkawy Aisha
- Eskandarieh Sharareh
- et al .
- Eyawo Oghenowede
- Ezzikouri Sayeh
- Fasanmi Abidemi O.
- Fasil Alebachew
- Fauk Nelsensius K.
- Feigin Valery L.
- Ferede Tomas Y.
- Fernandes Eduarda
- Fischer Florian
- Foigt Nataliya A.
- Folayan Morenike O.
- Foroutan Masoud
- Francis Joel M.
- Fukumoto Takeshi
- Gad Mohamed M.
- Geberemariyam Biniyam S.
- Gebregiorgis Birhan G.
- Gebremichael Berhe
- Gesesew Hailay A.
- Getacher Lemma
- Ghadiri Keyghobad
- Ghashghaee Ahmad
- Gilani Syed A.
- Ginindza Themba G.
- Glagn Mustefa G.
- Golechha Mahaveer
- Gona Philimon N.
- Goosmann Erik A.
- Gubari Mohammed I.
- Gugnani Harish C.
- Guido Davide
- Guled Rashid A.
- Haeuser Emily
- Hall Brian J.
- Hamidi Samer
- Handiso Demelash W.
- Hargono Arief
- Hashi Abdiwahab
- Hassanipour Soheil
- Hassankhani Hadi
- Hayat Khezar
- Herteliu Claudiu
- Hidru Hagos D.
- Holla Ramesh
- Hon Julia
- Hosgood H. Dean
- Hossain Naznin
- Hosseini Mostafa
- Hosseinzadeh Mehdi
- Househ Mowafa
- Hwang Bing-Fang
- Ibitoye Segun E.
- Ilesanmi Olayinka S.
- Ilic Irena M.
- Ilic Milena D.
- Irvani Seyed S.
- Iwu Chidozie C.
- Iwu Chinwe J.
- Iyamu Ihoghosa O.
- Jahagirdar Deepa
- Jain Vardhmaan
- Jakovljevic Mihajlo
- Jalilian Farzad
- Jha Ravi P.
- Johnson Kimberly B.
- Joshua Vasna
- Joukar Farahnaz
- Jozwiak Jacek J.
- Kabir Ali
- Kalankesh Leila R.
- Kalhor Rohollah
- Kamath Ashwin
- Kamyari Naser
- Kanchan Tanuj
- Karch Andre
- Karimi Salah E.
- Karyani Ali K.
- Kasa Ayele S.
- Kassahun Getinet
- Kayode Gbenga A.
- Keiyoro Peter N.
- Kelkay Bayew
- Khalid Nauman
- Khan Gulfaraz
- Khan Junaid
- Khan Md N.
- Khatab Khaled
- Khazaei Salman
- Kim Yun Jin
- Kisa Adnan
- Kisa Sezer
- Kochhar Sonali
- Kopec Jacek A.
- Kosen Soewarta
- Koyanagi Ai
- Krishan Kewal
- Kugbey Nuworza
- Kulkarni Vaman
- Kumar Manasi
- Kumar Nithin
- Kurmi Om P.
- Kusuma Dian
- Kuupiel Desmond
- Kyu Hmwe H.
- La Vecchia Carlo
- Lal Dharmesh K.
- Lam Jennifer O.
- Landires Ivan
- Lasrado Savita
- Laxminarayana Sindhura L.
- Lazarus Jeffrey V.
- Lazzar-Atwood Alice
- Lee Paul H.
- LeGrand Kate E.
- Leshargie Cheru T.
- Li Bingyu
- Liu Xuefeng
- Lopukhov Platon D.
- Madi Deepak
- Mahasha Phetole W.
- Majeed Azeem
- Maleki Afshin
- Maleki Shokofeh
- Mamun Abdullah A.
- Manafi Navid
- Mansournia Mohammad A.
- Martins-Melo Francisco R.
- Masoumi Seyedeh Z.
- Matin Behzad K.
- Mayala Benjamin K.
- Meharie Birhanu G
- Meheretu Hailemariam A.
- Meles Hagazi G.
- Melku Mulugeta
- Mendoza Walter
- Mengesha Endalkachew W.
- Meretoja Tuomo J.
- Mersha Abera M.
- Mestrovic Tomislav
- Miller Ted R.
- Mirica Andreea
- Mirzaei-Alavijeh Mehdi
- Mohamad Osama
- Mohammad Yousef
- Mohammadian-Hafshejani Abdollah
- Mohammed Jemal A.
- Mohammed Salahuddin
- Mohammed Shafiu
- Mokdad Ali H.
- Mokonnon Taklu M.
- Molla Meseret D.
- Molokhia Mariam
- Moradi Masoud
- Moradi Yousef
- Moradzadeh Rahmatollah
- Moraga Paula
- Mosser Jonathan F.
- Munro Sandra B.
- Mustafa Ghulam
- Muthupandian Saravanan
- Naderi Mehdi
- Nagaraja Sharath Burugina
- Nagarajan Ahamarshan J.
- Naghavi Mohsen
- Naveed Muhammad
- Nayak Vinod C.
- Nazari Javad
- Ndejjo Rawlance
- Nepal Samata
- Netsere Henok B.
- Ngalesoni Frida N.
- Nguefack-Tsague Georges
- Ngunjiri Josephine W.
- Nigatu Yeshambel T.
- Nigussie Samuel N.
- Nnaji Chukwudi A.
- Noubiap Jean J.
- Nunez-Samudio Virginia
- Oancea Bogdan
- Odukoya Oluwakemi O.
- Ogbo Felix A. (R18978)
- Perkins Samantha
- Quintanilla Beatriz P.
- Sartorius Benn
- Schaeffer Lauren E.
- Serfes Audrey L.
- Tantawi Maha E.
- VanderHeide John D.
- Weaver Nicole D.
- Yang Mingyou
- Zaki Maysaa E.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2 ·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676· 5 (513· 6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique, had the highest estimated HIV incidence (4661·7 [2544·8–8120·3]) cases per 100000 people in 2018 and Inhassunge District, Zambezia Province, Mozambique, had the highest estimated HIV mortality rate (1163·0 [679·0–1866·8]) deaths per 100 000 people. Further, the rate of reduction in HIV incidence and mortality from 2000 to 2018, as well as the ratio of new infections to the number of people living with HIV was highly variable. Although most second-level administrative units had declines in the number of new cases (3316 [81· 1%] of 4087 units) and number of deaths (3325 [81·4%]), nearly all appeared well short of the targeted 75% reduction in new cases and deaths between 2010 and 2020. Interpretation: Our estimates suggest that most second-level administrative units in sub-Saharan Africa are falling short of the targeted 75% reduction in new cases and deaths by 2020, which is further compounded by substantial within-country variability. These estimates will help decision makers and programme implementers expand access to ART and better target health resources to higher burden subnational areas
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir H.
- Abolhassani Hassan
- Abosetugn Akine E.
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas G.
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz K.
- Abu-Gharbieh Eman
- Abu-Raddad Laith J.
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac A.
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun M.
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed M.
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar B.
- Aji Budi
- Akalu Temesgen Y.
- Akinyemi Rufus O.
- Akinyemiju Tomi
- Akombi Blessing J.
- Akunna Chisom J.
- Al-Aly Ziyad
- Al-Mekhlaf Hesham M.
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad M.
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline E.
- Alema Niguse M.
- Alemu Biresaw W.
- Alemu Yihun M.
- Alhabib Khalid F.
- Alhassan Robert K.
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed M.
- Alla François
- Allebeck Peter
- Almadi Majid A.
- Almasi Ali
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Almulhim Abdulaziz M.
- Alonso Jordi
- Altirkawi Khalid A.
- Alumran Arwa K.
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
- Amare Bekalu
- Amini Saeed
- Amini-Rarani Mostafa
- Aminorroaya Arya
- Amiri Fatemeh
- Amit Arianna M.
- Amugsi Dickson A.
- Amul Gianna G.
- Anbesu Etsay W.
- Ancuceanu Robert
- Anderlini Deanna
- Anderson Jason A.
- Andrei Catalina L.
- Andrei Tudorel
- Androudi Sofia
- Angus Colin
- Anjomshoa Mina
- Ansari Fereshteh
- Ansari Iman
- Ansari-Moghaddam Alireza
- Antonazzo Ippazio C.
- Antonio Carl A.
- Antony Catherine M.
- Antriyandarti Ernoiz
- Anvari Davood
- Anwer Razique
- Appiah Seth C.
- Arab-Zozani Morteza
- Arabloo Jalal
- Aravkin Aleksandr Y.
- Arba Aseb A.
- Aremu Olatunde
- Ariani Filippo
- Aripov Timur
- Armoon Bahram
- Arowosegbe Oluwaseyi O.
- Aryal Krishna K.
- Arzani Afsaneh
- Asaad Malke
- Asadi-Aliabadi Mehran
- Asadi-Pooya Ali A.
- Asgari Samaneh
- Asghari Jafarabadi Mohammad
- Asghari Babak
- Ashbaugh Charlie
- Assmus Michael
- Atafar Zahra
- Athari Seyyed S.
- Atnafu Desta D.
- Atout Maha M.
- Atre Sachin R.
- Atteraya Madhu
- Ausloos Floriane
- Ausloos Marcel
- Avila-Burgos Leticia
- Avokpaho Euripide Frinel G. Arthur
- Ayala Quintanilla Beatriz P.
- Ayano Getinet
- Ayanore Martin A.
- Aynalem Getie L.
- Aynalem Yared A.
- Ayza Muluken A.
- Azari Samad
- Azarian Ghasem
- Azene Zelalem N.
- Azhar Gulrez
- Azzopardi Peter
- B Darshan B.
- Babaee Ebrahim
- Badawi Alaa
- Badiye Ashish D.
- Bagherzadeh Mojtaba
- Bagli Eleni
- Bahrami Mohammad A.
- Baig Atif A.
- Bairwa Mohan
- Bakhshaei Mohammad H.
- Bakhtiari Ahad
- Bakkannavar Shankar M.
- Balachandran Arun
- Balakrishnan Senthilkumar
- Balalla Shivanthi
- Balassyano Shelly
- Baldasseroni Alberto
- Bali Ahmed O.
- Ball Kylie
- Ballew Shoshana
- Balzi Daniela
- Banach Maciej
- Banerjee Srikanta K.
- Banik Palash C.
- Bannick Marlena S.
- Bante Agegnehu B.
- Bante Simachew A.
- Baraki Adhanom G.
- Barboza Miguel A.
- Barker-Collo Suzanne L.
- Barrero Lope H.
- Barthelemy Celine M.
- Barua Lingkan
- Barzegar Akbar
- Basaleem Huda B.
- Bassat Quique
- Basu Sanjay
- Baune Bernhard T.
- Bayati Mohsen
- Baye Bayisa A.
- Bazmandegan Gholamreza
- Becker Jacob S.
- Bedi Neeraj
- Beghi Ettore
- Behzadifar Masoud
- Bekuma Tariku T.
- Bell Michelle L.
- Bello Aminu K.
- Bender Rose G.
- Bennett Derrick A.
- Bennitt Fiona B.
- Bensenor Isabela M.
- Benziger Catherine P.
- Berhe Kidanemaryam
- Berman Adam E.
- Bernabe Eduardo
- Bernstein Robert
- Bertolacci Gregory J.
- Bhagavathula Akshaya S.
- Bhageerathy Reshmi
- Bhala Neeraj
- Bhandari Dinesh
- Bhardwaj Pankaj
- Bhat Anusha G.
- Bhattacharyya Krittika
- Bhattarai Suraj
- Bhutta Zulfiqar A.
- Bibi Sadia
- Biehl Molly H.
- Bijani Ali
- Bikbov Boris
- Bilano Ver
- Bin Sayeed Muhammad S.
- Biondi Antonio
- Birihane Binyam M.
- Bisanzio Donal
- Bisignano Catherine
- Biswas Raaj K.
- Bitew Helen
- Bjorge Tone
- Bockarie Moses J.
- Bohlouli Somayeh
- Bohluli Mehdi
- Bojia Hunduma A.
- Bolla Srinivasa R.
- Boloor Archith
- Boon-Dooley Alexandra S.
- Borges Guilherme
- Borzouei Shiva
- Borzì Antonio M.
- Bose Dipan
- Bosetti Cristina
- Boufous Soufiane
- Bourne Rupert R.
- Brady Oliver J.
- Braithwaite Dejana
- Brauer Michael
- Brayne Carol E.
- Breitborde Nicholas J.
- Breitner Susanne
- Brenner Hermann
- Breusov Alexey V.
- Briant Paul S.
- Briggs Andrew M.
- Briko Andrey N.
- Briko Nikolay I.
- Britton Gabrielle
- Brugha Traolach
- Bryazka Dana
- Buchbinder Rachelle
- Bumgarner Blair R.
- Burkart Katrin
- Burnett Richard
- Burugina Nagaraja Sharath
- Busse Reinhard
- Butt Zahid A.
- Bärnighausen Till
- Béjot Yannick
- Caetano dos Santos Florentino L.
- Cahill Leah E.
- Cahuana-Hurtado Lucero
- Cai Tianji
- Callender Charlton S.
- Camera Luis A.
- Campos-Nonato Ismael R.
- Campuzano Rincon Julio C.
- Cao Jackie
- Car Josip
- Cardenas Rosario
- Carreras Giulia
- Carrero Juan J.
- Carvalho Felix
- Castaldelli-Maia Joao M.
- Castañeda-Orjuela Carlos A.
- Castelpietra Giulio
- Castle Chris D.
- Castro Emma
- Castro Franz
- Catalá-López Ferrán
- Causey Kate
- Cederroth Christopher R.
- Cercy Kelly
- Cerin Ester
- Chalek Julian
- Chandan Joht S.
- Chang Alex R.
- Chang Angela Y.
- Chang Jung-Chen
- Chang Kai-Lan
- Charan Jaykaran
- Charlson Fiona J.
- Chattu Vijay K.
- Chaturvedi Sarika
- Cherbuin Nicolas
- Chimed-Ochir Odgerel
- Chin Ken L.
- Chirinos-Caceres Jesus L.
- Cho Daniel Y.
- Choi Jee-Young
- Christensen Hanne
- Chu Dinh-Toi
- Chung Michael T.
- Chung Sheng-Chia
- Cicuttini Flavia M.
- Ciobanu Liliana G.
- Cirillo Massimo
- Cislaghi Beniamino
- Classen Thomas K.
- Cohen Aaron J.
- Collins Emma L.
- Comfort Haley
- Compton Kelly
- Conti Sara
- Cooper Owen R.
- Corso Barbara
- Cortesi Paolo A.
- Costa Vera M.
- Cousin Ewerton
- Cowden Richard G.
- Cowie Benjamin C.
- Cromwell Elizabeth A.
- Croneberger Andrew J.
- Cross Di H.
- Cross Marita
- Crowe Christopher S.
- Cruz Jessica A.
- Cummins Steven
- Cunningham Matthew
- Dahlawi Saad M.
- Dai Haijiang
- Dai Hancheng
- Damasceno Albertino
- Damiani Giovanni
- Dandona Lalit
- Dandona Rakhi
- Daneshpajouhnejad Parnaz
- Dangel William J.
- Danielsson Anna-Karin
- Dargan Paul I.
- Darwesh Aso M.
- Daryani Ahmad
- Das Gupta Rajat
- das Neves Jose
- Das Jai K.
- Dash Aditya P.
- Davey Gail
- Davila-Cervantes Claudio A.
- Davis Adrian C.
- Davitoiu Dragos V.
- Davletov Kairat
- De Leo Diego
- De Neve Jan-Walter
- Dean Frances E.
- DeCleene Nicole K.
- Deen Amanda
- Degenhardt Louisa
- DeLang Marissa
- Dellavalle Robert P.
- Demeke Feleke M.
- Demoz Gebre
- Demsie Desalegn G.
- Denova-Gutierrez Edgar
- Dereje Dereje Nebiyu
- Deribe Kebede
- Dervenis Nikolaos
- Desai Rupak
- Desalew Assefa
- Dessie Getenet A.
- Deuba Keshab
- Dharmaratne Samath D.
- Dhungana Govinda P.
- Dianatinasab Mostafa
- Dias da Silva Diana
- Diaz Daniel
- Dibaji Forooshani Zahra S.
- Dichgans Martin
- Didarloo Alireza
- Dingels Zachary V.
- Dippenaar Ilse N.
- Dirac M. Ashworth
- Djalalinia Shirin
- Do Hoa Thi
- Dokova Klara
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- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.
Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. Global annual livebirths increased from 134·5 million (131·5–137·8) in 2000 to a peak of 139·6 million (133·0–146·9) in 2016. Global livebirths then declined to 135·3 million (127·2–144·1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2·1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27·1% (95% UI 26·4–27·8) of global livebirths. Global life expectancy at birth increased from 67·2 years (95% UI 66·8–67·6) in 2000 to 73·5 years (72·8–74·3) in 2019. The total number of deaths increased from 50·7 million (49·5–51·9) in 2000 to 56·5 million (53·7–59·2) in 2019. Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. Global population increased by 25·7%, from 6·2 billion (6·0–6·3) in 2000 to 7·7 billion (7·5–8·0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58·6 years (56·1–60·8) in 2000 to 63·5 years (60·8–66·1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019
Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019
- Author
- Abadi Kidanemariam Berhe
- Abbas Mosapour
- Abdallah M Samy
- Abdelrahman I Abushouk
- Abdiwahab Hashi
- Abdollah Mohammadian-Hafshejani
- Abdullah A Mamun
- Abdullah T Khoja
- Abhay Motiramji Gaidhane
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- Tanvir M Huda
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- Tauseef Ahmad
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- Teklehaimanot Gereziher Haile
- Tesega Tesega Mengistu Birhanu
- Teshome Gebre
- Theo Vos
- Thirunavukkarasu Sathish
- Till Winfried Bärnighausen
- Tomas Y Ferede
- Tomasz Miazgowski
- Tomislav Mestrovic
- Tommi Juhani Vasankari
- Traian Vasile Constantin
- Tuomo J Meretoja
- Turki M Alanzi
- Ulrich Otto Mueller
- Usman Iqbal
- Vafa Rahimi-Movaghar
- Vahid Rashedi
- Vahid Yazdi-Feyzabadi
- Valentin Yurievich Skryabin
- Valery L Feigin
- Van Charles Lansingh
- Vasily Vlassov
- Vegard Skirbekk
- Veincent Christian Filipino Pepito
- Vera Marisa Costa
- Victor Adekanmbi
- Vijay Kumar Chattu
- Vinay Nangia
- Vinod C Nayak
- Virendra Singh
- Virginia Nuñez-Samudio
- Vivekanand Jha
- Walter Mendoza
- Xiaochen Dai
- Xiu-Ju George Zhao
- Xuefeng Liu
- Yafeng Wang
- Yanzhong Wang
- Yared Asmare Aynalem
- Yasir Waheed
- Yong Yu
- Yordanos Gizachew Yeshitila
- Young-Eun Kim
- Yuan-Pang Wang
- Yuichiro Yano
- Yuming Guo
- Yun Jin Kim
- Yunquan Zhang
- Zahid A Butt
- Zahiruddin Quazi Syed
- Zelalem Nigussie Azene
- Zhi-Jiang Zhang
- Ziyad Al-Aly
- Zohra S Lassi
- Zubair Kabir
- Zulfiqar A Bhutta
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background: Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10–24 years during the past three decades. Methods: Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10–14, 15–19, and 20–24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings: In 2019, 369 061 deaths (of which 214 337 [58%] were transport related) and 31·1 million DALYs (of which 16·2 million [52%] were transport related) among adolescents aged 10–24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34·4% (from 17·5 to 11·5 per 100 000) for transport injuries, and by 47·7% (from 15·9 to 8·3 per 100 000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80·5% to 42 774 for transport injuries and by 39·4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010–19, the rate per 100 000 of transport injury DALYs was reduced by 16·7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48·5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0·2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010–19. Interpretation: As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low–middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Funding: Bill & Melinda Gates Foundation
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