8 research outputs found
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
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- Bondar Irina
- Bott Jochen
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- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
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- Budhraja Madhusudan
- Bull Georgina
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- Cervantes-Escárcega Jose-Luis
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- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
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- Davila William
- Dawood Saleem
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- De Cosmo Salvatore
- De Loredo Luis
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- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
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- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
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- Diaz Ernesto
- Dimitriadis Georgios
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- Dominguez Andrea
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- Thorpe Karl
- Thorpe Karl M
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- Torres-Colores Jose Juan
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- Tripathy Devjit
- Trznadel-Morawska Iwona
- Tsapas Apostolos
- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
Effect of Real-time Patient-Centered Education Bundle on Administration of Venous Thromboembolism Prevention in Hospitalized Patients
- Author
- Aggarwal
- Baillie
- Brown
- Des Jarlais
- Elder
- Fan
- Fanikos
- Farrow
- Finkelstein
- Follmann
- Gottlieb
- Grosse
- Haut
- Haut
- Haut
- Haut
- Hempel
- Hurtado
- Institute of Medicine Committee on Quality of Health Care in America
- Itri
- Johnbull
- Kucher
- Lau
- Lau
- Lau
- Lau
- Lau
- Lau
- Lau
- Louis
- Maynard
- Maynard
- Methodology Committee of the Patient-Centered Outcomes Research Institute (PCORI)
- Piazza
- Popoola
- Shekelle
- Shekelle
- Shermock
- Spyropoulos
- Stewart
- Streiff
- Streiff
- Streiff
- Streiff
- Tooher
- Wong
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- Field of study
Patient-reported outcomes in the practice-based opportunities for weight reduction (POWER) trial
- Author
- A Anandacoomarasamy
- A Bidulescu
- A. Dalcin
- AG Renehan
- AL Lee
- C Dias Barbosa
- D Rohm Young
- DA Williamson
- Diabetes Prevention Program Research Group
- DJ Buysse
- DW Haslam
- EA Finkelstein
- G. Daumit
- G. J. Jerome
- GR Norman
- GW Landman
- H Jia
- H.-C. Yeh
- HC Yeh
- J Kruger
- J. W. Coughlin
- JE Siegel
- JE Ware Jr
- JR Jennings
- JS Carpenter
- K Kroenke
- KM Flegal
- KM Flegal
- L. J. Appel
- LJ Appel
- M. Peyrot
- ML Maciejewski
- N. Durkin
- N.-Y. Wang
- P Clarke
- Panel on Missing Data in Clinical Trials
- R. R. Rubin
- RJ Little
- RL Kolotkin
- RR Rubin
- RT Ackermann
- S. L. Fitzpatrick
- SM Issa
- T. A. Louis
- TH Sach
- The Look AHEAD Research Group
- TW Strine
- W. L. Bennett
- Y.-T. Chang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Chapter 7. Philosophy, Divinity, and Religion in the Periods of Presidents Eliot, Lowell, and Conant, 1869–1953
- Author
- 4.a The Tercentenary of Harvard University
- Adams James Luther
- Address School
- After
- After
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- Ahlstrom Sydney E.
- Allen Cf.
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- Annual Report to the President of Harvard College
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- As President
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- Assyriologist An
- Atlantic Monthly
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- Berlin First German
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- Biblical Journal
- Blackman George L.
- Blackman George L.
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- Boston Poetical Works
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- Cadbury
- Calder Noted
- Cambridge
- Cambridge
- Cambridge
- Cambridge
- Cambridge
- Cambridge Back
- Cambridge Learning
- Catholics Roman
- Centuries Three
- Centuries Three
- Charles Edward Park The Tercentenary
- Chicago
- Christ Unitarianism
- Christianity The Problem
- Church Formerly Third
- Class Report Second Report
- Commemoration Record
- Conant
- Conant James Bryant
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- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
Gynecologic and Obstetric Consequences of Obesity in Adolescent Girls
- Author
- Ahmed
- Akers
- Aksglaede
- Aksglaede
- Ali
- Anders
- Anderson
- Assi
- Atisha
- Azziz
- Baer
- Barfield
- Beksinska
- Berclaz
- Bianca Nieblas
- Biro
- Biro
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- Bordini
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- Fisher
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- Goldberg
- Goodman
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- Greydanus
- Grodstein
- Gutiérrez
- Halloran
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- Han
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- Harper
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- Herold
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- Hillman
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- Kaplowitz
- Kelly
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- Lee
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- Leonard
- Leticia Elizondo-Montemayor
- Li
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- Mangan
- Marcovecchio
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- Merith Gómez-Carmona
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- Michalakis
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- West
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- Wise
- Wolff
- Wolfswinkel
- Wood
- Xu
- Yoo
- Zeller
- Zeller
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Price-Fixing Overcharges: Legal and Economic Evidence
- Author
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- __________ Antitrust Law
- __________ Export Cartels
- __________ White Salt
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- A Cawson
- A Sheer
- Adair B Morse
- Adelaide Walters
- Akira Kudo
- Albert F Calvert
- Alec Burnside
- Alexander Schaub
- Alexis Jacquemin
- Alexis Jacquemin
- Alfred A Parker
- Allen T Demaree
- Almarin Phillips
- Ananth N Madhavan
- Andre E Sayous
- Andrew Gavin
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- Archibald H Stockder
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- B B Wallace
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- Barbara Alexander
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- Barbara Epstein
- Bjarke Fog
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- Charles A Bane
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- Charles J Bullock
- Christer Fallenius
- Christopher Harding
- Cindy R Alexander
- Clemens A Wurm
- Corwin Edwards
- Craig A Gallet
- Craig M Newmark
- D C Coleman
- D E Buschena
- D F Leach
- D Filson
- D G Goyder
- D J Lecraw
- D Johnsen
- D Low
- Dale R Funderburk
- Daniel Barbezat
- Daniel L Rubinfeld
- Darren Bush
- David Besanko
- David Boies
- David C Smith
- David F Lean
- David Genesove
- David Genesove
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- David R Kamerschen
- De Rousiers
- Deborah Spar
- Dennis Swann
- Dennis W Carlton
- Dennis W Carlton
- Dermot Gately
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- Douglas F Greer
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- Durand E Dana
- E Andrews
- E B Whitney
- E O Merchant
- E Timberlake
- Earle Gray
- Ec
- Edmund Newell
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- Elliot Jones
- Ervin Hexner
- Eugene Staley
- F C Fourie
- F M Scherer
- F M Scherer
- Fiona Wood
- Francis W Hirst
- Francis Walker
- Frank A Fetter
- Frank A Scott
- Franklin Fisher
- Franklin M Fisher
- Frederic Jenny
- Fritz Kleinw�chter
- Frode Steen
- Ftc
- G B Richardson
- G C Allen
- G D Thompson
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- Gary Becker
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- George A Hay
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- Glenn Ellison
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- Greta Devos
- H R Tosdal
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- Hideaki Miyajima
- Howard Adler
- Hugh Grant
- In Lee
- In Lee
- J Bosch
- J Leitzinger
- J Mcclave
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- James B Lieber
- James B Stewart
- James E Duggan
- James M Clabault
- James M Griffin
- James M Griffin
- Janice Kinghorn
- Jeffery H Howard
- Jeffrey E Zimmerman
- Jeffrey K Mackie-Mason
- Jeffrey M Marvel
- Jens Fej�
- Jeremiah W Jenks
- Jeremiah W Jenks
- Jesse W Markham
- Joel Davidow
- John C Beyer
- John D Graubert
- John D Guilfoil
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- John Heath
- John Herling
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- John M Blair
- John M Connor
- John M Connor
- John M Crespi
- John M Kuhlman
- John M. Connor
- John S Mcgee
- John S Thompson
- Jon P Nelson
- Jonathan B Baker
- Jonathan B Baker
- Jonathan Groner
- Jonathan S Feinstein
- Joseph E Harrington
- Joseph Stiglitz
- Julian L Clarke
- June H Taylor
- Karen Clay
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- Karl Aiginger
- Karl Aiginger
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- Kenneth G Elzinga
- Kenneth G Elzinga
- Kenneth Hendricks
- Kftc
- Kishi
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- Kristine Bruland
- Kurt Eichenwald
- Kurt Wiedenfeld
- Kwangshik Shin
- L A Fisher
- L F Haber
- Lars-Hendrik R�ller
- Laura H Baldwin
- Lawrence J White
- Lawrence Shepard
- Lewis H Haney
- Louis Domeratzky
- Louis Lister
- Louis Marlio
- Luke M Froeb
- M C L Benni
- M Finkelstein
- M J Peck
- M Rieber
- Margaret C Levenstein
- Margaret C Levenstein
- Margaret Levenstein
- Margaret Levenstein
- Mark A Cohen
- Mark A Cohen
- Mark A Cohen
- Mark Tilton
- Martin Pesendorfer
- Matthew Josephson
- Mcmillan John
- Merih Uctum
- Michael Beckmann
- Michael Block
- Michael D Hausfeld
- Michael F Sproul
- Michael L Denger
- Milton Friedman
- Morris A Adelman
- Mukesh Eswaran
- Nancy S Borgeson
- Nicholas J Powers
- Nicolas De Roos
- Nicolas Schmitt
- Oecd
- Oris C Herfindahl
- Orley C Ashenfelter
- Patrick Bajari
- Paul A Grout
- Paul G Barnett
- Paul Joskow
- Paul L Eckbo
- Paul M Sweezy
- Paul W Macavoy
- Peter Asch
- Peter Crampton
- Peter Reuter
- Peter Z Grossman
- Philip C Newman
- R A Ippolito
- R Prain
- R S Daggett
- Ralph G M Sultan
- Ray Rees
- Richard A Lord
- Richard A Posner
- Richard E Just
- Richard F Adams
- Richard J Pierce
- Richard S Newfarmer
- Richard Smith
- Robert F Lanzillotti
- Robert G Hansen
- Robert H Lande
- Robert H Porter
- Robert H Porter
- Robert Liefmann
- Robert M Price
- Robert Read
- Robert S Pyndyck
- Robert W Crandall
- Rolf Weder
- Roman Piotrowski
- Roy Curtis
- Rudolf K Michels
- Runar Br�nnlund
- Salil K Mehra
- Samuel M Loescher
- Sanjib Bhuhan
- Schr�ter
- Scott Morton
- Seonghoon Jeon
- Shin Hasagawa
- Sigmund J Prais
- Simon J Evenett
- Srabana Gupta
- Stat-Usa
- Stephen C Pirrong
- Steven A Morrison
- Steven B Webb
- Steven Berry
- Steven C Salop
- Steven K Holloway
- Steven Martin
- Steven N Wiggins
- Svend Albaek
- Takkeo Kikkawa
- Tay-Cheng Ma
- Taylor C Robert
- Tftc
- Tftc-Oecd
- Thurman W Arnold
- U S Congress
- Ukcc
- Ussg Advisory Group
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- Van Eden
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- W C Labys
- W Erickson
- W G Taylor
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- W Oualid
- W S Comanor
- Wayne E Baker
- Wendell Berge
- Wilbur L Fugate
- Willard F Mueller
- William E Kovacic
- William Elliott
- William F Notz
- William G Christie
- William G Shepard
- William Graebner
- William H Landes
- William J Hausman
- William Page
- William S Stevens
- William Sjostrom
- Wils
- Wyatt Wells
- Xuezheng Wang
- Yinne Yu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2005
- Field of study
Table of Contents
- Author
- Abramson
- Adams
- Aguirre
- Albert
- Alexander
- Allan
- Allen
- Allen-Meares
- Alstete
- Amabile
- Andersen
- Andersen
- Arends
- Association of Governing Boards of Universities and Colleges
- Astin
- Astin
- Astin
- Athena University
- Austin
- Austin
- Austin
- Avolio
- Baez
- Baker
- Banks
- Bardaracco
- Barker
- Barker
- Barnard
- Barzun
- Bass
- Bass
- Bates
- Batson
- Bauer
- Belenky
- Bennis
- Bennis
- Bensimon
- Bensimon
- Bergquist
- Birnbaum
- Birnbaum
- Blanchard
- Blum
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- Bogue
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- Bower
- Bowker
- Bowker
- Boyer
- Boyer
- Boyer
- Boyer
- Boyer Commission on Educating Undergraduates in Research Universities
- Bradford
- Breneman
- Brewer
- Brittingham
- Bronstein
- Brown
- Brown
- Brubacher
- Burgos-Sasscer
- Burns
- Caelleigh
- Cahn
- California Higher Education Policy Center
- Callan
- Camic
- Cantor
- Cantú-Weber
- Caplan
- Caplan
- Caplow
- Carbone
- Carnegie Foundation for the Advancement of Teaching
- Carr
- Cashman
- Castenell
- Catsambio
- Cheney
- Chickering
- Chickering
- Chliwniak
- Cleveland
- Cohen
- Cohen
- Coladarci
- Cole
- Collins
- Committee C on College and University Teaching Research, and Publication of the American Association of University Professors
- Conger
- Conger
- Conger
- Connolly
- Cook
- Corson
- Cosgrove
- Costello
- Cottrell
- Coughlan
- Covey
- Covey
- Covrig
- Cox
- Cox
- Crawford
- Creswell
- Cronin
- Curry
- Cyphert
- Darling
- Davis
- Davis
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- Dawis
- Dawis
- Day
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- DePree
- Dibden
- Dill
- Dilts
- Doughtrey
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- Dupont
- Dziech
- Eamon
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- Ehrmann
- Ehrmann
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- Fitzgerald
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- Fullan
- Fullan
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- Galbo
- Garcia
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- Gardner
- Gardner
- George
- Gewirth
- Gilbert
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- Gitlow
- Gladieux
- Glazer-Raymo
- Gmelch
- Gmelch
- Gmelch
- Gmelch
- Gmelch
- Gmelch
- Gmelch
- Gmelch
- Gmelch
- Gmelch
- Goleman
- Goleman
- Goleman
- Gorman
- Gould
- Grace
- Green
- Green
- Green
- Green
- Green
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- Grossman
- Guskin
- Guskin
- Guskin
- Haimann
- Hall
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- Hare
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- Heck
- Heenan
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- Kahn
- Kahn
- Kahn
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- Mangan
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- March
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- Markie
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- Martin
- Maslen
- Massy
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- Tracy
- Tucker
- Twale
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- U.S. General Accounting Office
- University of Phoenix
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- Ward
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- Weeks
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- Welsh
- West
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- Wolverton
- Wolverton
- Woodburne
- Woolf
- Yarger
- Yingling
- Yukl
- Zamson
- Zemsky
- Zimpher
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2001
- Field of study
The Famlily Vibrionaceae
- Author
- A Böck
- A Camilli
- A Can-Gomez
- A Coelho
- A Coelho
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