Current Concepts in Chronic Rhinosinusitis and Nasal Polyposis Therapy

Catedra Otorinolaringologie USMF “ Nicolae Testemiţanu”The exact pathophysiological mechanisms leading to chronic rhinosinusitis (CRS) still remain mainly obscure. However, recently some progress has been achieved in elucidating the etiology of nasal polyposis, especially regarding tissue eosinophilia, the role of aspirin intolerance and eicosanoid mediators. Endonasal sinus surgery has evolved to be the treatment of choice in CRS and nasal polyposis in all cases where conservative treatment has failed or resulted in only a partial or temporary relief. Mecanismele pato-fiziologice de bază în dezvoltarea RinoSinusitei Cronice (RSC) încă nu sunt pe deplin elucidate. Însă, în ultima vreme, au fost notate succese remarcabile în elucidarea etiologiei polipozei nazale, cu accent deosebit asupra rolului eozinofilelor tisulare, intoleranţei la aspirină, şi a mediatorilor eicosanoizi. Chirurgia endonazală rino-sinusală a ajuns să fie privită ca tratament de elecţie a polipozei nazale în cazurile cu tratament conservativ puţin eficace şi rezultate insatisfăcătoare. Acest review aduce la cunoştinţă şi pune în discuţie conceptele moderne şi inovaţiile în tratamentul contemporan al RSC şi a polipozei nazale

Многогранность подходов в оказании ургентной психиатрической помощи при эпилепсии

USMF Nicolae Testemiţanu, Colegiul Naţional de Medicină şi Farmacie Raisa Pocalo, Spitalul Clinic de PsihiatrieThe paper describes an extremely vast and difficult field – psychiatric emergencies in epilepsy, the authors referring to their own experience of specific assisted cases as part of specialized services of Clinical Psychiatric Hospital in Chisinau. The psychiatric emergencies of epileptic character are currently being studied both epileptic paroxysm malmanifestations in terms of intra- or post critical character, due to the organic and functional basic disorders which characterize or accompany the epilepsy, and under the individualized therapeutic approach in accordance with the entire block of morbid circumstances that contribute to the exacerbation of psychosis containing all medical and often legal repercussions that imply them as well. The authors describe briefly step by step the scenario of assistance that should be given to epileptic patients who all of a sudden have developed a psychiatric emergency, specifying the multidisciplinary nature of these activities. Optimal management of psychiatric emergencies of epileptic etiology implies a precise diagnosis which will not be limited to etiological determination alone Данная статья охватывает очень широкую и сложную область психиатрии – неотложные состояния при эпилепсии, в которой авторы делятся опытом, основанным на конкретных случаях в Психиатричекой клинической больнице г. Кишинэу. Представленные неотложные состояния эпилептического генеза и были проанализированы как со стороны пароксизмальных проявлений интра- и посткритического характера, которые обусловлены органической и функциональной дисфункцией, характеризующие или сопровождающие эпилепсию, так и со стороны терапевтического и индивидуального подхода, зависящего от коморбидного состояния пациента, имеющее определенное значение в обострении психоза с медицинскими и законодательными последствиями. Авторы кратко и многопрофильно описывают шаг за шагом сценарий помощи, которую должны получить больные эпилепсией, нуждающиеся в неотложной медицинской помощи. Оптимальное решение неотложной психиатрической помощи накладывает обязательство установить уверенный диагноз, который не должен быть ограничен только этиологическим подтверждением

Remote Control of Railway Switch Heating Using GSM Modems

This research activity examines the possibility of remote control of the heating of railway switches. The study and implementation of the remote-control system of resistive heaters using the Global Mobile Communication System (GSM) through SMS messages (Short Message Service) and AT (attention) commands is presented in this article. The research works envisaged are convergent on the functionality of a GSM protocol, which allows the user to control the heating of the remote railway switches, away from the place where the switches were installed. The notions of serial communication, electronic control and AT control have been applied to expand the system. To increase the robustness of the system, a feedback mechanism was introduced so that users will be able to get a feedback status of the system when the command was successfully sent or in the case of voltage drops and system restarts

Epilepsia la adult: protocol clinic național PCN-290

USMF „Nicolae Testemiţanu”, IMSP Institutul de Medicină Urgentă, IMSP Spitalul Clinic de PsihiatrieAcest protocol a fost elaborat de grupul de lucru al Ministerului Sănătăţii al Republicii Moldova (MS RM), constituit din specialiști neurologi, neurofiziologi și epileptologi ai Laboratorului de Neurobiologie și Genetică Medicală ai Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Centrului Național de Epileptologie în cadrul IMSP Institutul de Medicină Urgentă sub conducerea academicianului, d.h.ș.m., prof. univ., Stanislav Groppa. Pentru elaborarea recomandărilor au fost studiate, analizate si consultate informațiile din literatura de specialitate, bazele de date MEDLINE/PubMed, Cochrane Trials Register, documentele de specialitate ale Ligii Internaționale de Combatere a Epilepsiei, Institutului National de Excelență Clinică, Subcomitetului Standardelor de Calitate al Academiei Americane de Neurologie și al Societății Americane de Epilepsie, al Academiei Europene de Neurologie. Prezentul protocol este recomandat în abordarea diagnostică și terapeutică a cazurilor de epilepsie a adultului, dar nu limitează si nu absolvă specialistul de responsabilitatea individualizării cazului

Ancient DNA reveals interstadials as a driver of common vole population dynamics during the last glacial period

Aim Many species experienced population turnover and local extinction during the Late Pleistocene. In the case of megafauna, it remains challenging to disentangle climate change and the activities of Palaeolithic hunter-gatherers as the main cause. In contrast, the impact of humans on rodent populations is likely to be negligible. This study investigated which climatic and/or environmental factors affect the population dynamics of the common vole. This temperate rodent is widespread across Europe and was one of the most abundant small mammal species throughout the Late Pleistocene. Location Europe. Taxon Common vole (Microtus arvalis). Methods We generated a dataset comprised of 4.2 kb long fragment of mitochondrial DNA (mtDNA) from 148 ancient and 51 modern specimens sampled from multiple localities across Europe and covering the last 60 thousand years (ka). We used Bayesian inference to reconstruct their phylogenetic relationships and to estimate the age of the specimens that were not directly dated. Results We estimated the time to the most recent common ancestor of all last glacial and extant common vole lineages to be 90 ka ago and the divergence of the main mtDNA lineages present in extant populations to between 55 and 40 ka ago, which is earlier than most previous estimates. We detected several lineage turnovers in Europe during the period of high climate variability at the end of Marine Isotope Stage 3 (MIS 3; 57-29 ka ago) in addition to those found previously around the Pleistocene/Holocene transition. In contrast, data from the Western Carpathians suggest continuity throughout the Last Glacial Maximum (LGM) even at high latitudes. Main Conclusions The main factor affecting the common vole populations during the last glacial period was the decrease in open habitat during the interstadials, whereas climate deterioration during the LGM had little impact on population dynamics. This suggests that the rapid environmental change rather than other factors was the major force shaping the histories of the Late Pleistocene faunas.info:eu-repo/semantics/publishedVersio

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions

Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era

The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2×1034 cm−2s−1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b → sl+l−and b → dl+l− transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 → μ+μ−)/B(Bs → μ+μ−). Probing charm CP violation at the 10−5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier

LHCb upgrade software and computing : technical design report

This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis

Search for exotic resonances decaying into WZ/ZZ in pp collisions at √s=7 TeV

Journal of High Energy Physics 2013.2 (2013): 036 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMA search for new exotic particles decaying to the VZ final state is performed, where V is either a W or a Z boson decaying into two overlapping jets and the Z decays into a pair of electrons, muons or neutrinos. The analysis uses a data sample of pp collisions corresponding to an integrated luminosity of 5 fb-1 collected by the CMS experiment at the LHC at √s=7 TeV in 2011. No significant excess is observed in the mass distribution of the VZ candidates compared with the background expectation from standard model processes. Model-dependent upper limits at the 95% confidence level are set on the product of the cross section times the branching fraction of hypothetical particles decaying to the VZ final state as a function of mass. Sequential standard model W′ bosons with masses between 700 and 940 GeV are excluded. In the Randall-Sundrum model for graviton resonances with a coupling parameter of 0.05, masses between 750 and 880 GeV are also exclude