179 research outputs found
Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data
- Author
- Agarwal D
- Amiro B
- Ammann C
- Arain MA
- Ardö J
- Arkebauer T
- Arndt SK
- Arriga N
- Aubinet M
- Aurela M
- Baldocchi D
- Barr A
- Beamesderfer E
- Bergeron O
- Beringer J
- Bernhofer C
- Berveiller D
- Billesbach D
- Biraud S
- Black TA
- Blanken PD
- Bohrer G
- Boike J
- Bolstad PV
- Bonal D
- Bonnefond J-M
- Bowling DR
- Bracho R
- Brodeur J
- Brümmer C
- Buchmann N
- Burban B
- Burns SP
- Buysse P
- Cale P
- Canfora E
- Cavagna M
- Cellier P
- Cheah Y-W
- Chen J
- Chen S
- Chini I
- Christensen TR
- Christianson D
- Chu H
- Cleverly J
- Collalti A
- Consalvo C
- Cook BD
- Cook D
- Coursolle C
- Cremonese E
- Curtis PS
- da Rocha H
- Dai X
- Davis KJ
- De Cinti B
- de Dios VR
- de Grandcourt A
- De Ligne A
- De Oliveira RC
- Delpierre N
- Desai AR
- Di Bella CM
- di Tommasi P
- Dolman H
- Domingo F
- Dong G
- Dore S
- Duce P
- Dufrêne E
- Dunn A
- Dušek J
- D’Andrea E
- Eamus D
- Eichelmann U
- Elbashandy A
- ElKhidir HAM
- Eugster W
- Ewenz CM
- Ewers B
- Famulari D
- Fares S
- Feigenwinter I
- Feitz A
- Fensholt R
- Filippa G
- Fischer M
- Frank J
- Galvagno M
- Gharun M
- Gianelle D
- Gielen B
- Gioli B
- Gitelson A
- Goded I
- Goeckede M
- Goldstein AH
- Gough CM
- Goulden ML
- Graf A
- Griebel A
- Gruening C
- Grünwald T
- Hammerle A
- Han S
- Han X
- Hansen BU
- Hanson C
- Hatakka J
- He Y
- Hehn M
- Heinesch B
- Hinko-Najera N
- Humphrey M
- Hutley L
- Hörtnagl L
- Ibrom A
- Ikawa H
- Isaac P
- Jackowicz-Korczynski M
- Janouš D
- Jans W
- Jassal R
- Jiang S
- Kato T
- Khomik M
- Klatt J
- Knohl A
- Knox S
- Kobayashi H
- Koerber G
- Kolle O
- Kosugi Y
- Kotani A
- Kowalski A
- Kruijt B
- Kurbatova J
- Kutsch WL
- Kwon H
- Launiainen S
- Laurila T
- Law B
- Leuning R
- Li Y
- Li Y
- Liddell M
- Limousin J-M
- Lion M
- Liska AJ
- Lohila A
- Loubet B
- Loustau D
- Lucas-Moffat A
- López-Ballesteros A
- López-Blanco E
- Lüers J
- Ma S
- Macfarlane C
- Magliulo V
- Maier R
- Mammarella I
- Manca G
- Marchesini LB
- Marcolla B
- Margolis HA
- Marras S
- Massman W
- Mastepanov M
- Matamala R
- Matthes JH
- Mazzenga F
- McCaughey H
- McHugh I
- McMillan AMS
- Merbold L
- Meyer W
- Meyers T
- Miller SD
- Minerbi S
- Moderow U
- Monson RK
- Montagnani L
- Moore CE
- Moors E
- Moreaux V
- Moureaux C
- Munger JW
- Nakai T
- Neirynck J
- Nesic Z
- Nicolini G
- Noormets A
- Northwood M
- Nosetto M
- Nouvellon Y
- Novick K
- Oechel W
- Olesen JE
- Ourcival J-M
- Papale D
- Papuga SA
- Parmentier F-J
- Pastorello G
- Paul-Limoges E
- Pavelka M
- Peichl M
- Pendall E
- Phillips RP
- Pilegaard K
- Pirk N
- Poindexter C
- Polidori D
- Posse G
- Powell T
- Prasse H
- Prober SM
- Rambal S
- Rannik Ü
- Raz-Yaseef N
- Rebmann C
- Reed D
- Reichstein M
- Restrepo-Coupe N
- Reverter BR
- Ribeca A
- Roland M
- Sabbatini S
- Sachs T
- Saleska SR
- Sanchez-Mejia ZM
- Schmid HP
- Schmidt M
- Schneider K
- Schrader F
- Schroder I
- Scott RL
- Sedlák P
- Serrano-OrtÃz P
- Shao C
- Shi P
- Shironya I
- Siebicke L
- Silberstein R
- Sirca C
- Spano D
- Steinbrecher R
- Stevens RM
- Sturtevant C
- Suyker A
- Sánchez-Cañete EP
- Tagesson T
- Takanashi S
- Tang Y
- Tapper N
- Thom J
- Tomassucci M
- Torn M
- Trotta C
- Tuovinen J-P
- Urbanski S
- Valentini R
- van der Molen M
- van Gorsel E
- van Huissteden K
- van Ingen C
- Varlagin A
- Verfaillie J
- Vesala T
- Vincke C
- Vitale D
- Vuichard N
- Vygodskaya N
- Walker JP
- Walter-Shea E
- Wang H
- Weber R
- Westermann S
- Wille C
- Wofsy S
- Wohlfahrt G
- Wolf S
- Woodgate W
- Zampedri R
- Zhang J
- Zhang L
- Zhou G
- Zona D
- Å igut L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/02/2021
- Field of study
The following authors were omitted from the original version of this Data Descriptor: Markus Reichstein and Nicolas Vuichard. Both contributed to the code development and N. Vuichard contributed to the processing of the ERA-Interim data downscaling. Furthermore, the contribution of the co-author Frank Tiedemann was re-evaluated relative to the colleague Corinna Rebmann, both working at the same sites, and based on this re-evaluation a substitution in the co-author list is implemented (with Rebmann replacing Tiedemann). Finally, two affiliations were listed incorrectly and are corrected here (entries 190 and 193). The author list and affiliations have been amended to address these omissions in both the HTML and PDF versions
The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data.
- Author
- Agarwal D
- Amiro B
- Ammann C
- Arain MA
- Ardö J
- Arkebauer T
- Arndt SK
- Arriga N
- Aubinet M
- Aurela M
- Baldocchi D
- Barr A
- Beamesderfer E
- Bergeron O
- Beringer J
- Bernhofer C
- Berveiller D
- Billesbach D
- Biraud S
- Black TA
- Blanken PD
- Bohrer G
- Boike J
- Bolstad PV
- Bonal D
- Bonnefond J-M
- Bowling DR
- Bracho R
- Brodeur J
- Brümmer C
- Buchmann N
- Burban B
- Burns SP
- Buysse P
- Cale P
- Canfora E
- Cavagna M
- Cellier P
- Cheah Y-W
- Chen J
- Chen S
- Chini I
- Christensen TR
- Christianson D
- Chu H
- Cleverly J
- Collalti A
- Consalvo C
- Cook BD
- Cook D
- Coursolle C
- Cremonese E
- Curtis PS
- D'Andrea E
- da Rocha H
- Dai X
- Davis KJ
- De Cinti B
- de Dios VR
- de Grandcourt A
- De Ligne A
- De Oliveira RC
- Delpierre N
- Desai AR
- Di Bella CM
- di Tommasi P
- Dolman H
- Domingo F
- Dong G
- Dore S
- Duce P
- Dufrêne E
- Dunn A
- Dušek J
- Eamus D
- Eichelmann U
- Elbashandy A
- ElKhidir HAM
- Eugster W
- Ewenz CM
- Ewers B
- Famulari D
- Fares S
- Feigenwinter I
- Feitz A
- Fensholt R
- Filippa G
- Fischer M
- Frank J
- Galvagno M
- Gharun M
- Gianelle D
- Gielen B
- Gioli B
- Gitelson A
- Goded I
- Goeckede M
- Goldstein AH
- Gough CM
- Goulden ML
- Graf A
- Griebel A
- Gruening C
- Grünwald T
- Hammerle A
- Han S
- Han X
- Hansen BU
- Hanson C
- Hatakka J
- He Y
- Hehn M
- Heinesch B
- Hinko-Najera N
- Humphrey M
- Hutley L
- Hörtnagl L
- Ibrom A
- Ikawa H
- Isaac P
- Jackowicz-Korczynski M
- Janouš D
- Jans W
- Jassal R
- Jiang S
- Kato T
- Khomik M
- Klatt J
- Knohl A
- Knox S
- Kobayashi H
- Koerber G
- Kolle O
- Kosugi Y
- Kotani A
- Kowalski A
- Kruijt B
- Kurbatova J
- Kutsch WL
- Kwon H
- Launiainen S
- Laurila T
- Law B
- Leuning R
- Li Y
- Li Y
- Liddell M
- Limousin J-M
- Lion M
- Liska AJ
- Lohila A
- Loubet B
- Loustau D
- Lucas-Moffat A
- López-Ballesteros A
- López-Blanco E
- Lüers J
- Ma S
- Macfarlane C
- Magliulo V
- Maier R
- Mammarella I
- Manca G
- Marchesini LB
- Marcolla B
- Margolis HA
- Marras S
- Massman W
- Mastepanov M
- Matamala R
- Matthes JH
- Mazzenga F
- McCaughey H
- McHugh I
- McMillan AMS
- Merbold L
- Meyer W
- Meyers T
- Miller SD
- Minerbi S
- Moderow U
- Monson RK
- Montagnani L
- Moore CE
- Moors E
- Moreaux V
- Moureaux C
- Munger JW
- Nakai T
- Neirynck J
- Nesic Z
- Nicolini G
- Noormets A
- Northwood M
- Nosetto M
- Nouvellon Y
- Novick K
- Oechel W
- Olesen JE
- Ourcival J-M
- Papale D
- Papuga SA
- Parmentier F-J
- Pastorello G
- Paul-Limoges E
- Pavelka M
- Peichl M
- Pendall E
- Phillips RP
- Pilegaard K
- Pirk N
- Poindexter C
- Polidori D
- Posse G
- Powell T
- Prasse H
- Prober SM
- Rambal S
- Rannik Ü
- Raz-Yaseef N
- Reed D
- Restrepo-Coupe N
- Reverter BR
- Ribeca A
- Roland M
- Sabbatini S
- Sachs T
- Saleska SR
- Sanchez-Mejia ZM
- Schmid HP
- Schmidt M
- Schneider K
- Schrader F
- Schroder I
- Scott RL
- Sedlák P
- Serrano-OrtÃz P
- Shao C
- Shi P
- Shironya I
- Siebicke L
- Silberstein R
- Sirca C
- Spano D
- Steinbrecher R
- Stevens RM
- Sturtevant C
- Suyker A
- Sánchez-Cañete EP
- Tagesson T
- Takanashi S
- Tang Y
- Tapper N
- Thom J
- Tiedemann F
- Tomassucci M
- Torn M
- Trotta C
- Tuovinen J-P
- Urbanski S
- Valentini R
- van der Molen M
- van Gorsel E
- van Huissteden K
- van Ingen C
- Varlagin A
- Verfaillie J
- Vesala T
- Vincke C
- Vitale D
- Vygodskaya N
- Walker JP
- Walter-Shea E
- Wang H
- Weber R
- Westermann S
- Wille C
- Wofsy S
- Wohlfahrt G
- Wolf S
- Woodgate W
- Zampedri R
- Zhang J
- Zhang L
- Zhou G
- Zona D
- Å igut L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 24/08/2020
- Field of study
The FLUXNET2015 dataset provides ecosystem-scale data on CO2, water, and energy exchange between the biosphere and the atmosphere, and other meteorological and biological measurements, from 212 sites around the globe (over 1500 site-years, up to and including year 2014). These sites, independently managed and operated, voluntarily contributed their data to create global datasets. Data were quality controlled and processed using uniform methods, to improve consistency and intercomparability across sites. The dataset is already being used in a number of applications, including ecophysiology studies, remote sensing studies, and development of ecosystem and Earth system models. FLUXNET2015 includes derived-data products, such as gap-filled time series, ecosystem respiration and photosynthetic uptake estimates, estimation of uncertainties, and metadata about the measurements, presented for the first time in this paper. In addition, 206 of these sites are for the first time distributed under a Creative Commons (CC-BY 4.0) license. This paper details this enhanced dataset and the processing methods, now made available as open-source codes, making the dataset more accessible, transparent, and reproducible
The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data
- Author
- Agarwal Deb
- Amiro Brian
- Ammann Christof
- Arain M. Altaf
- Ardö Jonas
- Arkebauer Timothy
- Arndt Stefan K.
- Arriga Nicola
- Aubinet Marc
- Aurela Mika
- Baldocchi Dennis
- Barr Alan
- Beamesderfer Eric
- Bergeron Onil
- Beringer Jason
- Bernhofer Christian
- Berveiller Daniel
- Billesbach Dave
- Biraud Sebastien
- Black Thomas Andrew
- Blanken Peter D.
- Bohrer Gil
- Boike Julia
- Bolstad Paul V.
- Bonal Damien
- Bonnefond Jean Marc
- Bowling David R.
- Bracho Rosvel
- Brodeur Jason
- Brümmer Christian
- Buchmann Nina
- Burban Benoit
- Burns Sean P.
- Buysse Pauline
- Cale Peter
- Canfora Eleonora
- Cavagna Mauro
- Cellier Pierre
- Cheah You Wei
- Chen Jiquan
- Chen Shiping
- Chini Isaac
- Christensen Torben R.
- Christianson Danielle
- Chu Housen
- Cleverly James
- Collalti Alessio
- Consalvo Claudia
- Cook Bruce D.
- Cook David
- Coursolle Carole
- Cremonese Edoardo
- Curtis Peter S.
- D'Andrea Ettore
- da Rocha Humberto
- Dai Xiaoqin
- Davis Kenneth J.
- De Cinti Bruno
- de Dios Victor Resco
- de Grandcourt Agnes
- De Ligne Anne
- De Oliveira Raimundo C.
- Delpierre Nicolas
- Desai Ankur R.
- Di Bella Carlos Marcelo
- di Tommasi Paul
- Dolman Han
- Domingo Francisco
- Dong Gang
- Dore Sabina
- Duce Pierpaolo
- Dufrêne Eric
- Dunn Allison
- DuÅ¡ek JiÅ™Ã
- Eamus Derek
- Eichelmann Uwe
- Elbashandy Abdelrahman
- ElKhidir Hatim Abdalla M.
- Eugster Werner
- Ewenz Cacilia M.
- Ewers Brent
- Famulari Daniela
- Fares Silvano
- Feigenwinter Iris
- Feitz Andrew
- Fensholt Rasmus
- Filippa Gianluca
- Fischer Marc
- Frank John
- Galvagno Marta
- Gharun Mana
- Gianelle Damiano
- Gielen Bert
- Gioli Beniamino
- Gitelson Anatoly
- Goded Ignacio
- Goeckede Mathias
- Goldstein Allen H.
- Gough Christopher M.
- Goulden Michael L.
- Graf Alexander
- Griebel Anne
- Gruening Carsten
- Grünwald Thomas
- Hammerle Albin
- Han Shijie
- Han Xingguo
- Hansen Birger Ulf
- Hanson Chad
- Hatakka Juha
- He Yongtao
- Hehn Markus
- Heinesch Bernard
- Hinko-Najera Nina
- Humphrey Marty
- Hutley Lindsay
- Hörtnagl Lukas
- Ibrom Andreas
- Ikawa Hiroki
- Isaac Peter
- Jackowicz-Korczynski Marcin
- Janouš Dalibor
- Jans Wilma
- Jassal Rachhpal
- Jiang Shicheng
- Kato Tomomichi
- Khomik Myroslava
- Klatt Janina
- Knohl Alexander
- Knox Sara
- Kobayashi Hideki
- Koerber Georgia
- Kolle Olaf
- Kosugi Yoshiko
- Kotani Ayumi
- Kowalski Andrew
- Kruijt Bart
- Kurbatova Julia
- Kutsch Werner L.
- Kwon Hyojung
- Launiainen Samuli
- Laurila Tuomas
- Law Bev
- Leuning Ray
- Li Yingnian
- Li Yuelin
- Liddell Michael
- Limousin Jean Marc
- Lion Marryanna
- Liska Adam J.
- Lohila Annalea
- Loubet Benjamin
- Loustau Denis
- Lucas-Moffat Antje
- López-Ballesteros Ana
- López-Blanco Efrén
- Lüers Johannes
- Ma Siyan
- Macfarlane Craig
- Magliulo Vincenzo
- Maier Regine
- Mammarella Ivan
- Manca Giovanni
- Marchesini Luca Belelli
- Marcolla Barbara
- Margolis Hank A.
- Marras Serena
- Massman William
- Mastepanov Mikhail
- Matamala Roser
- Matthes Jaclyn Hatala
- Mazzenga Francesco
- McCaughey Harry
- McHugh Ian
- McMillan Andrew M.S.
- Merbold Lutz
- Meyer Wayne
- Meyers Tilden
- Miller Scott D.
- Minerbi Stefano
- Moderow Uta
- Monson Russell K.
- Montagnani Leonardo
- Moore Caitlin E.
- Moors Eddy
- Moreaux Virginie
- Moureaux Christine
- Munger J. William
- Nakai Taro
- Neirynck Johan
- Nesic Zoran
- Nicolini Giacomo
- Noormets Asko
- Northwood Matthew
- Nosetto Marcelo
- Nouvellon Yann
- Novick Kimberly
- Oechel Walter
- Olesen Jørgen Eivind
- Ourcival Jean Marc
- Papale Dario
- Papuga Shirley A.
- Parmentier Frans Jan
- Pastorello Gilberto
- Paul-Limoges Eugenie
- Pavelka Marian
- Peichl Matthias
- Pendall Elise
- Phillips Richard P.
- Pilegaard Kim
- Pirk Norbert
- Poindexter Cristina
- Polidori Diego
- Posse Gabriela
- Powell Thomas
- Prasse Heiko
- Prober Suzanne M.
- Rambal Serge
- Rannik Ãœllar
- Raz-Yaseef Naama
- Rebmann Corinna
- Reed David
- Reichstein Marcus
- Restrepo-Coupe Natalia
- Reverter Borja R.
- Ribeca Alessio
- Roland Marilyn
- Sabbatini Simone
- Sachs Torsten
- Saleska Scott R.
- Sanchez-Mejia Zulia M.
- Schmid Hans Peter
- Schmidt Marius
- Schneider Karl
- Schrader Frederik
- Schroder Ivan
- Scott Russell L.
- Sedlák Pavel
- Serrano-OrtÃz Penélope
- Shao Changliang
- Shi Peili
- Shironya Ivan
- Siebicke Lukas
- Silberstein Richard
- Sirca Costantino
- Spano Donatella
- Steinbrecher Rainer
- Stevens Robert M.
- Sturtevant Cove
- Suyker Andy
- Sánchez-Cañete Enrique P.
- Tagesson Torbern
- Takanashi Satoru
- Tang Yanhong
- Tapper Nigel
- Thom Jonathan
- Tomassucci Michele
- Torn Margaret
- Trotta Carlo
- Tuovinen Juha Pekka
- Urbanski Shawn
- Valentini Riccardo
- van der Molen Michiel
- van Gorsel Eva
- van Huissteden Ko
- van Ingen Catharine
- Varlagin Andrej
- Verfaillie Joseph
- Vesala Timo
- Vincke Caroline
- Vitale Domenico
- Vuichard Nicolas
- Vygodskaya Natalia
- Walker Jeffrey P.
- Walter-Shea Elizabeth
- Wang Huimin
- Weber Robin
- Westermann Sebastian
- Wille Christian
- Wofsy Steven
- Wohlfahrt Georg
- Wolf Sebastian
- Woodgate William
- Zampedri Roberto
- Zhang Junhui
- Zhang Leiming
- Zhou Guoyi
- Zona Donatella
- Å igut Ladislav
- Publication venue
- Publication date
- 01/01/2020
- Field of study
The FLUXNET2015 dataset provides ecosystem-scale data on CO2, water, and energy exchange between the biosphere and the atmosphere, and other meteorological and biological measurements, from 212 sites around the globe (over 1500 site-years, up to and including year 2014). These sites, independently managed and operated, voluntarily contributed their data to create global datasets. Data were quality controlled and processed using uniform methods, to improve consistency and intercomparability across sites. The dataset is already being used in a number of applications, including ecophysiology studies, remote sensing studies, and development of ecosystem and Earth system models. FLUXNET2015 includes derived-data products, such as gap-filled time series, ecosystem respiration and photosynthetic uptake estimates, estimation of uncertainties, and metadata about the measurements, presented for the first time in this paper. In addition, 206 of these sites are for the first time distributed under a Creative Commons (CC-BY 4.0) license. This paper details this enhanced dataset and the processing methods, now made available as open-source codes, making the dataset more accessible, transparent, and reproducible.Peer reviewe
Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data
- Author
- Agarwal Deb
- Amiro Brian
- Ammann Christof
- Arain M. Altaf
- Ardö Jonas
- Arkebauer Timothy
- Arndt Stefan K.
- Arriga Nicola
- Aubinet Marc
- Aurela Mika
- Baldocchi Dennis
- Barr Alan
- Beamesderfer Eric
- Bergeron Onil
- Beringer Jason
- Bernhofer Christian
- Berveiller Daniel
- Billesbach Dave
- Biraud Sebastien
- Black Thomas Andrew
- Blanken Peter D.
- Bohrer Gil
- Boike Julia
- Bolstad Paul V.
- Bonal Damien
- Bonnefond Jean-Marc
- Bowling David R.
- Bracho Rosvel
- Brodeur Jason
- Brümmer Christian
- Buchmann Nina
- Burban Benoit
- Burns Sean P.
- Buysse Pauline
- Cale Peter
- Canfora Eleonora
- Cavagna Mauro
- Cellier Pierre
- Cheah You-Wei
- Chen Jiquan
- Chen Shiping
- Chini Isaac
- Christensen Torben R.
- Christianson Danielle
- Chu Housen
- Cleverly James
- Collalti Alessio
- Consalvo Claudia
- Cook Bruce D.
- Cook David
- Coursolle Carole
- Cremonese Edoardo
- Curtis Peter S.
- Dai Xiaoqin
- Davis Kenneth J.
- De Cinti Bruno
- De Ligne Anne
- De Oliveira Raimundo C.
- Delpierre Nicolas
- Desai Ankur R.
- Di Bella Carlos Marcelo
- Dios Victor Resco de
- Dolman Han
- Domingo Francisco
- Dong Gang
- Dore Sabina
- Duce Pierpaolo
- Dufrêne Eric
- Dunn Allison
- DuÅ¡ek JiÅ™Ã
- D’Andrea Ettore
- Eamus Derek
- Eichelmann Uwe
- Elbashandy Abdelrahman
- ElKhidir Hatim Abdalla M.
- Eugster Werner
- Ewenz Cacilia M.
- Ewers Brent
- Famulari Daniela
- Fares Silvano
- Feigenwinter Iris
- Feitz Andrew
- Fensholt Rasmus
- Filippa Gianluca
- Fischer Marc
- Frank John
- Galvagno Marta
- Gharun Mana
- Gianelle Damiano
- Gielen Bert
- Gioli Beniamino
- Gitelson Anatoly
- Goded Ignacio
- Goeckede Mathias
- Goldstein Allen H.
- Gorsel Eva van
- Gough Christopher M.
- Goulden Michael L.
- Graf Alexander
- Grandcourt Agnes de
- Griebel Anne
- Gruening Carsten
- Grünwald Thomas
- Hammerle Albin
- Han Shijie
- Han Xingguo
- Hansen Birger Ulf
- Hanson Chad
- Hatakka Juha
- He Yongtao
- Hehn Markus
- Heinesch Bernard
- Hinko-Najera Nina
- Huissteden Ko van
- Humphrey Marty
- Hutley Lindsay
- Hörtnagl Lukas
- Ibrom Andreas
- Ikawa Hiroki
- Ingen Catharine van
- Isaac Peter
- Jackowicz-Korczynski Marcin
- Janouš Dalibor
- Jans Wilma
- Jassal Rachhpal
- Jiang Shicheng
- Kato Tomomichi
- Khomik Myroslava
- Klatt Janina
- Knohl Alexander
- Knox Sara
- Kobayashi Hideki
- Koerber Georgia
- Kolle Olaf
- Kosugi Yoshiko
- Kotani Ayumi
- Kowalski Andrew
- Kruijt Bart
- Kurbatova Julia
- Kutsch Werner L.
- Kwon Hyojung
- Launiainen Samuli
- Laurila Tuomas
- Law Bev
- Leuning Ray
- Li Yingnian
- Li Yuelin
- Liddell Michael
- Limousin Jean-Marc
- Lion Marryanna
- Liska Adam J.
- Lohila Annalea
- Loubet Benjamin
- Loustau Denis
- Lucas-Moffat Antje
- López-Ballesteros Ana
- López-Blanco Efrén
- Lüers Johannes
- Ma Siyan
- Macfarlane Craig
- Magliulo Vincenzo
- Maier Regine
- Mammarella Ivan
- Manca Giovanni
- Marchesini Luca Belelli
- Marcolla Barbara
- Margolis Hank A.
- Marras Serena
- Massman William
- Mastepanov Mikhail
- Matamala Roser
- Matthes Jaclyn Hatala
- Mazzenga Francesco
- McCaughey Harry
- McHugh Ian
- McMillan Andrew M. S.
- Merbold Lutz
- Meyer Wayne
- Meyers Tilden
- Miller Scott D.
- Minerbi Stefano
- Moderow Uta
- Molen Michiel van der
- Monson Russell K.
- Montagnani Leonardo
- Moore Caitlin E.
- Moors Eddy
- Moreaux Virginie
- Moureaux Christine
- Munger J. William
- Nakai Taro
- Neirynck Johan
- Nesic Zoran
- Nicolini Giacomo
- Noormets Asko
- Northwood Matthew
- Nosetto Marcelo
- Nouvellon Yann
- Novick Kimberly
- Oechel Walter
- Olesen Jørgen Eivind
- Ourcival Jean-Marc
- Papale Dario
- Papuga Shirley A.
- Parmentier Frans-Jan
- Pastorello Gilberto
- Paul-Limoges Eugenie
- Pavelka Marian
- Peichl Matthias
- Pendall Elise
- Phillips Richard P.
- Pilegaard Kim
- Pirk Norbert
- Poindexter Cristina
- Polidori Diego
- Posse Gabriela
- Powell Thomas
- Prasse Heiko
- Prober Suzanne M.
- Rambal Serge
- Rannik Ãœllar
- Raz-Yaseef Naama
- Rebmann Corinna
- Reed David
- Reichstein Markus
- Restrepo-Coupe Natalia
- Reverter Borja R.
- Ribeca Alessio
- Rocha Humberto da
- Roland Marilyn
- Sabbatini Simone
- Sachs Torsten
- Saleska Scott R.
- Sanchez-Mejia Zulia M.
- Schmid Hans Peter
- Schmidt Marius
- Schneider Karl
- Schrader Frederik
- Schroder Ivan
- Scott Russell L.
- Sedlák Pavel
- Serrano-OrtÃz Penélope
- Shao Changliang
- Shi Peili
- Shironya Ivan
- Siebicke Lukas
- Silberstein Richard
- Sirca Costantino
- Spano Donatella
- Steinbrecher Rainer
- Stevens Robert M.
- Sturtevant Cove
- Suyker Andy
- Sánchez-Cañete Enrique P.
- Tagesson Torbern
- Takanashi Satoru
- Tang Yanhong
- Tapper Nigel
- Thom Jonathan
- Tomassucci Michele
- Tommasi Paul di
- Torn Margaret
- Trotta Carlo
- Tuovinen Juha-Pekka
- Urbanski Shawn
- Valentini Riccardo
- Varlagin Andrej
- Verfaillie Joseph
- Vesala Timo
- Vincke Caroline
- Vitale Domenico
- Vuichard Nicolas
- Vygodskaya Natalia
- Walker Jeffrey P.
- Walter-Shea Elizabeth
- Wang Huimin
- Weber Robin
- Westermann Sebastian
- Wille Christian
- Wofsy Steven
- Wohlfahrt Georg
- Wolf Sebastian
- Woodgate William
- Zampedri Roberto
- Zhang Junhui
- Zhang Leiming
- Zhou Guoyi
- Zona Donatella
- Å igut Ladislav
- Publication venue
- Nature Research
- Publication date
- 27/10/2021
- Field of study
Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET
- Author
- Abel I.
- Afanesyev V.
- Aftanas M.
- Agarici G.
- Aggarwal K.M.
- Aho-Mantila L.
- Ahonen E.
- Aints M.
- Airila M.
- Akers R.
- Alarcon T.
- Albanese R.
- Alexeev A.
- Alfier A.
- Allan P.
- Almaviva S.
- Alonso A.
- Alper B.
- Altmann H.
- Alves D.
- Ambrosino G.
- Amosov V.
- Amwiddowson A.M.Widdowson
- Andersson F.
- Anderssonsund´en E.
- Andreev V.
- Andrew Y.
- Angelone M.
- Anghel A.
- Anghel M.
- Angioni C.
- Apruzzese G.
- Arcis N.
- Arena P.
- Argouarch A.
- Ariola M.
- Armitano A.
- Armstrong R.
- Arnoux G.
- Arshad S.
- Artaserse G.
- Artaud J.F.
- Ash A.
- Asp E.
- Asunta O.
- Atanasiu C.V.
- Athyagaraja A.Thyagaraja
- Atkins G.
- Avotina L.
- Awilson A.Wilson
- Axton M.D.
- Ayres C.
- Baciero A.
- Bailescu V.
- Baiocchi B.
- Baker R.A.
- Balboa I.
- Balden M.
- Balorin N Balshaw C. Balorin N. Balshaw
- Banks J.W.
- Baranov Y.F.
- Barbier D.
- Barlow I.L.
- Barnard M.A.
- Barnsley R.
- Barrena L.
- Barrera L.
- Baruzzo M.
- Basiuk V.
- Bateman G.
- Batistoni P.
- Baumgarten N.
- Baylor L.
- Bazylev B.
- Beaumont P.S.
- Beausang K.
- Bekris N.
- Beldishevski M.
- Bell A.C.
- Belli F.
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- Bellizio T.
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- Publication venue
- 'AIP Publishing'
- Publication date
- 01/01/2014
- Field of study
The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR
Relationship of edge localized mode burst times with divertor flux loop signal phase in JET
- Author
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- Afanesyev V.
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- Publication venue
- 'AIP Publishing'
- Publication date
- 01/01/2014
- Field of study
A phase relationship is identified between sequential edge localized modes (ELMs) occurrence times in a set of H-mode tokamak plasmas to the voltage measured in full flux azimuthal loops in the divertor region. We focus on plasmas in the Joint European Torus where a steady H-mode is sustained over several seconds, during which ELMs are observed in the Be II emission at the divertor. The ELMs analysed arise from intrinsic ELMing, in that there is no deliberate intent to control the ELMing process by external means. We use ELM timings derived from the Be II signal to perform direct time domain analysis of the full flux loop VLD2 and VLD3 signals, which provide a high cadence global measurement proportional to the voltage induced by changes in poloidal magnetic flux. Specifically, we examine how the time interval between pairs of successive ELMs is linked to the time-evolving phase of the full flux loop signals. Each ELM produces a clear early pulse in the full flux loop signals, whose peak time is used to condition our analysis. The arrival time of the following ELM, relative to this pulse, is found to fall into one of two categories: (i) prompt ELMs, which are directly paced by the initial response seen in the flux loop signals; and (ii) all other ELMs, which occur after the initial response of the full flux loop signals has decayed in amplitude. The times at which ELMs in category (ii) occur, relative to the first ELM of the pair, are clustered at times when the instantaneous phase of the full flux loop signal is close to its value at the time of the first ELM
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
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- Abecasis G. R.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Aarno Palotie
- Abdolmajid Hosseini
- Abdulaziz AlMalik
- Abdulraheem Alshareef
- Achille Iolascon
- Adam S. Butterworth
- Afshar Etemadi Aleagha
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ahmadreza Niavarani
- Ahna Girshick
- Aida Fiz-Lopez
- Alba Parra Martınez
- Albandary M. Alowayn
- Albert Tenesa
- Albert V. Smith
- Alessandra Guarnaccia
- Alessandra Renieri
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alex Serra-Llovich
- Alex Soriano
- Alex Stuckey
- Alexander Labkowsky
- Alexander T. Williams
- Alexander W. Charney
- Alexandra Aksentijevich
- Alexandre Belisle
- Ali Amirsavadkouhi
- Ali Sobh
- Alice Donati
- Alicia de Felipe Mimbrera
- Alicia R. Martin
- Alireza Adamsara
- Altaf Ali
- Amal Al Mutairi
- Amin K. Khattab
- Amr M. Yassen
- Amr Samir
- Amy Trankiem
- Anastasia Lucas
- Andre G. Uitterlinden
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Ganna
- Andrea Martın-Nalda
- Andrea Tommasi
- Andres Metspalu
- Andrew Beck
- Andrew P. Boughton
- Anil P. S. Ori
- Ann E. Woolley
- Anna Canaccini
- Anna Carreras
- Anna Dominguez-Mayoral
- Anna L. Guyatt
- Anna M. Planas
- Anna Maria Pinto
- Annarita Giliberti
- Anne E. Justice
- Anne Kallaste
- Anne Marie O’Connell
- Anne Richmond
- Anne Richmond
- Anne-Sophie Sauvage
- Annique Claringbould
- Anoud Albader
- Antonella D’Arminio Monforte
- Antonella Vincenti
- Antonio Di Biagio
- Antonio Perrella Francesco Bianchi
- Anu Tamm
- Anurag Verma
- Archie Campbell
- Archie Campbell
- Arianna Emiliozzi
- Arianna Gabrieli
- Aris Baras
- Arthur Timothy D
- Asher Haug Baltzell
- Ashish Yadav
- Athanasios Kousathanas
- Attia A. S. Mohamed
- Aubrey Annis
- Augusto Rendon
- Avromie Karp
- Bader Alghamdi
- Bahareh Sharififard
- Bandar A. Suliman
- Barbara Rossetti
- Bari Britvan
- Bartlomiej P. Przychodzen
- Beatriz Cortes
- Beatriz Dietl
- Ben M. Brumpton
- Benjamin M. Neale
- Benoit Misset
- Bernard Lambermont
- Bhavi Trivedi
- Binglan Li
- Biswarup Ghosh
- Bjørn Olav Asvold
- Bluma Brenner
- Brett L. Collins
- Brooke Rhead
- Brooke Wolford
- Brooke Wolford
- Brooke Wolford Sebastian Zo¨ llner
- Bruno Frediani
- Carlo Rivolta
- Carlos Domingo
- Carlota Dobano
- Carmelo Piscopo
- Carmen Marciano
- Carolina Medina-Gomez
- Caroline Cusick
- Caroline Hayward
- Caroline Hayward
- Caterina Lo Rizzo
- Catherine A. Ball
- Catherine E. Bee
- Catherine John
- Cathy Voide
- Cesira Nencioni
- Charlotte Guzman
- Chiara Barbieri
- Chiara Batini
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Fawns-Ritchie
- Chloe Fawns-Ritchie
- Chris C. A. Spencer
- Chris Tselios
- Christelle Meuris
- Christian Von Frenckell
- Christine Stevens
- Christine Stevens
- Christopher A. Odhams
- Christopher J. Griffiths
- Christopher J. O’Donnell
- Christopher R. Gignoux
- Christos Polymeropoulos
- Chureerat Phokaew
- Claire Churchhouse
- Claudia Suardi
- Claudio Ferri
- Clive Hoggart
- Cotton Seed
- CRiPSI
- Cristen Willer
- Cristina Mussini
- D'Antonio Matteo
- D'Antonio-Chronowska Agnieszka
- Daiana Aguero
- Dan Mason
- Daniel Auld
- Daniel E. Kaufmann
- Daniel I. Chasman
- Daniel J. Wilson
- Daniel King
- Daniel M. Jordan
- Daniel Rader
- Daniel Rhodes
- Daniela Francisci
- Danielle Henry
- Danilo Tacconi
- Danny Park
- Darin Adra
- Dave J. Carey
- David A. van Heel
- David Bennett
- David Bernardo
- David Dalmau
- David H. Wyllie
- David J. Porteous
- David J. Porteous
- David R. Morrison
- David Torrents
- Davide Grassi
- Davide Romani
- Deema AlZahrani
- Derrick W. Crook
- Dhryata Kamdar
- Diana Alaverdian
- Diego Ripamonti
- Dionysios Neofytos
- Doaa Shahin
- Domenico A. Coviello
- Dona Baraka
- Donatella Acquilini
- Dorota Pasko
- Douglas M. Shaw
- Duncan Emma
- Duncan S. Palmer
- Ebrahim S. Mahmoud
- Ebtehal Alsolm
- Eco (E. J. C. ) de geus
- Edoardo Conticini
- Edward J. Hollox
- Edward Laane
- Eimear E. Kenny
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elena Jimenez-Xarrie
- Elena Muino
- Eliecer Coto
- Elisa Arribas
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Elizabeth G. Atkinson
- Elizabeth W. Karlson
- Eman Barhoush
- Emanuele Catena
- Emanuele Di Angelantonio
- Emma F. Perez
- Emma L. Adams
- Ene Reimann
- Enrico Martinelli
- Eric E. Schadt
- Erik Solligard
- Erwin Schurr
- Esteban Lopera
- Esther Gonzalez-Villa
- Eugenia Quiros-Roldan
- Eurie L. Hong
- F. Kyle Satterstrom
- Fabio Lena
- Faisal Almalki
- Fatimah Alqubaishi
- Fawz Al Harthi
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- FHoGID RegCOVID
- Filippo Aucella
- Filippo Biscarini
- FinnGen
- Floriana Valentino
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Paciosi
- Francesco Paciosi
- Francesco Raimondi
- Francesco Vladimiro Segala
- Francisca Ruiz-Jaen
- Francisco Lozano
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- Miklos Lipcsey
- Milos Pavlovic
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- Mohamed R. El-shanshory
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- Mohamed S. Torky
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- Shea J. Andrews
- Shea J. Andrews
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- Silvia Rojo
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- Souad Rahmouni
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- Ste´ phanie Gofflot
- Stuart C. Sealfon
- Susan Walker
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- Susanna Guerrini
- Tala Abdullah
- Tamer A. Elhadidy
- Tess Levy
- Thanyawee Puthanakit
- Thitima B. Suttichet
- Tim D. Spector
- Tiziana Bachetti
- Tom Fowler
- Tomas Segura
- Tomislav Maricic
- Tomoko Nakanishi
- Tomoko Nakanishi
- Tonu Esko
- Tooraj Mirshahi
- Tormod Rogne
- Triin Laisk
- Tullio Trotta
- Valentina Anemoli
- Vasilios Polymeropoulos
- Veronica Rico
- Veronica Robles
- Ve´ronique Erard
- Victor Moreno
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Forgetta
- Voraphoj Nilaratanakul
- Vorasuk Shotelersuk
- Walaa A. Felemban
- Walaa M. El-Lawaty
- Walid T. Khafaga
- Wanna Chetruengchai
- Watsamon Jantarabenjakul
- Wei Zhou
- Wei Zhou
- Wenhan Lu
- Werner Albrich
- Xavier Farre
- Xiao Chang
- Xiao Chang
- Xiaoqing Xue
- Xueyang Wang
- Yan V. Sun
- Yaseen M. Arabi
- Yasmine Belhaj
- Yasser M. El-Sherbiny
- Yen-Chen Anne Feng
- Yuk-Lam Ho
- Yuki Bradford
- Yunsung Lee
- Yuval Itan
- Yves Beguin
- Zaman Afrasiabi
- Zeinab Naderpour
- Zhu Wanying
- Ziab Z. Alahmadey
- Øyvind Helgeland
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
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- B Johnston
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- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
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- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
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- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
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- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
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- Danilo Tacconi
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- Domenico A Coviello
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- E Dooks
- E Fisher
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- E Lee
- E London
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- E Massey
- E McKenna
- E Meadows
- E Moncur
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- E Watson
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- Elisabetta Schiaroli
- Ellie Mcmaster
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- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
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- Ewen M Harrison
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- Federico Anedda
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- Ferdinando Giannattasio
- Filip Taneski
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- Gabriella Coiro
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- Samreen Ijaz
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- Sandro Panese
- Sara Amitrano
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- Saye Khoo
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- Serafina Valente
- Serena Ludovisi
- Sergio Daga
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- Shen Xia
- Shih Barbara
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- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
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- T Coventry
- T Duncan
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- T O Jones
- T Pogreban
- T Rees
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- T Smith
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- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
- Adams C.
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- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Agüero D.
- Ahmad N.
- Ahmadi S.
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- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich A.
- Al Harthi F.
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- Al-Afghani H.
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- Alaamery M.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
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