118 research outputs found
De Novo and Rare Inherited Copy-Number Variations in the Hemiplegic Form of Cerebral Palsy
- Author
- A Colver
- A Kirton
- AJ Verkerk
- Anna McCormick
- Anne Kawamura
- AP Basu
- Bhooma Thiruvahindrapuram
- BP Coe
- Carolyn Hunt
- Christian R Marshall
- Craig Campbell
- CS Gibson
- CY C Yuen
- CY Fong
- D Pinto
- D Wu
- Daniele Merico
- Darcy L Fehlings
- Dawa Samdup
- Dimitri J Stavropoulos
- DS Hong
- E Wood
- Edward J Higginbotham
- F Madia
- G Barnby
- G McMichael
- Gabrielle deVeber
- Guillermo Casallo
- H Najmabadi
- I Iossifov
- Jan Willem Gorter
- Jeffrey R MacDonald
- JK Grether
- KA Aldinger
- Karizma Mawjee
- KB Nelson
- Lauren Switzer
- M Lek
- M Oskoui
- M Shinawi
- M Uddin
- M Zarrei
- M Zarrei
- MA van Es
- Marie Kim
- Matthew J Gazzellone
- Mehdi Zarrei
- MJ Gazzellone
- MM Motazacker
- Mohammed Uddin
- O Mercati
- Pam Frid
- R Segel
- Richard F Wintle
- Ronit Mesterman
- S Rainier
- S Smile
- SJ Sanders
- SM Reid
- Stephen W Scherer
- Susan Walker
- T Harel
- T Kadotani
- TM Centanni
- Y Yoneda
- YW Wu
- Publication venue
- Scholarship@Western
- Publication date
- 03/08/2017
- Field of study
PurposeHemiplegia is a subtype of cerebral palsy (CP) in which one side of the body is affected. Our earlier study of unselected children with CP demonstrated de novo and clinically relevant rare inherited genomic copy-number variations (CNVs) in 9.6% of participants. Here, we examined the prevalence and types of CNVs specifically in hemiplegic CP.MethodsWe genotyped 97 unrelated probands with hemiplegic CP and their parents. We compared their CNVs to those of 10,851 population controls, in order to identify rare CNVs
Nutrition and cancer: A review of the evidence for an anti-cancer diet
- Author
- A Sakalova
- A Seow
- AE Fletcher
- AG Schuurman
- AH Mokdad
- AJ Duffield-Lillico
- AL Frazier
- AM Barreto
- AP Femia
- AR Folsom
- AT Fleischauer
- AT Fleischauer
- AW Hsing
- AW Hsing
- AW Hsing
- B Vastag
- BA Lashner
- BC Blount
- BR Goldin
- C Garland
- C La Vecchia
- C La Vecchia
- C La Vecchia
- CF Garland
- CH Hennekens
- CL Hanchette
- CL Rock
- CR Jonas
- CS Fuchs
- CS Tsao
- CS Tsao
- D Bagga
- D Lauer
- D Li
- D Sarkar
- DJ Bernard-Gallon
- DJ Hunter
- DM Harvell
- DS Michaud
- DS Michaud
- DS Michaud
- E Benito
- E Cho
- E Cho
- E De Stefani
- E Fernandez
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Kampman
- E Kampman
- E Riboli
- EA Platz
- EA Platz
- EB Mawer
- ED Gorham
- ED Stefani
- EE Calle
- EE Calle
- EJ Konings
- EM John
- ES Lefkowitz
- EW Tiemersma
- F Levi
- F Marotta
- F Meyer
- FB Hu
- G Block
- GG Schwartz
- GG Schwartz
- GL Hildenbrand
- GS Omenn
- GW Comstock
- H Li
- H Mukhtar
- HD Riordan
- I Kato
- I Kato
- IA Brouwer
- IR Rowland
- J Beuth
- J Chen
- J Chen
- J Chen
- J Ma
- J Ma
- J Matsuzaki
- J Satia-Abouta
- J Tangrea
- JD Brooks
- JD Brooks
- JH Cohen
- JH Fowke
- JL Freudenheim
- JM Yuan
- JM Yuan
- JP Pierce
- JW Fahey
- K Foster-Powell
- K Oh
- K Wu
- K Wu
- K Yoshizawa
- KA Steinmetz
- KB Michels
- KE Anderson
- KJ Helzlsouer
- KJ Joshipura
- KP Tan
- KR Silvester
- KT Khaw
- KW Lee
- L Desser
- L Harnack
- L Le Marchand
- L Le Marchand
- L Le Marchand
- L O'Mahony
- L Yan
- LA Colangelo
- LC Clark
- LJ Su
- LN Kolonel
- LS Augustin
- LS Augustin
- LS Augustin
- LS Augustin
- LU Thompson
- LU Thompson
- M Ferraroni
- M Friedrich
- M Gago-Dominguez
- M Wald
- M Wald
- MD Holmes
- ME Martinez
- ME Martinez
- ME Reid
- MF Holick
- MH Ahonen
- MH Criqui
- Michael S Donaldson
- MJ Dirx
- MJ Shrubsole
- MJ Thun
- ML Cravo
- ML Slattery
- ML Slattery
- ML Slattery
- ML Slattery
- MS Donaldson
- MS Gujral
- MS Sandhu
- MV Grau
- N Shimizu
- N Simonsen
- NH Riordan
- O Kucuk
- P Bowen
- P Cos
- P Ghadirian
- P Knekt
- P Terry
- P Tuohimaa
- P van 't Veer
- PA Egner
- PA Egner
- PA van den Brandt
- PA van den Brandt
- PA van den Brandt
- PA van Noord
- PD Terry
- PH Gann
- PH Gann
- PN Singh
- PR Holt
- PS Dale
- R Garcia-Closas
- R Hughes
- R Medhekar
- R Sinha
- R Sturm
- R Vieth
- RE Schoen
- RM Bostick
- S Chernomorsky
- S Franceschi
- S Franceschi
- S Higginbotham
- S Higginbotham
- S Mannisto
- S Rothman
- S Sieri
- S Zhang
- SA Bingham
- SA Bingham
- SA Glynn
- SD Hursting
- SH Saydah
- SJ London
- SJ London
- SJ Padayatty
- SL Goodstine
- SM Finegold
- SM Zhang
- SM Zhang
- SS Coughlin
- SW Choi
- T Fung
- T Norat
- T Popiela
- TA Sellers
- TA Sellers
- TA Shapiro
- TE Rohan
- TE Rohan
- V Maillard
- V Pala
- V Tangpricha
- W Demark-Wahnefried
- WB Grant
- WB Grant
- WC Willett
- WCRF/AICR
- WE Moore
- X Lin
- Y Aso
- Y Aso
- Y Ito
- Y Nishizawa
- Y Nishizawa
- Publication venue
- BioMed Central
- Publication date
- 01/01/2004
- Field of study
It has been estimated that 30â40 percent of all cancers can be prevented by lifestyle and dietary measures alone. Obesity, nutrient sparse foods such as concentrated sugars and refined flour products that contribute to impaired glucose metabolism (which leads to diabetes), low fiber intake, consumption of red meat, and imbalance of omega 3 and omega 6 fats all contribute to excess cancer risk. Intake of flax seed, especially its lignan fraction, and abundant portions of fruits and vegetables will lower cancer risk. Allium and cruciferous vegetables are especially beneficial, with broccoli sprouts being the densest source of sulforophane. Protective elements in a cancer prevention diet include selenium, folic acid, vitamin B-12, vitamin D, chlorophyll, and antioxidants such as the carotenoids (α-carotene, ÎČ-carotene, lycopene, lutein, cryptoxanthin). Ascorbic acid has limited benefits orally, but could be very beneficial intravenously. Supplementary use of oral digestive enzymes and probiotics also has merit as anticancer dietary measures. When a diet is compiled according to the guidelines here it is likely that there would be at least a 60â70 percent decrease in breast, colorectal, and prostate cancers, and even a 40â50 percent decrease in lung cancer, along with similar reductions in cancers at other sites. Such a diet would be conducive to preventing cancer and would favor recovery from cancer as well
Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at root s=13 TeV
- Author
- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WW
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Adam W
- Adamidis K
- Adams E
- Adams M
- Adams T
- Addesa F
- Adloff C
- Adzic P
- AdĂĄn DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
- Aime` C
- Akchurin N
- Akgun B
- Akpinar A
- Albergo S
- Albert A
- Albrecht S
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Almond J
- Alonso AG
- Alpana K
- Alvarez JR
- Alverson G
- Alves G
- Aly R
- Alyari M
- Amapane N
- Amaral SSD
- Amarilo KM
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
- An S
- An Y
- Anagnostou G
- Anampa KH
- Andrea J
- Andreassi G
- Andreev V
- Andreev Y
- Andrejkovic J
- Andrews M
- Androsov K
- Angioni GP
- Anguiano J
- Antchev G
- Antequera JB
- Anthony D
- Antunovic Z
- Anuar AB
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton M
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar M
- Asilar E
- Askew A
- Asmuss P
- Atakisi I
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan M
- Ayala E
- Ayala G
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand M
- Babaev A
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakshi A
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banos LE
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes V
- Barney D
- Baron O
- Barrera CB
- Barrera CO
- Barria P
- Bartek R
- Bartosik N
- BartĂłk M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick L
- Baxter S
- Bayatmakou M
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerra DS
- Bechtel J
- Bedoya CF
- Beghin D
- Behera P
- Behera S
- Behnke O
- Bein S
- Belforte S
- Bell K
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Benitez J
- Benussi L
- Bergauer T
- Berger P
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- Bernardes C
- Bernet C
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- Bertacchi V
- Besancon M
- Bestintzanos I
- Bethani A
- Beyrouthy T
- Bhal E
- Bhardwaj A
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- Bhattacharya R
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- Bhowmik D
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- Bindhu VMN
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- Bocci A
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- Bouhali O
- Bourgatte G
- Bourilkov D
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- Cifuentes JB
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- Citron M
- Cittolin S
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- Evangelou I
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- Yusli M
- Yzquierdo AP
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- Zanetti M
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- Zghiche A
- Zhang F
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- Zhizhin I
- Zhokin A
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- Ziemons T
- Zoi I
- Zolkapli Z
- Zorbakir I
- Zorbilmez C
- Zotto P
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- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
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- Acharya H
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- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution
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- Zhang Z
- Zhao J
- Zhokin A
- Zhu DH
- Zhu RY
- Zientek M
- Zlebcik R
- Zobec J
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2020
- Field of study
We describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in proton-proton collisions at an energy of s = 13 TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb - 1 . A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ÂŻ
Search for invisible decays of the Higgs boson produced via vector boson fusion in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim A
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
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- Alhusseini M
- Alimena J
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- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for gravitational waves associated with gamma-ray bursts detected by Fermi and Swift during the LIGOâVirgo run O3b
- Author
- Abbott R
- Abbott TD
- Acernese F
- Ackley K
- Adams C
- Adhikari N
- Adhikari RX
- Adya VB
- Affeldt C
- Agarwal D
- Agathos M
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- Arellano FEP
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- Arun KG
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- Bartos I
- Bassiri R
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- Bayley JC
- Baylor AC
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- Zhou R
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- Zhu XJ
- Zhu Z-H
- Zimmerman AB
- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2022
- Field of study
We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTCâ2020 March 27 17:00 UTC). We conduct two independent searches: a generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate
Search for dark matter produced in association with a leptonically decaying Z boson in protonâproton collisions at sâ=13TeV
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- Yi K
- Yohay R
- Yoo HD
- Yoo J
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- Yuan S
- Yumiceva F
- Yusli MN
- Yzquierdo AP-C
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zenaiev O
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang W
- Zhang Y
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- Zhao J
- Zhizhin I
- Zhokin A
- Zhu DH
- Zhu RY
- Ziemons T
- Zientek M
- Zlebcik R
- Zobec J
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/12/2020
- Field of study
A search for dark matter particles is performed using events with a Z boson candidate and large missing transverse momentum. The analysis is based on protonâproton collision data at a center-of-mass energy of 13TeV, collected by the CMS experiment at the LHC in 2016â2018, corresponding to an integrated luminosity of 137fbâ1. The search uses the decay channels Zâee and ZâΌΌ. No significant excess of events is observed over the background expected from the standard model. Limits are set on dark matter particle production in the context of simplified models with vector, axial-vector, scalar, and pseudoscalar mediators, as well as on a two-Higgs-doublet model with an additional pseudoscalar mediator. In addition, limits are provided for spin-dependent and spin-independent scattering cross sections and are compared to those from direct-detection experiments. The results are also interpreted in the context of models of invisible Higgs boson decays, unparticles, and large extra dimensions.SCOAP
Recommended from our members
Precision measurement of the W boson decay branching fractions in proton-proton collisions at âs=13 TeV
- Author
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- Zorbilmez C
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- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 26/04/2022
- Field of study
The leptonic and inclusive hadronic decay branching fractions of the W boson are measured using
proton-proton collision data collected at ffiffi s p Œ 13 TeV by the CMS experiment at the CERN LHC,
corresponding to an integrated luminosity of 35.9 fbâ1. Events characterized by the production of one or
two W bosons are selected and categorized based on the multiplicity and flavor of reconstructed leptons, the
number of jets, and the number of jets identified as originating from the hadronization of b quarks. A
binned maximum likelihood estimate of the W boson branching fractions is performed simultaneously in
each event category. The measured branching fractions of the W boson decaying into electron, muon, and
tau lepton final states are Ă°10.83 0.10Ă%, Ă°10.94 0.08Ă%, and Ă°10.77 0.21Ă%, respectively,
consistent with lepton flavor universality for the weak interaction. The average leptonic and inclusive
hadronic decay branching fractions are estimated to be Ă°10.89 0.08Ă% and Ă°67.32 0.23Ă%, respec tively. Based on the hadronic branching fraction, three standard model quantities are subsequently derived: the sum of squared elements in the first two rows of the CabibboâKobayashiâMaskawa (CKM) matrix
P ij jVijj 2 Œ 1.984 0.021, the CKM element jVcsj Œ 0.967 0.011, and the strong coupling constant at
the W boson mass scale, αSĂ°m2 WĂ ÂŒ 0.095 0.033
Recommended from our members
Search for low-mass dilepton resonances in Higgs boson decays to four-lepton final states in protonâproton collisions at âs=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
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- Wang X
- Wang Y
- Wang Y
- Wang Z
- Wang Z
- Waqas M
- Wardle N
- Wassmer M
- Watson IJ
- Wayne M
- Webb SN
- Weber HA
- Weber M
- Wen Y
- Wertz S
- West C
- Wetzel J
- Wezenbeek L
- Whitbeck A
- Wichmann K
- Wickramage N
- Wickramarathna DDC
- Wiedenbeck S
- Wightman A
- Wildridge A
- Williams J
- Williams T
- Willmott C
- Wilson G
- Wilson J
- Wimpenny S
- Winer BL
- Winterbottom D
- Wisecarver A
- Wissing C
- Wittich P
- Wolf M
- Wolf R
- Wolfe E
- Wong K
- Wong WY
- Wood D
- Woodard A
- Wozniak KA
- Wozniewski S
- Wright D
- Wu Z
- Wuchterl S
- Wulz C-E
- Wuyckens S
- Wyslouch B
- WĂŒrthwein F
- Xia F
- Xiao J
- Xiao M
- Xiao R
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yang UK
- Yang YC
- Yao Y
- YARAR H
- Yates BR
- Yazgan E
- Ye Z
- Yetkin EA
- Yi K
- Yohay R
- Yoo HD
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu GB
- Yu I
- Yu SS
- Yuan L
- Yuan S
- Yuldashev BS
- Yumiceva F
- Yusli MN
- Yzquierdo AP-C
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zenaiev O
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang W
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu DH
- Zhu RY
- Ziemons T
- Zientek M
- Zlebcik R
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Data Availability: This manuscript has no associated data or the data will not be deposited. [Authorsâ comment: For CMS Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2).]Copyright © CERN for the benefit of the CMS collaboration 2022. A search for low-mass dilepton resonances in Higgs boson decays is conducted in the four-lepton final state. The decay is assumed to proceed via a pair of beyond the standard model particles, or one such particle and a Z boson. The search uses protonâproton collision data collected with the CMS detector at the CERN LHC, corresponding to an integrated luminosity of 137fbâ1, at a center-of-mass energy sâ=13TeV. No significant deviation from the standard model expectation is observed. Upper limits at 95% confidence level are set on model-independent Higgs boson decay branching fractions. Additionally, limits on dark photon and axion-like particle production, based on two specific models, are reported.SCOAP3
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