Spatio-temporal composition and dynamics of zooplankton in the Kalmar Sound (western Baltic Sea) in 2009-2010

In pelagic food webs, zooplankton is the link between lower and higher trophic levels. It is thus essential to know how the zooplankton community structure varies with its environment. We investigated the seasonal and spatial variation in the zooplankton diversity and community structure during two consecutive years in the Kalmar Sound, along the Swedish east coast, an area with a strong bathymetric gradient and of high ecological importance for e.g. commercial fish species. Two zooplankton communities were identified in the area: a coastal/estuarine community in the south and an open-water community in the north. They were separated mainly by differing salinity and temperature conditions. Biodiversity increased from spring to autumn and was higher in the open waters. © 2014.C. Díaz-Gil, M. Werner, O. Lövgren, O. Kaljuste and M. Casini were partially funded by the Swedish PLAN FISH project, financed by the Swedish Environmental Protection Agency and the Swedish Agency for Marine and Water Management. C. Díaz-Gil was also funded by the EU Erasmus Program for international mobility of studentsPeer Reviewe

Spatio-temporal composition and dynamics of zooplankton in the Kalmar Sound (western Baltic Sea) in 2009–2010

In pelagic food webs, zooplankton is the link between lower and higher trophic levels. It is thus essential to know how the zooplankton community structure varies with its environment. We investigated the seasonal and spatial variation in the zooplankton diversity and community structure during two consecutive years in the Kalmar Sound, along the Swedish east coast, an area with a strong bathymetric gradient and of high ecological importance for e.g. commercial fish species. Two zooplankton communities were identified in the area: a coastal/estuarine community in the south and an open-water community in the north. They were separated mainly by differing salinity and temperature conditions. Biodiversity increased from spring to autumn and was higher in the open waters

Risk and promotive effects in the explanation of persistent serious delinquency in boys

Risk and promotive effects were investigated as predictors of persistent serious delinquency in male participants of the Pittsburgh Youth Study (R. Loeber, D. P. Farrington, M. Stouthamer-Loeber, & W. B. van Kammen, 1998), living in different neighborhoods. Participants were studied over ages 13–19 years for the oldest sample and 7–13 years for the youngest sample. Risk and promotive effects were studied in 6 domains: child behavior, child attitudes, school and leisure activities, peer behaviors, family functioning, and demographics. Regression models improved when promotive effects were included with risk effects in predicting persistent serious delinquency. Disadvantaged neighborhoods, compared with better neighborhoods, had a higher prevalence of risk effects and a lower prevalence of promotive effects. However, predictive relations between risk and promotive effects and persistent serious delinquency were linear and similar across neighborhood socioeconomic status. Although advances have been made in the study of predictors of serious delinquency (Hawkins et al., 1998; Lipsey & Derzon, 1998), little is known about predictors of persistent serious offend-ing, which from a societal point of view is of particular concern. Most youth commit some delinquent acts in childhood or adoles

Research in Monumental Constructions in Antiquity

Ancient civilizations have passed down to us a vast range of monumental structures. Monumentality is a complex phenomenon that we address here as ‘XXL’. It encompasses a large range of different aspects, such as sophisticated technical and logistical skills and the vast economic resources required. This contribution takes a closer look at the special interdependence of space and knowledge represented by such XXL projects. We develop a set of objective criteria for determining whether an object qualifies as ‘XXL’, in order to permit a broadly framed study comparing manifestations of the XXL phenomenon in different cultures and describing the functional and conceptional role of the phenomenon in antiquity. Finally, we illustrate how these criteria are being applied in the study of large construction projects in ancient civilizations through six case studies

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Niraparib in patients with metastatic castration-resistant prostate cancer and DNA repair gene defects (GALAHAD): a multicentre, open-label, phase 2 trial

Background Metastatic castration-resistant prostate cancers are enriched for DNA repair gene defects (DRDs) that can be susceptible to synthetic lethality through inhibition of PARP proteins. We evaluated the anti-tumour activity and safety of the PARP inhibitor niraparib in patients with metastatic castration-resistant prostate cancers and DRDs who progressed on previous treatment with an androgen signalling inhibitor and a taxane. Methods In this multicentre, open-label, single-arm, phase 2 study, patients aged at least 18 years with histologically confirmed metastatic castration-resistant prostate cancer (mixed histology accepted, with the exception of the small cell pure phenotype) and DRDs (assessed in blood, tumour tissue, or saliva), with progression on a previous next-generation androgen signalling inhibitor and a taxane per Response Evaluation Criteria in Solid Tumors 1.1 or Prostate Cancer Working Group 3 criteria and an Eastern Cooperative Oncology Group performance status of 0–2, were eligible. Enrolled patients received niraparib 300 mg orally once daily until treatment discontinuation, death, or study termination. For the final study analysis, all patients who received at least one dose of study drug were included in the safety analysis population; patients with germline pathogenic or somatic biallelic pathogenic alterations in BRCA1 or BRCA2 (BRCA cohort) or biallelic alterations in other prespecified DRDs (non-BRCA cohort) were included in the efficacy analysis population. The primary endpoint was objective response rate in patients with BRCA alterations and measurable disease (measurable BRCA cohort). This study is registered with ClinicalTrials.gov, NCT02854436. Findings Between Sept 28, 2016, and June 26, 2020, 289 patients were enrolled, of whom 182 (63%) had received three or more systemic therapies for prostate cancer. 223 (77%) of 289 patients were included in the overall efficacy analysis population, which included BRCA (n=142) and non-BRCA (n=81) cohorts. At final analysis, with a median follow-up of 10·0 months (IQR 6·6–13·3), the objective response rate in the measurable BRCA cohort (n=76) was 34·2% (95% CI 23·7–46·0). In the safety analysis population, the most common treatment-emergent adverse events of any grade were nausea (169 [58%] of 289), anaemia (156 [54%]), and vomiting (111 [38%]); the most common grade 3 or worse events were haematological (anaemia in 95 [33%] of 289; thrombocytopenia in 47 [16%]; and neutropenia in 28 [10%]). Of 134 (46%) of 289 patients with at least one serious treatment-emergent adverse event, the most common were also haematological (thrombocytopenia in 17 [6%] and anaemia in 13 [4%]). Two adverse events with fatal outcome (one patient with urosepsis in the BRCA cohort and one patient with sepsis in the non-BRCA cohort) were deemed possibly related to niraparib treatment. Interpretation Niraparib is tolerable and shows anti-tumour activity in heavily pretreated patients with metastatic castration-resistant prostate cancer and DRDs, particularly in those with BRCA alterations