Enzyme link Immunosorbent Assay-based Detection of Hepatitis B Virus Infection in Correctional Facilities in Sokoto Metropolis, Sokoto State Nigeria

ELISA-Based detection of HBV infection in correctional facilities in Sokoto metropolis, Sokoto state Nigeria was carried out using a questionnaire survey to determine the associated risk factors of the disease and serological method using [Enzyme link immunosorbent Assay (ELISA)] to determine hepatitis B surface antigen (HBSAg) among inmates. Of the 180 participants from the two correctional facilities in Sokoto state (Sokoto central prison and Remand home) overall prevalence rate of (42.2%) was obtained. The distribution of HBV infection according to age was statistically significant, and the age groups of 21-25 and 36-40 years had the highest prevalence rates (61.3%). However higher prevalence was recorded among males (42.6%) than females (36.4%). Analysis of spatial distribution of prevalence of HBV infection showed that Remand home (juvenile detention centre) had the highest prevalence rate of (75%). It was concluded that hepatitis B virus infection was found to be prevalent in correctional facilities in Sokoto state in which duration of stay and multiple sexual partners were the main risk factors. Furthermore there is need for Nigerian government to establish a policy that would make general screening of all the inmates in correctional facilities for HBV infection and vaccinate them against the disease

Treatment of Schistosomiasis Haematobium with Praziquantel in Children : Its Effect on Educational Performance in Rural Nigeria

Schistosoma haematobium infection is highly endemic in Adim, a rural rice-farming community located within the rain forest of South-eastern Nigeria. With support from Rockefeller Foundation we initiated a treatment programme among the pupils of the only primary school in the community. All children in the school were screened yearly for infection using reagent strips and light microscopy. Infected children were treated with praziquantel (40 mg/kg body weight). To determine the effect of repeated treatment on the educational performance we followed up children (aged 8.0 - 8.9 years) who were in the same school grade through a three-year period. The prevalence of infection in the cohort measured at 12-monthly intervals with a session of treatment in between the screening were 69.1% at the beginning of the programme then 45.2% and 21.6% at the second and third yearly evaluation respectively. The school attendance rate in the cohort decreased from 86.7% at onset of treatment programme to 81.1% by the third yearly evaluation (p=0.24). Standardized, teacher-made educational tests were given to the pupils in between the treatment exercises. The pass rate among the cohort improved following the first treatment session from 81.4% to 90.7%, latter declined to 84.2% following the second treatment session but the net improvement in performance was statistically significant (x^2=7.20; p=0.027). The possibility of enhancement of educational performance as observed in this study should make regular, periodic treatment of children in communities with endemic schistosomiasis a more cost-effective and beneficial public health intervention strategy than was previously assumed

Observed Reductions in Schistosoma mansoni Transmission from Large-Scale Administration of Praziquantel in Uganda: A Mathematical Modelling Study

To date schistosomiasis control programmes based on chemotherapy have largely aimed at controlling morbidity in treated individuals rather than at suppressing transmission. In this study, a mathematical modelling approach was used to estimate reductions in the rate of Schistosoma mansoni reinfection following annual mass drug administration (MDA) with praziquantel in Uganda over four years (2003-2006). In doing this we aim to elucidate the benefits of MDA in reducing community transmission.Age-structured models were fitted to a longitudinal cohort followed up across successive rounds of annual treatment for four years (Baseline: 2003, TREATMENT: 2004-2006; n = 1,764). Instead of modelling contamination, infection and immunity processes separately, these functions were combined in order to estimate a composite force of infection (FOI), i.e., the rate of parasite acquisition by hosts.MDA achieved substantial and statistically significant reductions in the FOI following one round of treatment in areas of low baseline infection intensity, and following two rounds in areas with high and medium intensities. In all areas, the FOI remained suppressed following a third round of treatment.This study represents one of the first attempts to monitor reductions in the FOI within a large-scale MDA schistosomiasis morbidity control programme in sub-Saharan Africa. The results indicate that the Schistosomiasis Control Initiative, as a model for other MDA programmes, is likely exerting a significant ancillary impact on reducing transmission within the community, and may provide health benefits to those who do not receive treatment. The results obtained will have implications for evaluating the cost-effectiveness of schistosomiasis control programmes and the design of monitoring and evaluation approaches in general

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic

Brucellosis as an Emerging Threat in Developing Economies:Lessons from Nigeria

Nigeria is the most populous country in Africa, has a large proportion of the world's poor livestock keepers, and is a hotspot for neglected zoonoses. A review of the 127 accessible publications on brucellosis in Nigeria reveals only scant and fragmented evidence on its spatial and temporal distribution in different epidemiological contexts. The few bacteriological studies conducted demonstrate the existence of Brucella abortus in cattle and sheep, but evidence for B. melitensis in small ruminants is dated and unclear. The bulk of the evidence consists of seroprevalence studies, but test standardization and validation are not always adequately described, and misinterpretations exist with regard to sensitivity and/or specificity and ability to identify the infecting Brucella species. Despite this, early studies suggest that although brucellosis was endemic in extensive nomadic systems, seroprevalence was low, and brucellosis was not perceived as a real burden; recent studies, however, may reflect a changing trend. Concerning human brucellosis, no studies have identified the Brucella species and most reports provide only serological evidence of contact with Brucella in the classical risk groups; some suggest brucellosis misdiagnoses as malaria or other febrile conditions. The investigation of a severe outbreak that occurred in the late 1970s describes the emergence of animal and human disease caused by the settling of previously nomadic populations during the Sahelian drought. There appears to be an increasing risk of re-emergence of brucellosis in sub-Saharan Africa, as a result of the co-existence of pastoralist movements and the increase of intensive management resulting from growing urbanization and food demand. Highly contagious zoonoses like brucellosis pose a threat with far-reaching social and political consequences

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4 (62.3 (55.1�70.8) million) to 6.4 (58.3 (47.6�70.7) million), but is predicted to remain above the World Health Organization�s Global Nutrition Target of <5 in over half of LMICs by 2025. Prevalence of overweight increased from 5.2 (30 (22.8�38.5) million) in 2000 to 6.0 (55.5 (44.8�67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic. © 2020, The Author(s)

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)

An amendment to this paper has been published and can be accessed via a link at the top of the paper. © 2020, The Author(s)

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)

An amendment to this paper has been published and can be accessed via a link at the top of the paper. © 2020, The Author(s)

The relationship between urinary schistosomiasis and the prevailing socio-economic factors of a rural community in Cameroon

The relationship between the transmission of urinary schistosomiasis and the prevailing socio-economic factors was investigated in some villages in Lagdo District of the Republic of Cameroon in 2005. Urine samples obtained from participants in the study were examined microscopically for the presence of eggs of Schistosoma haematobium. Questionnaires were administered to school children to study their perception of the disease, and local socio-economic factors that may stabilize the infection in the community. Schistosoma haematobium was confirmed amongst 39.2% of the study-population. Mixed infecfions of S. mansoni and S. haematobium occurred in only 4.5% of the pupils. Subjects aged 5-9 years were most infected (45.7%). Male subjects (23.5%) were significantly (p < 0.05) more infected than females (15.7%). There was a statistically significant difference in the distribution of urinary schistosomasis from villages studied (p < 0.05). Infection occurred most in Boule Village (70%). The type of water and the location of the village from the lake significantly influenced the rate of acquisition of schistosomiasis (p < 0.05). Children of farmers and fishermen were more infected (82.3%) and (95.2%) respectively than children of civil servants (50%). Children out-of-school were significantly more infected than those in school (p < 0.05). The study support the immediate treatment of subjects in these villages and the investigation of the endemicity of S. mansoni infection in the area. Keywords: urinary schistosomiasis, socio-economic factors, rural community, Cameroon.Nigerian Journal of Parasitology Vol. 29 (1) 2008 pp. 5-1