Expansión volumétrica y comportamineto de oligoamnios / Volumetric expansion and behavior of the oligoamnios

Con el objetivo de demostrar la efectividad de la expansión volumétrica materna en el incremento del volumen de líquido amniótico en pacientes con tiempo de gestación de 28 a 39 semanas y oligoamnios, mediante la infusión endovenosa con soluciones isotónicas, se realizó una investigación de intervención-acción, analítica y de cohorte en el Hospital "Abel Santamaría" durante el año 2007. Se seleccionó un grupo estudio conformado por las embarazadas con tiempo de gestación de 28 a 39 semanas, con oligoamnios, a las que se les indicó expansión volumétrica (n=125) y dos grupos de control: el primero conformado por las embarazadas sin oligoamnios y que parieron en ese mismo período (n=125); el segundo, por las embarazadas con oligoamnios detectado a las 40 semanas y más de gestación y que no tuvieron posibilidad de la expansión volumétrica (n=125) y finalmente, la muestra quedó constituida por 375 gestantes. En el análisis estadístico se utilizó el porcentaje y el Ji cuadrado al 95% de certeza. Se obtuvo un incremento del índice de líquido amniótico (ILA) en el 96,8% de las gestantes posterior a 3 dosis de tratamiento, las rincipales causas de cesárea fueron: el sufrimiento fetal agudo, la presentación pelviana e inducción fallida asociado a bajo índice de inducciones y nacimientos pretérminos con morbilidad neonatal baja. Por lo que se concluye que la expansión volumétrica es una opción terapéutica eficaz en el tratamiento del oligoamnios, pues permitió prolongar el embarazo sin incremento de la morbilidad neonatal.Palabras clave: expansores del volumen de plasma, trabajo de parto inducido, cesárea; morbilidad. ABSTRACT An intervention-action, analytical and cohort research was conducted at "Abel Santamaria Cuadrado" University Hospital-2007, aimed at showing the effectiveness of maternal volumetric expansion in the increase of the amniotic-fluid volume in 28-39 weeks-pregnant women presenting oligoamnios by means of intravenous infusion with isotonic solutions. The study group was comprised of 28-39 weeks-pregnant women presenting oligoamnios, to whom volumetric expansion was indicated (n=125) and two control groups: the first comprised of pregnant women without oligoamnios and delivering in the same period (n=125); the second group of pregnant women that presented oligoamnios detected at 40 weeks or more of pregnancy and without the possibility of volumetric expansion (n=125), 375 pregnant women were in the final sample. To the statistical analysis the percentage method and the chi-square test with 95% of certainty were used. An increase was obtained in the amniotic-fluid rate (AFR), 96, 8% of the pregnant women after the third dose of treatment, the main causes to perform the cesarean section were: acute fetal distress, pelvic presentation and failed labor induction associated to a low rate of induction and preterm births with low neonatal morbidity. Concluding that; volumetric expansion is an efficient therapeutic option in the treatment of oligoamnios, extending pregnancy without increasing neonatal morbidity. Key words: plasma volume expander, induced labor, cesarean section, morbidity

Expansión volumétrica y comportamineto de oligoamnios / Volumetric expansion and behavior of the oligoamnios

Con el objetivo de demostrar la efectividad de la expansión volumétrica materna en el incremento del volumen de líquido amniótico en pacientes con tiempo de gestación de 28 a 39 semanas y oligoamnios, mediante la infusión endovenosa con soluciones isotónicas, se realizó una investigación de intervención-acción, analítica y de cohorte en el Hospital "Abel Santamaría" durante el año 2007. Se seleccionó un grupo estudio conformado por las embarazadas con tiempo de gestación de 28 a 39 semanas, con oligoamnios, a las que se les indicó expansión volumétrica (n=125) y dos grupos de control: el primero conformado por las embarazadas sin oligoamnios y que parieron en ese mismo período (n=125); el segundo, por las embarazadas con oligoamnios detectado a las 40 semanas y más de gestación y que no tuvieron posibilidad de la expansión volumétrica (n=125) y finalmente, la muestra quedó constituida por 375 gestantes. En el análisis estadístico se utilizó el porcentaje y el Ji cuadrado al 95% de certeza. Se obtuvo un incremento del índice de líquido amniótico (ILA) en el 96,8% de las gestantes posterior a 3 dosis de tratamiento, las rincipales causas de cesárea fueron: el sufrimiento fetal agudo, la presentación pelviana e inducción fallida asociado a bajo índice de inducciones y nacimientos pretérminos con morbilidad neonatal baja. Por lo que se concluye que la expansión volumétrica es una opción terapéutica eficaz en el tratamiento del oligoamnios, pues permitió prolongar el embarazo sin incremento de la morbilidad neonatal.Palabras clave: expansores del volumen de plasma, trabajo de parto inducido, cesárea; morbilidad. ABSTRACT An intervention-action, analytical and cohort research was conducted at "Abel Santamaria Cuadrado" University Hospital-2007, aimed at showing the effectiveness of maternal volumetric expansion in the increase of the amniotic-fluid volume in 28-39 weeks-pregnant women presenting oligoamnios by means of intravenous infusion with isotonic solutions. The study group was comprised of 28-39 weeks-pregnant women presenting oligoamnios, to whom volumetric expansion was indicated (n=125) and two control groups: the first comprised of pregnant women without oligoamnios and delivering in the same period (n=125); the second group of pregnant women that presented oligoamnios detected at 40 weeks or more of pregnancy and without the possibility of volumetric expansion (n=125), 375 pregnant women were in the final sample. To the statistical analysis the percentage method and the chi-square test with 95% of certainty were used. An increase was obtained in the amniotic-fluid rate (AFR), 96, 8% of the pregnant women after the third dose of treatment, the main causes to perform the cesarean section were: acute fetal distress, pelvic presentation and failed labor induction associated to a low rate of induction and preterm births with low neonatal morbidity. Concluding that; volumetric expansion is an efficient therapeutic option in the treatment of oligoamnios, extending pregnancy without increasing neonatal morbidity. Key words: plasma volume expander, induced labor, cesarean section, morbidity

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Delaying surgery for patients with a previous SARS-CoV-2 infection

Not availabl

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele