730 research outputs found
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Trends and challenges in neuroengineering: toward "Intelligent" neuroprostheses through brain-"brain inspired systems" communication
Future technologies aiming at restoring and enhancing organs function will intimately rely on near-physiological and energy-efficient communication between living and artificial biomimetic systems. Interfacing brain-inspired devices with the real brain is at the forefront of such emerging field, with the term "neurobiohybrids" indicating all those systems where such interaction is established. We argue that achieving a "high-level" communication and functional synergy between natural and artificial neuronal networks in vivo, will allow the development of a heterogeneous world of neurobiohybrids, which will include "living robots" but will also embrace âintelligentâ neuroprostheses for augmentation of brain function. The societal and economical impact of intelligent neuroprostheses is likely to be potentially strong, as they will offer novel therapeutic perspectives for a number of diseases, and going beyond classical pharmaceutical schemes. However, they will unavoidably raise fundamental ethical questions on the intermingling between man and machine and more specifically, on how deeply it should be allowed that brain processing is affected by implanted "intelligent" artificial systems. Following this perspective, we provide the reader with insights on ongoing developments and trends in the field of neurobiohybrids. We address the topic also from a "community building" perspective, showing through a quantitative bibliographic analysis, how scientists working on the engineering of brain-inspired devices and brain-machine interfaces are increasing their interactions. We foresee that such trend preludes to a formidable technological and scientific revolution in brain-machine communication and to the opening of new avenues for restoring or even augmenting brain function for therapeutic purposes
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Processing and analysis of multichannel extracellular neuronal signals: state-of-the-art and challenges
In recent years multichannel neuronal signal acquisition systems have allowed scientists to focus on research questions which were otherwise impossible. They act as a powerful means to study brain (dys)functions in in-vivo and in in-vitro animal models. Typically, each session of electrophysiological experiments with multichannel data acquisition systems generate large amount of raw data. For example, a 128 channel signal acquisition system with 16 bits A/D conversion and 20 kHz sampling rate will generate approximately 17 GB data per hour (uncompressed). This poses an important and challenging problem of inferring conclusions from the large amounts of acquired data. Thus, automated signal processing and analysis tools are becoming a key component in neuroscience research, facilitating extraction of relevant information from neuronal recordings in a reasonable time. The purpose of this review is to introduce the reader to the current state-of-the-art of open-source packages for (semi)automated processing and analysis of multichannel extracellular neuronal signals (i.e., neuronal spikes, local field potentials, electroencephalogram, etc.), and the existing Neuroinformatics infrastructure for tool and data sharing. The review is concluded by pinpointing some major challenges that are being faced, which include the development of novel benchmarking techniques, cloud-based distributed processing and analysis tools, as well as defining novel means to share and standardize data
The First Italian Farmers: The Role of Stone Ornaments in Tradition, Innovation, and Cultural Change
When the first farmers landed on the eastern coast of the Italian peninsula (end of seventh millennium cal BC), they brought with them a system of knowledge and technologies that quickly spread along both the Tyrrhenian and Adriatic coasts. The study of the material culture, therefore, assumes an important role in understanding the social and cultural identity of these incoming groups. Analyses of ornament productionâââinvolving manufacture technology, raw materials, and stylistic choicesâââmay supply information about the cultural choices and the technical skills of human groups and shed light on the social and symbolic system of these ancient populations. Data obtained from this work show that the ornaments became symbols of a growing cultural identity, which began to be developed within Italian territory. In the ornamental assemblages of the newcomers, the relevance of shaped lithic items is clearly visible, and there was the development of types that will become more and more standardized during the Neolithic period. However, elements in the symbolic culture of these first settlers, such as the use of Columbella rustica and the exclusive production of hard animal matter ornaments in some sites, recall previous traditions. This study intends to extend our knowledge on the ornamental customs of the first Italian Neolithic communities. It will attempt to establish if the chronological and the geographical differences that emerge from our analyses reflect diversities in the cultural and symbolic systems of the incoming farmers and different possible interactions with the native population
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An automated method for characterization of evoked single-trial local field potentials recorded from rat barrel cortex under mechanical whisker stimulation
Rodents explore their surroundings through whisking by localizing objects and detecting textures very precisely. During such tactile exploration, whisker deflection is first mechanically transduced by receptors and then information encoded throughout the somatosensory pathway ending in the somatosensory âbarrelâ cortex. In the barrel cortex, tactile information from a single whisker is segregated and processed in a cortical column corresponding to the deflected whisker. Local Field Potentials (LFPs) generated by whisker deflection in the barrel cortex present typical signatures in terms of shape and amplitude that are related to the activation of the local neuronal populations. Therefore, rigorous analysis of such responses may reveal important features about the function of underlying neuronal microcircuits. In this context, software methods for characterizing single-trial LFPs are needed that are also suitable for online extraction of LFP features and for brainâmachine interfacing applications. In this work, we present an automated and efficient method to analyze evoked LFP responses in the rat barrel cortex through automatic removal of stimulation artifacts, detection of single events and characterization of their relevant parameters. Evoked single-trial LFPs recorded under two different anesthetics are examined to demonstrate the feasibility, accuracy and applicability of the method
Algorithm and software to automatically identify latency and amplitude features of local field potentials recorded in electrophysiological investigation
A function that is called by main_script.m to compute the onset and the maximum latencies and amplitudes from the signal time-derivative. Also the functions that guarantee the correct running of main_script.m. To test the algorithm, invoking only main_script.m is necessary (all the other functions must be contained in the same folder). (M 1ĂÂ kb
A geographically distributed bio-hybrid neural network with memristive plasticity
Throughout evolution the brain has mastered the art of processing real-world
inputs through networks of interlinked spiking neurons. Synapses have emerged
as key elements that, owing to their plasticity, are merging neuron-to-neuron
signalling with memory storage and computation. Electronics has made important
steps in emulating neurons through neuromorphic circuits and synapses with
nanoscale memristors, yet novel applications that interlink them in
heterogeneous bio-inspired and bio-hybrid architectures are just beginning to
materialise. The use of memristive technologies in brain-inspired architectures
for computing or for sensing spiking activity of biological neurons8 are only
recent examples, however interlinking brain and electronic neurons through
plasticity-driven synaptic elements has remained so far in the realm of the
imagination. Here, we demonstrate a bio-hybrid neural network (bNN) where
memristors work as "synaptors" between rat neural circuits and VLSI neurons.
The two fundamental synaptors, from artificial-to-biological (ABsyn) and from
biological-to- artificial (BAsyn), are interconnected over the Internet. The
bNN extends across Europe, collapsing spatial boundaries existing in natural
brain networks and laying the foundations of a new geographically distributed
and evolving architecture: the Internet of Neuro-electronics (IoN).Comment: 16 pages, 10 figure
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SigMate: a MATLAB-based automated tool for extracellular neuronal signal processing and analysis
Rapid advances in neuronal probe technology for multisite recording of brain activity have posed a significant challenge to neuroscientists for processing and analyzing the recorded signals. To be able to infer meaningful conclusions quickly and accurately from large datasets, automated and sophisticated signal processing and analysis tools are required. This paper presents a Matlab-based novel tool, âSigMateâ, incorporating standard methods to analyze spikes and EEG signals, and in-house solutions for local field potentials (LFPs) analysis. Available modules at present are â 1. In-house developed algorithms for: data display (2D and 3D), file operations (file splitting, file concatenation, and file column rearranging), baseline correction, slow stimulus artifact removal, noise characterization and signal quality assessment, current source density (CSD) analysis, latency estimation from LFPs and CSDs, determination of cortical layer activation order using LFPs and CSDs, and single LFP clustering; 2. Existing modules: spike detection, sorting and spike train analysis, and EEG signal analysis. SigMate has the flexibility of analyzing multichannel signals as well as signals from multiple recording sources. The in-house developed tools for LFP analysis have been extensively tested with signals recorded using standard extracellular recording electrode, and planar and implantable multi transistor array (MTA) based neural probes. SigMate will be disseminated shortly to the neuroscience community under the open-source GNU-General Public License
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