301 research outputs found
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A controlled trial of Partners in Dementia Care: veteran outcomes after six and twelve months
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/05/2014
- Field of study
Introduction: āPartners in Dementia Careā (PDC) tested the effectiveness of a care-coordination program integrating healthcare and community services and supporting veterans with dementia and their caregivers. Delivered via partnerships between Veterans Affairs medical centers and Alzheimerās Association chapters, PDC targeted both patients and caregivers, distinguishing it from many non-pharmacological interventions. Hypotheses posited PDC would improve five veteran self-reported outcomes: 1) unmet need, 2) embarrassment about memory problems, 3) isolation, 4) relationship strain and 5) depression. Greater impact was expected for more impaired veterans. A unique feature was self-reported research data collected from veterans with dementia. Methods and Findings: Five matched communities were study sites. Two randomly selected sites received PDC for 12 months; comparison sites received usual care. Three structured telephone interviews were completed every 6 months with veterans who could participate. Results: Of 508 consenting veterans, 333 (65.6%) completed baseline interviews. Among those who completed baseline interviews, 263 (79.0%) completed 6-month follow-ups and 194 (58.3%) completed 12-month follow-ups. Regression analyses showed PDC veterans had significantly less adverse outcomes than those receiving usual care, particularly for more impaired veterans after 6 months, including reduced relationship strain (B = ā0.09; p = 0.05), depression (B = ā0.10; p = 0.03), and unmet need (B = ā0.28; p = 0.02; and B = ā0.52; p = 0.08). PDC veterans also had less embarrassment about memory problems (B = ā0.24; p = 0.08). At 12 months, more impaired veterans had further reductions in unmet need (B = ā0.96; p < 0.01) and embarrassment (B = ā0.05; p = 0.02). Limitations included use of matched comparison sites rather than within-site randomization and lack of consideration for variation within the PDC group in amounts and types of assistance provided. Conclusions: Partnerships between community and health organizations have the potential to meet the dementia-related needs and improve the psychosocial functioning of persons with dementia. Trial Registry NCT0029116
Setting our sights on infectious diseases
- Author
- Aldridge Bree
- Amewu Richard K.
- Barry Clifton E.
- Buckner Frederick S.
- Cook Sarah
- De Rycker Manu
- Ferguson Michael A. J.
- Gilbert Ian H.
- Gobeau Nathalie
- Herrling Paul
- Herrmann Jennifer
- Hope William
- Horn David
- Keiser Jennifer
- Lafuente-Monasterio Maria Jose
- Leeson Paul D.
- Leroy Didier
- Manjunatha Ujjini H.
- McCarthy James
- Miles Timothy J.
- Mizrahi Valerie
- Moshynets Olena
- Niles Jacquin
- Overington John P.
- Pottage John
- Rao Srinivasa P. S.
- Read Kevin D.
- Ribeiro Isabela
- Silver Lynn L.
- Southern Jen
- Spangenberg Thomas
- Sundar Shyam
- Taylor Caitlin
- Van Voorhis Wesley C.
- White Nicholas J.
- Wyatt Paul G.
- Wyllie Susan
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 01/01/2019
- Field of study
In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings
Health and Oral Health Care Needs and Health Care-Seeking Behavior Among Homeless Injection Drug Users in San Francisco
- Author
- A Umbricht-Schneiter
- AH Kral
- Alex H. Kral
- AM Laslett
- AS Reece
- AS Reece
- B Tempalski
- Caroline Shiboski
- DD Chitwood
- DD Chitwood
- DD Chitwood
- DI Rosenstein
- ED Riley
- GD Klasser
- GD Slade
- GM McCarthy
- J Fan
- J Neale
- Jennifer Lorvick
- JK Watters
- JN Burdine
- Jonathan Leserman Robbins
- JW Shaner
- KA McGeary
- KA Sporer
- KG Heinzerling
- LA Cohen
- LR Metsch
- Lynn Wenger
- M Conte
- M Weinert
- MT French
- P Bourgois
- PG Colon
- R Padilla
- RG Deiss
- RS Garfein
- S Reece
- StataCorp
- V Shetty
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
Few existing studies have examined health and oral health needs and treatment-seeking behavior among the homeless and injection drug users (IDUs). This paper describes the prevalence and correlates of health and oral health care needs and treatment-seeking behaviors in homeless IDUs recruited in San Francisco, California, from 2003 to 2005 (Nā=ā340). We examined sociodemographic characteristics, drug use patterns, HIV status via oral fluid testing, physical health using the Short Form 12 Physical Component Score, self-reported needs for physical and oral health care, and the self-reported frequency of seeking medical and oral health care. The sample had a lower health status as compared to the general population and reported a frequent need for physical and oral health care. In bivariate analysis, being in methadone treatment was associated with care-seeking behavior. In addition, being enrolled in Medi-Cal, Californiaās state Medicaid program, was associated with greater odds of seeking physical and oral health care. Methamphetamine use was not associated with higher odds of needing oral health care as compared to people who reported using other illicit drugs. Homeless IDUs in San Francisco have a large burden of unmet health and oral health needs. Recent cuts in Medi-Calās adult dental coverage may result in a greater burden of oral health care which will need to be provided by emergency departments and neighborhood dental clinics
COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records
- Author
- Abbasizanjani Hoda
- Ahmed Badar
- Ahmed Nida
- Akbari Ashley
- Akbari Ashley
- Akinoso-Imran Abdul Qadr
- Allara Elias
- Allery Freya
- Angelantonio Emanuele Di
- Ashworth Mark
- Ayyar-Gupta Vandana
- Babu-Narayan Sonya
- Bacon Seb
- Ball Steve
- Banerjee Ami
- Banerjee Amitava
- Barber Mark
- Barrett Jessica
- Bennie Marion
- Berry Colin
- Beveridge Jennifer
- Birney Ewan
- BojaniÄ Lana
- Bolton Thomas
- Bone Anna
- Boyle Jon
- Braithwaite Tasanee
- Bray Ben
- Briffa Norman
- Brind David
- Brown Katherine
- Buch Maya
- Canoy Dexter
- Caputo Massimo
- Carragher Raymond
- Carson Alan
- Cezard Genevieve
- Chang Jen-Yu Amy
- Cheema Kate
- Chin Richard
- Chudasama Yogini
- Cooper Jennifer
- Cooper Jennifer
- Copland Emma
- Crallan Rebecca
- Cripps Rachel
- Cromwell David
- Curcin Vasa
- Curry Gwenetta
- Dale Caroline
- Danesh John
- Das-Munshi Jayati
- Dashtban Ashkan
- Davies Alun
- Davies Gareth
- Davies Joanna
- Davies Neil
- Day Joshua
- Delmestri Antonella
- Denaxas Spiros
- Denaxas Spiros
- Denholm Rachel
- Dennis John
- Denniston Alastair
- Deo Salil
- Dhillon Baljean
- Docherty Annemarie
- Dong Tim
- Douiri Abdel
- Downs Johnny
- Dregan Alexandru
- Ellins Elizabeth A
- Elwenspoek Martha
- Falck Fabian
- Falter Florian
- Fan Yat Yi
- Firth Joseph
- Fraser Lorna
- Friebel Rocco
- Gavrieli Amir
- Gerstung Moritz
- Gilbert Ruth
- Gillies Clare
- Glickman Myer
- Goldacre Ben
- Goldacre Raph
- Greaves Felix
- Green Mark
- Grieco Luca
- Griffiths Rowena
- Gurdasani Deepti
- Halcox Julian
- Hall Nick
- Hama Tuankasfee
- Handy Alex
- Handy Alex
- Hansell Anna
- Hardelid Pia
- Hardy Flavien
- Harris Daniel
- Harrison Camille
- Harron Katie
- Hassaine Abdelaali
- Hassan Lamiece
- Healey Russell
- Hemingway Harry
- Hemingway Harry
- Henderson Angela
- Herz Naomi
- Heyl Johannes
- Hidajat Mira
- Higginson Irene
- Hinchliffe Rosie
- Hippisley-Cox Julia
- Ho Frederick
- Hocaoglu Mevhibe
- Hollings Sam
- Hollings Sam
- Horne Elsie
- Hughes David
- Humberstone Ben
- Inouye Mike
- Ip Samantha
- Islam Nazrul
- Jackson Caroline
- Jenkins David
- Jiang Xiyun
- Johnson Shane
- Kadam Umesh
- Kallis Costas
- Karim Zainab
- Kasan Jake
- Katsoulis Michalis
- Kavanagh Kim
- Kee Frank
- Keene Spencer
- Kent Seamus
- Khalid Sara
- Khawaja Anthony
- Khunti Kamlesh
- Killick Richard
- Kinnear Deborah
- Knight Rochelle
- Kolamunnage-Dona Ruwanthi
- Kontopantelis Evan
- Kurdi Amanj
- Lacey Ben
- Lai Alvina
- Lai Alvina G
- Lambarth Andrew
- Larzjan Milad Nazarzadeh
- Lawler Deborah
- Lawrence Thomas
- Lawson Claire
- Li Ken
- Li Kezhi
- Li Qiuju
- Llinares Miguel Bernabeu
- Lorgelly Paula
- Lowe Deborah
- Lyons Jane
- Lyons Ronan
- Machado Pedro
- Macleod John
- Macleod Mary Joan
- Malgapo Evaleen
- Mamas Mamas
- Mamouei Mohammad
- Manohar Sinduja
- Mapeta Rutendo
- Martelli Javiera Leniz
- Martos David Moreno
- Mateen Bilal
- Mateen Bilal A
- McCarthy Aoife
- Melville Craig
- Milton Rebecca
- Mizani Mehrdad
- Mizani Mehrdad A
- Moncusi Marta Pineda
- Morales Daniel
- Mordi Ify
- Morrice Lynn
- Morris Carole
- Morris Eva
- Mu Yi
- Mueller Tanja
- Murdock Lars
- Nafilyan VahƩ
- Nicholson George
- Nikiphorou Elena
- Nolan John
- Norris Ruth
- Norris Tom
- North Laura
- North Teri-Louise
- O'Connell Dan
- Oliver Dominic
- Oluyase Adejoke
- Olvera-Barrios Abraham
- Omigie Efosa
- Onida Sarah
- Padmanabhan Sandosh
- Pagel Christina
- Palmer Tom
- Pasea Laura
- Patel Riyaz
- Payne Rupert
- Pell Jill
- Petitjean Carmen
- Pherwani Arun
- Pickrell Owen
- Pierotti Livia
- Pirmohamed Munir
- Priedon Rouven
- Prieto-Alhambra Dani
- Proudfoot Alastair
- Quinn Terry
- Quint Jennifer
- Raffetti Elena
- Rahimi Kazem
- Rao Shishir
- Razieh Cameron
- Roberts Brian
- Rogers Caroline
- Rossdale Jennifer
- Salim Safa
- Samani Nilesh
- Sattar Naveed
- Sattar Naveed
- Schnier Christian
- Schwartz Roy
- Selby David
- Seminog Olena
- Shabnam Sharmin
- Shah Ajay
- Shelton Jon
- Sheppard James
- Sinha Shubhra
- Skrypak Mirek
- Slapkova Martina
- Sleeman Katherine
- Smith Craig
- Sofat Reecha
- Sofat Reecha
- Sosenko Filip
- Sperrin Matthew
- Steeg Sarah
- Sterne Jonathan
- Sterne Jonathan AC
- Stoica Serban
- Sudell Maria
- Sudlow Cathie
- Sudlow Cathie
- Sun Luanluan
- Suseeladevi Arun Karthikeyan
- Sweeting Michael
- Sydes Matt
- Takhar Rohan
- Tang Howard
- Thygesen Johan
- Thygesen Johan H
- Tilston George
- Tochel Claire
- Toit Clea du
- Tomlinson Christopher
- Tomlinson Christopher
- Toms Renin
- Torabi Fatemeh
- Torralbo Ana
- Torralbo Ana
- Townson Julia
- Tufail Adnan
- Tungamirai Tapiwa
- Varma Susheel
- Vollmer Sebastian
- Walker Venexia
- Wang Huan
- Wang Tianxiao
- Warwick Alasdair
- Watkinson Ruth
- Watson Harry
- Whiteley William
- Whiteley William N
- Whittaker Hannah
- Wilde Harry
- Wilkinson Tim
- Williams Gareth
- Williams Michelle
- Williams Richard
- Withnell Eloise
- Wolfe Charles
- Wood Angela
- Wood Angela
- Wright Lucy
- Wu Honghan
- Wu Honghan
- Wu Jianhua
- Wu Jinge
- Yates Tom
- Zaccardi Francesco
- Zhang Haoting
- Zhang Huayu
- Zuccolo Luisa
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/06/2022
- Field of study
BACKGROUND:
Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework.
METHODS:
In this cohort study, we used eight linked National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Data on COVID-19 testing, vaccination, primary and secondary care records, and death registrations were collected until Nov 30, 2021. We defined ten COVID-19 phenotypes reflecting clinically relevant stages of disease severity and encompassing five categories: positive SARS-CoV-2 test, primary care diagnosis, hospital admission, ventilation modality (four phenotypes), and death (three phenotypes). We constructed patient trajectories illustrating transition frequency and duration between phenotypes. Analyses were stratified by pandemic waves and vaccination status.
FINDINGS:
Among 57ā032ā174 individuals included in the cohort, 13ā990ā423 COVID-19 events were identified in 7ā244ā925 individuals, equating to an infection rate of 12Ā·7% during the study period. Of 7ā244ā925 individuals, 460ā737 (6Ā·4%) were admitted to hospital and 158ā020 (2Ā·2%) died. Of 460ā737 individuals who were admitted to hospital, 48ā847 (10Ā·6%) were admitted to the intensive care unit (ICU), 69ā090 (15Ā·0%) received non-invasive ventilation, and 25ā928 (5Ā·6%) received invasive ventilation. Among 384ā135 patients who were admitted to hospital but did not require ventilation, mortality was higher in wave 1 (23ā485 [30Ā·4%] of 77ā202 patients) than wave 2 (44ā220 [23Ā·1%] of 191ā528 patients), but remained unchanged for patients admitted to the ICU. Mortality was highest among patients who received ventilatory support outside of the ICU in wave 1 (2569 [50Ā·7%] of 5063 patients). 15ā486 (9Ā·8%) of 158ā020 COVID-19-related deaths occurred within 28 days of the first COVID-19 event without a COVID-19 diagnoses on the death certificate. 10ā884 (6Ā·9%) of 158ā020 deaths were identified exclusively from mortality data with no previous COVID-19 phenotype recorded. We observed longer patient trajectories in wave 2 than wave 1.
INTERPRETATION:
Our analyses illustrate the wide spectrum of disease trajectories as shown by differences in incidence, survival, and clinical pathways. We have provided a modular analytical framework that can be used to monitor the impact of the pandemic and generate evidence of clinical and policy relevance using multiple EHR sources.
FUNDING:
British Heart Foundation Data Science Centre, led by Health Data Research UK
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĆ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave FranƧois
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe ValƩrie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis VĆ©ronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blƶcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- BrĆ¼ls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
- Clark Graham
- Clark Kevin
- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
- Clark Sue
- Clarke Adrian
- Clarke Betty
- Clarke Eddie
- Clarke Kay
- Clarke Laura
- Clawson Hiram
- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
- Collier Rachael
- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
- Cooper Rachel
- Cooper Robert
- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
- Cordray Rebecca
- Cornell Christine
- Cornell Earl
- Cornell Linda
- Cornell Ruth
- Corum Ben
- Cottage Amanda
- Cotton Sara
- Coulson Alan
- Couronne Olivier
- Courtney Laura P.
- Coville Gez
- Cox Anthony
- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
- Craig Matthew
- Crane Tom
- Crawford Amanda L.
- Crawley Matt
- Cree Andrew
- Crespeau HervƩ
- Crew Victor
- Critchlow Terrance
- Critz Paul
- Cruaud Corinne
- Cuff James
- Cui Hongjuan
- Cui Jinhui
- Cui Peng
- Cui Peng
- Culley Karl
- Cummings Auli
- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
- Danganan Linda
- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
- Davidson Lucy
- Davidson Stuart
- Davies Jonathon
- Davies Joy
- Davies Nicholas
- Davies Robert
- Davila Mary Louise
- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
- Davis Jayne
- Davis John
- Davis Matthew
- Davy-Carroll Latarsha
- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
- Dean Peter
- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
- Deguzman Maria
- Dehal Paramvir
- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
- Deng Yajun
- Dennis Janet
- Denson Shawn
- Denys Mirian
- Deramo Christine
- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
- Dhami Pawandeep
- Dhongsar Chemey
- Dias Jennifer
- Dias Victoria
- Dibartolo Genevieve
- Dibling Catherine
- Dickson Mark
- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
- Ding Keyue
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- Dinh Huyen H.
- Dixon Kami
- Do Long
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- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
- Dorje Passang
- Dorjee Kunsang
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- Dorsett Victor
- Doucette-Stamm Lynn
- Douthwaite Karen J.
- Down Thomas
- Draper Heather
- Du Feiyu
- Du Hui
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- Dubchak Inna
- Duffy Noah
- Dugan-Rocha Shannon
- Dunham Andrew
- Dunham Ian
- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
- Dunwell Erin
- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
- Edgar Darren
- Edionwe Susan Omwanghe Osayanro
- Edwards Carol
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- Egan Amy
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- Elkin Chris
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- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
- Endrizzi Matthew
- Engh Ger van den
- Engle David
- Erickson Jeffery
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- Errington Helen
- Escobar Julio
- Escotto Michael
- Eugene Craig S.
- Evans Gareth
- Evans John
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- Eveleth Gerald
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- Footman Simon
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- Fuller Liam
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- Furey Terrence S.
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- Fƶrste Silke
- Gabisi Abdul M.
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- Garcia Ricardo M, III
- Garcia-Martinez Antonio
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- Garnes Jeffrey A.
- Garnett Jane
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- Gatland Leigh
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- Griffiths Coline
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- Hitchens Matthew Edward
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- Wohldmann Patty
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- Woods Eric
- Woodwark Cara
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- Wray Paul
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- Wright Debbie
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- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
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- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
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- Xu Zhihong
- Xu Zuyuan
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- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
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- Yang Shudong
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- Yang Xiaonan
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- Yao Zhijian
- Yao Zhijian
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- Ye Chen
- Yeager Shane
- Yeh Mimi
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- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ā¼99% of the euchromatic genome and is accurate to an error rate of ā¼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat RĆ¼deger
- Albert LoĆÆc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Ćtienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
- Brannen Judith L.
- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
- Bright Stacey N.
- Broiles Brian J.
- Bromenschenkel Asa
- Brooks Brian H.
- Brooks Keira J.
- Brown Bob
- Brown Bruce
- Brown Thomas M.
- Bruce Barry W.
- Bryson Jonathan G.
- Bujanda Edwin D.
- Bullock Blake M.
- Bunker A. J.
- Bureo Rafael
- Burt Irving J.
- Bush James Aaron
- Bushouse Howard A.
- Bussman Marie C.
- Bƶker Torsten
- Cabaud Olivier
- Cale Steven
- Calhoon Charles D.
- Calvani Humberto
- Canipe Alicia M.
- Caputo Francis M.
- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
- Cherinka Brian
- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
- Clark Kerry W.
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- Walker Jr. Frederick E.
- Wander Michel
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- Weilert Mark
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- Wislowski Emily Christine
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- Woo Cindy
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- Wu Carl
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- Young Gary
- Yu Gene
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- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Ćlvarez-MĆ”rquez Javier
- Ćstlin Gƶran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
TRY plant trait database ā enhanced coverage and open access
- Author
- Aakala Tuomas
- Abedi Mehdi
- Acosta Alicia T. R.
- Adamidis George C.
- Adamson Kairi
- Aiba Masahiro
- Albert CĆ©cile H.
- AlcƔntara Julio M.
- AlcƔzar C Carolina
- Aleixo Izabela
- Ali Hamada
- Amiaud Bernard
- Ammer Christian
- Amoroso Mariano M.
- Anand Madhur
- Anderson Carolyn
- Anten Niels
- Antos Joseph
- Apgaua Deborah Mattos GuimarĆ£es
- Ashman TiaāLynn
- Asmara Degi Harja
- Asner Gregory P.
- Aspinwall Michael
- Atkin Owen
- Aubin Isabelle
- BaastrupāSpohr Lars
- Bahalkeh Khadijeh
- Bahn Michael
- Baker Timothy
- Baker William J.
- Bakker Jan P.
- Baldocchi Dennis
- Baltzer Jennifer
- Banerjee Arindam
- Baranger Anne
- Barlow Jos
- Barneche Diego R.
- Baruch Zdravko
- Bastianelli Denis
- Battles John
- Bauerle William
- Bauters Marijn
- Bazzato Erika
- Beckmann Michael
- Beeckman Hans
- Beer Arend Jacobus
- Beest Mariska
- Beierkuhnlein Carl
- Bekker Renee
- Belfry Gavin
- Belluau Michael
- Beloiu Mirela
- Benavides Raquel
- Benomar Lahcen
- BerdugoāLattke Mary Lee
- Berenguer Erika
- Bergamin Rodrigo
- Bergmann Carlucci Marcos
- Bergmann Joana
- Berner Logan
- BernhardtāRƶmermann Markus
- Bigler Christof
- Bjorkman Anne D.
- Blackman Chris
- Blanco Carolina
- Blonder Benjamin
- Blumenthal Dana
- BocanegraāGonzĆ”lez Kelly T.
- Bodegom Peter M.
- Boeckx Pascal
- Bohlman Stephanie
- BoisvertāMarsh Laura
- Bond William
- BondāLamberty Ben
- Boom Arnoud
- Boonman Coline C. F.
- Bordin Kauane
- Boughton Elizabeth H.
- Boukili Vanessa
- Bowman David M. J. S.
- Bravo Sandra
- Brendel Marco Richard
- Breugel Michiel
- Broadley Martin R.
- Brown Kerry A.
- Bruelheide Helge
- Brumnich Federico
- Bruun Hans Henrik
- Bruy David
- Buchanan Serra W.
- Bucher Solveig Franziska
- Buchmann Nina
- Buitenwerf Robert
- Bunker Daniel E.
- Burrascano Sabina
- Burslem David F. R. P.
- Butterfield Bradley J.
- Byun Chaeho
- BƶhningāGaese Katrin
- Bƶnisch Gerhard
- BĆ¼rger Jana
- Caccianiga Marco
- Cadotte Marc
- Cailleret Maxime
- Camac James
- Camarero JesĆŗs Julio
- Campany Courtney
- Campetella Giandiego
- Campos Juan Antonio
- CanoāArboleda Laura
- Canullo Roberto
- Carbognani Michele
- Carvalho Fabio
- Casanoves Fernando
- Castagneyrol Bastien
- Catford Jane A.
- CavenderāBares Jeannine
- Cerabolini Bruno E. L.
- Cervellini Marco
- ChacĆ³nāMadrigal Eduardo
- Chapin F. Stuart
- Chapin Kenneth
- Chelli Stefano
- Chen Anping
- Chen SiāChong
- Cherubini Paolo
- Chianucci Francesco
- Choat Brendan
- Chung KyongāSook
- ChytrĆ½ Milan
- Ciccarelli Daniela
- Coll LluĆs
- Collins Courtney G.
- Conti Luisa
- Coomes David
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- Csecserits AnikĆ³
- Cufar Katarina
- Cuntz Matthias
- Dahlin Kyla M.
- Dainese Matteo
- Dalke Igor
- Dalle Fratte Michele
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- De Long Jonathan R.
- Dechant Benjamin
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- Derroire GĆ©raldine
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- DiazāToribio Milton Hugo
- Dimitrakopoulos Panayiotis G.
- Dios Victor Resco
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- Domingues Tomas F.
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- Dransfield John
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- Durka Walter
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- DÅevojan Pavel
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- Ejtehadi Hamid
- Elser James
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- Engemann Kristine
- Erfanian Mohammad Bagher
- Erfmeier Alexandra
- EsquivelāMuelbert Adriane
- Esser Gerd
- Estiarte Marc
- EāVojtkĆ³ Anna
- Fagan William F.
- FagĆŗndez Jaime
- Falster Daniel S.
- Fan Ying
- Fang Jingyun
- Farris Emmanuele
- Fazlioglu Fatih
- Feng Yanhao
- FernandezāMendez Fernando
- Ferrara Carlotta
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- Finegan Bryan
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- Flowers Timothy J.
- Flynn Dan F. B.
- Fontana Veronika
- Forey Estelle
- Forgiarini Cristiane
- Frangipani Marcelo
- Frank Dorothea
- FranƧois Louis
- FrenetteāDussault Cedric
- Freschet GrƩgoire T.
- Fry Ellen L.
- Fyllas Nikolaos M.
- Gachet Sophie
- Gallagher Rachael
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- Ganga Francesca
- GarcĆaāPalacios Pablo
- Gargaglione VerĆ³nica
- Garnier Eric
- Garrido Jose Luis
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- GeaāIzquierdo Guillermo
- Gibson David
- Gillison Andrew N.
- Giroldo Aelton
- Glasenhardt MaryāClaire
- Gleason Sean
- Gliesch Mariana
- Goldberg Emma
- GonzalezāAkre Erika
- GonzalezāAndujar Jose L.
- GonzĆ”lezāMelo AndrĆ©s
- GonzĆ”lezāRobles Ana
- Graae Bente Jessen
- Granda Elena
- Graves Sarah
- Green Walton A.
- Gregor Thomas
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- GutiƩrrez Alvaro G.
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- Herz Katharina
- Heuertz Myriam
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- Higuchi Pedro
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- Hirons Andrew
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- Hornstein Daniel
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- Jactel HervƩ
- Jagodzinski Andrzej M.
- Jandt Ute
- Jansen Steven
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- Jespersen Jens Rasmus Plantener
- Jiang GuoāFeng
- Johansen Jesper Liengaard
- Johnson David
- Jokela Eric J.
- Joly Carlos Alfredo
- Jordan Gregory J.
- Joseph Grant Stuart
- Junaedi Decky
- Junker Robert R.
- Justes Eric
- Kabzems Richard
- Kane Jeffrey
- Kaplan Zdenek
- Kattenborn Teja
- Kattge Jens
- Kavelenova Lyudmila
- Kearsley Elizabeth
- Kempel Anne
- Kenzo Tanaka
- Kerkhoff Andrew
- Khalil Mohammed I.
- Kinlock Nicole L.
- Kissling Wilm Daniel
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- Knops Johannes M. H.
- Kohyama Takashi
- Koike Fumito
- Kollmann Johannes
- Komac Benjamin
- Komatsu Kimberly
- Kraft Nathan J. B.
- Kramer Koen
- Kreft Holger
- Kumarathunge Dushan
- Kuppler Jonas
- Kurokawa Hiroko
- Kurosawa Yoko
- Kuyah Shem
- Kƶnig Christian
- KĆ¼hn Ingolf
- Laclau JeanāPaul
- Lafleur Benoit
- Lallai Erik
- Lamb Eric
- Lamprecht Andrea
- Larkin Daniel J.
- Laughlin Daniel
- Lavorel Sandra
- Le BagousseāPinguet Yoann
- Leadley Paul
- Lee Tali
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- Lewis Simon L.
- Lhotsky Barbara
- Li Xine
- Li Yuanzhi
- Lichstein Jeremy W.
- Liebergesell Mario
- Lim Jun Ying
- Lin YanāShih
- Linares Juan Carlos
- Liu Chunjiang
- Liu Daijun
- Liu Udayangani
- Livingstone Stuart
- LlusiĆ Joan
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- LopezāGonzalez Gabriela
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- Luo Yunjian
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- Maire Guerric
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- Mallik Azim
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- Manzoni Stefano
- Marchetti Zuleica
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- MarcilioāSilva Vinicius
- Marcon Eric
- Marignani Michela
- Markesteijn Lars
- Marques Marcia
- Martin Adam
- MartĆnezāGarza Cristina
- MartĆnezāVilalta Jordi
- Mason Kelly
- Mason Norman
- Massad Tara Joy
- Masse Jacynthe
- Mayrose Itay
- Mazzochini Guilherme G.
- MaÅ”kovĆ” Tereza
- McCarthy James
- McCormack M. Luke
- McCulloh Katherine
- McFadden Ian R.
- McGill Brian J.
- McPartland Mara Y.
- Medeiros Juliana S.
- Medlyn Belinda
- Meerts Pierre
- Mehrabi Zia
- Meir Patrick
- Melo Felipe P. L.
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- Merwe Stephni
- Messier Julie
- Metsaranta Juha
- Michaletz Sean T.
- Michelaki Chrysanthi
- Migalina Svetlana
- Milla Ruben
- Miller Jesse E. D.
- Minden Vanessa
- Ming Ray
- Mokany Karel
- Moles Angela T.
- MolnƔr Attila, V
- Molofsky Jane
- Molz Martin
- Montgomery Rebecca A.
- Monty Arnaud
- MoravcovĆ” Lenka
- MorenoāMartĆnez Alvaro
- Moretti Marco
- Mori Akira S.
- Mori Shigeta
- Morris Dave
- Morrison Jane
- Mucina Ladislav
- Mueller Sandra
- Muir Christopher D.
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- MyersāSmith Isla H.
- Myster Randall W.
- MƤkelƤ Annikki
- MƤkinen Harri
- MƩszƔros Ilona
- MĆ¼ller Sandra Cristina
- Nagano Masahiro
- Naidu Shawna
- Narayanan Ayyappan
- Natesan Balachandran
- Negoita Luka
- Nelson Andrew S.
- Neuschulz Eike Lena
- Ni Jian
- Niedrist Georg
- Nieto Jhon
- Niinemets Ćlo
- Nolan Rachael
- Nottebrock Henning
- Nouvellon Yann
- Novakovskiy Alexander
- Nystuen Kristin Odden
- O\u27Grady Anthony
- O\u27Hara Kevin
- O\u27ReillyāNugent Andrew
- Oakley Simon
- Oberhuber Walter
- Ohtsuka Toshiyuki
- Oliveira Ricardo
- Olson Mark E.
- Onipchenko Vladimir
- Onoda Yusuke
- Onstein Renske E.
- Ordonez Jenny C.
- Osada Noriyuki
- Ostonen Ivika
- Ottaviani Gianluigi
- Otto Sarah
- Overbeck Gerhard E.
- Ozinga Wim A.
- Pahl Anna T.
- Paine C. E. Timothy
- Pakeman Robin J.
- Papageorgiou Aristotelis C.
- Parfionova Evgeniya
- Patacca Marco
- Paula Susana
- Paule Juraj
- Pauli Harald
- Pausas Juli G.
- Peco BegoƱa
- Penuelas Josep
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- PetiscoāSouza Ana Carolina
- Petraglia Alessandro
- Petritan Any Mary
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- Pierce Simon
- Pillar ValƩrio D.
- Pinho Bruno X.
- Pisek Jan
- Plas Fons
- Pomogaybin Alexandr
- Poorter Hendrik
- Portsmuth Angelika
- Poschlod Peter
- Potvin Catherine
- Pounds Devon
- Powell A. Shafer
- Power Sally A.
- Prentice Iain Colin
- Prinzing Andreas
- Puglielli Giacomo
- PyŔek Petr
- PƤrtel Meelis
- Raevel Valerie
- Rammig Anja
- Ransijn Johannes
- Ray Courtenay A.
- Reich Peter B.
- Reichstein Markus
- Reid Douglas E. B.
- Ribeiro Sabina
- Richardson Sarah
- Riibak Kersti
- Rillig Matthias C.
- Riviera Fiamma
- Robert Elisabeth M. R.
- Roberts Scott
- Robroek Bjorn
- Roddy Adam
- Rodrigues Arthur Vinicius
- Rogers Alistair
- Rollinson Emily
- Rolo Victor
- Ronzhina Dina
- Roscher Christiane
- Rosell Julieta A.
- Rosenfield Milena Fermina
- Rossi Christian
- Roux Elizabeth
- Roux Peter C.
- Roy David B.
- RoyerāTardif Samuel
- RuizāPeinado Ricardo
- Rumpf Sabine B.
- Rusch Graciela M.
- Ryo Masahiro
- RĆ©jouāMĆ©chain Maxime
- Rƶmermann Christine
- RĆ¼ger Nadja
- Sack Lawren
- SaldaƱa Angela
- SalgadoāNegret Beatriz
- SalgueroāGomez Roberto
- Sande Masha T.
- SantacruzāGarcĆa Ana Carolina
- SantaāRegina Ignacio
- Santos Joaquim
- Sardans Jordi
- Scalon Marina C.
- Schamp Brandon
- SchererāLorenzen Michael
- Schleuning Matthias
- Schmid Bernhard
- Schmidt Marco
- Schmitt Sylvain
- Schneider Julio V.
- Schowanek Simon D.
- Schrader Julian
- Schrodt Franziska
- Schuldt Bernhard
- Schurr Frank
- Selaya Garvizu Galia
- Semchenko Marina
- Seymour Colleen
- Sfair Julia C.
- Sharpe Joanne M.
- Sheppard Christine S.
- Sheremetiev Serge
- Shiodera Satomi
- Shipley Bill
- Shovon Tanvir Ahmed
- SiebenkƤs Alrun
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- Silva Vasco
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- Sjƶman Henrik
- Slot Martijn
- Smith Nicholas G.
- Sodhi Darwin
- Soltis Douglas
- Soltis Pamela
- Somers Ben
- Sonnier GrƩgory
- Sosinski Enio Egon, Jr
- Soudzilovskaia Nadejda A.
- Souza Alexandre F.
- Spasojevic Marko
- Sperandii Marta Gaia
- Stan Amanda B.
- Stegen James
- Steinbauer Klaus
- Stephan Jƶrg G.
- Sterck Frank
- Stojanovic Dejan B.
- Strydom Tanya
- Suarez Maria Laura
- Svenning JensāChristian
- SvitkovĆ” Ivana
- Svitok Marek
- Svoboda Miroslav
- Swaine Emily
- Swenson Nathan
- SĆørensen Mia Vedel
- Tabarelli Marcelo
- Takagi Kentaro
- Tappeiner Ulrike
- Tarifa RubƩn
- Tarin Tonantzin
- Tautenhahn Susanne
- Tauugourdeau Simon
- Tavsanoglu Cagatay
- Tedersoo Leho
- Thiffault Nelson
- Thom Dominik
- Thomas Evert
- Thompson Ken
- Thornton Peter E.
- Thuiller Wilfried
- TichĆ½ LubomĆr
- Tissue David
- Tjoelker Mark G.
- Tng David Yue Phin
- Tobias Joseph
- TorresāRuiz JosĆ© M.
- Treurnicht Martina
- Trivellone Valeria
- Trolliet Franck
- Trotsiuk Volodymyr
- Tsakalos James L.
- Tsiripidis Ioannis
- Tysklind Niklas
- TĆ³thmĆ©rĆ©sz BĆ©la
- Tƶrƶk PƩter
- Umehara Toru
- Usoltsev Vladimir
- Vadeboncoeur Matthew
- Vaezi Jamil
- Valladares Fernando
- Vamosi Jana
- Van Cleemput Elisa
- Van Meerbeek Koenraad
- Vanderwel Mark
- Vanselow Kim AndrƩ
- Varone Laura
- Vasquez Valderrama Maribel Yesenia
- Vassilev Kiril
- Vellend Mark
- Veneklaas Erik J.
- Verbeeck Hans
- Verheyen Kris
- Vibrans Alexander
- Vieira Ima
- VillacĆs Jaime
- Violle Cyrille
- Vivek Pandi
- VĆ„rhammar Angelica
- Wagner Katrin
- Waldram Matthew
- Waldron Anthony
- Walker Anthony P.
- Waller Martyn
- Walther Gabriel
- Wang Feng
- Wang Han
- Wang Weiqi
- Watkins Harry
- Watkins James
- Weber Ulrich
- Weedon James T.
- Weg Martine
- Wei Liping
- Weigelt Patrick
- Weiher Evan
- Wells Aidan W.
- Wellstein Camilla
- Wenk Elizabeth
- Werner Gijsbert D. A.
- Westoby Mark
- Westwood Alana
- White Philip John
- Whitten Mark
- Williams Mathew
- Winkler Daniel E.
- Winter Klaus
- Wirth Christian
- Womack Chevonne
- Wright Ian J.
- Wright Justin
- Wright S. Joseph
- Ximenes Fabiano
- Yamada Toshihiro
- Yamaji Keiko
- Yanai Ruth
- Yankov Nikolay
- Yguel Benjamin
- Zanini KƔtia Janaina
- Zanne Amy E.
- ZelenĆ½ David
- Zhao YunāPeng
- Zheng Ji
- Zheng Jingming
- ZiemiÅska Kasia
- Zirbel Chad R.
- Zizka Georg
- Zotz Gerhard
- ZoāBi IriĆ© Casimir
- Ćllerer Kinga
- Publication venue
- John Wiley and Sons
- Publication date
- 10/01/2020
- Field of study
Plant traits - the morphological, anatomical, physiological, biochemical and phenological characteristics of plants - determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of traitābased plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits - almost complete coverage for āplant growth formā. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and traitāenvironmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives
Search for dark matter produced in association with bottom or top quarks in ās = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro GuimarĆ£es da Costa JoĆ£o
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
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- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
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- Berlendis Simon
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- Bernius Catrin
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- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertram Iain
- Bertsche Carolyn
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
- Bethani Agni
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- Bevan Adrian
- Beyer Julien-christopher
- Bianchi Riccardo-Maria
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- Bielski Rafal
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- Blue Andrew
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- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
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- Bock Christopher
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- Boerner Daniela
- Bogavac Danijela
- Bogdanchikov Alexander
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- Brost Elizabeth
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- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
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- Buzatu Adrian
- Buzykaev Aleksey
- BĆ¼scher Daniel
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- Cabrera UrbƔn Susana
- Caforio Davide
- Cai Huacheng
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- Calfayan Philippe
- Callea Giuseppe
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- Calvente Lopez Sergio
- Calvet David
- Calvet Samuel
- Calvet Thomas
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- Weingarten Jens
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- Yamanaka Takashi
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- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven
- Ye Jingbo
- Ye Shuwei
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- Yigitbasi Efe
- Yildirim Eda
- Yorita Kohei
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- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Ć kesson Torsten
- Å filigoj Tina
- ŽeniŔ Tibor
- ŽivkoviÄ Lidija
- Īlvarez Piqueras DamiĆ”n
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fbā1 of protonāproton collision data recorded by the ATLAS experiment at ās = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- AbrahaĢo JoĢnatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez GuzmaĢn
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- ArtiĢa Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- BalanĢa-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- BognaĢr Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
- Chu Shaoyou
- Chua Benjamin Soon Kai
- Chuah Janelle
- Chung Zara
- Chuong Patrick
- Ciccia Alberto
- Cildir GoĢkhan
- Cione Erika
- Clayton W. Brent
- Coles John G.
- Colomba Audrey
- Colotti Gianni
- Conn Graeme L.
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- Contreras Stephanie
- Cools Julie
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- Corson Timothy W.
- Cortopassi Gino
- Corvo Ileana
- Costoya Jose A.
- Cowen Leah E.
- Cox Bryan D.
- Cuddihy Andrew R.
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- Cunningham Kathryn A.
- Dahal Gopal
- Dallman Sydney
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- Davtyan Aram
- De Keulenaer Gilles
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- de Oliveira Aldo Sena
- de Oliveira Saulo
- de Sousa Alessandra Mara
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- Lisabeth Erika Mathes
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- Taylor Richard E.
- Teixeira Thaiz Rodrigues
- Teramoto Tadahisa
- Thai Van Chi
- Thayer Desiree
- Thomas Bill
- Thompson Erik W.
- Tilford Hannah
- Tiwari Rakesh Kumar
- Toh Alan Kie Leong
- Tomilov Alexey
- Toogood Peter
- Torner Carles
- Trabocchi Andrea
- Trader Darci J.
- Trakhtenberg Ephraim F.
- Trinh Nguyen Mai
- Truong Ha
- Tse-Dinh Yuk-Ching
- Tsimbalyuk Sofiya
- Tumes Damon J.
- Tye Mark A.
- Uribe Ruben Vazquez
- Valli Marilia
- van den Akker Focco
- van den Bedem Henry
- Van Doren Steven R.
- Van Grack Tessa
- Van Hung Le Vuong
- Van Pelt Natascha
- Van Remmen Holly
- Van Voorhis Wesley C.
- Vandenberg Robert J.
- Veit Guido
- Verhamme Ingrid M.
- Verma Rajkumar
- Viola Ronald E.
- Virtanen Anniina
- Vizeacoumar Franco J.
- Vizeacoumar Frederick S.
- Vleminckx Margot
- von Hundelshausen Philipp
- Voss Jan Hendrik
- Vrielink Alice
- Waggoner Stephen N.
- Walensky Loren D.
- Wallach Izhar
- Wang Feng
- Wang Jianghai
- Wang Jun
- Wang Xingyou
- Wang Zhenghe
- Warrington Jeffrey M.
- Watkins Joshua
- Wazir Sarah
- Weber Christian
- Welsbie Derek S.
- Wentworth Kelly L.
- Wert-Lamas Leon
- White Andrew
- White Simon J.
- Whitesell Luke
- Williams Tiffany
- Wilson Cornelia M.
- Wilson Mark A.
- Windisch Marc P.
- Wong Keith S.
- Woods Virgil A.
- Worley Brad
- Wu Pengpeng
- Wu Xiaoyang
- Wulff Heike
- Xiang Fei
- Xu Hongyang
- Xu Jiake
- Xu Jingyi
- Xu Sophia Q.
- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNetĀ® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNetĀ® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements
- Author
- Adlard Julian
- Ahmed Munaza
- Aich Anshul
- Aitman Tim
- Alachkar Hana
- Alle Hana Lango
- Allsup David
- Almeida-King Jeff
- Ambrose J. C.
- Amin Aliya S.
- Ancliff Philip
- Antrobus Richard
- Armstrong Ruth
- Arno Gavin
- Arumugam P.
- Ashford Sofie
- Astle William
- Attwood Anthony
- Babbs Chris
- Bakchoul Tamam
- Bariana Tadbir
- Barwell Julian
- Bennett David
- Bentley David
- Bevers R.
- Bierzynska Agnieszka
- Biss Tina
- Bleda M.
- Bleda Marta
- Boardman-Pretty F.
- Bogaard Harm
- Bourne Christian
- Boustred C. R.
- Boyce Sara
- Bradley John
- Breen Gerome
- Brennan Paul
- Brewer Carole
- Brittain H.
- Brod Naomi Clements
- Brown M. A.
- Brown Matthew
- Browning Michael
- Buchan Rachel
- Buckland Matthew
- Bueser Teofila
- Burns Siobhan
- Burren Oliver
- Calleja Paul
- Carr-White Gerald
- Carss Keren
- Casey Ruth
- Caulfield M. J.
- Caulfield Mark
- Cebola InĆŖs
- Chambers Jennifer
- Chambers Jenny
- Chambers John
- Chan G. C.
- Chan Melanie M. Y.
- Cheng Floria
- Chinnery Patrick F.
- Christian Martin
- Church Colin
- Coghlan Gerry
- Colby Elizabeth
- Cole Trevor
- Collins Janine
- Collins Peter
- Colombo Camilla
- Condliffe Robin
- Cook Stuart
- Cook Terry
- Cooley Sharon
- Cooper Nichola
- Corris Paul
- Crisp-Hihn Abigail
- Curry Nicola
- Danesino Cesare
- Daniels Matthew
- Daugherty Louise
- Davis John
- Deevi Sri V. V.
- Dent Timothy
- Dewhurst Eleanor
- Dixon Peter
- Dixon Peter H.
- Donnelly Jennifer
- Downes Kate
- Drazyk Anna
- Drewe Elizabeth
- Dutt Tina
- Edgar David
- Edwards Karen
- Egner William
- Erber Wendy
- Erwood Marie
- Estiu Maria C.
- Estiu Maria Cecilia
- Evans Dafydd Gareth
- Evans Gillian
- Everington Tamara
- Eyries MĆ©lanie
- Favier Remi
- Fletcher Debra
- Fowler T.
- Fox James
- Frary Amy
- French Courtney
- Freson Kathleen
- Frontini Mattia
- Gale Daniel
- Gale Daniel P.
- Gall Henning
- Geary Michael
- Geoghegan Claire
- Gerighty Terry
- Ghio Stefano
- Ghofrani Hossein-Ardeschir
- Gibbs Simon
- Giess A.
- Gilmour Kimberley
- Girerd Barbara
- Goddard Sarah
- Gomez Keith
- Gordins Pavels
- Gosal David
- Grassi Luigi
- Greene Daniel
- Greenhalgh Lynn
- Greinacher Andreas
- Gresele Paolo
- Griffiths Philip
- Grigoriadou Sofia
- Grocock Russell
- Grozeva Detelina
- GrƤf Stefan
- Hackett Scott
- Hadinnapola Charaka
- Hague William
- Hague William M.
- Haimel Matthias
- Hall Matthew
- Hamblin A.
- Hanson Helen
- Harkness Kirsty
- Harper Andrew
- Harris Claire
- Hart Daniel
- Hassan Ahamad
- Hayman Grant
- Henderson Alex
- Henderson S.
- Hoffmann Jonathan
- Horvath Rita
- Houweling Arjan
- Howard Luke
- Hu Fengyuan
- Hubbard T. J. P.
- Hudson Gavin
- Hughes Joseph
- Huissoon Aarnoud
- Humbert Marc
- Humphray Sean
- Hunter Sarah
- Hurles Matthew
- Izatt Louise
- Jackson R.
- James Roger
- Johnson Sally
- Jolles Stephen
- Jolley Jennifer
- Jones L. J.
- Jurkute Neringa
- Kasanicki Mary
- Kasperaviciute D.
- Kayikci M.
- Kazkaz Hanadi
- Kazmi Rashid
- Kelleher Peter
- Kiely David
- Kingston Nathalie
- Klima Robert
- Kostadima Myrto
- Kousathanas A.
- Kovacs Gabor
- Koziell Ania
- Kreuzhuber Roman
- Kuijpers Taco
- Kumar Ajith
- Kumararatne Dinakantha
- Kuria Manju
- Laffa Michael
- Lahnstein L.
- Lalloo Fiona
- Lamber Michele
- Lawrie Allan
- Layton Mark
- Leigh S. E. A.
- Lentaigne Claire
- Leong I. U. S.
- Levine Adam
- Levine Adam P.
- Linger Rachel
- Longhurst Hilary
- Lopez F. J.
- Louka Eleni
- Madan Bella
- Maher Eamonn
- Maimaris Jesmeen
- Maleady-Crowe F.
- Mangles Sarah
- Mapeta Rutendo
- Marchbank Kevin
- Marks Stephen
- Markus Hugh S.
- Marschall Hanns-Ulrich
- Marshall Andrew
- Martin Jennifer
- Mathias Mary
- Matthews Emma
- Maude Hannah
- Maxwell Heather
- McAlinden Paul
- McCarthy Mark
- McEntagart M.
- Meacham Stuart
- Mead Adam
- Megy Karyn
- Mehta Sarju
- Michaelides Michel
- Millar Carolyn
- Minneci F.
- Mitchell Alice L.
- Moledina Shahin
- Montani David
- Moor Tony
- Morrell Nicholas
- Moutsianas L.
- Mozere Monika
- Mueller M.
- Muir Keith
- Mumford Andrew
- Murugaesu N.
- Need A. C.
- Newnham Michael
- Nicolaides Kypros
- Noordegraaf Anton Vonk
- O'Donovan P.
- O'Sullivan Jennifer
- Obaji Samya
- Odhams C. A.
- Okoli Steven
- Olschewski Andrea
- Olschewski Horst
- Ong Kai Ren
- Ormondroy Elizabeth
- Ouwehan Willem
- Papadi Sofia
- Park Soo-Mi
- Parry David
- Patch C.
- Paterson Joan
- Peacock Andrew
- Peden John
- Peerlinck Kathelijne
- Penkett Christopher
- Pepke-Zaba Joanna
- Pereira M. B.
- Perez-Gil D.
- Petersen Romina
- Pullinger J.
- Pyle Angela
- Rahim T.
- Rankin Stuart
- Rao Anupama
- Raymond F. Lucy
- Rayner-Matthew Paula
- Rees Christine
- Rendon A.
- Rendon Augusto
- Renton Tara
- Rice Andrew
- Richardson Sylvia
- Richter Alex
- Roberts Irene
- Rogers T.
- Ross Robert MacKenzie
- Roughley Catherine
- Roy Noemi
- Sadeghi-Alavijeh Omid
- Saleem Moin
- Samani Nilesh
- Sanchis-Juan Alba
- Sargur Ravishankar
- Satchell Simon
- Savage K.
- Savic Sinisa
- Sawant K.
- Scelsi Laura
- Schulman Sol
- Scott R. H.
- Scully Marie
- Searle Claire
- Seeger Werner
- Sewell Carrock
- Seyres Denis
- Shapiro Susie
- Sharmardina Olga
- Shtoyerman Rakefet
- Sibson Keith
- Siddiq A.
- Side Lucy
- Sieghart A.
- Simeoni Ilenia
- Simpson Michael
- Sivapalaratnam Suthesh
- Skytte Anne-Bine
- Smith Katherine
- Smith Kenneth G. C.
- Smith S. C.
- Snape Katie
- Sosinsky A.
- Soubrier Florent
- Staines Simon
- Staples Emily
- Stark Hannah
- Stephens Jonathan
- Stirrups Kathleen
- Stock Sophie
- Stuckey A.
- Suntharalingam Jay
- Swietlik Emilia
- Syngelaki Argyro
- Tait R. Campbell
- Talks Kate
- Tan Rhea
- Tanguy M.
- Taylor Tavares A. L.
- Thaventhiran James
- Themistocleous Andreas
- Thomas E. R. A.
- Thomas Moira
- Thompson S. R.
- Thomson Kate
- Thorsell Malin
- Thrasher Adrian
- Thys Chantal
- Tischkowitz Marc
- Titterton Catherine
- Toh Cheng-Hock
- Toshner Mark
- Traylor Matthew
- Treacy Carmen
- Trembath Richard
- Tucci A.
- Tuna Salih
- Turek Wojciech
- Turro Ernest
- Vale Tom
- Van Geet Chris
- Van Zuydam Natalie
- Vazquez-Lopez Marta
- von Ziegenweidt Julie
- Waisfisz Quintin
- Walker Suellen
- Ware James
- Watkins Hugh
- Watt Christopher
- Webster Andrew
- Wei Wei
- Welch Steven
- Welland M. J.
- Wessels Julie
- Westbury Sarah
- Westwood John-Paul
- Wharton John
- Whitehorn Deborah
- Whitworth James
- Wilkins Martin R.
- Williams E.
- Williamson Catherine
- Witkowska K.
- Wong Edwin
- Wood Nicholas
- Wood S. M.
- Wood Yvette
- Woods Geoff
- Woodward Emma
- Wort Stephen
- Worth Austen
- Yates Katherine
- Yong Patrick
- Young Tim
- Yu Ping
- Yu-Wai-Man Patrick
- Zhang Jun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/08/2022
- Field of study
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5ā2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility
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