An integrative multi‐scale approach to regional agriculture to support the assessment and benefit of pest‐regulation services delivered by biodiversity

Ecology is first of all a scientific discipline, with its body of theories and methods, and a constant renewal of its main specific fields and principles. In that regard, Ecology is not different from the other scientific disciplines and produces an increasing number of outstanding publications on both fundamental and applied grounds. Ecology can produce highly theoretical works, which is essential, but Ecology can be -and even moremust be an applied science. Currently, practical applications of Ecology for the benefits of our societies have become more numerous and increasingly urgent. ‘Interactions’, sensu lato, are at the very heart of Ecology which makes it by definition THE science of Biodiversity. Beyond the knowledge of how Life has appeared and developed, Ecology can provide the basis for the preservation of Biodiversity and ensure its management is relevant and efficient into the future. By being more integrative and global, Ecology could establish itself as the cornerstone of sustainable development. In this beginning of the 21st century, the influence of Ecology will inevitably grow and play a key role for Planet Earth and human well-being. Sfécologie2016, an International Conference on ecological sciences would not have taken place without 2 years of hard work from the staff of my Institute (IMBE). That is thus with a real pleasure that we welcome you today in Marseille. (Thierry TATONI IMBE Director

Le projet SEBIOPAG-PHYTO : déterminants agricoles parcellaires et paysagers des variations de niveaux de régulation biologique

Ce séminaire est une restitution des principales avancées obtenues dans le cadre des projets ANR PEERLESS «viabilité d’une gestion écologique renforcée de la santé des plantes dans les paysages agricoles » (2013-2017) et FRB SEBIOPAG-PHYTO «déterminants agricoles parcellaires et paysagers des variations de niveaux de régulation biologique » (2014-2017). Le séminaire a rassemblé 60 scientifiques, pour moitié extérieure aux unités INRA partenaires de ces projets. Il s'est déroulé à Paris Paris les 27-28 novembre 2017

Les effets conjugués de la gestion parcellaire et du contexte paysager et de sa dynamique sur les bioagresseurs et les niveaux de régulation biologique

Ce séminaire est une restitution des principales avancées obtenues dans le cadre des projets ANR PEERLESS «viabilité d’une gestion écologique renforcée de la santé des plantes dans les paysages agricoles » (2013-2017) et FRB SEBIOPAG-PHYTO «déterminants agricoles parcellaires et paysagers des variations de niveaux de régulation biologique » (2014-2017). Le séminaire a rassemblé 60 scientifiques, pour moitié extérieure aux unités INRA partenaires de ces projets. Il s'est déroulé à Paris Paris les 27-28 novembre 2017

Multi-host disease management: the why and the how to include wildlife

<p>In recent years, outbreaks caused by multi-host pathogens (MHP) have posed a serious challenge to public and animal health authorities. The frequent implication of wildlife in such disease systems and a lack of guidelines for mitigating these diseases within wild animal populations partially explain why the outbreaks are particularly challenging. To face these challenges, the French Ministry of Agriculture launched a multi-disciplinary group of experts that set out to discuss the main wildlife specific concepts in the management of MHP disease outbreaks and how to integrate wildlife in the disease management process. This position paper structures the primary specific concepts of wildlife disease management, as identified by the working group. It is designed to lay out these concepts for a wide audience of public and/or animal health officers who are not necessarily familiar with wildlife diseases. The group's discussions generated a possible roadmap for the management of MHP diseases. This roadmap is presented as a cycle for which the main successive step are: step 1-descriptive studies and monitoring; step 2-risk assessment; step 3-management goals; step 4-management actions and step 5-assessment of the management plan. In order to help choose the most adapted management actions for all involved epidemiological units, we integrated a decision-making framework (presented as a spreadsheet). This tool and the corresponding guidelines for disease management are designed to be used by public and health authorities when facing MHP disease outbreaks. These proposals are meant as an initial step towards a harmonized transboundary outbreak response framework that integrates current scientific understanding adapted to practical intervention.</p

Genetic, Phenotypic, and Interferon Biomarker Status in ADAR1-Related Neurological Disease

International audienceWe investigated the genetic, phenotypic, and interferon status of 46 patients from 37 families with neurological disease due to mutations in ADAR1. The clinicoradiological phenotype encompassed a spectrum of Aicardi–Goutières syndrome, isolated bilateral striatal necrosis, spastic paraparesis with normal neuroimaging, a progressive spastic dystonic motor disorder, and adult-onset psychological difficulties with intracranial calcification. Homozygous missense mutations were recorded in five families. We observed a p.Pro193Ala variant in the heterozygous state in 22 of 23 families with compound heterozygous mutations. We also ascertained 11 cases from nine families with a p.Gly1007Arg dominant-negative mutation, which occurred de novo in four patients, and was inherited in three families in association with marked phenotypic variability. In 50 of 52 samples from 34 patients, we identified a marked upregulation of type I interferon-stimulated gene transcripts in peripheral blood, with a median interferon score of 16.99 (interquartile range [IQR]: 10.64–25.71) compared with controls (median: 0.93, IQR: 0.57–1.30). Thus, mutations in ADAR1 are associated with a variety of clinically distinct neurological phenotypes presenting from early infancy to adulthood, inherited either as an autosomal recessive or dominant trait. Testing for an interferon signature in blood represents a useful biomarker in this context

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements