Reconsolidation of episodic memories:a subtle reminder triggers integration of new information

Recent demonstrations of “reconsolidation” suggest that memories can be modified when they are reactivated. Reconsolidation has been observed in human procedural memory and in implicit memory in infants. This study asks whether episodic memory undergoes reconsolidation. College students learned a list of objects on Day 1. On Day 2, they received a reminder or not, and then learned a second list. Memory for List 1 was tested immediately on Day 2 (Experiment 2) or on Day 3 (Experiment 1). Although the reminder did not moderate the number of items recalled from List 1 on either day, subjects who received a reminder incorrectly intermixed items from the second list when recalling List 1 on Day 3. Experiment 2 showed that this effect does not occur immediately and thus is time-dependent. The reminder did not affect memory for List 2 on Day 3 (Experiment 3), demonstrating that modification occurred only for the original memory (List 1). The study demonstrates the crucial role of reminders for the modification of episodic memory, that reconsolidation of episodic memory is time-dependent, and, in contrast to previous reconsolidation findings, that reconsolidation is also a constructive process, one that supports the incorporation of new information in memory

This is not a love story: A semiotic discourse analysis of romantic comedies

This study is an examination of the ideologies present in the highest-grossing romantic comedy from each year in the past decade. Because romantic comedies feature prominent romantic relationships, repeated exposure to romantic comedies may influence audiences\u27 perceptions of what romantic relationships should be like. People who are exposed to media content depicting romantic relationships may rely on those portrayals when they are either considering beginning a new romantic relationship, or evaluating a current romantic relationship

Doctor of Philosophy

dissertationWithin the U.S., particular anxieties surrounding racially and ethnically marked "others" reflect particular historical moments, and today ours are prompted by contemporized fears of immigration and terrorism. In this dissertation, I take up these issues, focusing on contemporary instantiations and negotiations of hybridity within U.S. culture. While hybridity has been examined at length, the ways in which hybridity is mobilized in distinctive ways through or by various bodies have been relatively overlooked. Thus, I examine the ways in which hybridity is rhetorically embodied and mobilized within contemporary mainstream media. I take up these issues with a focus on two questions: (a) How is hybridity mobilized in distinctive ways in, through, or by various bodies, particularly as reflective of historical context? (b) How does "the body"-in particular, specific deployments of the body-feature in contemporary articulations of hybridity? I answer these questions through a critical analysis of texts, drawing from both critical rhetoric and critical performance studies. I focus on two competition-style reality dance shows, So You Think You Can Dance (SYTYCD) and Dancing with the Stars (DWTS); the competition-style reality show America's Next Top Model (ANTM); and three Food Network cooking shows, Simply Delicioso with Ingrid Hoffmann, Aarti Party, and Everyday Italian. Analysis of these texts suggest that hybridity is mobilized in varied and distinctive ways by, through, and on variously marked bodies. Ultimately, this study refines extant theorizing on hybridity: While borders are inevitably critical to any conceptualizations of hybridity, this project reveals nuance and complexities of how borders are accomplished and navigated across these various embodied mobilizations and illuminate particularized contemporary anxieties regarding race/ethnicity. Hybridity in a current context appears to be articulated as-conflated with-individual uniqueness and authenticity, the expression of which is encouraged and celebrated, but only within very specific contexts or confines. Ultimately, then, via its location in and deployment by particular bodies, hybridity is articulated as a feature and expression of the unique, authentic self, as opposed to a politics of identity, in ways that justify discipline of race/ethnicity if and when hybridity "crosses the line.

Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis

Streptococcus pneumoniae is responsible for diseases causing major global public health problems, including meningitis, pneumonia and septicaemia. Despite recent advances in antimicrobial therapy, pneumococcal meningitis remains a life-threatening disease. Furthermore, long-term sequelae are a major concern for survivors. Hence, a better understanding of the processes occurring in the central nervous system is crucial to the development of more effective management strategies. We used mass spectrometry based quantitative proteomics to identify protein changes in cerebrospinal fluid from children with Streptococcus pneumoniae infection, compared with children admitted to hospital with bacterial meningitis symptoms but negative diagnosis. Samples were analysed, by label free proteomics, in two independent cohorts (cohort 1: cases (n = 8) and hospital controls (n = 4); cohort 2: cases (n = 8), hospital controls (n = 8)). Over 200 human proteins were differentially expressed in each cohort, of which 65% were common to both. Proteins involved in the immune response and exosome signalling were significantly enriched in the infected samples. For a subset of proteins derived from the proteome analysis, we corroborated the proteomics data in a third cohort (hospital controls (n = 15), healthy controls (n = 5), cases (n = 20)) by automated quantitative western blotting, with excellent agreement with our proteomics findings. Proteomics data are available via ProteomeXchange with identifier PXD004219

Precipitation of hydroxyapatite at 37 °C in a meso oscillatory flow reactor operated in batch at constant power density

A meso oscillatory flow reactor (OFR) was successfully applied for the precipitation of hydroxyapatite (HAp) nanoparticles. Mixing efficiency of the mesoreactor operated batchwise in a vertical tube was evaluated at constant power density, by monitoring variation of hue values upon mixing both spatially and temporally. The best operating conditions for fast mixing and a more homogeneous reaction medium were verified for f = 0.83 Hz and x0 = 4.5 mm. HAp precipitation was then carried out under these conditions at 37 °C for different mixing Ca/P molar ratios. HAp nanoparticles with a mean size (d50) of about 67 nm and a narrow size distribution were obtained. Furthermore, the obtained results show the advantages of the meso-OFR over a stirred tank batch reactor due to the production, about four times faster, of smaller and more uniform HAp nanoparticles. © 2013 American Institute of Chemical Engineers AIChE J, 2013This work was supported by the Portuguese Foundation for Science and Technology (SFRH/BD/42992/2008) through the MIT-Portugal Program, Bioengineering Systems Focus Area. The authors are thankful to Dr Jorge Ferreira from LNEG (Laboratorio Nacional de Energia e Geologia, Portugal) for carrying out the X-ray measurements and his help with the interpretation of results

An Examination of Motives, Attitudes and Charitable Intentions for Running in a Charity Event

Running, as a form of leisure time physical activity is generally popular due to its low-cost entry, easy access to practice, and the convenience and accessible nature of the activity. Specifically, one type of running experience sought by many is charitable running or running for a cause (i.e., cause-related sport event). While there is a growing body of literature on charity sport events, little is known about how the charitable motives and participant identity with the event affect future behaviors associated with the cause and the event. Grounded in identity theory, the purpose of this article was to examine the effect of salient identities and charitable motives on future intentions associated with a cause-related event. Data were collected from the second annual Norfolk Freedom Half Marathon, in Virginia, via an online survey that was sent to all registered runners (1,372) one week after the race and 557 participants responded. We found charity motives to be the dominant influence on both charitable and purchase intentions in cause-event participants. This study contributes to the existing amateur sport literature as one of the first to report on a military-oriented sport event with military affiliated participants; the creation of the Charitable Motives in Sport Scale (CMISS), the Runner Identity Scale (RIS) and the Military Identity Scale (MIS); and the addition of a new military/runner identity typology, which we hope would be useful for future military-affiliated running events

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

Measurement of D*+/- meson production in jets from pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

This paper reports a measurement of D*+/- meson production in jets from proton-proton collisions at a center-of-mass energy of sqrt(s) = 7 TeV at the CERN Large Hadron Collider. The measurement is based on a data sample recorded with the ATLAS detector with an integrated luminosity of 0.30 pb^-1 for jets with transverse momentum between 25 and 70 GeV in the pseudorapidity range |eta| < 2.5. D*+/- mesons found in jets are fully reconstructed in the decay chain: D*+ -> D0pi+, D0 -> K-pi+, and its charge conjugate. The production rate is found to be N(D*+/-)/N(jet) = 0.025 +/- 0.001(stat.) +/- 0.004(syst.) for D*+/- mesons that carry a fraction z of the jet momentum in the range 0.3 < z < 1. Monte Carlo predictions fail to describe the data at small values of z, and this is most marked at low jet transverse momentum.Comment: 10 pages plus author list (22 pages total), 5 figures, 1 table, matches published version in Physical Review