Sarkisov links from toric weighted blowups of P3\mathbb{P}^3 and P4\mathbb{P}^4 at a point

We study Sarkisov links initiated by the toric weighted blowup of a point in $\mathbb{P}^3$ or $\mathbb{P}^4$ using variation of GIT. We completely classify which of these initiate Sarkisov links and describe the links explicitly. Moreover, if $X$ is the toric weighted blowup of $\mathbb{P}^d$ at a point, we give a simple criterion in terms of the weights of the blowup that characterises when $X$ is weak Fano.Comment: 21 pp., Comments are welcom

Blowups of smooth Fano hypersurfaces, their birational geometry and divisorial stability

Let $\Gamma$ be a smooth $k$-dimensional hypersurface in $\mathbb P^{k+1}$ and $X \supset \Gamma$ a smooth $n$-dimensional Fano hypersurface in $\mathbb P^{n+1}$ where $n\geq 3$ and $k\geq 1$. Let $Y \rightarrow X$ be the blowup of $X$ along $\Gamma$. We give a constructive proof that $Y$ is a Mori dream space. In particular, we describe its Mori chamber decomposition and the associated birational models of $Y$. We classify for which $X$ and $\Gamma$ the variety $Y$ is a Fano manifold and we initiate the study of K-stability of $Y$.Comment: 20 page

K-stability of Casagrande-Druel varieties

We introduce a new subclass of Fano varieties (Casagrande-Druel varieties), that are $n$-dimensional varieties constructed from Fano double covers of dimension $n-1$. We conjecture that a Casagrande-Druel variety is K-polystable if the double cover and its base space are K-polystable. We prove this for smoothable Casagrande-Druel threefolds, and for Casagrande-Druel varieties constructed from double covers of $\mathbb{P}^{n-1}$ ramified over smooth hypersurfaces of degree $2d$ with $n>d>\frac{n}{2}>1$. As an application, we describe the connected components of the K-moduli space parametrizing smoothable K-polystable Fano threefolds in the families 3.9 and 4.2 in the Mori-Mukai classification.Comment: 58 page

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Relatório final de estágio pedagógico realizado na Escola Secundária com 3º ciclo de Gama Barros, no ano letivo 2011-2012

Mestrado em Ensino da Educação Física nos Ensinos Básico e SecundárioO relatório pretende analisar o processo de Estágio Pedagógico desenvolvido no ano letivo 2011/2012, integrado no Mestrado em Ensino da Educação Física nos Ensinos Básico e Secundário da Faculdade de Motricidade Humana. A atividade de Estágio realizou-se na Escola Secundária com 3º Ciclo de Gama Barros, localizada no Cacém. O trabalho foi conduzido pelo Guia de Estágio Pedagógico 2011/2012, onde estão expressos os objetivos gerais e específicos, relativos a quatro áreas de intervenção: Organização e Gestão do Ensino e da Aprendizagem (Área 1), Inovação e Investigação Pedagógica (Área 2), Participação na Escola (Área 3) e Relação com a Comunidade (Área 4). É apresentada uma contextualização do estágio, onde é destacada as caraterísticas da escola, do grupo de Educação Física e da turma. Posteriormente, em cada uma das áreas é realizada uma reflexão crítica sobre as principais dificuldades sentidas e as estratégias utilizadas para a superação das mesmas, fundamentais para o meu crescimento e formação. Por fim, é realizada uma reflexão crítica sobre todo o processo de formação, abordando o estágio pedagógico vivido durante o presente ano letivo e os anos anteriores de formação académica

Explicity birational geometry of Fano 3-folds of high index

We complete the analysis on the birational rigidity of quasismooth Fano 3-fold deformation families appearing in the Graded Ring Database as a complete intersection. When such a deformation family X has Fano index at least 2 and is minimally embedded in a weighted projective space in codimension 2, we determine which cyclic quotient singularity is a maximal centre. If a cyclic quotient singularity is a maximal centre, we construct a Sarkisov link to a non-isomorphic Mori fibre space or a birational involution. We define linear cyclic quotient singularities on X and prove that these are maximal centres by explicitly computing Sarkisov links centred at them. It turns out that each X has a linear cyclic quotient singularity leading to a new birational model. As a consequence, we show that if X is birationally rigid then its Fano index is 1. If the new birational model is a strict Mori fibre space, we determine its fibration type explicitly. In this case, a general member of X is birational to a del Pezzo fibration of degrees 1, 2 or 3 or to a conic bundle Y/S where S is a weighted projective plane with at most A2 singularities

Non-solidity of uniruled varieties

We give conditions for a uniruled variety of dimension at least 2 to be non-solid. This study provides further evidence to a conjecture by Abban and Okada on the solidity of Fano 3-folds. To complement our results we write explicit birational links from Fano 3-folds of high codimension embedded in weighted projective spaces.Comment: Improvements to the main statements. Title modified accordingly. 21 pages. 4 tables. 3 figures. Comments welcom