Ein contract-net-basiertes Lernverfahren für eine benutzeradaptive Interface-Agentur

Lenzmann B, Wachsmuth I. Ein contract-net-basiertes Lernverfahren für eine benutzeradaptive Interface-Agentur. Forschungsberichte Künstliche Intelligenz. München: TU München; 1996.In diesem Beitrag wird ein agentenorientierter Ansatz zur Adaption an Benutzerpräferenzen vorgestellt. Eine Interface-Agentur – bestehend aus mehreren kommunizierenden und kooperierenden Unteragenturen – adaptiert an unterschiedliche Benutzerpräferenzen durch die Erstellung eines impliziten, in der Agentur verteilten Benutzermodells. Durch Ausnutzung von Benutzer-Feedback organisieren sich Agenten im contract-net-basierten Verhandlungsaustausch mit anderen Agenten so, daß eine dynamische Anpassung an Benutzerpräferenzen gemäß der aktuellen Situation realisiert werden kann

New insights from deep VLA data on the potentially recoiling black hole CID-42 in the COSMOS field

We present deep 3-GHz Karl G. Jansky Very Large Array (VLA) observations of the potentially recoiling black hole CID-42 in the Cosmic Evolution Survey (COSMOS) field. This galaxy shows two optical nuclei in the Hubble Space Telescope/Advanced Camera for Surveys (HST/ACS) image and a large velocity offset of ˜1300 km s-1 between the broad and narrow Hß emission line although the spectrum is not spacially resolved (Civano et al. 2010). The new 3 GHz VLA data have a bandwidth of 2 GHz and to correctly interpret the flux densities imaging was done with two different methods: multiscale multifrequency (MSMF) synthesis and spectral windows (SPWs) stacking. The final resolutions and sensitivities of these maps are 0.7 arcsec with rms = 4.6 µJy beam-1 and 0.9 arcsec with rms = 4.8 µJy beam-1, respectively. With a 7s detection, we find that the entire observed 3-GHz radio emission can be associated with the south-eastern component of CID-42, coincident with the detected X-ray emission. We use our 3 GHz data combined with other radio data from the literature ranging from 320 MHz to 9 GHz, which include the VLA, Very Long Baseline Array (VLBA) and Giant Metrewave Radio Telescope (GMRT) data, to construct a radio synchrotron spectrum of CID-42. The radio spectrum suggests a type I unobscured radio-quiet flat-spectrum active galactic nucleus (AGN) in the south-eastern component which may be surrounded by a more extended region of old synchrotron electron population or shocks generated by the outflow from the supermassive black hole (SMBH). Our data are consistent with the recoiling black hole picture but cannot rule out the presence of an obscured and radio-quiet SMBH in the north-western component

Nanomaterials for Neural Interfaces

This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the electronic properties of nanostructures can be tailored to match the charge transport requirements of electrical cellular interfacing. (ii) The unique mechanical and chemical properties of nanomaterials are critical for integration with neural tissue as long-term implants. (iii) Solutions to many critical problems in neural biology/medicine are limited by the availability of specialized materials. (iv) Neuronal stimulation is needed for a variety of common and severe health problems. This confluence of need, accumulated expertise, and potential impact on the well-being of people suggests the potential of nanomaterials to revolutionize the field of neural interfacing. In this review, we begin with foundational topics, such as the current status of neural electrode (NE) technology, the key challenges facing the practical utilization of NEs, and the potential advantages of nanostructures as components of chronic implants. After that the detailed account of toxicology and biocompatibility of nanomaterials in respect to neural tissues is given. Next, we cover a variety of specific applications of nanoengineered devices, including drug delivery, imaging, topographic patterning, electrode design, nanoscale transistors for high-resolution neural interfacing, and photoactivated interfaces. We also critically evaluate the specific properties of particular nanomaterials—including nanoparticles, nanowires, and carbon nanotubes—that can be taken advantage of in neuroprosthetic devices. The most promising future areas of research and practical device engineering are discussed as a conclusion to the review.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64336/1/3970_ftp.pd

Transmission electron microscopy study of the cell–sensor interface

An emerging number of micro- and nanoelectronics-based biosensors have been developed for non-invasive recordings of physiological cellular activity. The interface between the biological system and the electronic devices strongly influences the signal transfer between these systems. Little is known about the nanoscopic structure of the cell–sensor interface that is essential for a detailed interpretation of the recordings. Therefore, we analysed the interface between the sensor surface and attached cells using transmission electron microscopy (TEM). The maximum possible resolution of our TEM study, however, was restricted by the quality of the interface preparation. Therefore, we complemented our studies with imaging ellipsometry

Is there histomorphological evidence of plantar metatarsal fat pad atrophy in patients with diabetes?

The etiology of diabetic foot ulceration remains incompletely understood. Among other factors such as foot deformity in the presence of neuropathy, plantar fat pad atrophy has been identified as a contributory factor in diabetic foot ulceration. An association between fat pad atrophy and diabetic foot ulceration has been documented by imaging and histomorphological analysis of the calcaneal fat pad. However, histomorphological analysis of the metatarsal fat pad has not been performed to date. The present study entailed 14 patients with diabetes and 14 nondiabetic controls and was aimed at documenting histomorphological evidence for presumed plantar metatarsal fat pad atrophy in patients with diabetes. Histological stains and computer-assisted planimetry were performed on samples of metatarsal fat obtained during forefoot surgery. The histomorphological and planimetric analyses of adipocyte cross-sectional area and nuclear density demonstrated no differences between patients with diabetes and control patients. Our findings demonstrate that systemic atrophy of the metatarsal fat pad is not present in the diabetic foot and may not explain the structural changes previously proposed by noninvasive imaging. Level of Clinical Evidence: 3

Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes

Background: The clinical metrics used to date to assess the progression risk of newly diagnosed prostate cancer patients only partly represent the true biological aggressiveness of the underlying disease. Objective: Validation of the prognostic biomarker phosphodiesterase-4D7 (PDE4D7) in predicting longitudinal biological outcomes in a historical surgery cohort to improve postsurgical risk stratification. Design, patients, and methods: RNA was extracted from biopsy punches of resected tumors from 550 patients. PDE4D7 was quantified using one-step quantitative reverse transcription-polymerase chain reaction. PDE4D7 scores were calculated by normalization of PDE4D7 to reference genes. Multivariate analyses were adjusted for clinical prognostic variables. Outcomes tested were: prostate-specific antigen relapse, start of salvage treatment, progression to metastases, overall mortality, and prostate cancer-specific mortality. The PDE4D7 score was combined with the clinical risk model Cancer of the Prostate Risk Assessment Postsurgical Score (CAPRA-S) using multivariate regression modeling; the combined score was tested in post-treatment progression free survival prediction. Outcome measurements and statistical analysis: Correlations with outcomes were analyzed using multivariate Cox regression and logistic regression statistics. Results and limitations: The PDE4D7 score was significantly associated with time-to-prostate specific antigen failure after prostatectomy (hazard ratio [HR]: 0.53, 95% confidence interval [CI]: 0.41–0.67 for each unit increase, p < 0.0001). After adjustment for postsurgical prognostic variables the HR was 0.56 (95% CI: 0.43–0.73, p < 0.0001). The PDE4D7 score remained significant after adjusting the multi-variate analysis for the CAPRA-S model categories (HR = 0.54, 95% CI = 0.42–0.69, p < 0.0001). Combination of the PDE4D7 score with the CAPRA-S demonstrated a significant incremental value of 4–6% in 2-yr (p = 0.004) or 5-yr (p = 0.003) prediction of progression free survival after surgery. The combined model of PDE4D7 and CAPRA-S improves patient selection with very high risk of fast disease relapse after primary intervention. Conclusions: The PDE4D7 score has the potential to provide independent risk information and to restratify patients with clinical intermediate- to high-risk characteristics to a very low-risk profile