Analysis, characterization, and effects of heavy metal chealating agents in water

Students supported: 5 Student Assistants"The term 'chelating agents' refers to chemical ligands which bind to an element with more than one site. It is a ubiquitous term, since there are multitudes of compounds which fulfill the requirements for being called chelating agents. Their origin is both synthetic and natural, and the manner and fashion in which they bind is quite varied. Many of the vitamins and hormones essential to life are chelating agents. Chlorophyll, which is required for photosynthesis, consists of a porphyrin ring structure bound to magnesium. Hemoglobin binds iron in a similar pattern, and vitamin B-12 utilizes cobalt in the same fashion. In addition to these, there are quite a number of similar compounds in both plants and animals. Most metals transport and usage inside living things involve a chelation process. In natural water systems, the presence of chelating agents can have significant impact on the transport and toxicity of metals."--IntroductionProject # B-095-MO Agreement # 14-31-0001-409

Stellar Astrophysics and Exoplanet Science with the Maunakea Spectroscopic Explorer (MSE)

The Maunakea Spectroscopic Explorer (MSE) is a planned 11.25-m aperture facility with a 1.5 square degree field of view that will be fully dedicated to multi-object spectroscopy. A rebirth of the 3.6m Canada-France-Hawaii Telescope on Maunakea, MSE will use 4332 fibers operating at three different resolving powers (R ~ 2500, 6000, 40000) across a wavelength range of 0.36-1.8mum, with dynamical fiber positioning that allows fibers to match the exposure times of individual objects. MSE will enable spectroscopic surveys with unprecedented scale and sensitivity by collecting millions of spectra per year down to limiting magnitudes of g ~ 20-24 mag, with a nominal velocity precision of ~100 m/s in high-resolution mode. This white paper describes science cases for stellar astrophysics and exoplanet science using MSE, including the discovery and atmospheric characterization of exoplanets and substellar objects, stellar physics with star clusters, asteroseismology of solar-like oscillators and opacity-driven pulsators, studies of stellar rotation, activity, and multiplicity, as well as the chemical characterization of AGB and extremely metal-poor stars.Comment: 31 pages, 11 figures; To appear as a chapter for the Detailed Science Case of the Maunakea Spectroscopic Explore

Diabetic foot ulcers segmentation challenge report: benchmark and analysis

Monitoring the healing progress of diabetic foot ulcers is a challenging process. Accurate segmentation of foot ulcers can help podiatrists to quantitatively measure the size of wound regions to assist prediction of healing status. The main challenge in this field is the lack of publicly available manual delineation, which can be time consuming and laborious. Recently, methods based on deep learning have shown excellent results in automatic segmentation of medical images, however, they require large-scale datasets for training, and there is limited consensus on which methods perform the best. The 2022 Diabetic Foot Ulcers segmentation challenge was held in conjunction with the 2022 International Conference on Medical Image Computing and Computer Assisted Intervention, which sought to address these issues and stimulate progress in this research domain. A training set of 2000 images exhibiting diabetic foot ulcers was released with corresponding segmentation ground truth masks. Of the 72 (approved) requests from 47 countries, 26 teams used this data to develop fully automated systems to predict the true segmentation masks on a test set of 2000 images, with the corresponding ground truth segmentation masks kept private. Predictions from participating teams were scored and ranked according to their average Dice similarity coefficient of the ground truth masks and prediction masks. The winning team achieved a Dice of 0.7287 for diabetic foot ulcer segmentation. This challenge has now entered a live leaderboard stage where it serves as a challenging benchmark for diabetic foot ulcer segmentation

New Features in the SPOC Pipeline Release 4.0

The Science Processing Operations Center is in the process of testing and deploying Release 4.0 of the codebase in the March 2019 timeframe. This paper describes the new features of the software and their likely impact on the quality of the TESS science data products. The major goals of Release 4.0 are to improve the extraction of photometry from the pixels in light of the non-uniform pointing performance and the identification of instrumental signatures from the light curves. We also describe modifications to the FFI pipeline to allow the generation of FFI light curves, correction of the instrumental systematics therein, and planet searches, primarily for the purpose of validating the 2-min pipeline against the FFI pipeline, but also to be able to provide cotrending basis vectors (CBVs) derived directly from the FFIs to the public to aid them in their extraction and correction of photometry. We also discuss the improvements in photometric performance of the pipeline and its various components.The lapse in funding experienced between 22 December 2018 and 27 January 2019 significantly delayed our ability to conduct integration testing as planned for late December/early January, delaying the start of V&V by one month to the end of February 2019.The TESS Mission is funded by NASA's Science Mission Directorate as an Astrophysics Explorer Mission.The Science Processing Operations Center is in the process of testing and deplo!"ing Release 4.0 of thecodebase In the March 2019 tlmeframe. This paper describes the new features or the software and theirlikely impact on the quality of the TESS science data products. The major goals or Release 4.0 are to Imtheidentification of instrumental signatures from the light cuNes. We also describe modifications tothe FFI pipeline to allow the generation of FFI light curves, correction of the instrumental systematicstherein, and planet searches, primarily for the purpose of validating the 2-min pipelineagainst the FFI pipeline, but also to be able to provide cotrending basis vectors (C3Vs) ,,.~,.;.derived directly from the FFls to the public to aid them in their extractbn and correction , :-; ~'-'\'.'.of photometry. We also discuss the Improvements In photometric performance of ~~\":;:the pipeline and its various components. :,;.-.;The lapse In funding experienced between 22 December 2018 and 27January 2019 significantly delayed our ability to conduct Integrationtesting as planned for late December/early January, delaying thestart of V&V by one month to the end of February 2019.The TESS Mission is funded by NASA's Science Mission Directorateas an Astrophysics Explorer Mission.o.iu.c...,.....~~New Features in SPOC 4.01. Use of quatemions In photometry and centroiding.2. Use of quaternions to Identify high-motion cadences and exclude same.3. Use of the TPS detections to deemphasize pathological cadences ("skyline flattenlng"I.4. Improved CAL calculations for black and smear correction.5. PA brightness metric calculation improvements (induo'e crowding in calrulation)./ 6. Improved POC spike goodness metric.~ 7. Improved handling of gaps and momentum duni:>S in POC.8. Improved tuning of POC., 9. Improved attitude tweak correction in PDC.10. Improvements in PDC introduced noise and correlation goodness metrics11. Using the improved spike goodness metric to minimize overlitting in the spikeremover ' :,''l./ 12. Enable FFI processing through planet search.,,. , " ,;,,,.~'A , 13.1 D4.V S mtreinaim-relipnoinrgts d aartcah irveetrdie tvoa Ml aAnSdT p ersistence to database 15. Improved management of jobs on the NAS Pleiadss supercompute

Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth. Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Krüppel-like factor 5 (KLF5) pathways. Aberrations in these processes in cancer cells involve mutations and thus the suppression of genes that prevent growth, as well as mutation and activation of genes involved in driving cell growth. Using these pathways as examples, we prioritize molecular targets that might be leveraged to promote anti-growth signaling in cancer cells. Interestingly, naturally-occurring phytochemicals found in human diets (either singly or as mixtures) may promote anti-growth signaling, and do so without the potentially adverse effects associated with synthetic chemicals. We review examples of naturally-occurring phytochemicals that may be applied to prevent cancer by antagonizing growth signaling, and propose one phytochemical for each pathway. These are: epigallocatechin-3-gallate (EGCG) for the Rb pathway, luteolin for p53, curcumin for PTEN, porphyrins for Hippo, genistein for GDF15, resveratrol for ARID1A, withaferin A for Notch and diguelin for the IGF1-receptor pathway. The coordination of anti-growth signaling and natural compound studies will provide insight into the future application of these compounds in the clinical setting