On Editing

Covering the changes in Shakespeare editorial theory and practice over the decades between the publication of the Oxford Shakespeare (1986) and the New Oxford Shakespeare (2016), this article surveys a range of modern texts with different rationales and aimed at different readerships. The article has three sections: the imagery associated with editorial activity, issues of authorship and collaboration, and the place of performance in editions. We trace the conceptual changes between the Textual Companion that accompanied the 1986 edition, and the Authorship Companion that is the equivalent for the 2016 edition, discussing the role of quantitative and qualitative approaches to questions of authorship and collaboration. We pay particular attention to the metaphors and tropes that shape editorial discourse, finding their echoes in early modern paratextual material. Pervasive anthropomorphic textual imagery tends implicitly to feminize texts (and masculinize editors), and we discuss the changing demands on editors and the continued dominance of male editors, particularly for Shakespeare’s tragedies and histories. A final section discusses Arden editorial generations of Hamlet alongside the play’s own telos of interrupted succession and its preoccupation with ghosts and the past

Does believing something to be fiction allow a form of moral licencing or a 'fictive pass' in understanding others' actions?

Introduction: The human capacity to engage with fictional worlds raises important psychological questions about the mechanisms that make this possible. Of particular interest is whether people respond differently to fictional stories compared to factual ones in terms of how immersed they become and how they view the characters involved and their actions. It has been suggested that fiction provides us with a ‘fictive pass’ that allows us to evaluate in a more balanced, detached way the morality of a character’s behaviour. Methods: We use a randomised controlled experimental design to test this. Results and discussion: We show that, although knowing whether a substantial film clip is fact or fiction does not affect how engaged with (‘transported’ by) a troubling story an observer becomes, it does grant them a ‘fictive pass’ to empathise with a moral transgressor. However, a fictive pass does not override the capacity to judge the causes of a character’s moral transgression (at least as indexed by a causal attribution task)

Targeting the live market: recovery of Norway lobsters Nephrops norvegicus (L.) from trawl-capture as assessed by stress-related parameters and nucleotide breakdown

The recovery potential of Norway lobsters (Nephrops norvegicus) held in on-board seawater tanks after trawl-capture was assessed at two different times of the year (winter and summer). Survival recorded 24 h after trawl-capture was 84.83 ± 0.93% in the winter compared to 75.35 ± 2.92% in the summer. Stress-related parameters in the muscle (arginine phosphate, glycogen and L-lactate) and in the haemolymph (L-lactate) were measured, together with nucleotide breakdown products in the muscle (yielding the “Adenylate Energy Charge” or AEC ratio). All parameters analysed were responsive to the stress of the trawl-capture and subsequently recovered towards resting values, but did so at different rates. The fact that some measures recovered at a faster rate than others should be taken into account when trying to develop an index of metabolic stress for this species. Animals trawled in the winter recovered to AEC values above 0.8 within 4 h of placing them in on-board seawater tanks, whereas animals trawled in the summer took 24 h to reach these values. Furthermore, at the end of the trials animals trawled in the summer presented significantly higher haemolymph L-lactate and lower muscle glycogen reserves than the animals trawled in the winter, suggesting a faster recovery in the winter compared to the summer. Finally, animals in the winter were better able to endure further stresses (an emersion of 1 h while animals were transported to the commercial handling facilities). Therefore, as a code of practice it is advised that trawled N. norvegicus directed to the live trade should be allowed to recover for at least 4–6 h in on-board tanks, and extra care should be taken especially in the summer, if further stresses such as additional emersion are to be applied within the first 24 h after capture

Medication Holds in CKD During Acute Volume-Depleting Illnesses: A Randomized Controlled Trial of a "Sick-Day" Protocol.

RATIONALE & OBJECTIVE: Some drugs prescribed for chronic kidney disease (CKD) may become hazardous on sick days with volume depletion by increasing the risk of acute kidney injury (AKI) and kidney function loss; however, the risks and benefits of their use during intercurrent illness is unknown. STUDY DESIGN: 6-month pragmatic trial examining a sick-day protocol to determine if withholding prespecified drugs during a volume-depleting illness reduces the incidence AKI or kidney function loss in CKD. SETTING & PARTICIPANTS: 315 veterans with stage 3-5 CKD, treated with a renin-angiotensin-aldosterone inhibitor blocker, diuretic, nonsteroidal anti-inflammatory drug, or metformin were randomized into the study with n = 159 and n = 156 in sick-day protocol and usual care groups, respectively. INTERVENTION: Sick-day protocol administered via interactive voice response system (IVRS) or usual care with 6-month follow-up. OUTCOMES: The outcomes of the study are as follows: (1) Change in kidney function, (2) incidence of AKI based on International Classification of Diseases, Tenth Revision codes and ambulatory laboratory testing, (3) urgent service utilizations, and (4) sick days. RESULTS: The mean age was 70.1 ± 7.4 and 69.2 ± 8.1 years, with a mean baseline glomerular filtration rate (GFR) of 43.1 ± 13.1 and 43.8 ± 13.0 mL/min/1.73 m2, and 112 (70%) and 100 (64%) of participants with diabetes in the sick-day protocol and usual care groups, respectively. The mean change in GFR in the sick-day protocol and usual care groups from baseline to 6-month follow-up, adjusting for baseline GFR, was -0.71 (95% CI, -2.11 to 0.69) and -0.72 (95% CI, -2.12 to 0.68), respectively, with no significant difference, P = 0.99. Hospitalizations in the sick-day protocol and usual care groups were 11.5/100 and 8.4/100 events per person-months, respectively, with the adjusted rate ratio not significantly increased (prevalence ratio, 1.30; 95% CI, 0.96-1.76). Participants interacted with the IVRS in 81% of expected weeks and 19 had one or more qualifying events. In 33 true sick days, participants correctly followed the protocol in only 14. LIMITATIONS: Low incidence of sick days over the 6-month period of the study. CONCLUSIONS: The sick-day protocol was not associated with a significant reduction in AKI episodes or kidney function loss in a high-risk CKD population. Engagement with the IVRS was high, but successful implementation of the sick-day protocol was not optimal. TRIAL REGISTRATION: ClinicalTrials.gov; NCT03141905

Grey and white matter correlates of recent and remote autobiographical memory retrieval:Insights from the dementias

The capacity to remember self-referential past events relies on the integrity of a distributed neural network. Controversy exists, however, regarding the involvement of specific brain structures for the retrieval of recently experienced versus more distant events. Here, we explored how characteristic patterns of atrophy in neurodegenerative disorders differentially disrupt remote versus recent autobiographical memory. Eleven behavioural-variant frontotemporal dementia, 10 semantic dementia, 15 Alzheimer's disease patients and 14 healthy older Controls completed the Autobiographical Interview. All patient groups displayed significant remote memory impairments relative to Controls. Similarly, recent period retrieval was significantly compromised in behavioural-variant frontotemporal dementia and Alzheimer's disease, yet semantic dementia patients scored in line with Controls. Voxel-based morphometry and diffusion tensor imaging analyses, for all participants combined, were conducted to investigate grey and white matter correlates of remote and recent autobiographical memory retrieval. Neural correlates common to both recent and remote time periods were identified, including the hippocampus, medial prefrontal, and frontopolar cortices, and the forceps minor and left hippocampal portion of the cingulum bundle. Regions exclusively implicated in each time period were also identified. The integrity of the anterior temporal cortices was related to the retrieval of remote memories, whereas the posterior cingulate cortex emerged as a structure significantly associated with recent autobiographical memory retrieval. This study represents the first investigation of the grey and white matter correlates of remote and recent autobiographical memory retrieval in neurodegenerative disorders. Our findings demonstrate the importance of core brain structures, including the medial prefrontal cortex and hippocampus, irrespective of time period, and point towards the contribution of discrete regions in mediating successful retrieval of distant versus recently experienced events

Effect of wearing a face mask on hand-to-face contact by children in a simulated school environment: the Back-to-School COVID-19 Simulation Randomized Clinical Trial

Importance Wearing a face mask in school can reduce SARS-CoV-2 transmission but it may also lead to increased hand-to-face contact, which in turn could increase infection risk through self-inoculation. Objective To evaluate the effect of wearing a face mask on hand-to-face contact by children while at school. Design, Setting, and Participants This prospective randomized clinical trial randomized students from junior kindergarten to grade 12 at 2 schools in Toronto, Ontario, Canada, during August 2020 in a 1:1 ratio to either a mask or control class during a 2-day school simulation. Classes were video recorded from 4 angles to accurately capture outcomes. Interventions Participants in the mask arm were instructed to bring their own mask and wear it at all times. Students assigned to control classes were not required to mask at any time (grade 4 and lower) or in the classroom where physical distancing could be maintained (grade 5 and up). Main Outcomes and Measures The primary outcome was the number of hand-to-face contacts per student per hour on day 2 of the simulation. Secondary outcomes included hand-to-mucosa contacts and hand-to-nonmucosa contacts. A mixed Poisson regression model was used to derive rate ratios (RRs), adjusted for age and sex with a random intercept for class with bootstrapped 95% CIs. Results A total of 174 students underwent randomization and 171 students (mask group, 50.6% male; control group, 52.4% male) attended school on day 2. The rate of hand-to-face contacts did not differ significantly between the mask and the control groups (88.2 vs 88.7 events per student per hour; RR, 1.00; 95% CI, 0.78-1.28; P = >.99). When compared with the control group, the rate of hand-to-mucosa contacts was significantly lower in the mask group (RR, 0.12; 95% CI, 0.07-0.21), while the rate of hand-to-nonmucosa contacts was higher (RR, 1.40; 95% CI, 1.08-1.82). Conclusions and Relevance In this clinical trial of simulated school attendance, hand-to-face contacts did not differ among students required to wear face masks vs students not required to wear face masks; however, hand-to-mucosa contracts were lower in the face mask group. This suggests that mask wearing is unlikely to increase infection risk through self-inoculation. Trial Registration ClinicalTrials.gov Identifier: NCT0453125

Crop Updates 2007 - Weeds

This session covers thirty two papers from different authors: 1. ACKNOWLEDGEMENTS, Alexandra Douglas CONVENOR – WEEDS DEPARTMENT OF AGRICULTURE AND FOOD WILD RADISH MANAGEMENT 2. Decimate a wild radish seed bank in five years, Peter Newman, Sally Peltzer, Abul Hashem and Aik Cheam, Department of Agriculture and Food 3. High level of seed-set control in wild radish is achievable, Aik Cheam and Siew Lee,Department of Agriculture and Food 4. Wild radish: Best management practice, Aik Cheam and Siew Lee, Department of Agriculture and Food 5. Control of phenoxy resistant wild radish through the combined effects of wheat competition and phenoxy herbicides, Natalie Maguire and Michael Walsh, WAHRI, School of Plant Biology, University of Western Australia 6.Efficacy of florasulam on chlorsulfuron resistant and susceptible wild radish populations in Western Australia, Michael Walsh1 and Dan Cornally2, 1WAHRI, School of Plant Biology, University of Western Australia, 2Dow Agrosciences Australia 7. Does liming to increase soil pH limit the growth and development of wild radish (Raphanus raphanistrum)Matt Willis and Michael Walsh, WAHRI, School of Plant Biology, University of Western Australia IWM TECHNIQUES AND SEEDBANKS 8. Weed trimming – a potential technique to reduce weed seed set, Glen Riethmuller, Abul Hashem and Shahab Pathan, Department of Agriculture and Food 9. Burn narrow windrows in the wind, Peter Newman1and Michael Walsh2, 1Department of Agriculture and Food, 2Research Fellow, WA Herbicide Resistance Initiative 10. Winning the Weed War with the Weed Seed Wizard! Michael Renton, Sally Peltzer and Art Diggle, Department of Agriculture and Food HERBICIDE RESISTANCE AND GENE FLOW 11. Frequency of herbicide resistance in wild oat (Avena fatua) across the Western Australian wheatbelt, Mechelle Owen and Stephen Powles, WA Herbicide Resistance Initiative, School of Plant Biology, University of Western Australia 12. Pollen mediated gene flow of herbicide resistance can occur over long distances doe annual ryegrass (Lolium rigidum): Results of two years with different meteorological conditions, Roberto Busi, Robert Barrett-Lennard and Stephen B. Powles, Western Australian Herbicide Resistance Initiative, School of Plant Biology – University of Western Australia 13. Doublegee has developed resistance to metsulfuron-methyl within WA wheatbelt, Dr Abul Hashem1and Dr Shahab Pathan2, 1Senior Research Officer, and 2Research Officer, Department Agriculture and Food 14. Another case of glyphosate resistance in annual ryegrass confirmes within Western Australia, Dr Abul Hashem1and Dr Shahab Pathan2, 1Senior Research Officer, and 2Research Officer, Department Agriculture and Food 15. Glyphosate resistance in the northern NSW – implications for Western Australian farming systems, Andrew Storrie, Tamworth Agricultural Institute, NSW Department of Primary Industries ALTERNATIVES TO TRIFLURALIN, KNOCKDOWNS, TANK MIXES AND NOVEL USES 16. Alternative pre-emergent herbicides to trifluralin for annual ryegrass control, Mr David Minkey and Dr Abul Hashem, Department of Agriculture and Food, 17. Evaluation of a new pre-emergent herbicide alternative dor the control of trifluralin resistant Lolium rigidum Gaudin (annual ryegrass) in wheat and barley, Craig A. Ruchs, Syngenta Crop Protection Australia Pty Ltd and Dr Peter Boutsalis, University of Adelaide 18. Novel knockdown tank mixes: Results from 12 trials over four years, Shahab Pathan1, Abul Hashem2, Catherine Borger3, Nerys Wilkins and Julie Roche, Department of Agriculture and Food, Western Australia, and 3the University of Western Australia 19. Alternative herbicides for weed control in lupins, Peter Newman and Martin Harries, Department of Agriculture and Food 20. Novel use application of clopyealid in lupins, John Peirce, and Brad Rayner, Department of Agriculture and Food 21. A model to predict grass selective herbicide rates, John Moore, Department of Agriculture and Food CROP AND WEED MANAGEMENT 22. Inter-row weed control in wide row lupin using knockdown-based tank mixes, Dr Abul Hashem1, Ray Fulwood2 and Chris Roberts3, 1Senior Research Officer, Department of Agriculture and Food, 2Farmer, Meckering, WA, 3Technical Officer, Department of Agriculture and Food 23. Timing of weed removal in wide-row lupins, Sally Peltzer, Shahab Pathan and Paul Matson, Department of Agriculture and Food 24. The effect of row spacing and crop density on competitiveness of lupins with wild radish, Bob French and Laurie Maiolo, Department of Agriculture and Food 25. Is delayed sowing a good strategy for weed management in lupins? Bob French, Department of Agriculture and Food 26. Delayed sowing as a strategy to manage annual ryegrass, Department of Agriculture and Food HERBICIDE TOLERANCE 27. The effect of herbicides on nodulation in lupins, Lorne Mills1, Harmohinder Dhammu2 and Beng Tan1, 1Curtin University of Technology, and 2Department of Agriculture and Food 28. Response of new wheat varieties to herbicides, Harmohinder Dhammu, Department of Agriculture and Food 29. Herbicide tolerance of new barley varieties, Harmohinder Dhammu, Vince Lambert and Chris Roberts, Department of Agriculture and Food 30. Herbicide tolerance of new oat varieties, Harmohinder Dhammu, Vince Lambert and Chris Roberts, Department of Agriculture and Food OTHER WEEDY MATTERS 31. Research and extension need for wild radish and other cruciferous weeds, Aik Cheam, Department of Agriculture and Food 32. e-weed – an information resource of seasonal weed management issues, Vanessa Stewartand Julie Roche, Department of Agriculture and Foo

Enhanced tonic GABAA inhibition in typical absence epilepsy

The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired GABAergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABAA receptor–dependent ‘tonic’ inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA uptake by the GABA transporter GAT–1 in the genetic models tested, and GAT–1 is critical in governing seizure genesis. Extrasynaptic GABAA receptors are a requirement for seizures in two of the best characterized models of absence epilepsy, and the selective activation of thalamic extrasynaptic GABAA receptors is sufficient to elicit both electrographic and behavioural correlates of seizures in normal animals. These results identify an apparently common cellular pathology in typical absence seizures that may have epileptogenic significance, and highlight novel therapeutic targets for the treatment of absence epilepsy.peer-reviewe

Proceedings of Patient Reported Outcome Measure’s (PROMs) Conference Oxford 2017: Advances in Patient Reported Outcomes Research

A33-Effects of Out-of-Pocket (OOP) Payments and Financial Distress on Quality of Life (QoL) of People with Parkinson’s (PwP) and their Carer

GABAA receptor subtype involvement in addictive behaviour

GABAA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarise the evidence that variations in genes encoding GABAA receptor isoforms are associated with aspects of addictive behaviour in humans, while animal models of addictive behaviour also implicate certain subtypes of GABAA receptor. In addition to outlining the evidence for the involvement of specific subtypes in addiction, we summarise the particular contributions of these isoforms in control over the functioning of brain circuits, especially the mesolimbic system, and make a first attempt to bring together evidence from several fields to understanding potential involvement of GABAA Receptor Subtypes in addictive behaviour. While the weight of the published literature is on alcohol dependency, the underlying principles outlined are relevant across a number of different aspects of addictive behaviour