A non-invasive measure of minerals and electrolytes in tissue

A system for collecting epithelial cells from the oral mucosa for the determination of ion concentration is discussed with application to the study of man's adaptation to microgravity. A number of characteristics of these cells influenced the choice for clinical testing. They are non-cornified epithelial cells located on the inferior aspect of the tongue; therefore, they are well protected from trauma. They have the capability of reflecting relatively recent physiologic changes since they are renewed every three days and have aerobic metabolism. Most importantly, they are easily accessible and can be removed by a wooden applicator stick with minimum discomfort. Smears of cells removed in this manner show predominantly individual cells rather than sheets of contiuous cells. This facilitates the visual isolation of single cells with the electron microscope for analysis. NASA's principle effort in the development of a test to measure the ion concentration in sublingual cells has been research by the biomedical program carried out by scientists with expertise in skeletal metabolism. These efforts were directed toward determining the biological meaning and deviations in interacellular ions in nonhuman primates and in male volunteers for experiments in a model for weightlessness. A brief one page summary of the experiments and results are presented

Integrating Theory and Practice Into the Professional Responsibility Curriculum at the University of Texas

Teaching ethics to large classes has always proved to be a great challenge for those who teach professional responsibility at the University of Texas. A new program at the University of Texas to improve the professional responsibility curriculum is discussed

Oral Magnesium Supplementation in Chronic Kidney Disease Stages 3 and 4:Efficacy, Safety, and Effect on Serum Calcification Propensity-A Prospective Randomized Double-Blinded Placebo-Controlled Clinical Trial

Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. Recent evidence suggests that increases in both serum and intracellular magnesium (Mg) can slow or even prevent the development of vascular calcification seen in CKD. Serum calcification propensity (T50) is a novel functional test, which is associated with all-cause mortality in CKD and measures the ability of serum to delay the formation of crystalline nanoparticles. Theoretically, increasing serum Mg should improve T50 and thereby reduce the propensity towards ectopic calcification. Methods: We conducted a randomized placebo-controlled double-blinded clinical trial to investigate the safety of 2 different doses of oral Mg supplementation in subjects with CKD stages 3 and 4 as well as their effects on intracellular Mg and T50. Thirty-six subjects with CKD stages 3 and 4 were randomized to one of 3 groups (placebo, elemental Mg 15 mmol/d or elemental Mg 30 mmol/d) given as slow-release Mg hydroxide and followed for 8 weeks. Results: Thirty-four subjects completed the trial. Intracellular Mg remained stable throughout the trial despite significant increases in both serum and urine Mg. T50 increased significantly by 40 min from 256 ± 60 (mean ± SD) to 296 ± 64 minutes (95% confidence interval, 11–70, P < 0.05) in the Mg 30 mmol/d group after 8 weeks. No serious adverse events related to the study medication were reported during the study. Discussion: Oral Mg supplementation was safe and well tolerated in CKD stages 3 and 4 and improved T50, but did not increase intracellular Mg. Further studies are needed to investigate the long-term effects of Mg supplementation in CKD stage 3 and 4 and whether improvement in calcification propensity is related to clinical endpoints

Decision Model for Predicting Social Vulnerability Using Artificial Intelligence

The APC was funded by their authors.Social vulnerability, from a socio-environmental point of view, focuses on the identification of disadvantaged or vulnerable groups and the conditions and dynamics of the environments in which they live. To understand this issue, it is important to identify the factors that explain the difficulty of facing situations with a social disadvantage. Due to its complexity and multidimensionality, it is not always easy to point out the social groups and urban areas affected. This research aimed to assess the connection between certain dimensions of social vulnerability and its urban and dwelling context as a fundamental framework in which it occurs using a decision model useful for the planning of social and urban actions. For this purpose, a holistic approximation was carried out on the census and demographic data commonly used in this type of study, proposing the construction of (i) a knowledge model based on Artificial Neural Networks (Self-Organizing Map), with which a demographic profile is identified and characterized whose indicators point to a presence of social vulnerability, and (ii) a predictive model of such a profile based on rules from dwelling variables constructed by conditional inference trees. These models, in combination with Geographic Information Systems, make a decision model feasible for the prediction of social vulnerability based on housing information.This research was funded by the University of Granada, grant number PP2016-PIP0

Synthetic Biology: Mapping the Scientific Landscape

This article uses data from Thomson Reuters Web of Science to map and analyse the scientific landscape for synthetic biology. The article draws on recent advances in data visualisation and analytics with the aim of informing upcoming international policy debates on the governance of synthetic biology by the Subsidiary Body on Scientific, Technical and Technological Advice (SBSTTA) of the United Nations Convention on Biological Diversity. We use mapping techniques to identify how synthetic biology can best be understood and the range of institutions, researchers and funding agencies involved. Debates under the Convention are likely to focus on a possible moratorium on the field release of synthetic organisms, cells or genomes. Based on the empirical evidence we propose that guidance could be provided to funding agencies to respect the letter and spirit of the Convention on Biological Diversity in making research investments. Building on the recommendations of the United States Presidential Commission for the Study of Bioethical Issues we demonstrate that it is possible to promote independent and transparent monitoring of developments in synthetic biology using modern information tools. In particular, public and policy understanding and engagement with synthetic biology can be enhanced through the use of online interactive tools. As a step forward in this process we make existing data on the scientific literature on synthetic biology available in an online interactive workbook so that researchers, policy makers and civil society can explore the data and draw conclusions for themselves

Digital voices: Posthumanism and the generation of empathy

This chapter investigates digital technologies that variously assist, enable or simulate musical praxis. The first section sets up an opposition between the idea of the digital tool that augments human agency, and the machinic automatism predicated on the idea that reality is fundamentally number (dataism) and ticks along without the need for human consciousness. This gives rise to the idea that mechanical automatism is also intrinsic to human agency, a strand of posthuman thought on which the rest of the chapter turns. Accordingly, the second section shows how posing algorithmic composition as an expression of the posthuman is problematic. The final section focuses on the synthetic voices of digital assistants from online service providers that generate empathy at the price of a surrogate ‘conscience’. Accommodating this within a humanistic model is possible, but a closing case study of Tod Machover’s futurist opera, Death and the Powers (2010), raises the prospect of what might be called a ‘dark ontology’ of the digital

Geography and computers: Past, present, and future

The discipline of Geography has long been intertwined with the use of computers. This close interaction is likely to increase with the embeddedness of computers and concomitant growth of spatially referenced data. To better understand the current situation, and to be able to better speculate about the future, this article provides two parallel perspectives: first, we offer an historical perspective on the relationship between Geography and computers; second, we document developments—in particular the nascent field of data science—that are currently taking place outside of Geography and to which we argue the discipline should be paying close attention. Combining both perspectives, we identify the benefits of tighter integration between Geography and Data Science and argue for the establishment of a new space—that we term Geographic Data Science—in which cross‐pollination could occur to the benefit of both Geography and the larger data community