Ephemeris Updates for Seven Selected HATNet Survey Transiting Exoplanets

We refined the ephemeris of seven transiting exoplanets HAT-P-6b, HAT-P-12b, HAT-P-18b, HAT-P-22b, HAT-P-32b, HAT-P-33b, and HAT-P-52b. We observed 11 transits from eight observatories in different filters for HAT-P-6b and HAT-P-32b. Also, the Exoplanet Transit Database (ETD) observations for each of the seven exoplanets were analyzed, and the light curves of five systems were studied using Transiting light Exoplanet Survey Satellite (TESS) data. We used Exofast-v1 to simulate these ground- and space-based light curves and estimate mid-transit times. We obtained a total of 11, 175 and 67 mid-transit times for these seven exoplanets from our observations, ETD and TESS data, respectively, along with 155 mid-transit times from the literature. Then, we generated transit timing variation (TTV) diagrams for each using derived mid-transit times as well as those found in the literature. The systems' linear ephemeris was then refined and improved using the Markov Chain Monte Carlo (MCMC) method. All of the studied exoplanets, with the exception of the HAT-P-12b system, displayed an increasing trend in the orbital period in the TTV diagrams.Comment: 11 Pages, submitted to the Astrophysics journa

Study of the plutino object (208996) 2003 AZ84 from stellar occultations: size, shape and topographic features

We present results derived from four stellar occultations by the plutino object (208996) 2003~AZ$_{84}$, detected at January 8, 2011 (single-chord event), February 3, 2012 (multi-chord), December 2, 2013 (single-chord) and November 15, 2014 (multi-chord). Our observations rule out an oblate spheroid solution for 2003~AZ$_{84}$'s shape. Instead, assuming hydrostatic equilibrium, we find that a Jacobi triaxial solution with semi axes $(470 \pm 20) \times (383 \pm 10) \times (245 \pm 8)$~km % axis ratios $b/a= 0.82 \pm 0.05$ and $c/a= 0.52 \pm 0.02$, can better account for all our occultation observations. Combining these dimensions with the rotation period of the body (6.75~h) and the amplitude of its rotation light curve, we derive a density $\rho=0.87 \pm 0.01$~g~cm$^{-3}$ a geometric albedo $p_V= 0.097 \pm 0.009$. A grazing chord observed during the 2014 occultation reveals a topographic feature along 2003~AZ$_{84}$'s limb, that can be interpreted as an abrupt chasm of width $\sim 23$~km and depth $> 8$~km or a smooth depression of width $\sim 80$~km and depth $\sim 13$~km (or an intermediate feature between those two extremes)

Asteroids' physical models from combined dense and sparse photometry and scaling of the YORP effect by the observed obliquity distribution

The larger number of models of asteroid shapes and their rotational states derived by the lightcurve inversion give us better insight into both the nature of individual objects and the whole asteroid population. With a larger statistical sample we can study the physical properties of asteroid populations, such as main-belt asteroids or individual asteroid families, in more detail. Shape models can also be used in combination with other types of observational data (IR, adaptive optics images, stellar occultations), e.g., to determine sizes and thermal properties. We use all available photometric data of asteroids to derive their physical models by the lightcurve inversion method and compare the observed pole latitude distributions of all asteroids with known convex shape models with the simulated pole latitude distributions. We used classical dense photometric lightcurves from several sources and sparse-in-time photometry from the U.S. Naval Observatory in Flagstaff, Catalina Sky Survey, and La Palma surveys (IAU codes 689, 703, 950) in the lightcurve inversion method to determine asteroid convex models and their rotational states. We also extended a simple dynamical model for the spin evolution of asteroids used in our previous paper. We present 119 new asteroid models derived from combined dense and sparse-in-time photometry. We discuss the reliability of asteroid shape models derived only from Catalina Sky Survey data (IAU code 703) and present 20 such models. By using different values for a scaling parameter cYORP (corresponds to the magnitude of the YORP momentum) in the dynamical model for the spin evolution and by comparing synthetics and observed pole-latitude distributions, we were able to constrain the typical values of the cYORP parameter as between 0.05 and 0.6.Comment: Accepted for publication in A&A, January 15, 201

Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis

Recent evidence indicates that single multiple sclerosis (MS) susceptibility genes involved in interferon (IFN) signaling display altered transcript levels in peripheral blood of untreated MS subjects, suggesting that responsiveness to endogenous IFN is dysregulated during neuroinflammation. To prove this hypothesis we exploited the systematic collection of IFN regulated genes (IRG) provided by the Interferome database and mapped Interferome changes in experimental and human MS. Indeed, central nervous system tissue and encephalitogenic CD4 T cells during experimental autoimmune encephalomyelitis were characterized by massive changes in Interferome transcription. Further, the analysis of almost 500 human blood transcriptomes showed that (i) several IRG changed expression at distinct MS stages with a core of 21 transcripts concordantly dysregulated in all MS forms compared with healthy subjects; (ii) 100 differentially expressed IRG were validated in independent case-control cohorts; and (iii) 53 out of 100 dysregulated IRG were targeted by IFN-beta treatment in vivo. Finally, ex vivo and in vitro experiments established that IFN-beta administration modulated expression of two IRG, ARRB1 and CHP1, in immune cells. Our study confirms the impairment of Interferome in experimental and human MS, and describes IRG signatures at distinct disease stages which can represent novel therapeutic targets in MS

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented

Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain

The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients

Brown bear attacks on humans : a worldwide perspective

The increasing trend of large carnivore attacks on humans not only raises human safety concerns but may also undermine large carnivore conservation efforts. Although rare, attacks by brown bears Ursus arctos are also on the rise and, although several studies have addressed this issue at local scales, information is lacking on a worldwide scale. Here, we investigated brown bear attacks (n = 664) on humans between 2000 and 2015 across most of the range inhabited by the species: North America (n = 183), Europe (n = 291), and East (n = 190). When the attacks occurred, half of the people were engaged in leisure activities and the main scenario was an encounter with a female with cubs. Attacks have increased significantly over time and were more frequent at high bear and low human population densities. There was no significant difference in the number of attacks between continents or between countries with different hunting practices. Understanding global patterns of bear attacks can help reduce dangerous encounters and, consequently, is crucial for informing wildlife managers and the public about appropriate measures to reduce this kind of conflicts in bear country.Peer reviewe

Discovery of a young low-mass brown dwarf transiting a fast-rotating F-type star by the Galactic Plane eXoplanet (GPX) survey

We announce the discovery of GPX-1 b, a transiting brown dwarf with a mass of $19.7\pm 1.6$ $M_{\mathrm{Jup}}$ and a radius of $1.47\pm0.10$ $R_{\mathrm{Jup}}$, the first sub-stellar object discovered by the Galactic Plane eXoplanet (GPX) survey. The brown dwarf transits a moderately bright ($V$ = 12.3 mag) fast-rotating F-type star with a projected rotational velocity $v\sin{ i_*}=40\pm10$ km/s. We use the isochrone placement algorithm to characterize the host star, which has effective temperature $7000\pm200$ K, mass $1.68\pm0.10$ $M_{\mathrm{Sun}}$, radius $1.56\pm0.10$ $R_{\mathrm{Sun}}$ and approximate age $0.27_{-0.15}^{+0.09}$ Gyr. GPX-1 b has an orbital period of $\sim$1.75 d, and a transit depth of $0.90\pm0.03$ %. We describe the GPX transit detection observations, subsequent photometric and speckle-interferometric follow-up observations, and SOPHIE spectroscopic measurements, which allowed us to establish the presence of a sub-stellar object around the host star. GPX-1 was observed at 30-min integrations by TESS in Sector 18, but the data is affected by blending with a 3.4 mag brighter star 42 arcsec away. GPX-1 b is one of about two dozen transiting brown dwarfs known to date, with a mass close to the theoretical brown dwarf/gas giant planet mass transition boundary. Since GPX-1 is a moderately bright and fast-rotating star, it can be followed-up by the means of Doppler tomography.Comment: 13 pages, 13 figures, accepted to MNRAS in May 202

Network structure of vertebrate scavenger assemblages at the global scale: drivers and ecosystem functioning implications

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