26 research outputs found
Single mothers and self help groups.
- Author
- Publication venue
- 'University of Windsor Leddy Library'
- Publication date
- 01/01/1981
- Field of study
Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1981 .M222. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.S.W.)--University of Windsor (Canada), 1981
Rare coding variants and X-linked loci associated with age at menarche.
- Author
- Ailith Pirie
- Alanna C. Morrison
- Albert Hofman
- Alex P. Reiner
- Alexander Teumer
- Alison M. Dunning
- Andrea D. Coviello
- Andres Metspalu
- Andrew M. McIntosh
- André G. Uitterlinden
- Anna Murray
- Anne Tjonneland
- Antonietta Robino
- Antonis C. Antoniou
- Archie Campbell
- Aurelio Barricarte
- Beverley Balkau
- Blair H. Smith
- Carlos Gonzalez
- Carlotta Sacerdote
- Carmen Navarro
- Carol A. Wang
- Caroline Hayward
- Caterina Barbieri
- Cathy E. Elks
- Chunyan He
- Cinzia F. Sala
- Claudia Langenberg
- Craig E. Pennell
- Daniel F. Gudbjartsson
- Daniel I. Chasman
- Daniela Toniolo
- Daphne L. van der A
- David A. Hinds
- David Karasik
- David Porteous
- David Schlessinger
- Deborah J. Thompson
- Diego Vozzi
- Domenico Palli
- Doris Stöckl
- Douglas F. Easton
- Eleonora Porcu
- Elio Riboli
- Elisabeth Altmaier
- Elizabeth A. Streeten
- Ellen W. Demerath
- Eric Boerwinkle
- Ethan M. Lange
- Evelin Mihailov
- Felix R. Day
- Fernando Rivadeneira
- Francesco Cucca
- Frank B. Hu
- Heiner Boeing
- Henry Völzke
- Ian J. Deary
- Igor Rudan
- Ilaria Gandin
- InĂȘs Barroso
- J RamĂłn QuirĂłs
- James G. Wilson
- Jennifer E. Huffman
- Jennifer Kriebel
- Jenny A. Visser
- Jian'an Luan
- Jinyan Huang
- Joanne M. Murabito
- John R. B. Perry
- Joyce Y. Tung
- Julie E. Buring
- Kari Stefansson
- Katherine S. Ruth
- Kathryn L. Lunetta
- Ken K. Ong
- Kim Overvad
- Konstantin Strauch
- Larraitz Arriola
- Laura Crisponi
- Laura M. Yerges-Armstrong
- Leslie A. Lange
- Lisette Stolk
- Lynda M. Rose
- Lynne J. Hocking
- Marek Zygmunt
- Mark I. McCarthy
- MarĂaâJosĂ© SĂĄnchez
- Matt Sims
- Megan L. Grove
- Melissa Wellons
- Michela Traglia
- Nadia Slimani
- Nicholas J. Wareham
- Nicola D. Kerrison
- Nita G. Forouhi
- Nora Franceschini
- null null
- null null
- Olov Rolandsson
- Ozren Polasek
- Panos Deloukas
- Patrick Sulem
- Paul M. Ridker
- Paul W. Franks
- Peter M. Nilsson
- Rebecca D. Jackson
- Reedik MĂ€gi
- Robert A. Scott
- Rosario Tumino
- Rudolf Kaaks
- Salvatore Panico
- Sandosh Padmanabhan
- Sara Grioni
- Sheila Ulivi
- Simin Liu
- Stephen J. Sharp
- Timothy J. Key
- TÔnu Esko
- Unnur Thorsteinsdottir
- Ursula M. Schick
- Uwe Völker
- Xin Li
- Yvonne T. van der Schouw
- Publication venue
- Nat Commun
- Publication date
- 01/01/2015
- Field of study
More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only âŒ3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated with age at menarche (minor allele frequencies 0.08-4.6%; effect sizes 0.08-1.25 years per allele; P<5 Ă 10(-8)). In addition, we identify common X-chromosome loci at IGSF1 (rs762080, P=9.4 Ă 10(-13)) and FAAH2 (rs5914101, P=4.9 Ă 10(-10)). Highlighted genes implicate cellular energy homeostasis, post-transcriptional gene silencing and fatty-acid amide signalling. A frequently reported mutation in TACR3 for idiopathic hypogonatrophic hypogonadism (p.W275X) is associated with 1.25-year-later menarche (P=2.8 Ă 10(-11)), illustrating the utility of population studies to estimate the penetrance of reportedly pathogenic mutations. Collectively, these novel variants explain âŒ0.5% variance, indicating that these overlooked sources of variation do not substantially explain the 'missing heritability' of this complex trait.UK sponsors (see article for overseas ones):
This work made use of data and samples generated by the 1958 Birth Cohort (NCDS). Access to these resources was enabled via the 58READIE Project funded by Wellcome Trust and Medical Research Council (grant numbers WT095219MA and G1001799). A full list of the financial, institutional and personal contributions to the development of the 1958 Birth Cohort Biomedical resource is available at http://www2.le.ac.uk/projects/birthcohort. Genotyping was undertaken as part of the Wellcome Trust Case-Control Consortium (WTCCC) under Wellcome Trust award 076113, and a full list of the investigators who contributed to the generation of the data is available at www.wtccc.org.uk
...
The Fenland Study is funded by the Wellcome Trust and the Medical Research Council, as well as by the Support for Science Funding programme and CamStrad.
...
SIBS - CRUK ref: C1287/A8459 SEARCH - CRUK ref: A490/A10124 EMBRACE is supported by Cancer Research UK Grants C1287/A10118, C1287/A16563 and C1287/A17523. Genotyping was supported by Cancer Research - UK grant C12292/A11174D
and C8197/A16565. Gareth Evans and Fiona Lalloo are supported by an NIHR grant to the Biomedical Research Centre, Manchester.
The Investigators at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust are supported by an NIHR grant to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. Ros Eeles and Elizabeth Bancroft are supported by Cancer Research UK Grant C5047/A8385.
...
Generation Scotland - Scottish Executive Health Department, Chief Scientist Office, grant number CZD/16/6. Exome array genotyping for GS:SFHS was funded by the Medical Research Council UK. 23andMe - This work was supported in part by NIH Award 2R44HG006981-02 from the National Human Genome Research Institute.This is the final version of the article. It first appeared from NPG via http://dx.doi.org/10.1038/ncomms875
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- Author
- Afzal Uzma
- Ahluwalia Tarunveer Singh
- Bakker Stephan J. L.
- Bataille Veronique
- Bellis Claire
- Bennett David A.
- Bertram Lars
- Bishop D. Timothy
- Bishop Julia A. N.
- Blangero John
- BlĂŒher Matthias
- Boehnke Michael
- Boettcher Yvonne
- Bonnefond Amélie
- Borecki Ingrid B.
- Borodulin Katja
- Bouchard Claude
- Buchkovich Martin L.
- Buchman Aron S.
- Campbell Harry
- Cederholm Tommy
- Chambers John C.
- Cho Nam H.
- Choh Audrey C.
- Choi Hyung Jin
- Cooper Richard S.
- Cousminer Diana L.
- Cummings Steven R.
- Cupples L. Adrienne
- Curran Joanne E.
- Czerwinski Stefan A.
- Dastani Zari
- Day Felix R.
- De Groot Lisette C. P. G. M.
- De Jager Philip L.
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Demuth Ilja
- Dhonukshe-Rutten Rosalie A. M.
- Drong Alexander W.
- Döring Angela
- Eckardt Rahel
- Eklund Niina
- Enneman Anke W.
- Eriksson Johan G.
- Esko Toñu
- Eury Elodie
- Evans Daniel S.
- Evans David M.
- Falchi Mario
- Fatemifar Ghazaleh
- Feitosa Mary F.
- Ferreira Teresa
- Ferrucci Luigi
- Forouhi Nita G.
- Forrester Terrence
- Forsen Tom
- Fox Caroline
- Franco Oscar H.
- Franke Lude
- Friedrich Nele
- Froguel Philippe
- Fumeron Frédéric
- Furey Terrence S.
- Gansevoort Ron T.
- Garcia Melissa E.
- Gieger Christian
- Grallert Harald
- Grarup Niels
- Gudnason Vilmundur
- Gustafsson Stefan
- GĂ€rtner Simone
- Han Bok-Ghee
- Han Jiali
- Hansen Torben
- Haring Robin
- Harris Tamara B.
- Hastie Nicholas
- Havulinna Aki S.
- Hayward Caroline
- Hedman Ă sa K.
- Heliövaara Markku
- Hernandez Dena
- Hillege Hans
- Hingorani Aroon
- Hirschhorn Joel N.
- Hofman Albert
- Hunter David J.
- Hysi Pirro G.
- Iles Mark M.
- Ingelsson Erik
- Ittermann Till
- Jackson Anne U.
- Jordan Joanne M.
- Jousilahti Pekka
- Jula Antti
- Justice Anne E.
- JĂžrgensen Torben
- Kajantie Eero
- Kanoni Stavroula
- Kaplan Robert C.
- Karjalainen Juha
- Karpe Fredrik
- Kent Jack W.
- Kiel Douglas P.
- KilpelaĂŻnen Tuomas Oskari
- Kivimaki Mika
- Knekt Paul B.
- Kolcic Ivana
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kristiansson Kati
- Kumari Meena
- Kuulasmaa Teemu
- Kuusisto Johanna
- KÀhönen Mika
- KĂŒhnel Brigitte
- Laakso Markku
- Laatikainen Tiina
- Lagou Vasiliki
- Lahti Jari
- Langenberg Claudia
- Leach Irene Mateo
- Lee Christine G.
- Lee Jong-Young
- LehtimÀki Terho
- Li Rui
- Li Xin
- Lichtner Peter
- Lind Lars
- Lindgren Cecilia
- Linneberg Allan
- Liu Tian
- Liu Yongmei
- Liu Youfang
- Lobbens Stéphane
- Locke Adam
- Loh Marie
- Loos Ruth J. F.
- Lu Chen
- Lu Yingchang
- Luan Jian'an
- Luke Amy
- LyytikaĂŻnen Leo-Pekka
- Mahajan Anubha
- Mangino Massimo
- McCarthy Mark I.
- McKenzie Colin A.
- McKnight Barbara
- Medina-Gomez Carolina
- Menni Cristina
- Michaëlsson Karl
- Mohlke Karen L.
- Morris Andrew P.
- Murabito Joanne M.
- MĂ€gi Reedik
- MÀnnistö Satu
- Na Jianbo
- Nalls Mike A.
- NaranÀiÀ Nina Smolej
- Nielson Carrie M.
- North Kari E.
- O'Connell Jeffrey R.
- Ohlsson Claes
- Ong Ken K.
- Oostra Ben A.
- Oozageer Laticia
- Orwoll Eric S.
- Osmond Clive
- Palmer Cameron D.
- Palotie Aarno
- Pascoe Laura
- Paternoster Lavinia
- Pedersen Oluf
- Perola Markus
- Perry John R. B.
- Pers Tune H.
- Peters Annette
- PolaĆĄek Ozren
- Pospisilik John Andrew
- Prokopenko Inga
- PĂ©russe Louis
- Qi Qibin
- Raitakari Olli T.
- Rankinen Tuomo
- Rao
- Rice Treva K.
- Richards J. Brent
- Ried Janina S.
- Ripatti Samuli
- Rivadeneira Fernando
- Rudan Igor
- Salomaa Veikko
- Sanna Marianna
- Sarzynski Mark A.
- Schadt Eric E.
- Schmidt Ellen M.
- Scott Robert A.
- Scott William R.
- Shin Chan Soo
- Shuldiner Alan R.
- Shungin Dmitry
- Song Kijoung
- Spector Tim D.
- Spira Dominik
- Srikanth Priya
- StancĂĄkovĂĄ Alena
- Steinhagen-Thiessen Elisabeth
- Strauch Konstantin
- Stumvoll Michael
- Sung Yun Ju
- Swart Karin M. A.
- SĂžrensen Thorkild I. A.
- Taittonen Leena
- Tanaka Toshiko
- Tayo Bamidele O.
- Teumer Alexander
- Tikkanen Emmi
- Towne Bradford
- Tranah Gregory J.
- Tremblay Angelo
- Tönjes Anke
- Uitterlinden André G.
- Van Der Harst Pim
- Van Der Velde Nathalie
- Van Duijn Cornelia M.
- Van Schoor Natasja M.
- Vandenput Liesbeth
- Vartiainen Erkki
- Verweij Niek
- Viikari Jorma S.
- Vinkhuyzen Anna A. E.
- Vitart Veronique
- Vohl Marie-Claude
- Vollenweider Peter
- Völzke Henry
- Wagner Peter J.
- Walker Mark
- Walker Ryan W.
- Wallaschofski Henri
- Wareham Nicholas J.
- Westra Harm-Jan
- White Charles C.
- Widén Elisabeth
- Wild Sarah
- Willer Cristen J.
- Wilson James F.
- Wright Alan F.
- Yang Jian
- Yengo LoĂŻc
- Yu Lei
- Zhang Mingfeng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Zhihong
- Zillikens M. Carola
- Zmuda Joseph M.
- Publication venue
- Publication date
- 01/01/2016
- Field of study
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 Ă 10â8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk
The genetic architecture of type 2 diabetes
- Author
- Abboud Hanna E.
- Abecasis Goncalo
- Afzal Uzma
- Agarwala Vineeta
- Aguilar David
- Altshuler David
- Arya Rector
- Atzmon Gil
- Aung Tin
- Balkau Beverley
- Banks Eric
- Barroso Ines
- Barzilai Nir
- Beer Nicola L.
- Bell Graeme I.
- Below Jennifer E.
- Bergman Richard N.
- Bharadwaj Dwaipayan
- Blackwell Thomas W.
- Blancher Christine
- Blangero John
- Boehnke Michael
- Boeing Heiner
- Bonnycastle Lori L.
- Bork-Jensen Jette
- Bottinger Erwin P.
- Bowden Donald W.
- Brandslund Ivan
- Buck David
- Buck Gemma
- Burtt Noël P.
- Butterworth Adam S.
- Carey Jason
- Carneiro Mauricio O.
- Chambers John C.
- Chan Edmund
- Chan Juliana C.N.
- Chandak Giriraj R.
- Chen Han
- Chen Peng
- Chen Yuhui
- Cheng Ching-Yu
- Chia Kee Seng
- Chines Peter S.
- Cho Yoon Shin
- Christensen Cramer
- Cingolani Pablo
- Collins Francis S.
- Correa Adolfo
- Cox Nancy J.
- Curran Joanne E.
- Daly Mark J.
- Danesh John
- Day-Williams Aaron G.
- De Angelis Martin Hrabé
- DeFronzo Ralph A.
- Deloukas Panos
- DePristo Mark
- Doney Alex S.F.
- Donnelly Peter
- Duggirala Ravindranath
- Dupuis Josee
- Ebrahim Shah B.
- Elliott Paul
- Esko Tonu
- Fadista Joao
- Farjoun Yossi
- Farmer Andrew J.
- Farook Vidya S.
- Fennell Timothy
- Ferreira Teresa
- Fingerlin Tasha
- Flannick Jason
- Florez Jose C.
- Fontanillas Pierre
- Fowler Sharon P.
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Froguel Philippe
- Fuchsberger Christian
- Gabriel Stacey
- Gamazon Eric R.
- Gaulton Kyle J.
- Giedraitis Vilmantas
- Gieger Christian
- Gjesing Anette P.
- Glaser Benjamin
- Gloyn Anna L.
- Go Min Jin
- Gottesman Omri
- Grallert Harald
- Grant George
- Grarup Niels
- Green Todd
- Griswold Michael
- Groop Leif
- Groves Christopher J.
- Hakaste Liisa
- Hale Daniel Esten
- Han Bok-Ghee
- Hanis Craig L.
- Hansen Torben
- Hartl Christopher
- Hattersley Andrew T.
- Herder Christian
- Hicks Pamela J.
- Highland Heather M.
- Hodgkiss Dylan
- Hollensted Mette
- Horikoshi Momoko
- Howson Joanna M.M.
- Hu Cheng
- Hu Frank B.
- Huang Jinyan
- Huh Iksoo
- Huth Cornelia
- Huyghe Jeroen R.
- Ikram Mohammad Kamran
- Illig Thomas
- Im Hae Kyung
- Ingelsson Erik
- Isomaa Bo
- Jablonski Kathleen A.
- Jackson Anne U.
- Jenkinson Christopher P.
- Jia Weiping
- Jorgensen Marit E.
- Jorgensen Torben
- Jun Goo
- Justesen Johanne Marie
- Kang Hyun Min
- Karpe Fredrik
- Khor Chiea-Chuen
- Kim Bong-Jo
- Kim Yongkang
- Kim Young Jin
- Kinnunen Leena
- Koistinen Heikki A.
- Kooner Jaspal Singh
- Kravic Jasmina
- Kriebel Jennifer
- Kumar Ashish
- Kumar Satish
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kwak Soo-Heon
- Kwan Phoenix
- Kwon Min-Seok
- KÀrÀjÀmÀki Annemari
- Laakso Markku
- Ladenvall Claes
- Lam Vincent K.L.
- Lander Eric S.
- Langenberg Claudia
- Lannfelt Lars
- Lauritzen Torsten
- Lee Heung Man
- Lee Jaehoon
- Lee Jong-Young
- Lee Juyoung
- Lee Selyeong
- Lehman Donna M.
- Lehne Benjamin
- Levy Jonathan C.
- Liang Liming
- Lim Wei Yen
- Lin Keng-Han
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Jianjun
- Locke Adam E.
- Loh Marie
- Loos Ruth J.F.
- Lu Yingchang
- Lyssenko Valeriya
- Ma Clement
- Ma Ronald C.W.
- Maguire Jared
- Mahajan Anubha
- Mangino Massimo
- Manning Alisa
- Maxwell Taylor J.
- McCarthy Davis J.
- McCarthy Mark I.
- McVean Gilean
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Mohlke Karen L.
- Morris Andrew D.
- Morris Andrew P.
- Moutsianas Loukas
- Murphy Jacquelyn
- Musani Solomon K.
- MĂ€gi Reedik
- MĂŒller-Nurasyid Martina
- Nagai Yoshihiko
- Narisu Narisu
- Navarro Carmen
- Neale Benjamin M.
- Neville Matt
- Ng Maggie C.Y.
- Nilsson Peter
- Njolstad Pal Rasmus
- O'Rahilly Stephen P.
- Onofrio Robert
- Orho-Melander Marju
- Owen Katharine R.
- Palli Domenico
- Palmer Colin N.A.
- Palmer Nicholette D.
- Park Kyong Soo
- Park Taesung
- Parker Stephen C.J.
- Pasko Dorota
- Pearson Richard D.
- Pedersen Oluf
- Perry John R.B.
- Peters Annette
- Pollin Toni I.
- Poplin Ryan
- Prabhakaran Dorairaj
- Prokopenko Inga
- Puppala Sobha
- Purcell Shaun
- Qi Lu
- Qi Qibin
- Rathmann Wolfgang
- Rauramaa Rainer
- Rayner N. William
- Ried Janina S.
- Rivas Manuel A.
- Robertson Neil R.
- Roden Michael
- Rolandsson Olov
- Rosengren Anders H.
- Rybin Denis
- Saleheen Danish
- Salomaa Veikko
- Sandhu Manjinder
- Schwarzmayr Thomas
- Scott James
- Scott Laura J.
- Scott Robert A.
- Scott William R.
- Seielstad Mark
- Shakir Khalid
- Sim Xueling
- Sladek Rob
- Small Kerrin S.
- Smith Joshua D.
- So Wing Yee
- Spector Timothy D.
- StanÄĂĄkovĂĄ Alena
- Stirrups Kathleen
- Stitzel Michael L.
- Strauch Konstantin
- Stringham Heather M.
- Strom Tim M.
- Surdulescu Gabriela L.
- Swift Amy
- SyvÀnen Ann-Christine
- Tai E. Shyong
- Tajes Juan Fernandez
- Tam Claudia H.T.
- Tan Sian-Tsung
- Tandon Nikhil
- Taylor Herman A.
- Teo Yik Ying
- Teslovich Tanya M.
- Thameem Farook
- Thorand Barbara
- Thuillier Dorothée
- Trakalo Joseph
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Van De Bunt Martijn
- Van Der Schouw Yvonne T.
- Varga Tibor V.
- Voight Benjamin F.
- Walker Mark
- Wang Xu
- Wareham Nicholas J.
- Watanabe Richard M.
- Welch Ryan P.
- Wieland Thomas
- Wilson Gregory
- Wilson James G.
- Wong Tien Yin
- Wood Andrew R.
- Yengo Loic
- Yoon Joon
- Zeggini Eleftheria
- Zhang Weihua
- Zhao Wei
- Publication venue
- Publication date
- 01/01/2016
- Field of study
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- AasarĂžd Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso InĂȘs
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- BlĂŒher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
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- Song Kijoung
- Soranzo Nicole
- Sorice Rossella
- Soro-Paavonen Aino
- Sovio Ulla
- Spector Tim D
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- Speliotes Elizabeth K
- Spencer Kylee
- Srinivasan Sathanur R
- St Pourcain Beate
- Stacey Simon N
- Staessen Jan A
- StanÚåkovå Alena
- StanÄĂĄkovĂĄ Alena
- Stark Klaus
- Starr John M
- Stathopoulou Maria G
- Stavarachi Monica
- Stefansson Kari
- Steinle Nanette I
- Steinthorsdottir Valgerdur
- Stewart Alexandre F R
- Stirrups Kathleen
- Stolk Lisette
- Stolk Ronald P
- Strachan David P
- Stracke Sylvia
- Stram Daniel
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- Strawbridge Rona J
- Streeten Elizabeth A
- Stringham Heather M
- Struchalin Maksim
- Stumvoll Michael
- Styrkarsdottir Unnur
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- Sundström Johan
- Surakka Ida
- Surdulescu Gabriela
- Svensson Olle
- Swan Elizabeth J
- Swertz Morris A
- Swift Amy J
- Syreeni Anna
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- Söderlund Jenny
- Tabara Yasuharu
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- Tammesoo Mar-Liis
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- Tanaka Toshiko
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- Taylor Andrew
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- Teslovich Tanya M
- Teumer Alexander
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- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorn Lena M
- Thornton-Wells Tricia
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- Tiirikainen Maarit
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- Tin Adrienne
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- Toenjes Anke
- Tolonen Nina
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- Tregouet David-Alexandre
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- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
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- Tsoka Sophia
- Tsui Kim
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- Tuomilehto Jaakko
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- Van Duijn Cornelia
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- Van Zuydam Natalie
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- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
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- Wang Jie Jin
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- Wang Xiaoling
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- Wild Sarah H
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- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
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- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- WĂŒrtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo LoĂŻc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia MarĂa T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ărnlöv Johan
- Ăsterholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (PÂ <Â 5Â ĂÂ 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
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- Baker Richard
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- Bates Karen
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- Baumohl Jason
- Baynes Caroline
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- Coggill Penelope
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- Collings Simon
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- Considine Tony
- Constance Doug
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- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
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- Gregory Simon
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- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
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- Gu Wenyi
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- Guel Metzalli
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- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
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- Ha Chi
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- Hamilton Matt
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- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
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- Han Guiqing
- Han Shunsheng
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- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
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- Hashimoto Wakako
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- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
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- Heyen Joshua
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- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
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- Krawczyk Marie-Claude
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- Kube Michael
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- Madabhushi Ramki
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- Perez Lesette M.
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- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
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- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
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- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
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- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
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- Ye Chen
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- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
- Author
- Bandinelli Stefania
- Bhasin Shalender
- Bidlingmaier Martin
- Biffar Reiner
- Brabant Georg
- Chanock Stephen J.
- Chen Brian
- Chen Yuhui
- Coviello Andrea D.
- Cox David G.
- Cummings Steven
- de Jong Frank H.
- De Vivo Immaculata
- Eriksson Joel
- Ferrucci Luigi
- Fornage Myriam
- Franks Steve
- Frayling Timothy M.
- Garcia Melissa
- Gunter Marc J.
- Hankinson Susan E.
- Haring Robin
- Harris Tamara B.
- Hartikainen Anna-Liisa
- He Chunyan
- Hofman Albert
- Homuth Georg
- Hunter David J.
- Illig Thomas
- Jansson John-Olov
- Jarvelin Marjo-Riitta
- Johnson Andrew D.
- Kahonen Mika
- Karasik David
- Karlsson Magnus
- Keildson Sarah
- Kettunen Johannes
- Kiel Douglas P.
- Koster Annemarie
- Kraft Peter
- Lagou Vasiliki
- Lehtimaki Terho
- Liu Jingmin
- Liu Simin
- Ljunggren Osten
- Lohman Kurt
- Lorentzon Mattias
- Lunetta Kathryn L.
- Lyytikainen Leo-Pekka
- Maggio Marcello
- Mangino Massimo
- Markus Marcello R. P.
- Martikainen Hannu
- McCarthy Mark I.
- Mei Yong
- Mellstrom Dan
- Miljkovic Iva
- Mirel Daniel
- Murabito Joanne M.
- Murray Anna
- Nelson Sarah
- Ohlsson Claes
- Onland-Moret N. Charlotte
- Ouyang Pamela
- Papunen Laure Morin
- Peeters Petra H. M.
- Perry John R. B.
- Petersen Ann-Kristin
- Pouta Anneli
- Prescott Jennifer
- Prokopenko Inga
- Raffel Leslie
- Raitakari Olli
- Reincke Martin
- Reiner Alex P.
- Rexrode Kathryn
- Rivadeneira Fernando
- Ruokonen Aimo
- Schwartz Stephen M.
- Siscovick David
- Soranzo Nicole
- Spector Tim D.
- Stockl Doris
- Stolk Lisette
- Teumer Alexander
- Tworoger Shelley
- Uitterlinden Andre G.
- Vaidya Dhananjay
- van der Schouw Yvonne T.
- van Gils Carla H.
- Vandenput Liesbeth
- Vasan Ramachandran S.
- Viikari Jorma
- Wallaschofski Henri
- Wellons Melissa
- Wichmann H. -Erich
- Wood Andrew R.
- Zhai Guangju
- Zhuang Wei Vivian
- Publication venue
- Publication date
- 01/01/2012
- Field of study
WOS:000306840400020Peer reviewe
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- Author
- Afzal Uzma
- Ahluwalia Tarunveer Singh
- Bakker Stephan J. L.
- Bataille Veronique
- Bellis Claire
- Bennett David A.
- Bertram Lars
- Bishop D. Timothy
- Bishop Julia A. N.
- Blangero John
- Bluher Matthias
- Boehnke Michael
- Boettcher Yvonne
- Bonnefond Amelie
- Borecki Ingrid B.
- Borodulin Katja
- Bouchard Claude
- Buchkovich Martin L.
- Buchman Aron S.
- Campbell Harry
- Cederholm Tommy
- Chambers John C.
- Cho Nam H.
- Choh Audrey C.
- Choi Hyung Jin
- Cooper Richard S.
- Cousminer Diana L.
- Cummings Steven R.
- Cupples L. Adrienne
- Curran Joanne E.
- Czerwinski Stefan A.
- Dastani Zari
- Day Felix R.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Demuth Ilja
- Dhonukshe-Rutten Rosalie A. M.
- Doring Angela
- Drong Alexander W.
- Eckardt Rahel
- Enneman Anke W.
- Eriksson Johan G.
- Esko Tonu
- Eury Elodie
- Evans Daniel S.
- Evans David M.
- Falchi Mario
- Fatemifar Ghazaleh
- Feitosa Mary F.
- Ferreira Teresa
- Ferrucci Luigi
- Forouhi Nita G.
- Forrester Terrence
- Forsen Tom
- Fox Caroline
- Franco Oscar H.
- Franke Lude
- Friedrich Nele
- Froguel Philippe
- Fumeron Frederic
- Furey Terrence S.
- Gansevoort Ron T.
- Garcia Melissa E.
- Gartner Simone
- Gieger Christian
- Grallert Harald
- Grarup Niels
- Gudnason Vilmundur
- Gustafsson Stefan
- Han Bok-Ghee
- Han Jiali
- Hansen Torben
- Haring Robin
- Harris Tamara B.
- Hastie Nicholas
- Havulinna Aki S.
- Hayward Caroline
- Hedman Asa K.
- Heliovaara Markku
- Hernandez Dena
- Hillege Hans
- Hingorani Aroon
- Hirschhorn Joel N.
- Hofman Albert
- Hunter David J.
- Hysi Pirro G.
- Iles Mark M.
- Ingelsson Erik
- Ittermann Till
- Jackson Anne U.
- Jordan Joanne M.
- Jorgensen Torben
- Jousilahti Pekka
- Jula Antti
- Justice Anne E.
- Kahonen Mika
- Kajantie Eero
- Kanoni Stavroula
- Kaplan Robert C.
- Karjalainen Juha
- Karpe Fredrik
- Kent Jack W.
- Kiel Douglas P.
- Kilpelainen Tuomas Oskari
- Kivimaki Mika
- Knekt Paul B.
- Kolcic Ivana
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kristiansson Kati
- Kuhnel Brigitte
- Kumari Meena
- Kuulasmaa Teemu
- Kuusisto Johanna
- Laakso Markku
- Laatikainen Tiina
- Lagou Vasiliki
- Lahti Jari
- Langenberg Claudia
- Leach Irene Mateo
- Lee Christine G.
- Lee Jong-Young
- Lehtimaki Terho
- Li Rui
- Li Xin
- Lichtner Peter
- Lind Lars
- Lindgren Cecilia
- Linneberg Allan
- Liu Tian
- Liu Yongmei
- Liu Youfang
- Lobbens Stephane
- Locke Adam
- Loh Marie
- Loos Ruth J. F.
- Lu Chen
- Lu Yingchang
- Luan Jian'an
- Luke Amy
- Lyytikainen Leo-Pekka
- Magi Reedik
- Mahajan Anubha
- Mangino Massimo
- Mannisto Satu
- McCarthy Mark I.
- Mckenzie Colin A.
- Mcknight Barbara
- Medina-Gomez Carolina
- Menni Cristina
- Michaelsson Karl
- Mohlke Karen L.
- Morris Andrew P.
- Murabito Joanne M.
- Na Jianbo
- Nalls Mike A.
- Narancic Nina Smolej
- Nielson Carrie M.
- North Kari E.
- O'Connell Jeffrey R.
- Ohlsson Claes
- Ong Ken K.
- Oostra Ben A.
- Oozageer Laticia
- Orwoll Eric S.
- Osmond Clive
- Palmer Cameron D.
- Palotie Aarno
- Pascoe Laura
- Paternoster Lavinia
- Pedersen Oluf
- Pellikka Niina
- Perola Markus
- Perry John R. B.
- Pers Tune H.
- Perusse Louis
- Peters Annette
- Polasek Ozren
- Pospisilik John Andrew
- Prokopenko Inga
- Qi Qibin
- Raitakari Olli T.
- Rankinen Tuomo
- Rao D. C.
- Rice Treva K.
- Richards J. Brent
- Ried Janina S.
- Ripatti Samuli
- Rivadeneira Fernando
- Rudan Igor
- Salomaa Veikko
- Sanna Marianna
- Sarzynski Mark A.
- Schadt Eric E.
- Schmidt Ellen M.
- Scott Robert A.
- Scott William R.
- Shin Chan Soo
- Shuldiner Alan R.
- Shungin Dmitry
- Song Kijoung
- Sorensen Thorkild I. A.
- Spector Tim D.
- Spira Dominik
- Srikanth Priya
- Stancakova Alena
- Steinhagen-Thiessen Elisabeth
- Strauch Konstantin
- Stumvoll Michael
- Sung Yun Ju
- Swart Karin M. A.
- Taittonen Leena
- Tanaka Toshiko
- Tayo Bamidele O.
- Teumer Alexander
- Tikkanen Emmi
- Tonjes Anke
- Towne Bradford
- Tranah Gregory J.
- Tremblay Angelo
- Uitterlinden Andre G.
- van der Harst Pim
- van der Velde Nathalie
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenput Liesbeth
- Vartiainen Erkki
- Verweij Niek
- Viikari Jorma S.
- Vinkhuyzen Anna A. E.
- Vitart Veronique
- Vohl Marie-Claude
- Vollenweider Peter
- Volzke Henry
- Wagner Peter J.
- Walker Mark
- Walker Ryan W.
- Wallaschofski Henri
- Wareham Nicholas J.
- Westra Harm-Jan
- White Charles C.
- Widen Elisabeth
- Wild Sarah
- Willer Cristen J.
- Wilson James F.
- Wright Alan F.
- Yang Jian
- Yengo Loic
- Yu Lei
- Zhang Mingfeng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Zhihong
- Zillikens M. Carola
- Zmuda Joseph M.
- Publication venue
- Publication date
- 01/01/2016
- Field of study
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P <5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.Peer reviewe
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
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- De Bus Liesbet
- de Courcy-Golder Kim
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- del Sorbo Lorenzo
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- Dequin Pierre-François
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- Deye Nicolas
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- Krishnamurthy Vinodh
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- Xavier Kugan
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- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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