Adaptive reuse process of the Historic Urban Landscape post-Covid-19. The potential of the inner areas for a “new normal”

[EN] Often in the past, the great disasters (environmental calamities, earthquakes, epidemics) activated unexpressed energies, triggering transformations of the built environment, able to give rise unexpected conditions of economic, cultural and social development. The fragility of settlement systems in the face of unexpected threats brings out the need for a new planning, changing our gaze on the city.The new framework of needs drawn by the pandemic and the renewed sensitivity towards the combination of health – sustainability, rekindle the spotlight on inner areas. These emerged as "reservoirs of resilience", areas to look at, in order to reach an eco-systemic balance.The aim of the paper is to return an experience of adaptive reuse of the Historical Urban Landscape in an inner area of Southern Italy, where the needs of health and safety of the community are integrated with the transmission of the built heritage to future generations. The goal is the promotion of inclusive prosperity scenarios, towards the so-called "new normality".Starting from an in-depth literature review on the cases of pandemics in history and the strategies implemented, the research identifies health security requirements at the scale of the Historical Urban Landscape and design solutions aimed at reactivating lost synergies between communities and places.The authors would like to thank the architects Chiara Brio Albano, Chiara Coppa, Michela Di Palo, Raffaele Gala, Maria Laura Genito, Vera Nico Vitale, Anna Rita Villano and the engineers Valeria Orfeo, Silvana Santonicola, Eugenio Truono, for the design scenarios.Pinto, MR.; Viola, S.; Fabbricatti, K.; Pacifico, MG. (2020). Adaptive reuse process of the Historic Urban Landscape post-Covid-19. The potential of the inner areas for a “new normal”. VITRUVIO - International Journal of Architectural Technology and Sustainability. 5(2):87-105. https://doi.org/10.4995/vitruvio-ijats.2020.145218710552AA.VV. (2020) Manifesto di Camaldoli per una nuova centralità della montagna. Tra il Dire e il Fare, Notiziario dell'Archivio Osvaldo Piacentini, n. 15, Archivio Osvaldo Piacentini, Reggio Emilia.Agency for Territorial Cohesion (2014) Strategia Nazionale per le Aree Interne: definizione, obbiettivi, strumenti e governance, Roma [WWW document]. URL http://www.programmazioneeconomica.gov.it/wp-content/uploads/2017/02/Accordo-P-Strategia_nazionale_per_le_Aree_interne_definizione_obiettivi_strumenti_e_governance_2014.pdf (accessed 19 October 2020).Barca, F. (2018) In conclusione: immagini, sentimenti e strumenti eterodossi per una svolta radicale. In: A. De Rossi (a cura di), Riabitare l'Italia. Le aree interne tra abbandoni e riconquiste, Donzelli, Roma.Battaglini, L., Corrado, F. (2014) Il ritorno alla terra nei territorio rurali-montani: diversi aspetti di un fenomeno in atto. Scienze del Territorio, 2, 79-86. https://doi.org/10.13128/Scienze_Territorio-14324Beck, U. (2016) The metamorphosis of the world, Polity Press, Cambridge-Malen.Belfiglio, V.J. (2017) Control of epidemics in the Roman army: 27 B.C.-A.D. 476. Int. J. Community Med. Public Health, 4, 1387. https://doi.org/10.18203/2394-6040.ijcmph20171745Bollyky, TJ. (2019) The future of global health is urban health. Global Health Program. Council on Foreign Relations. [WWW document]. URL https://www.cfr.org/article/future-global-health-urban-health (accessed 10 October 2020).Carrosio, G. (2019), I margini al centro. L'Italia delle aree interne tra fragilità e innovazione, Donzelli, Roma.Caterina, G. (2016) Innovative strategies for the recovering of historical cities. TECHNE - Journal of Technology for Architecture and Environment, 12, 33-35. https://doi.org/10.13128/Techne-19330Cohen, M.J. (2020) Does the COVID-19 outbreak mark the onset of a sustainable consumption transition? Sustainability: Science, Practice and Policy, 16.1, 1-3. https://doi.org/10.1080/15487733.2020.1740472Connolly, C., Keil, R., Ali, S.H. (2020) Extended urbanisation and the spatialities of infectious disease: Demographic change, infrastructure and governance. [WWW document]. URL https://journals.sagepub.com/doi/full/10.1177/0042098020910873 (accessed 10 October 2020). https://doi.org/10.1177/0042098020910873Council of Europe (2005). Framework convention on the value of cultural heritage for society (Faro Convention), Faro [WWW document]. URL https://rm.coe.int/1680083746 (accessed 19 October 2020).Dematteis, G. (2018). Montagna e città: verso nuovi equilibri? In: A. De Rossi (a cura di), Riabitare l'Italia. Le aree interne tra abbandoni e riconquiste, Donzelli, Roma, pp. 285-295.Di Battista, V. (1989). Le parole e le cose. Recupero, manutenzione, restauro. Recuperare, 93.Dietz, L., Horve, P.F., Coil, D.A., Fretz, M., Eisen, J.A., Van DenWymelenberg, K. (2020) 2019 Novel Coronavirus. (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission. MSystems, 5. https://doi.org/10.1128/mSystems.00245-20European Communities (1999) ESDP European Spatial Development Perspective Towards Balanced and Sustainable Development of the Territory of the European, Union European Communities. [WWW document]. URL https://ec.europa.eu/regional_policy/sources/docoffic/official/reports/pdf/sum_en.pdf (accessed 19 October 2020).Eykelbosh, A. (2020) COVID-19 Precautions for Multi-Unit Residential Buildings. [WWW document]. URL https://ncceh.ca/sites/default/files/COVID-19%20Precautions%20for%20Multiunit%20Residential%20Buildings%20-%20March%2031%202020.pdf (accessed 10 September 2020).Frank, L.D., Iroz-Elardo, N., MacLeod, K.E., Hong, A. (2019) Pathways from built environment to health: A conceptual framework linking behavior and exposure-based impacts. J. Transp. Health, 12, 319-335 . https://doi.org/10.1016/j.jth.2018.11.008Herlihy, D, Cohn, SK Jr (1997) The Black Death and the transformation of the West. Harvard University Press, Cambridge, MA. https://doi.org/10.2307/j.ctvjghwgpLeal Filho,W., Brandli, L.L., Lange Salvia, A., Rayman-Bacchus, L., Platje, J. (2020) COVID-19 and the UN Sustainable Development Goals: Threat to Solidarity or an Opportunity Sustainability, 12.13, 5343. https://doi.org/10.3390/su12135343Marchetti, M. (2016) La questione delle Aree Interne, sfida e opportunità per il Paese e per il settore forestale. Forest@, 13, 35-40. https://doi.org/10.3832/efor0082-013Martini, M., Gazzaniga, V., Behzadifar, M., Bragazzi, N.L., Barberis, I. (2018) The history of tuberculosis: The social role of sanatoria for the treatment of tuberculosis in Italy between the end of the 19 th century and the middle of the 20 th. J. Prev. Med. Hyg. 59, E323-E327. https://doi.org/10.15167/2421-4248/jpmh2018.59.4.1103Neiderud, C.J. ( 2015) How urbanization affects the epidemiology of emerging infectious diseases. Infect. Ecol. Epidemiol., 5, 27060. https://doi.org/10.3402/iee.v5.27060OECD Policy Responses to Coronavirus (2020) The territorial impact of COVID-19: Managing the crisis across levels ofgovernment. [WWW document]. URL https://read.oecd-ilibrary.org/view/?ref=128_128287-5agkkojaaa&title=The-territorial-impactof-covid-19-managing-the-crisis-across-levels-of-government (accessed 10 October 2020).Oppido, S., Ragozino, S., Fabbricatti, K., Esposito De Vita G. (2020) Oltre la retorica del borgo: un approccio sistémico per il bilanciamento territoriale, In: Atti della XXIII Conferenza SIU Downscaling, rightsizing. Contrazione demografica e riorganizzazione spaziale, forthcoming.Oxley, D. (2003) 'The seat of death and terror': Urbanization, stunting, and smallpox. Econ. Hist. Rev., 56, 623-656. https://doi.org/10.1111/j.1468-0289.2003.00264.xPike, A., Dawleya, S., Tomane J. (2010) Resilience, adaptation and adaptability. Cambridge Journal of Regions, Economy and Society, 3.1, 59-70. https://doi.org/10.1093/cjres/rsq001Pinheiro, M.D., Luís, N.C. (2020) COVID-19 Could Leverage a Sustainable Built Environment. Sustainability, 12, 5863. https://doi.org/10.3390/su12145863Pinto M.R., De Medici S., Senia C., Fabbricatti K., De Toro P. (2017) Building reuse: multi-criteria assessment for compatible design, International Journal of Design Sciences and Technology, 22.2.Reyes, R., Ahn, R., Thurber, K., Burke, T.F. (2013) Urbanization and Infectious Diseases: General Principles, Historical Perspectives, and Contemporary Challenges. In: Fong I. (eds) Challenges in Infectious Diseases. Emerging Infectious Diseases of the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4496-1_4Rossi Doria, M. (1982) Scritti sul mezzogiorno, Einaudi.Szczygiel, B., Hewitt, R.(2000) Nineteenth-Century Medical Landscapes: John H. Rauch, Frederick Law Olmsted, and the Search for Salubrity. Bull. Hist. Med., 74, 708-734. https://doi.org/10.1353/bhm.2000.0197UNESCO (2011) Recommendation on the Historic Urban Landscape, UNESCO World Heritage Centre, Resolution 36C/23, Annex. Paris, France, 2011.Vereycken, K. (2010) Leonardo da Vinci Imagines The First Modern City. Exec. Intell. Rev., 37,53-55. [WWW document]. URL http://artkarel.com/wp-content/uploads/2010/12/romarantin-EN.pdf (accessed 10 September 2020).Zonneveld, W., Stead, D. (2007) European territorial cooperation and the concept of urban-rural relationships. Planning Practice & Research, 22, 439-453. https://doi.org/10.1080/0269745070166678

Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in Sardinia

<p>Abstract</p> <p>Background</p> <p>The Mediterranean island of Sardinia has a strikingly high incidence of the autoimmune disorders Type 1 Diabetes (T1D) and Multiple Sclerosis (MS). Furthermore, the two diseases tend to be co-inherited in the same individuals and in the same families. These observations suggest that some unknown autoimmunity variant with relevant effect size could be fairly common in this founder population and could be detected using linkage analysis.</p> <p>Methods</p> <p>To search for T1D and MS loci as well as any that predispose to both diseases, we performed a whole genome linkage scan, sequentially genotyping 593 microsatellite marker loci in 954 individuals distributed in 175 Sardinian families. In total, 413 patients were studied; 285 with T1D, 116 with MS and 12 with both disorders. Model-free linkage analysis was performed on the genotyped samples using the Kong and Cox logarithm of odds (LOD) score statistic.</p> <p>Results</p> <p>In T1D, aside from the HLA locus, we found four regions showing a lod-score ≥1; 1p31.1, 6q26, 10q21.2 and 22q11.22. In MS we found three regions showing a lod-score ≥1; 1q42.2, 18p11.21 and 20p12.3. In the combined T1D-MS scan for shared autoimmunity loci, four regions showed a LOD >1, including 6q26, 10q21.2, 20p12.3 and 22q11.22. When we typed more markers in these intervals we obtained suggestive evidence of linkage in the T1D scan at 10q21.2 (LOD = 2.1), in the MS scan at 1q42.2 (LOD = 2.5) and at 18p11.22 (LOD = 2.6). When all T1D and MS families were analysed jointly we obtained suggestive evidence in two regions: at 10q21.1 (LOD score = 2.3) and at 20p12.3 (LOD score = 2.5).</p> <p>Conclusion</p> <p>This suggestive evidence of linkage with T1D, MS and both diseases indicates critical chromosome intervals to be followed up in downstream association studies.</p

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia

Search for anomalous production of events with three or more leptons in pp collisions at √s = 8TeV

Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published articles title, journal citation, and DOI.A search for physics beyond the standard model in events with at least three leptons is presented. The data sample, corresponding to an integrated luminosity of 19.5fb-1 of proton-proton collisions with center-of-mass energy s=8TeV, was collected by the CMS experiment at the LHC during 2012. The data are divided into exclusive categories based on the number of leptons and their flavor, the presence or absence of an opposite-sign, same-flavor lepton pair (OSSF), the invariant mass of the OSSF pair, the presence or absence of a tagged bottom-quark jet, the number of identified hadronically decaying τ leptons, and the magnitude of the missing transverse energy and of the scalar sum of jet transverse momenta. The numbers of observed events are found to be consistent with the expected numbers from standard model processes, and limits are placed on new-physics scenarios that yield multilepton final states. In particular, scenarios that predict Higgs boson production in the context of supersymmetric decay chains are examined. We also place a 95% confidence level upper limit of 1.3% on the branching fraction for the decay of a top quark to a charm quark and a Higgs boson (t→cH), which translates to a bound on the left- and right-handed top-charm flavor-violating Higgs Yukawa couplings, λtcH and λctH, respectively, of |λtcH|2+|λctH|2<0.21

Measurement of associated W plus charm production in pp collisions at √s=7 TeV

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